Article
Radiology, Nuclear Medicine & Medical Imaging
Francesca Marturano, Priscilla Guglielmo, Andrea Bettinelli, Fabio Zattoni, Giacomo Novara, Alessandra Zorz, Matteo Sepulcri, Michele Gregianin, Marta Paiusco, Laura Evangelista
Summary: Radiomic analysis can assist in predicting biochemical recurrence in intermediate and high-risk prostate cancer patients. Combining clinical data with radiomic features improves the accuracy of prediction.
EUROPEAN RADIOLOGY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Maarten L. Donswijk, Marceline W. Piek, Zing Cheung, Maurits Wondergem, Marcel P. M. Stokkel, Jan Paul de Boer, Iris M. C. van der Ploeg
Summary: The objective of this study was to investigate the incidences of prostate-specific membrane antigen (PSMA) thyroid incidentaloma (PTI) using different methods to define PTI, to compare the incidence of PTI among different PSMA PET tracers, and to evaluate the clinical consequences of PTI. The results showed that the incidence of PTI varies greatly among different PSMA PET tracers and is strongly dependent on the analysis method applied.
EUROPEAN RADIOLOGY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Hyo Sang Lee, Hyun Woo Kwon, Seok-Byung Lim, Jin Cheon Kim, Chang Sik Yu, Yong Sang Hong, Tae Won Kim, Minyoung Oh, Sangwon Han, Jae Hwan Oh, Sohyun Park, Tae-Sung Kim, Seok-ki Kim, Hyun Joo Kim, Jae Young Kwak, Ho-Suk Oh, Sungeun Kim, Jung-Myun Kwak, Ji Sung Lee, Jae Seung Kim
Summary: This study developed and validated a prognostic model based on FDG metabolic parameters for predicting recurrence after surgery for colorectal cancer liver metastasis. The model showed good discrimination and calibration in external validation, and can be used for accurate risk stratification in patients with synchronous colorectal cancer liver metastasis.
EUROPEAN RADIOLOGY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Yoshiharu Ohno, Masao Yui, Daisuke Takenaka, Takeshi Yoshikawa, Hisanobu Koyama, Yoshimori Kassai, Kaori Yamamoto, Yuka Oshima, Nayu Hamabuchi, Satomu Hanamatsu, Yuki Obama, Takahiro Ueda, Hirotaka Ikeda, Hidekazu Hattori, Kazuhiro Murayama, Hiroshi Toyama
Summary: cDWI with a b-value of 600 sec/mm² may improve the accuracy of lymph node staging in NSCLC patients compared to aDWI, STIR, and PET/CT.
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2023)
Review
Radiology, Nuclear Medicine & Medical Imaging
Masaya Kawaguchi, Hiroki Kato, Yoshifumi Noda, Kazuhiro Kobayashi, Tatsuhiko Miyazaki, Fuminori Hyodo, Masayuki Matsuo
Summary: Accurate preoperative diagnosis is crucial for malignant skin tumors (MSTs) due to the different clinical management required for each histological subtype. Radiological imaging plays a significant role in evaluating the extent of local invasion, nodal involvement, and distant metastasis in MSTs. Recent studies have identified characteristic radiological features that aid in the differential diagnosis of MSTs, such as configuration, intratumoral homogeneity, signal intensity, cyst formation, and hemorrhage. Clinical data, including age, gender, and site of occurrence, are also important for determining the histological subtype of MSTs.
INSIGHTS INTO IMAGING
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Ji Hye Min, Seong Hyun Kim, Jeong Ah Hwang, Seung Hyup Hyun, Sang Yun Ha, Seo-Youn Choi, Seon Woo Kim, Hye Seung Kim
Summary: Both LI-RADS category on MRI and TLR on PET-CT are associated with the postoperative prognosis of PLCs. The prognosis of PLCs classified as LR-M can be further stratified according to the TLR group, but not for the PLCs classified as LR-4/5.
