Article
Chemistry, Analytical
Amineh Mashkoori, Ali Mostafavi, Tayebeh Shamspur, Masoud Torkzadeh-Mahani
Summary: In this study, a rapid, sensitive, and simple electrochemical biosensor (H-UOX/Ni-MOF/CPE) for UA detection was constructed by using the affinity between Ni and poly-histidine tags of recombinant urate oxidase and Ni-MOF for enzyme immobilization. The biosensor showed a short response time, linear response within a wide concentration range, and good stability and selectivity for UA detection.
Article
Plant Sciences
Yoon-Young Sung, Heung Joo Yuk, Dong-Seon Kim
Summary: The study showed that SMS-E has anti-hyperuricemic effects by reducing XO activity and regulating renal urate transporters. Additionally, SMS-E also has the ability to reduce renal inflammation and serum IL-1 beta levels.
JOURNAL OF GINSENG RESEARCH
(2021)
Article
Chemistry, Medicinal
Yu Zhang, Xiaohui Tan, Zhen Lin, Fangping Li, Chunyan Yang, Haiying Zheng, Lingyu Li, Huazhong Liu, Jianghua Shang
Summary: The study demonstrated that fucoidan (FPS) effectively inhibits the expression induction of urate transporters URAT1 and GLUT9 induced by uric acid, through repressing the activation of NF-kappa B, JNK, and PI3K/Akt signal pathways.
Article
Medicine, General & Internal
Michael A. Schwarzschild, Alberto Ascherio, Cindy Casaceli, Gary C. Curhan, Rebecca Fitzgerald, Cornelia Kamp, Codrin Lungu, Eric A. Macklin, Kenneth Marek, Dariush Mozaffarian, David Oakes, Alice Rudolph, Ira Shoulson, Aleksandar Videnovic, Burton Scott, Lisa Gauger, Jason Aldred, Melissa Bixby, Jill Ciccarello, Steven A. Gunzler, Claire Henchcliffe, Matthew Brodsky, Kellie Keith, Robert A. Hauser, Christopher Goetz, Mark S. LeDoux, Vanessa Hinson, Rajeev Kumar, Alberto J. Espay, Joohi Jimenez-Shahed, Christine Hunter, Chadwick Christine, Aaron Daley, Maureen Leehey, J. Antonelle de Marcaida, Joseph Harold Friedman, Albert Hung, Grace Bwala, Irene Litvan, David K. Simon, Tanya Simuni, Cynthia Poon, Mya C. Schiess, Kelvin Chou, Ariane Park, Danish Bhatti, Carolyn Peterson, Susan R. Criswell, Liana Rosenthal, Jennifer Durphy, Holly A. Shill, Shyamal H. Mehta, Anwar Ahmed, Andres F. Deik, John Y. Fang, Natividad Stover, Lin Zhang, Richard B. Dewey, Ashley Gerald, James T. Boyd, Emily Houston, Valerie Suski, Sherri Mosovsky, Leslie Cloud, Binit B. Shah, Marie Saint-Hilaire, Raymond James, Sarah Elizabeth Zauber, Stephen Reich, David Shprecher, Rajesh Pahwa, April Langhammer, Kathrin LaFaver, Peter A. LeWitt, Patricia Kaminski, John Goudreau, Doozie Russell, David J. Houghton, Ashley Laroche, Karen Thomas, Martha McGraw, Zoltan Mari, Carmen Serrano, Karen Blindauer, Marcie Rabin, Roger Kurlan, John C. Morgan, Michael Soileau, Melissa Ainslie, Ivan Bodis-Wollner, Ruth B. Schneider, Cheryl Waters, Amber Servi Ratel, Christopher A. Beck, Patrick Bolger, Katherine F. Callahan, Grace F. Crotty, David Klements, Melissa Kostrzebski, Gearoid Michael McMahon, Lindsay Pothier, Sushrut S. Waikar, Anthony Lang, Tiago Mestre
Summary: In this randomized clinical trial, treatment with oral inosine for up to 2 years did not slow the progression of Parkinson disease in early stage patients. The study found that there was no significant difference in clinical disease progression between the inosine group and the placebo group.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
(2021)
Article
Agriculture, Multidisciplinary
Bendong Yang, Meiling Xin, Shufei Liang, Yuhong Huang, Jingda Li, Chao Wang, Chao Liu, Xinhua Song, Jinyue Sun, Wenlong Sun
Summary: Naringenin reduces hyperuricemia and renal inflammation by promoting uric acid excretion and attenuating the release of inflammatory cytokines.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2022)
Article
Environmental Sciences
Barakat M. ALRashdi, Hassan A. Elgebaly, Mousa O. Germoush, Moath M. Qarmush, Mona S. Azab, Reem S. Alruhaimi, Ahmad F. Ahmeda, Mohammad H. Abukhalil, Emadeldin M. Kamel, Hany H. Arab, Mohammed A. Alzoghaibi, Mohammed F. Alotaibi, Ayman M. Mahmoud
Summary: This study investigated the effects of Monolluma quadrangula extract (MQE) on hyperuricemic rats and found that MQE exhibited renoprotective properties by inhibiting xanthine oxidase activity, reducing oxidative stress and inflammation, and modulating urate transporters.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Article
Chemistry, Analytical
Muhammad Idrees Khan, Qiang Zhang, Youli Tian, Shah Saud, Yiren Cao, Jicun Ren, Weiwen Liu, Chengxi Cao
Summary: Researchers have developed a visual and portable method for cholesterol testing in blood samples based on an electrophoresis titration model. The method combines selective enzymatic reaction with electrophoretic titration to quantify cholesterol in blood serum. The experiments validate the feasibility of the method and demonstrate its high selectivity, portability, and visuality.
