Chondroitinase improves anatomical and functional outcomes after primate spinal cord injury

Therapeutic efficacy of microtube-embedded chondroitinase ABC in a canine clinical model of spinal cord injury

(2018) Hilary Z Hu et al.   BRAIN

Restorative effects of human neural stem cell grafts on the primate spinal cord

(2018) Ephron S Rosenzweig et al.   NATURE MEDICINE

The Biology of Regeneration Failure and Success After Spinal Cord Injury

(2018) Amanda Phuong Tran et al.   PHYSIOLOGICAL REVIEWS

Points of Significance: Principal component analysis

(2017) Jake Lever et al.   NATURE METHODS

A data-driven approach for evaluating multi-modal therapy in traumatic brain injury

(2017) Jenny Haefeli et al.   Scientific Reports

A Unilateral Cervical Spinal Cord Contusion Injury Model in Non-Human Primates (Macaca mulatta)

(2016) Ernesto A. Salegio et al.   JOURNAL OF NEUROTRAUMA

Progesterone neuroprotection: The background of clinical trial failure

(2016) Michael Schumacher et al.   JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY

Impact of treatment duration and lesion size on effectiveness of chondroitinase treatment post-SCI

(2015) S.E. Mondello et al.   EXPERIMENTAL NEUROLOGY

Chondroitinase gene therapy improves upper limb function following cervical contusion injury

(2015) Nicholas D. James et al.   EXPERIMENTAL NEUROLOGY

Pronounced species divergence in corticospinal tract reorganization and functional recovery after lateralized spinal cord injury favors primates

(2015) Lucia Friedli et al.   Science Translational Medicine

Entrapment via Synaptic-Like Connections between NG2 Proteoglycan+ Cells and Dystrophic Axons in the Lesion Plays a Role in Regeneration Failure after Spinal Cord Injury

(2014) Angela R. Filous et al.   JOURNAL OF NEUROSCIENCE

Modulation of the proteoglycan receptor PTPσ promotes recovery after spinal cord injury

(2014) Bradley T. Lang et al.   NATURE

Perilesional Treatment with Chondroitinase ABC and Motor Training Promote Functional Recovery After Stroke in Rats

(2013) L. Gherardini et al.   CEREBRAL CORTEX

Bringing rigour to translational medicine

(2013) David W. Howells et al.   Nature Reviews Neurology

Derivation of Multivariate Syndromic Outcome Metrics for Consistent Testing across Multiple Models of Cervical Spinal Cord Injury in Rats

(2013) Adam R. Ferguson et al.   PLoS One

The ADAS-Cog revisited: Novel composite scales based on ADAS-Cog to improve efficiency in MCI and early AD trials

(2012) Nandini Raghavan et al.   Alzheimers & Dementia

Delayed treatment with chondroitinase ABC promotes sensorimotor recovery and plasticity after stroke in aged rats

(2012) Sara Soleman et al.   BRAIN

The perineuronal net and the control of CNS plasticity

(2012) Difei Wang et al.   CELL AND TISSUE RESEARCH

Chondroitinase ABC promotes compensatory sprouting of the intact corticospinal tract and recovery of forelimb function following unilateral pyramidotomy in adult mice

(2012) Michelle L. Starkey et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Animal Models of Neurologic Disorders: A Nonhuman Primate Model of Spinal Cord Injury

(2012) Yvette S. Nout et al.   Neurotherapeutics

Intracerebral chondroitinase ABC and heparan sulfate proteoglycan glypican improve outcome from chronic stroke in rats

(2012) J. J. Hill et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Chondroitinase ABC Promotes Recovery of Adaptive Limb Movements and Enhances Axonal Growth Caudal to a Spinal Hemisection

(2011) S. C. Jefferson et al.   JOURNAL OF NEUROSCIENCE

Functional regeneration of respiratory pathways after spinal cord injury

(2011) Warren J. Alilain et al.   NATURE

PTEN deletion enhances the regenerative ability of adult corticospinal neurons

(2010) Kai Liu et al.   NATURE NEUROSCIENCE

Extensive spontaneous plasticity of corticospinal projections after primate spinal cord injury

(2010) Ephron S Rosenzweig et al.   NATURE NEUROSCIENCE

Assessing Spinal Axon Regeneration and Sprouting in Nogo-, MAG-, and OMgp-Deficient Mice

(2010) Jae K. Lee et al.   NEURON

Multivariate evaluation of pharmacological responses in early clinical trials - a study of rIL-21 in the treatment of patients with metastatic melanoma

(2009) Morten Arendt Rasmussen et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

Extensive spinal decussation and bilateral termination of cervical corticospinal projections in rhesus monkeys

(2009) Ephron S. Rosenzweig et al.   JOURNAL OF COMPARATIVE NEUROLOGY

Functional and Anatomical Reorganization of the Sensory-Motor Cortex after Incomplete Spinal Cord Injury in Adult Rats

(2009) A. Ghosh et al.   JOURNAL OF NEUROSCIENCE

Chondroitinase ABC treatment opens a window of opportunity for task-specific rehabilitation

(2009) Guillermo García-Alías et al.   NATURE NEUROSCIENCE

Neuronal activity enhances aryl hydrocarbon receptor-mediated gene expression and dioxin neurotoxicity in cortical neurons

(2008) Chun-Hua Lin et al.   JOURNAL OF NEUROCHEMISTRY

Single, High-Dose Intraspinal Injection of Chondroitinase Reduces Glycosaminoglycans in Injured Spinal Cord and Promotes Corticospinal Axonal Regrowth after Hemisection but Not Contusion

(2008) Tsutomu Iseda et al.   JOURNAL OF NEUROTRAUMA

Neuroprotection for ischemic stroke: Past, present and future

(2008) Myron D. Ginsberg   NEUROPHARMACOLOGY

Therapeutic time window for the application of chondroitinase ABC after spinal cord injury

(2007) Guillermo García-Alías et al.   EXPERIMENTAL NEUROLOGY

Chondroitinase ABC improves basic and skilled locomotion in spinal cord injured cats

(2007) Nicole J. Tester et al.   EXPERIMENTAL NEUROLOGY

CNS injury, glial scars, and inflammation: Inhibitory extracellular matrices and regeneration failure

(2007) Michael T. Fitch et al.   EXPERIMENTAL NEUROLOGY