EUROPEAN RADIOLOGY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Virginia Liberini, Michael Messerli, Lars Husmann, Ken Kudura, Hannes Grunig, Alexander Maurer, Stephan Skawran, Erika Orita, Daniele A. Pizzuto, Desiree Deandreis, Reinhard Dummer, Joanna Mangana, Daniela Mihic-Probst, Niels Rupp, Martin W. Huellner
Summary: BSREM detects significantly more ITM than OSEM, with higher SUVmax, higher TBR, and less blurring. BSREM is particularly helpful in small and less avid lesions, which are more often missed with OSEM.
EUROPEAN RADIOLOGY
(2021)
Article
Urology & Nephrology
Dennie Meijer, Hilda A. de Barros, Pim J. van Leeuwen, Yves J. L. Bodar, Henk G. van der Poel, Maarten L. Donswijk, N. Harry Hendrikse, R. Jeroen A. van Moorselaar, Jakko A. Nieuwenhuijzen, Daniela E. Oprea-Lager, Andre N. Vis
Summary: The study aimed to determine whether an extended pelvic lymph node dissection during robot-assisted laparoscopic radical prostatectomy could be omitted in patients with no lymph node metastasis shown in preoperative prostate specific membrane antigen positron emission tomography. Results showed that the negative predictive value of PSMA PET in patients with intermediate risk prostate cancer was higher, indicating a potential to avoid unnecessary extended lymph node dissection in these patients.
JOURNAL OF UROLOGY
(2021)
Article
Oncology
Li Zhang, Yu Liu, Ying Ding, Yinqian Deng, Huanyu Chen, Fan Hu, Jun Fan, Xiaoli Lan, Wei Cao
Summary: This study investigated the predictive value of intratumoral-metabolic heterogeneity (IMH) and conventional metabolic parameters derived from F-18-FDG PET/CT for microsatellite instability (MSI) in patients with stages I-III colorectal carcinoma (CRC). The study found that intratumoral-metabolic heterogeneity was positively correlated with microsatellite instability and could predict the MSI status in CRC patients.
FRONTIERS IN ONCOLOGY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Yu Zhang, Haijing Zhao, Yayi Liu, Manqin Zeng, Jun Zhang, Dapeng Hao
Summary: This study assessed the diagnostic performance of DCE-MRI and 18F-FDG PET/CT parameters in evaluating the biological behavior of soft tissue tumors. The results showed that these parameters can effectively differentiate between benign and malignant tumors as well as high and low-proliferation malignant tumors.
ACADEMIC RADIOLOGY
(2022)
Review
Gastroenterology & Hepatology
Riccardo Inchingolo, Cesare Maino, Roberto Cannella, Federica Vernuccio, Francesco Cortese, Michele Dezio, Antonio Rosario Pisani, Teresa Giandola, Marco Gatti, Valentina Giannini, Davide Ippolito, Riccardo Faletti
Summary: The main therapeutic options for colorectal cancer are surgical resection and adjuvant chemotherapy. Radiomics, the analysis of radiological images using computer-based techniques, is expanding in oncology to understand tumor biology and develop imaging biomarkers. Efforts have been made to develop radiomics signatures for colorectal cancer using computed tomography (CT) and magnetic resonance imaging (MRI) to predict metastasis and assess treatment response. Radiomics has potential as an additional tool in clinical settings, but further studies are needed to assess its performance in stratifying high-risk patients.
WORLD JOURNAL OF GASTROENTEROLOGY
(2023)
Article
Oncology
Keunyoung Kim, In-Joo Kim, Kyoungjune Pak, Taewoo Kang, Young Mi Seol, Young Jin Choi, Hyojeong Kim
Summary: This study evaluated the metabolic activity of the psoas muscle in predicting treatment outcomes for resectable breast cancer. Factors such as N3 stage and SUVRmax > 0.565 were associated with recurrence and disease-free survival. The higher SUVRmax may be a potential independent prognostic factor for recurrence.
Article
Urology & Nephrology
Dennie Meijer, Henk B. Luiting, Pim J. van Leeuwen, Sebastiaan Remmers, Bernard H. E. Jansen, Yves J. L. Bodar, Thelma Witteveen, Eva E. Schaake, Henk G. van der Poel, Maurits Wondergem, Martijn B. Busstra, Jakko A. Nieuwenhuijzen, Philip Meijnen, Tessa Brabander, R. Jeroen A. van Moorselaar, N. Harry Hendrikse, Daniela E. Oprea-Lager, Monique J. Roobol, Andre N. Vis
Summary: Salvage radiation therapy in patients without evidence of metastases on prostate specific membrane antigen positron emission tomography/computerized tomography showed a good overall treatment response of 75%. Predictors of treatment response included lower prostate specific antigen values at initiation of salvage radiation therapy, local recurrent disease on imaging, and lower pathological T stage (pT2 vs pT3a/b).
