The PARP inhibitor olaparib exerts beneficial effects in mice subjected to cecal ligature and puncture and in cells subjected to oxidative stress without impairing DNA integrity: A potential opportunity for repurposing a clinically used oncological drug for the experimental therapy of sepsis

标题

The PARP inhibitor olaparib exerts beneficial effects in mice subjected to cecal ligature and puncture and in cells subjected to oxidative stress without impairing DNA integrity: A potential opportunity for repurposing a clinically used oncological drug for the experimental therapy of sepsis

作者

关键词

Sepsis, Shock, Multiorgan dysfunction, DNA, Mitochondria, Cell death, Treg, Th17

出版物

PHARMACOLOGICAL RESEARCH

Volume 145, Issue -, Pages 104263

出版商

Elsevier BV

发表日期

2019-05-09

DOI

10.1016/j.phrs.2019.104263