ANALYTICAL METHODS
(2023)
Review
Biochemistry & Molecular Biology
Masayuki Hakoda, Kimiyoshi Ichida
Summary: A genetic defect in URAT1 is the main cause of renal hypouricemia. The prevalence of mutant URAT1 alleles is around 0.1% in Japan and 3% in the general population. Exercise-induced acute kidney injury is more common in individuals with homozygous/compound heterozygous URAT1 mutations.
Article
Nutrition & Dietetics
Yoon-Young Sung, Dong-Seon Kim
Summary: The study found that eggshell membrane (EM) exhibits antihyperuricemic effects by promoting renal urate excretion and regulating renal urate transporters, resulting in reduced serum uric acid levels in hyperuricemic rats.
Article
Chemistry, Medicinal
Shuxie Wu, Gao Wu, Hong Jiang, Hanbin Wu
Summary: Polydatin exerts an antihyperuricemic effect by modulating the activity of renal urate transporters and xanthine oxidase, thereby protecting the kidneys.
PHARMACOGNOSY MAGAZINE
(2022)
Article
Multidisciplinary Sciences
Yoshiro Tanaka, Tomohisa Nagoshi, Hirotake Takahashi, Yuhei Oi, Rei Yasutake, Akira Yoshii, Haruka Kimura, Yusuke Kashiwagi, Toshikazu D. Tanaka, Masayuki Shimoda, Michihiro Yoshimura
Summary: This study found that selective inhibition of urate transporter-1 (URAT1) can improve cardiac fibrosis, inflammatory responses, and cardiac dysfunction induced by high-fat diet. URAT1 is also expressed in cardiomyocytes. Additionally, palmitic acid significantly increases URAT1 expression and induces apoptosis, oxidative stress, and inflammatory responses in cardiomyocytes, which can be attenuated by URAT1 selective inhibitor dotinurad.
Article
Gastroenterology & Hepatology
Rui Zhao, Zimai Li, Yuqing Sun, Wei Ge, Mingyu Wang, Huaiwei Liu, Luying Xun, Yongzhen Xia
Summary: Hyperuricemia, the second most prevalent metabolic disease, can be effectively treated by introducing recombinant urate-degrading bacteria to enhance intestinal secretion, according to a study.
Review
Medicine, General & Internal
Federica Piani, Arrigo F. G. Cicero, Claudio Borghi
Summary: There is a strong association between high SUA levels and hypertension, but a causal relationship has not been proven. The effectiveness of urate-lowering therapy in the management of hypertension patients varies in clinical trials.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Chemistry, Analytical
Da Chen, Shuaibin Shao, Wei Zhang, Jingbo Zhao, Meiling Lian
Summary: Through doping with thiourea, a new structure composed of nitrogen and sulfur co-doped on the surface of Ti3C2 nanosheets was successfully synthesized, showing excellent biosensing performance, providing a new avenue for the development of electrochemical biosensors.
