Article
Genetics & Heredity
Le Shi, Tao Liang, Fan Yang, Fang-Fang Zhu, Jin Liu, Jia-Qian Jiang, Xiao-Wei Wu, An-Sheng Chen, Dong-Ping Yuan, Xin-Li Liang
Summary: Gout is an inflammatory arthritis caused by the precipitation of monosodium urate crystals in joints and surrounding tissues. The mechanism underlying the development of gouty arthritis from high levels of uric acid remains unclear. This study found that high levels of uric acid can increase the expression of Matrix Metalloproteinase-3 (MMP-3), leading to proteoglycan degradation and subsequent formation of MSU crystals. Additionally, a low temperature environment is an important factor in the development of gout.
Article
Medicine, Research & Experimental
Deng-Ho Yang, Hsiang-Cheng Chen, James Cheng-Chung Wei
Summary: This study evaluated the effect of early urate-lowering therapy on acute flares of gouty arthritis. The results showed that early aggressive control of hyperuricemia using probenecid plus colchicine led to a rapid decrease in serum uric acid levels, but did not significantly alleviate arthritis pain.
EUROPEAN JOURNAL OF MEDICAL RESEARCH
(2023)
Article
Rheumatology
Dongmei Liu, Binbin Zhou, Zhen Li, Zhuojun Zhang, Xiaojuan Dai, Zongfei Ji, Huiyong Chen, Ying Sun, Lindi Jiang
Summary: This study aimed to compare the effectiveness of benzbromarone and febuxostat in reducing serum urate in gouty patients classified with different types of hyperuricaemia. The results showed that these two drugs had comparable effectiveness. However, benzbromarone was more effective in lowering serum urate in patients with eGFR >= 70 mL/min/1.73 m(2), while febuxostat had a renal protective effect.
CLINICAL RHEUMATOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Fengmao Zou, Xiaofang Li, Rong Yang, Ruowen Zhang, Xu Zhao
Summary: Gouty arthritis, characterized by urate crystal deposition, is increasing globally. Food polyphenols have been found to have anti-inflammatory and antioxidant effects, making them potential treatments for gouty arthritis.
JOURNAL OF FOOD BIOCHEMISTRY
(2022)
Article
Chemistry, Medicinal
Yu Zhang, Xiaohui Tan, Zhen Lin, Fangping Li, Chunyan Yang, Haiying Zheng, Lingyu Li, Huazhong Liu, Jianghua Shang
Summary: The study demonstrated that fucoidan (FPS) effectively inhibits the expression induction of urate transporters URAT1 and GLUT9 induced by uric acid, through repressing the activation of NF-kappa B, JNK, and PI3K/Akt signal pathways.
Article
Agriculture, Multidisciplinary
Bendong Yang, Meiling Xin, Shufei Liang, Yuhong Huang, Jingda Li, Chao Wang, Chao Liu, Xinhua Song, Jinyue Sun, Wenlong Sun
Summary: Naringenin reduces hyperuricemia and renal inflammation by promoting uric acid excretion and attenuating the release of inflammatory cytokines.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2022)
Article
Multidisciplinary Sciences
Ruedee Hemstapat, Peeradon Duangiad, Borwornporn Tangketsarawan, Thitiya Phuagpan, Sinthida Chienwiwattanawong, Nuttinee Tangsrianugul, Akio Ojida, Jirarut Wongkongkatep
Summary: This study investigated methods to improve the sensitivity of polarized light microscopy for detecting gouty crystals. Coating glass slides with poly-L-lysine enhanced crystal attachment and improved crystal images. Selective dissolution using formalin phosphate buffer for MSUM crystals and EDTA for CPPD crystals further enhanced detection sensitivity. These methods were successfully applied to detect gouty crystals in biological samples.
SCIENTIFIC REPORTS
(2023)
Editorial Material
Urology & Nephrology
Federica Piani, Richard J. Johnson
Summary: Gout is common in patients with CKD, and those with kidney dysfunction may have hyperechoic medullas, potentially linked to increased risk of hypertension and kidney dysfunction. More research is needed to validate these findings.
