The PARP inhibitor olaparib exerts beneficial effects in mice subjected to cecal ligature and puncture and in cells subjected to oxidative stress without impairing DNA integrity: A potential opportunity for repurposing a clinically used oncological drug for the experimental therapy of sepsis

Title

The PARP inhibitor olaparib exerts beneficial effects in mice subjected to cecal ligature and puncture and in cells subjected to oxidative stress without impairing DNA integrity: A potential opportunity for repurposing a clinically used oncological drug for the experimental therapy of sepsis

Authors

Keywords

Sepsis, Shock, Multiorgan dysfunction, DNA, Mitochondria, Cell death, Treg, Th17

Journal

PHARMACOLOGICAL RESEARCH

Volume 145, Issue -, Pages 104263

Publisher

Elsevier BV

Online

2019-05-09

DOI

10.1016/j.phrs.2019.104263