ANALYTICA CHIMICA ACTA
(2022)
Review
Cardiac & Cardiovascular Systems
Ichiro Hisatome, Peili Li, Junichiro Miake, Fikri Taufiq, Endang Mahati, Nani Maharani, Sulistiyati Bayu Utami, Masanari Kuwabara, Udin Bahrudin, Haruaki Ninomiya
Summary: High uric acid levels can impair endothelial function and are associated with chronic kidney disease and cardiovascular disease. Whether hyperuricemia is causally related to these diseases has been debated. Guidelines from the US and Japan provide different recommendations for treating hyperuricemia, with studies in Japan suggesting certain medications may be effective for treating hyperuricemia patients.
CIRCULATION JOURNAL
(2021)
Article
Chemistry, Analytical
Sang Won Lee, Hyo Gi Jung, Jae Won Jang, Dongsung Park, Dongtak Lee, Insu Kim, Yonghwan Kim, Da Yeon Cheong, Kyo Seon Hwang, Gyudo Lee, Dae Sung Yoon
Summary: Research on manufacturing graphene-based electronic textiles into two-dimensional sheets shows promising results in improved sensing performance, increased sensitivity to hazardous gases, and characteristics of being lighter and thinner. Furthermore, applying this technology to wearable devices can detect toxic environmental gases and monitor health through exhalation.
SENSORS AND ACTUATORS B-CHEMICAL
(2021)
Article
Chemistry, Analytical
Jae Won Jang, Hyunji Kim, Insu Kim, Sang Won Lee, Hyo Gi Jung, Kyo Seon Hwang, Jeong Hoon Lee, Gyudo Lee, Dongtak Lee, Dae Sung Yoon
Summary: In this study, we improved the selectivity and stability of colorimetric glucose sensors by adding erythrocyte membrane. The detection limit of the sensors was enhanced by functionalizing glucose-oxidase-coronated gold nanoparticles with erythrocyte membrane. The membrane proteins GLUT1 and AQP1 on the erythrocyte membrane were shown to be key components for selective glucose detection.
ANALYTICAL CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Da Yeon Cheong, Wonseok Lee, Insu Park, Jinsung Park, Gyudo Lee
Summary: In this study, the nucleation and formation process of lysozyme amyloid fibrils were observed using a microfluidic system. It was found that the lag phase of amyloid nucleation and growth can be reduced by using smaller droplet volumes. Furthermore, a peculiar phenomenon of high amyloid formation at the edge of droplets was discovered, and it was observed that fibrils synthesized in nanoliter droplets are shorter and thicker compared to those synthesized via conventional heating method.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Chemistry, Physical
Hyunjun Park, Joohyung Park, Gyudo Lee, Woong Kim, Jinsung Park
Summary: Chlorpyrifos is an organophosphorus insecticide that is harmful to both humans and livestock due to its developmental neurotoxicity and genotoxicity. A study found that Ag-NG fabricated from natural lawns can serve as a SERS platform for the sensitive detection of CPF, enhancing its detection efficiency.
Article
Chemistry, Multidisciplinary
Woong Kim, Wonseok Lee, Hyunjun Park, Joohyung Park, Woochang Kim, Byungjeon Kang, Eunpyo Choi, Chang-Sei Kim, Jong-Oh Park, Gyudo Lee, Doyeon Bang, Jinsung Park
Summary: In this study, a biomimetic nano-pine-pollen nanostructure (NPP-NS)-based SERS sensing platform was developed for the hypersensitive detection of toxicants. The NPP-NS showed effective SERS performance with high stability, and was capable of detecting various toxicants in drinking water and human plasma samples.
ACS SUSTAINABLE CHEMISTRY & ENGINEERING
(2022)
Article
Chemistry, Multidisciplinary
Taeha Lee, Changheon Kim, Jiyeon Kim, Jung Bae Seong, Youngjeon Lee, Seokbeom Roh, Da Yeon Cheong, Wonseok Lee, Jinsung Park, Yoochan Hong, Gyudo Lee
Summary: This study demonstrates a hydrogel complex containing polyaniline nanoparticles, which can be used as a pH sensor and for cancer cell metabolite detection. The complex exhibits rapid chemical reactions and stability, showing potential as a disposable patch-type wearable biosensing platform.
Article
Chemistry, Analytical
Hyun Jung Kim, Insu Park, Seung Pil Pack, Gyudo Lee, Yoochan Hong
Summary: This study successfully developed a polyaniline-based single-sensor platform for sensing lactate in human sweat using a CIELAB color system-based colorimetric device. The platform offers shorter detection time, sensitivity, and portability, and can measure lactate concentration.
