Article
Endocrinology & Metabolism
Johan Vande Voorde, Rory T. Steven, Arafath K. Najumudeen, Catriona A. Ford, Alex Dexter, Ariadna Gonzalez-Fernandez, Chelsea J. Nikula, Yuchen Xiang, Lauren Ford, Stefania Maneta Stavrakaki, Kathryn Gilroy, Lucas B. Zeiger, Kathryn Pennel, Phimmada Hatthakarnkul, Efstathios A. Elia, Ammar Nasif, Teresa Murta, Eftychios Manoli, Sam Mason, Michael Gillespie, Tamsin R. M. Lannagan, Nikola Vlahov, Rachel A. Ridgway, Colin Nixon, Alexander Raven, Megan Mills, Dimitris Athineos, Georgios Kanellos, Craig Nourse, David M. Gay, Mark Hughes, Amy Burton, Bin Yan, Katherine Sellers, Vincen Wu, Kobe De Ridder, Engy Shokry, Alejandro Huerta Uribe, William Clark, Graeme Clark, Kristina Kirschner, Bernard Thienpont, Vivian S. W. Li, Oliver D. K. Maddocks, Simon T. Barry, Richard J. A. Goodwin, James Kinross, Joanne Edwards, Mariia O. Yuneva, David Sumpton, Zoltan Takats, Andrew D. Campbell, Josephine Bunch, Owen J. Sansom
Summary: In this study, the potential of untargeted metabolomics as a stratification tool for colorectal cancer (CRC) was investigated. The researchers presented a comprehensive pipeline to uncover metabolic vulnerabilities in CRC based on its genetic origin. Perturbations in methionine metabolism linked to APC deficiency were observed, and adenosylhomocysteinase was identified as an actionable therapeutic target.
Review
Biochemistry & Molecular Biology
Caitlin Molczyk, Rakesh K. Singh
Summary: Therapy resistance is a concern in treating malignant disease, as evidence suggests that a subset of cancer cells called cancer stem cells (CSCs) promote tumor survival, therapy resistance, and relapse. The inflammatory tumor microenvironment, particularly the CXCR1/2 pathway, plays a crucial role in maintaining the CSC pool. CXCR1 is known for its role as a CSC marker and potential therapeutic target in solid tumors.
Review
Oncology
Mansi Saxena, Sjoerd H. van der Burg, Cornelis J. M. Melief, Nina Bhardwaj
Summary: Therapeutic cancer vaccines aim to induce tumor regression, eradicate minimal residual disease, establish lasting anti-tumor memory, and avoid non-specific or adverse reactions. However, challenges arise due to tumor-induced immunosuppression and immunoresistance, hindering the achievement of these goals.
NATURE REVIEWS CANCER
(2021)
Review
Chemistry, Multidisciplinary
Wen-Hao Li, Jing-Yun Su, Yan-Mei Li
Summary: Cancer vaccines aim to enhance tumor-specific immune responses by engaging both T-cell and B-cell immunity. Different factors, including antigen selection, immune activation, vaccine delivery, and repeatable vaccination, should be considered for the rational design of therapeutic cancer vaccines. Chemical strategies such as adjuvants and nanomaterials play crucial roles in advancing the development of effective T-cell- and B-cell-based cancer vaccines.
ACCOUNTS OF CHEMICAL RESEARCH
(2022)
Review
Biochemistry & Molecular Biology
Hui Zhao, Tianqi Ming, Shun Tang, Shan Ren, Han Yang, Maolun Liu, Qiu Tao, Haibo Xu
Summary: The Wnt signaling pathway is a complex network involved in embryonic development and cancer, as well as normal physiological processes. It plays a crucial role in cell differentiation and the progression of colorectal cancer.
Article
Oncology
Zhao-liang Yu, Yu-feng Chen, Bin Zheng, Ze-rong Cai, Yi-feng Zou, Jia Ke, Ping Lan, Feng Gao, Xiao-jian
Summary: The study reveals the critical role of TMEM17 in colorectal cancer, showing that TMEM17 depletion can suppress the proliferation of CRC cells and increase sensitivity to chemotherapy drugs. Enrichment analysis indicates that TMEM17 expression is associated with the activation of the Wnt/beta-catenin pathway, and clinical samples show higher TMEM17 expression in tumors is associated with poor survival in CRC patients.
CANCER CELL INTERNATIONAL
(2021)
Review
Cell & Tissue Engineering
Gang Guo, Zhaobang Tan, Yaping Liu, Feiyu Shi, Junjun She
Summary: For the treatment of UC and CRC, MSC-Exo can exert beneficial effects through modulating immune responses and inducing anti-tumor responses via different mechanisms.
