Mitochondria-Targeted Peptide SS31 Attenuates Renal Tubulointerstitial Injury via Inhibiting Mitochondrial Fission in Diabetic Mice

A mitochondrial-targeted peptide ameliorated podocyte apoptosis through a HOCl-alb-enhanced and mitochondria-dependent signalling pathway in diabetic rats and in vitro

(2019) Xiaoqiao Wang et al.   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

Perturbations in mitochondrial dynamics by p66Shc lead to renal tubular oxidative injury in human diabetic nephropathy

(2018) Ming Zhan et al.   CLINICAL SCIENCE

The antioxidant peptide SS31 prevents oxidative stress, downregulates CD36 and improves renal function in diabetic nephropathy

(2018) Yanjuan Hou et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Reactive oxygen species promote tubular injury in diabetic nephropathy: The role of the mitochondrial ros-txnip-nlrp3 biological axis

(2018) Yachun Han et al.   Redox Biology

Combined Therapy with SS31 and Mitochondria Mitigates Myocardial Ischemia-Reperfusion Injury in Rats

(2018) Fan-Yen Lee et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The mitochondrial antioxidant SS-31 increases SIRT1 levels and ameliorates inflammation, oxidative stress and leukocyte-endothelium interactions in type 2 diabetes

(2018) Irene Escribano-Lopez et al.   Scientific Reports

Mitochondrial Fission Is Required for Blue Light-Induced Apoptosis and Mitophagy in Retinal Neuronal R28 Cells

(2018) Jia-Yu Li et al.   Frontiers in Molecular Neuroscience

Mitochondrial energetics in the kidney

(2017) Pallavi Bhargava et al.   Nature Reviews Nephrology

Probucol ameliorates renal injury in diabetic nephropathy by inhibiting the expression of the redox enzyme p66Shc

(2017) Shikun Yang et al.   Redox Biology

The mitochondria-targeted antioxidant MitoQ ameliorated tubular injury mediated by mitophagy in diabetic kidney disease via Nrf2/PINK1

(2017) Li Xiao et al.   Redox Biology

Curcumin prevents mitochondrial dynamics disturbances in early 5/6 nephrectomy: Relation to oxidative stress and mitochondrial bioenergetics

(2016) Omar Emiliano Aparicio-Trejo et al.   BIOFACTORS

Urinary kidney injury molecule-1 and neutrophil gelatinase-associated lipocalin as indicators of tubular damage in normoalbuminuric patients with type 2 diabetes

(2016) José Antonio M. de Carvalho et al.   CLINICAL BIOCHEMISTRY

Kallistatin protects against diabetic nephropathy in  db/db mice by suppressing AGE-RAGE-induced oxidative stress

(2016) Wai Han Yiu et al.   KIDNEY INTERNATIONAL

Sirtuin 3–dependent mitochondrial dynamic improvements protect against acute kidney injury

(2015) Marina Morigi et al.   JOURNAL OF CLINICAL INVESTIGATION

Protective effects of SS31 on t-BHP induced oxidative damage in 661W cells

(2015) WEI MA et al.   Molecular Medicine Reports

Changing epidemiology of type 2 diabetes mellitus and associated chronic kidney disease

(2015) Merlin C. Thomas et al.   Nature Reviews Nephrology

New developments concerning the proximal tubule in diabetic nephropathy:in vitromodels and mechanisms

(2015) Jennifer Slyne et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

The Concept and the Epidemiology of Diabetic Nephropathy Have Changed in Recent Years

(2015) Alberto Martínez-Castelao et al.   Journal of Clinical Medicine

Abnormal mitochondrial fusion–fission balance contributes to the progression of experimental sepsis

(2014) A. S. Gonzalez et al.   FREE RADICAL RESEARCH

Disruption of Renal Tubular Mitochondrial Quality Control by Myo-Inositol Oxygenase in Diabetic Kidney Disease

(2014) M. Zhan et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Mitochondria-Targeted Antioxidant Peptide SS31 Prevents Hypoxia/Reoxygenation-Induced Apoptosis by Down-Regulating p66Shc in Renal Tubular Epithelial Cells

(2013) Wen-Yu Zhao et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Rap1 Ameliorates Renal Tubular Injury in Diabetic Nephropathy

(2013) L. Xiao et al.   DIABETES

Mitochondrial dynamics: regulatory mechanisms and emerging role in renal pathophysiology

(2013) Ming Zhan et al.   KIDNEY INTERNATIONAL

Mitochondria-targeted peptides prevent on contrast-induced acute kidney injury in the rats with hypercholesterolemia

(2013) Shao-Bin Duan et al.   RENAL FAILURE

Mitochondrial Fission Triggered by Hyperglycemia Is Mediated by ROCK1 Activation in Podocytes and Endothelial Cells

(2012) Wenjian Wang et al.   Cell Metabolism

The pathogenic role of the renal proximal tubular cell in diabetic nephropathy

(2012) S. C. W. Tang et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

A Glimpse of Various Pathogenetic Mechanisms of Diabetic Nephropathy

(2011) Yashpal S. Kanwar et al.   Annual Review of Pathology-Mechanisms of Disease

Mitochondria-Targeted Antioxidant Peptides

(2010) Milagros Rocha et al.   CURRENT PHARMACEUTICAL DESIGN