Therapeutic application of hydrogen sulfide donors: the potential and challenges

NIR light controlled release of caged hydrogen sulfide based on upconversion nanoparticles

(2015) Wansong Chen et al.   CHEMICAL COMMUNICATIONS

Utilizing hydrogen sulfide as a novel anti-cancer agent by targeting cancer glycolysis and pH imbalance

(2014) Z-W Lee et al.   BRITISH JOURNAL OF PHARMACOLOGY

Controllable Hydrogen Sulfide Donors and Their Activity against Myocardial Ischemia-Reperfusion Injury

(2013) Yu Zhao et al.   ACS Chemical Biology

S-Propargyl-Cysteine, a Novel Water-Soluble Modulator of Endogenous Hydrogen Sulfide, Promotes Angiogenesis Through Activation of Signal Transducer and Activator of Transcription 3

(2013) Juntao Kan et al.   ANTIOXIDANTS & REDOX SIGNALING

Selectivity of commonly used pharmacological inhibitors for cystathionine β synthase (CBS) and cystathionine γ lyase (CSE)

(2013) Antonia Asimakopoulou et al.   BRITISH JOURNAL OF PHARMACOLOGY

The hydrogen sulfide donor, GYY4137, exhibits anti-atherosclerotic activity in high fat fed apolipoprotein E−/−mice

(2013) Zhen Liu et al.   BRITISH JOURNAL OF PHARMACOLOGY

H 2 S Protects Against Pressure Overload–Induced Heart Failure via Upregulation of Endothelial Nitric Oxide Synthase

(2013) Kazuhisa Kondo et al.   CIRCULATION

Hydrogen Sulfide Attenuates sFlt1-Induced Hypertension and Renal Damage by Upregulating Vascular Endothelial Growth Factor

(2013) K. M. Holwerda et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Hydrogen sulphide vasodilates human pulmonary arteries: A possible role in pulmonary hypertension?

(2013) Priyadharshanan Ariyaratnam et al.   MICROVASCULAR RESEARCH

Potential therapeutic effects of functionally active compounds isolated from garlic

(2013) Hyung-Mun Yun et al.   PHARMACOLOGY & THERAPEUTICS

Cardioprotective Effects of a Novel Hydrogen Sulfide Agent–Controlled Release Formulation of S-Propargyl-Cysteine on Heart Failure Rats and Molecular Mechanisms

(2013) Chengrong Huang et al.   PLoS One

Biology and therapeutic potential of hydrogen sulfide and hydrogen sulfide-releasing chimeras

(2012) Khosrow Kashfi et al.   BIOCHEMICAL PHARMACOLOGY

Thioglycine and l-thiovaline: Biologically active H2S-donors

(2012) Zongmin Zhou et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Physiological Implications of Hydrogen Sulfide: A Whiff Exploration That Blossomed

(2012) Rui Wang   PHYSIOLOGICAL REVIEWS

NOSH-Aspirin: A Novel Nitric Oxide–Hydrogen Sulfide-Releasing Hybrid: A New Class of Anti-inflammatory Pharmaceuticals

(2012) Ravinder Kodela et al.   ACS Medicinal Chemistry Letters

S-Propargyl-cysteine (SPRC) attenuated lipopolysaccharide-induced inflammatory response in H9c2 cells involved in a hydrogen sulfide-dependent mechanism

(2011) Li-Long Pan et al.   AMINO ACIDS

Hydrogen sulfide-releasing NSAIDs inhibit the growth of human cancer cells: A general property and evidence of a tissue type-independent effect

(2011) Mitali Chattopadhyay et al.   BIOCHEMICAL PHARMACOLOGY

Emerging role of hydrogen sulfide in health and disease: critical appraisal of biomarkers and pharmacological tools

(2011) Matthew Whiteman et al.   CLINICAL SCIENCE

Diallyl trisulfide (DATS) inhibits mouse colon tumor in mouse CT-26 cells allograft model in vivo

(2011) Ping-Ping Wu et al.   PHYTOMEDICINE

The Slow-Releasing Hydrogen Sulfide Donor, GYY4137, Exhibits Novel Anti-Cancer Effects In Vitro and In Vivo

(2011) Zheng Wei Lee et al.   PLoS One

H2S Donor, S-Propargyl-Cysteine, Increases CSE in SGC-7901 and Cancer-Induced Mice: Evidence for a Novel Anti-Cancer Effect of Endogenous H2S?

(2011) Kaium MA et al.   PLoS One

Synthesis and biological evaluation of novel leonurine–SPRC conjugate as cardioprotective agents

(2010) Chunhua Liu et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

S-Propargyl-cysteine, a novel hydrogen sulfide-modulated agent, attenuates lipopolysaccharide-induced spatial learning and memory impairment: Involvement of TNF signaling and NF-κB pathway in rats

(2010) Qi-Hai Gong et al.   BRAIN BEHAVIOR AND IMMUNITY

Detection of exhaled hydrogen sulphide gas in healthy human volunteers during intravenous administration of sodium sulphide

(2010) Christopher F. Toombs et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

Consumption ofS-Allylcysteine Inhibits the Growth of Human Non-Small-Cell Lung Carcinoma in a Mouse Xenograft Model

(2010) Feng-Yao Tang et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Cysteine-Activated Hydrogen Sulfide (H2S) Donors

(2010) Yu Zhao et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Aged garlic extract lowers blood pressure in patients with treated but uncontrolled hypertension: A randomised controlled trial

(2010) Karin Ried et al.   MATURITAS

Hydrogen Sulfide, a Gaseous Transmitter, Stimulates Proliferation of Interstitial Cells of Cajal via Phosphorylation of AKT Protein Kinase

(2010) Ying Huang et al.   TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE

Protective Effects of Cysteine Analogues on Acute Myocardial Ischemia: Novel Modulators of Endogenous H2S Production

(2009) Qian Wang et al.   ANTIOXIDANTS & REDOX SIGNALING

GYY4137, a novel hydrogen sulfide-releasing molecule, protects against endotoxic shock in the rat

(2009) Ling Li et al.   FREE RADICAL BIOLOGY AND MEDICINE

Characterization of a Novel, Water-Soluble Hydrogen Sulfide–Releasing Molecule (GYY4137)

(2008) Ling Li et al.   CIRCULATION

Structural Basis for the Inhibition Mechanism of Human Cystathionine γ-Lyase, an Enzyme Responsible for the Production of H2S

(2008) Qingxiang Sun et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

H2S as a Physiologic Vasorelaxant: Hypertension in Mice with Deletion of Cystathionine  -Lyase

(2008) G. Yang et al.   SCIENCE