Dietary Methionine Restriction Reduces Inflammation Independent of FGF21 Action

A Dozen Years of Discovery: Insights into the Physiology and Pharmacology of FGF21

(2019) Steven A. Kliewer et al.   Cell Metabolism

Short-term methionine deprivation improves metabolic health via sexually dimorphic, mTORC1-independent mechanisms

(2018) Deyang Yu et al.   FASEB JOURNAL

The Components of Age-Dependent Effects of Dietary Methionine Restriction on Energy Balance in Rats

(2018) Desiree Wanders et al.   Obesity

Fibroblast growth factor 21 increases insulin sensitivity through specific expansion of subcutaneous fat

(2018) Huating Li et al.   Nature Communications

Deficiency of fibroblast growth factor 21 (FGF21) promotes hepatocellular carcinoma (HCC) in mice on a long term obesogenic diet

(2018) Garima Singhal et al.   Molecular Metabolism

Methionine Restriction Extends Lifespan in Progeroid Mice and Alters Lipid and Bile Acid Metabolism

(2018) Clea Bárcena et al.   Cell Reports

Anti-inflammatory effects of exercise training in adipose tissue do not require FGF21

(2017) Jay W Porter et al.   JOURNAL OF ENDOCRINOLOGY

Concentration-dependent linkage of dietary methionine restriction to the components of its metabolic phenotype

(2017) Laura A. Forney et al.   Obesity

Dysregulation of SOCS-Mediated Negative Feedback of Cytokine Signaling in Carcinogenesis and Its Significance in Cancer Treatment

(2017) Mengmeng Jiang et al.   Frontiers in Immunology

Metabolic phenotype and adipose and liver features in a high-fat Western diet-induced mouse model of obesity-linked NAFLD

(2016) Yuwen Luo et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

A Long-Acting FGF21 Molecule, PF-05231023, Decreases Body Weight and Improves Lipid Profile in Non-human Primates and Type 2 Diabetic Subjects

(2016) Saswata Talukdar et al.   Cell Metabolism

FGF21 Lowers Plasma Triglycerides by Accelerating Lipoprotein Catabolism in White and Brown Adipose Tissues

(2016) Christian Schlein et al.   Cell Metabolism

Inflammation in Alcoholic and Nonalcoholic Fatty Liver Disease: Friend or Foe?

(2016) Bin Gao et al.   GASTROENTEROLOGY

Fibroblast growth factor 21 (FGF21) inhibits macrophage-mediated inflammation by activating Nrf2 and suppressing the NF-κB signaling pathway

(2016) Yinhang Yu et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Muscle mitochondrial stress adaptation operates independently of endogenous FGF21 action

(2016) Mario Ost et al.   Molecular Metabolism

Distinct Hepatic Macrophage Populations in Lean and Obese Mice

(2016) Rafael Mayoral Monibas et al.   Frontiers in Endocrinology

Fibroblast Growth Factor 21 (FGF21) Protects against High Fat Diet Induced Inflammation and Islet Hyperplasia in Pancreas

(2016) Garima Singhal et al.   PLoS One

Fibroblast growth factor 21 deficiency exacerbates chronic alcohol-induced hepatic steatosis and injury

(2016) Yanlong Liu et al.   Scientific Reports

High-fat diet induced obesity primes inflammation in adipose tissue prior to liver in C57BL/6j mice

(2015) Roel A van der Heijden et al.   Aging-US

Activated Kupffer cells inhibit insulin sensitivity in obese mice

(2015) Michaela Tencerova et al.   FASEB JOURNAL

Regulation of metabolism by the innate immune system

(2015) Denise E. Lackey et al.   Nature Reviews Endocrinology

Mechanisms of Increased In Vivo Insulin Sensitivity by Dietary Methionine Restriction in Mice

(2014) Kirsten P. Stone et al.   DIABETES

A systems biology analysis of the unique and overlapping transcriptional responses to caloric restriction and dietary methionine restriction in rats

(2014) Sujoy Ghosh et al.   FASEB JOURNAL

Hydrodynamic delivery of FGF21 gene alleviates obesity and fatty liver in mice fed a high-fat diet

(2014) Mingming Gao et al.   JOURNAL OF CONTROLLED RELEASE

Establishment of a General NAFLD Scoring System for Rodent Models and Comparison to Human Liver Pathology

(2014) Wen Liang et al.   PLoS One

STAT3 Target Genes Relevant to Human Cancers

(2014) Richard Carpenter et al.   Cancers

Transcriptional impact of dietary methionine restriction on systemic inflammation: Relevance to biomarkers of metabolic disease during aging

(2013) Desiree Wanders et al.   BIOFACTORS

Cellular Mechanisms by Which FGF21 Improves Insulin Sensitivity in Male Mice

(2013) João Paulo G. Camporez et al.   ENDOCRINOLOGY

The signal transducers Stat1 and Stat3 and their novel target Jmjd3 drive the expression of inflammatory genes in microglia

(2013) Piotr Przanowski et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Inflammation Is Necessary for Long-Term but Not Short-Term High-Fat Diet-Induced Insulin Resistance

(2011) Y. S. Lee et al.   DIABETES

Dietary methionine restriction enhances metabolic flexibility and increases uncoupled respiration in both fed and fasted states

(2010) Barbara E. Hasek et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Adipose Tissue Dysfunction Signals Progression of Hepatic Steatosis Towards Nonalcoholic Steatohepatitis in C57Bl/6 Mice

(2010) C. Duval et al.   DIABETES

Signal Transducer and Activator of Transcription-3, Inflammation, and Cancer

(2009) Bharat B. Aggarwal et al.   Annals of the New York Academy of Sciences

Ablation of CD11c-Positive Cells Normalizes Insulin Sensitivity in Obese Insulin Resistant Animals

(2008) David Patsouris et al.   Cell Metabolism

Fibroblast Growth Factor 21 Reverses Hepatic Steatosis, Increases Energy Expenditure, and Improves Insulin Sensitivity in Diet-Induced Obese Mice

(2008) J. Xu et al.   DIABETES

Fibroblast Growth Factor 21 Corrects Obesity in Mice

(2008) Tamer Coskun et al.   ENDOCRINOLOGY