STEM CELL RESEARCH & THERAPY
(2022)
Article
Multidisciplinary Sciences
Adam E. Hall, Sebastian Other-Gee Pohl, Patrizia Cammareri, Stuart Aitken, Nicholas T. Younger, Michela Raponi, Caroline V. Billard, Alfonso Bolado Carrancio, Aslihan Bastem, Paz Freile, Fiona Haward, Ian R. Adams, Javier F. Caceres, Paula Preyzner, Alex von Kriegsheim, Malcolm G. Dunlop, Farhat V. Din, Kevin B. Myant
Summary: This study identifies dysregulated RNA splicing as a key driver of tumour cell plasticity in colorectal cancer. The splicing factor SRSF1 controls Kras splicing and maintains stemness in CRC cells, and its expression correlates with cancer stem cell markers in human tumours.
NATURE COMMUNICATIONS
(2022)
Review
Oncology
Muthu Vijai, Mursaleen Baba, Satish Ramalingam, Anand Thiyagaraj
Summary: DCLK1 is a microtubule-associated protein with roles in early neurogenesis and the gastrointestinal tract, as well as implications in various types of cancer. Its underlying molecular mechanisms remain unclear, but potential therapeutic strategies targeting cancer cells are being explored through understanding its interactions with similar proteins.
Review
Pharmacology & Pharmacy
Xuyan Zhou, Haiying Lian, Hongpeng Li, Meiling Fan, Wei Xu, Ye Jin
Summary: Immunotherapy is a promising method for treating cervical cancer, but its clinical application is limited by adverse effects. Nanotechnology offers potential advantages in cervical cancer treatment by enhancing drug delivery, reducing adverse effects, and improving the immune microenvironment.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Medicine, Research & Experimental
Kuei-Yen Tsai, Yu-Jia Chang, Chien-Yu Huang, G. M. Shazzad Hossain Prince, Hsin-An Chen, Precious Takondwa Makondi, Ying-Rou Shen, Po-Li Wei
Summary: This study found that heavily fucosylated glycans (HFGs) are overexpressed in colorectal cancer tissues compared to normal tissues. Treatment with anti-HFG monoclonal antibody showed cytotoxic effects in colorectal cancer cells and inhibited tumor growth in a xenograft mouse model. HFGs could be a potential therapeutic target for colorectal cancer.
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
Review
Pharmacology & Pharmacy
Yaaqub Abiodun Uthman, Kasimu Ghandi Ibrahim, Bilyaminu Abubakar, Muhammad Bashir Bello, Ibrahim Malami, Mustapha Umar Imam, Naeem Qusty, Natalia Cruz-Martins, Gaber El-Saber Batiha, Murtala Bello Abubakar
Summary: In recent years, cancer metastasis research has become a significant topic in the development of anticancer therapies. MALAT1, a non-coding RNA associated with metastatic colorectal cancer, plays a role in tumor cell proliferation, migration, metastasis, and survival.
BIOCHEMICAL PHARMACOLOGY
(2021)
Review
Immunology
Espen Basmo Ellingsen, Sara M. Mangsbo, Eivind Hovig, Gustav Gaudernack
Summary: Telomerase-based therapeutic cancer vaccines have shown potential in clinical research and may enhance the efficacy of checkpoint inhibition. With its almost universal presence in cancer and essential role in tumor growth, telomerase is an attractive therapeutic target. Rational treatment combinations, such as checkpoint inhibitors, are likely necessary to fully unlock the clinical potential of telomerase-based cancer vaccines.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Plant Sciences
Guoliang Dai, Dong Wang, Shitang Ma, Shengwei Hong, Kang Ding, Xiying Tan, Wenzheng Ju
Summary: Emodin inhibits proliferation and invasion of CRC cells by suppressing ACSL4 and reducing VEGF secretion and VEGFR1/VEGFR2 expression, providing a potential therapeutic strategy for CRC.
Article
Cell Biology
Zhenzhen Chen, Jiayi Wu, Benyu Liu, Guangtan Zhang, Zhiwei Wang, Lulu Zhang, Kaili Wang, Zusen Fan, Pingping Zhu
Summary: The study reveals the significant impact of cis-HOX on colorectal tumor-initiating cells, and the high expression of HOXC10 in colorectal tumors and TICs triggers Wnt/b-catenin activation by activating FZD3. The HOXC10 inhibitor salinomycin shows effective therapeutic effects in APC-wild-type colorectal tumors.
Review
Medicine, Research & Experimental
Weizhuo Lu, Zhiwu Chen, Jiyue Wen
Summary: Ischemic stroke is a common and serious disease, and neuroinflammation plays a crucial role in its progression. Microglia, astrocytes, and infiltrating immune cells are involved in the complicated neuroinflammation cascade, releasing different molecules that affect inflammation. Flavonoids, plant-specific compounds, have shown protective effects against cerebral ischemia injury by modulating the inflammatory responses.
BIOMEDICINE & PHARMACOTHERAPY
(2024)