KIDNEY INTERNATIONAL
(2021)
Article
Acoustics
Si-Hui Deng, Wan-Tai Dang, Jian Liu, Yang Bai, Lan-Lan You, Jin Hu, Hui Luo
Summary: This study analyzed multi-joint ultrasound findings of 129 patients with gouty arthritis to differentiate between acute and chronic stages, finding that synovitis was more common in acute joints while bone lesions and tophi were more prevalent in non-acute joints. Thus, multi-joint ultrasound scanning may be useful for assessing disease severity and distinguishing between stages of gouty arthritis.
ULTRASOUND IN MEDICINE AND BIOLOGY
(2021)
Article
Biophysics
Insu Kim, Young Im Kim, Sang Won Lee, Hyo Gi Jung, Gyudo Lee, Dae Sung Yoon
Summary: The study found that the uric acid transporter 1 (URAT1) abundant in kidney cell membranes can be utilized to develop a biosensor capable of selectively detecting uric acid.
BIOSENSORS & BIOELECTRONICS
(2021)
Review
Biochemistry & Molecular Biology
Masayuki Hakoda, Kimiyoshi Ichida
Summary: A genetic defect in URAT1 is the main cause of renal hypouricemia. The prevalence of mutant URAT1 alleles is around 0.1% in Japan and 3% in the general population. Exercise-induced acute kidney injury is more common in individuals with homozygous/compound heterozygous URAT1 mutations.
Article
Nutrition & Dietetics
Yoon-Young Sung, Dong-Seon Kim
Summary: The study found that eggshell membrane (EM) exhibits antihyperuricemic effects by promoting renal urate excretion and regulating renal urate transporters, resulting in reduced serum uric acid levels in hyperuricemic rats.
Article
Medicine, Research & Experimental
Li Dong, Shanhui Zhang, Lina Chen, Jun Lu, Fuhui Zhao, Tiemei Long, Jinlan Wen, Jiayu Huang, Yuanhu Mao, Zhengfang Qi, Jiquan Zhang, Lei Li, Yongxi Dong
Summary: The incidence of hyperuricemia and gout is increasing year by year, particularly among younger individuals. However, the current first-line drugs for hyperuricemia and gouty arthritis have serious side effects that limit their clinical use. Amomum villosum Lour., a traditional medicinal and edible plant in China, has been found to effectively inhibit the activity of xanthine oxidase. This study further explored the mechanism of action and demonstrated that the ethanol extract of Amomum villosum Lour. can treat hyperuricemia by reducing uric acid production and increasing its excretion, while also offering protective effects against hepatic and renal damage. Furthermore, the extract showed potential in relieving inflammation associated with gouty arthritis by reducing the expression of inflammatory cytokines. Thus, the extract should be further studied and developed as a potential medicine, health care product, or dietary supplement for the prevention and treatment of hyperuricemia and gouty arthritis.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Medicine, General & Internal
Tsung-Ju Chuang, Yu-Hsun Wang, James Cheng-Chung Wei, Chih-Jung Yeh
Summary: Long-term use of benzbromarone may reduce the risk of dementia in gout patients, especially with a more pronounced effect in males. Further prospective trials are needed to confirm these findings.
FRONTIERS IN MEDICINE
(2021)
Review
Orthopedics
Ruiting Zhu, Yirou Niu, Wei Zhou, Saikun Wang, Jing Mao, Yingze Guo, Yangyang Lei, Xuance Xiong, Yingzhi Li, Lirong Guo
Summary: This study explored the effects of nanoparticles on gouty arthritis and provided evidence for their preclinical application and ideas for improvement in nanomedicine for researchers. The results showed that nanoparticles were effective in reducing uric acid levels but not better than allopurinol, and they were safer. Various factors contributed to the heterogeneity in the results.
BMC MUSCULOSKELETAL DISORDERS
(2023)