JOURNAL OF UROLOGY
(2021)
Article
Oncology
Marcus Unterrainer, Christophe M. Deroose, Ken Herrmann, Markus Moehler, Lennart Blomqvist, Roberto Cannella, Caroline Caramella, Damiano Caruso, Manil D. Chouhan, Timm Denecke, Carolina De la Pinta, Lioe-Fee De Geus-Oei, Audrius Dulskas, Michel Eisenblatter, Kieran G. Foley, Sofia Gourtsoyianni, Frederic E. Lecouvet, Egesta Lopci, Monique Maas, Markus M. Obmann, Daniela E. Oprea-Lager, Joost J. C. Verhoeff, Ines Santiago, Sylvain Terraz, Melvin D'Anastasi, Daniele Regge, Andrea Laghi, Regina G. H. Beets-Tan, Volker Heinemann, Florian Lordick, Elizabeth C. Smyth, Jens Ricke, Wolfgang G. Kunz
Summary: This study aimed to establish an imaging protocol for colorectal cancer that promotes standardization and reduces variations. Through the formation of a multidisciplinary panel and the use of the Delphi method, the EORTC-ESOI-ESGAR core imaging protocol was identified.
EUROPEAN JOURNAL OF CANCER
(2022)
Article
Oncology
Young Shin Chung, Yup Kim, Hyun-Soo Kim, Jung-Yun Lee, Won Jun Kang, Sunghoon Kim, Sang Wun Kim
Summary: This study investigated the prognostic value of complete metabolic response (CMR) on F-18-fluorodeoxyglucose positron emission tomography/computed tomography (F-18-FDG-PET/CT) after 3 cycles of neoadjuvant chemotherapy (NAC) in advanced high-grade serous ovarian cancer (HGSC). The results showed that CMR can serve as a prognostic factor for both recurrence and death.
JOURNAL OF GYNECOLOGIC ONCOLOGY
(2022)
Article
Public, Environmental & Occupational Health
Ana Carolina Puin da Silva, Michely Fernandes Vieira, Maristela Pinheiro Freire, Lumena Vaz, Patricia Rodrigues Bonazzi, Karim Yaqub Ibrahim, Maria Del Pilar Esteves Diz, Paulo Marcelo Hoff, Juliana Pereira, Vanderson Geraldo Rocha, Edson Abdala
Summary: This study evaluated the interference of MBI-LCBI criteria on CLABSI incidence density and the proportion of CRBSIs among those classified as MBI. The results showed that 15.0% of CLABSIs were classified as MBI-LCBI, and among these, 19.6% were classified as CRBSIs.
INFECTION CONTROL AND HOSPITAL EPIDEMIOLOGY
(2023)
Article
Oncology
Josep Tabernero, Paulo M. Hoff, Lin Shen, Atsushi Ohtsu, Manish A. Shah, Asna Siddiqui, Sarah Heeson, Astrid Kiermaier, Harrison Macharia, Eleonora Restuccia, Yoon-Koo Kang
Summary: This study aimed to evaluate the long-term efficacy and safety of pertuzumab plus trastuzumab and chemotherapy in previously untreated HER2-positive metastatic gastric or gastroesophageal junction cancer. The results showed increased overall survival and progression-free survival, higher objective response rate, and comparable safety in the pertuzumab arm.
Article
Otorhinolaryngology
Amina Nemmour, Thomas M. Stadler, Alexander Maurer, Zsofia Kovacs, Bettina Serrallach, Diana Born, Constanze M. Nemes, Martina A. Broglie, Shila Pazahr, Niels J. Rupp, Martin W. Huellner, Sandro J. Stoeckli, Gregoire B. Morand
Summary: The aim of this study was to investigate the value of metabolic tumor imaging using hybrid PET for the preoperative detection of extranodal extension (ENE) in lymph node metastases of oropharyngeal squamous cell carcinoma (OPSCC). CT achieved the best specificity, while MRI had the best sensitivity to detect ENE. Nodal metabolic tumor parameters differed significantly between ENE-positive/negative and p16-positive/negative patients. Hence, quantitative data obtained by metabolic imaging might predict the presence of ENE and, therefore, could be helpful in customizing therapy management.
EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY
(2023)
Article
Oncology
Sandra N. Freiberger, David Holzmann, Gregoire B. Morand, Martin Huellner, Mitchell P. Levesque, Reinhard Dummer, Viktor H. Koelzer, Niels J. Rupp
Summary: This study investigates novel biomarkers in mucosal melanoma that predict response to combined ipilimumab and nivolumab immunotherapy. The results suggest that the testis antigens CTAG1B (NY-ESO-1), MAGE-A3, and MAGE-A4 are predominantly expressed in responding tumors, and could potentially be used for future routine diagnostics to predict treatment outcomes.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2023)
Article
Acoustics
Larissa Cristina Berti, Evelyn Alves Spazzapan, Marcelo Queiroz, Pedro Leyton Pereira, Flaviane Romani Fernandes-Svartman, Beatriz Raposo de Medeiros, Marcus Vinicius Moreira Martins, Leticia Santiago Ferreira, Ingrid Gandolfi Gomes da Silva, Ester Cerdeira Sabino, Anna Sara Levin, Marcelo Finger
Summary: This study compares fundamental frequency (f(o)) and fundamental frequency standard deviation (f(o)SD) of COVID-19 patients with the same parameters in the speech of subjects without COVID-19, and investigates the influence of age and sex in the patient group. Results show that patients with COVID-19 exhibit vocal differences in f(o)-related parameters compared to healthy subjects, with higher f(o) and f(o)SD values. Furthermore, there is an age and sex effect on f(o)SD values in the patient group. These findings suggest that f(o)-related parameters can be tested as vocal biomarkers for screening respiratory insufficiency in severe COVID-19 patients.
JOURNAL OF THE ACOUSTICAL SOCIETY OF AMERICA
(2023)
Article
Oncology
Sebastian M. Christ, Philip Heesen, Urs J. Muehlematter, Kaspar Pohl, Gabriel William Thiel, Jonas Willmann, Maiwand Ahmadsei, Tiuri E. Kroese, Michael Mayinger, Panagiotis Balermpas, Andreas Wicki, Nicolaus Andratschke, Martin Huellner, Matthias Guckenberger
Summary: This study aimed to analyze the recognition of and treatment recommendations for oligometastatic patients by multidisciplinary tumor boards (MDTs) in order to better understand current treatment patterns. The results showed that more than half of oligometastatic cases were discussed in MDTs, and the majority received a recommendation including the addition of local therapy. This highlights the importance of multidisciplinary decision-making and the need for standardization in MDT discussions.
CLINICAL AND TRANSLATIONAL RADIATION ONCOLOGY
(2023)
Editorial Material
Radiology, Nuclear Medicine & Medical Imaging
Falko Ensle, Jan A. Schaab, Florentia Dimitriou, Martin W. Huellner, Alexander Maurer
Summary: We report the F-18-FDG PET/CT findings of an internal thoracic vein tumor thrombus in a 76-year-old woman with melanoma. The restaging F-18-FDG PET/CT revealed disease progression with an internal thoracic vein tumor thrombus associated with sternal bone metastasis. Although cutaneous malignant melanoma can metastasize to any organ, direct tumor invasion of veins leading to tumor thrombus formation is an extremely rare complication.
CLINICAL NUCLEAR MEDICINE
(2023)
Correction
Radiology, Nuclear Medicine & Medical Imaging
Abdullah A. Alharbi, Fahad M. Alshehri, Abdulrahman A. Albatly, Bert-Ram Sah, Christoph Schmid, Gerhard F. Huber, Martin W. Huellner
MOLECULAR IMAGING AND BIOLOGY
(2023)
Editorial Material
Oncology
Gregoire B. Morand, Martin W. Huellner
TRANSLATIONAL CANCER RESEARCH
(2023)
Article
Oncology
Lorenzo Bianchi, Paolo Castellucci, Andrea Farolfi, Matteo Droghetti, Carlos Artigas, Jose Leite, Paola Corona, Qaid Ahmed Shagera, Renata Moreira, Christian Gonzalez, Marcelo Queiroz, Felipe de Galiza Barbosa, Riccardo Schiavina, Desiree Deandreis, Stefano Fanti, Francesco Ceci
Summary: This study performed external validation of a nomogram developed to predict the results of 68Ga-labeled prostate-specific membrane antigen-11 positron emission tomography/computed tomography in recurrent prostate cancer patients. The nomogram showed excellent predictive accuracy, and it was found that performing PSMA-PET when the predicted probability is >= 20% can reduce the incidence of false negative scans.
EUROPEAN UROLOGY ONCOLOGY
(2023)
Editorial Material
Radiology, Nuclear Medicine & Medical Imaging
Niklas Lohaus, Jan Schaab, Dominik Schaer, Stefan Balabanov, Martin W. Huellner
Summary: A 77-year-old man presented with symptoms of weight loss and recurrent subfebrile temperatures for 6 months. CT revealed lung infiltrate and despite antibiotic treatment, inflammation markers remained high. The patient developed eczematous skin changes, uveitis, and macrocytic anemia. Further examination with FDG PET/CT showed metabolically active foci in various tissues, and bone marrow aspiration confirmed a UBA1 mutation indicative of VEXAS syndrome.
CLINICAL NUCLEAR MEDICINE
(2023)
Article
Multidisciplinary Sciences
Moritz Schwyzer, Stephan Skawran, Antonio G. Gennari, Stephan L. Waelti, Joan Elias Walter, Alessandra Curioni-Fontecedro, Marlena Hofbauer, Alexander Maurer, Martin W. Huellner, Michael Messerli
Summary: A machine learning classifier was used to evaluate the image quality of maximum intensity projection (MIP) images from F18-FDG-PET scans. 400 MIP images with different acquisition times were created using block sequential regularized expectation maximization (BSREM) algorithm. The machine learning classifier showed comparable performance to manual assessment by experienced radiologists in assessing the image quality of F18-FDG-PET images.
SCIENTIFIC REPORTS
(2023)
Article
Oncology
Matthias Guckenberger, Ricarda Stella Guninski, Martin Hullner, Adrian Kobe, Klaus-D. Schaser, Andreas Wicki
Summary: A large number of cancer patients develop bone metastases, which can lead to oncological and/or surgical emergencies due to symptoms such as pain, loss of function, and neurological symptoms. This paper presents the evidence-based interdisciplinary treatment of bone metastases, highlighting the importance of interdisciplinary collaboration for optimal treatment.
Article
Radiology, Nuclear Medicine & Medical Imaging
Andreas M. Hotker, Urs Muhlematter, Stephan Beintner-Skawran, Soleen Ghafoor, Irene Burger, Martin Huellner, Daniel Eberli, Olivio F. Donati
Summary: The purpose of this study was to compare the accuracy of mpMRI, 68Ga-PSMA PET, and the Briganti 2019 nomogram in predicting metastatic pelvic lymph nodes in prostate cancer. The results showed that the Briganti 2019 nomogram performed better than mpMRI parameters and 68Ga-PSMA PET in predicting PLN metastases, and better than MRI parameters in predicting PSMA PET positive PLN. The addition of parameters from mpMRI improved the accuracy of the Briganti model.
EUROPEAN JOURNAL OF RADIOLOGY OPEN
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Felipe S. S. Furtado, Alvaro Badenes-Romero, Mina Hesami, Leila Mostafavi, Zahra Najmi, Marcelo Queiroz, Amirkasra Mojtahed, Mark A. A. Anderson, Onofrio A. A. Catalano
Summary: This study externally validated an algorithm for non-invasive differentiation of hepatic mucinous cystic neoplasms (MCN) from benign hepatic cysts (BHC). The algorithm showed an accuracy of 98.1%, a positive predictive value of 100.0%, and a negative predictive value of 97.9%. It holds promise as a clinical decision support tool.
ABDOMINAL RADIOLOGY
(2023)