Article
Medicine, General & Internal
Byoungjun Jeon, Hyo Gi Jung, Sang Won Lee, Gyudo Lee, Jung Hee Shim, Mi Ok Kim, Byung Jun Kim, Sang-Hyon Kim, Hyungbeen Lee, Sang Woo Lee, Dae Sung Yoon, Seong Jin Jo, Tae Hyun Choi, Wonseok Lee
Summary: Melanoma and benign nevus exhibit significant differences in local elastic properties, with multimodal Gaussian distributions observed in the melanoma's elastic modulus histograms and increased non-linearity in force-distance curves. Atomic force microscopy indentation of histological specimens may complement conventional histopathological analysis and enable earlier and more precise detection of melanoma.
Article
Chemistry, Physical
Taeha Lee, Woong Kim, Jinsung Park, Gyudo Lee
Summary: In this study, a label-free method for antibody detection using microcantilever-based nanomechanical resonators functionalized with erythrocyte membrane (EM) was proposed. The method focuses on the phenomenon of antibody binding to oligosaccharides on the surface of erythrocytes and demonstrated excellent selectivity. This method can be applied in criminal investigations to identify blood types or evaluate individual immunity.
Article
Chemistry, Multidisciplinary
Yeonjin Kim, Taeha Lee, Minsu Kim, Soojin Park, Jiashu Hu, Kyungwon Lee, Yoochan Hong, Insu Park, Gyudo Lee
Summary: A fast responsive colorimetric hydrogel called FACH was developed for real-time pH monitoring. FACH exhibits fast color change performance, high reactivity, and penetrability to ambient pH changes. It also shows reversibility and repeatability, making it a sustainable pH monitoring platform.
Article
Chemistry, Multidisciplinary
Seokbeom Roh, Taeha Lee, Da Yeon Cheong, Yeonjin Kim, Soohwan Oh, Gyudo Lee
Summary: In this study, the surface charge and stiffness of metaphase chromosomes were measured using atomic force microscopy. The results showed that the chromosomes were positively charged and had uniform stiffness when covered with extra materials, but became strongly negatively charged and showed non-uniform and augmented stiffness after removing the extra materials. This study provides new insights into the structure and analysis of chromosomes.
NANOSCALE ADVANCES
(2023)
Article
Biophysics
Ki Sung Park, Anna Choi, Hyun Jung Kim, Insu Park, Mi-Suk Eom, Sang-Gu Yeo, Ryeo Gang Son, Tae-In Park, Gyudo Lee, Hyongsok Tom Soh, Yoochan Hong, Seung Pil Pack
Summary: COVID-19, caused by SARS-CoV-2, has led to a global pandemic and significant economic and social disruptions. To control the virus spread, a rapid, accurate, and easy-to-use diagnostic platform for detecting SARS-CoV-2 variants of concern is necessary. Researchers developed an ultra-sensitive label-free aptasensor based on surface-enhanced Raman scattering, which successfully detected SARS-CoV-2, including the wild-type, Delta, and Omicron variants.
BIOSENSORS & BIOELECTRONICS
(2023)
Article
Chemistry, Multidisciplinary
Taeha Lee, Dain Kang, Minsu Kim, Sukyung Choi, Da Yeon Cheong, Seokbeom Roh, Seung Hyeon Oh, Insu Park, Gyudo Lee
Summary: This study introduces a method to control the movement of P. polycephalum by drawing hydrophobic lines and patterns, demonstrating the effectiveness of hydrophobic barriers in regulating propulsion and navigation. Additionally, it shows that using such geometric constraints can significantly reduce the experimental time required for toxicity testing based on P. polycephalum.
Article
Chemistry, Analytical
Taeha Lee, Hyung-Tak Lee, Jiho Hong, Seokbeom Roh, Da Yeon Cheong, Kyungwon Lee, Yeojin Choi, Yoochan Hong, Han-Jeong Hwang, Gyudo Lee
Summary: Colorimetric paper sensors are widely used due to their convenience and intuitive nature, but they often lack accuracy in practical use. In this study, a machine learning-based paper sensor platform is developed to accurately determine color changes. By training and testing regression models, accurate estimations of pH levels and glucose concentrations can be achieved.
ANALYTICAL METHODS
(2022)
Article
Chemistry, Physical
Hyo Gyeong Lee, Seokbeom Roh, Hyun Jung Kim, Seokho Kim, Yoochan Hong, Gyudo Lee, Ok Hee Jeon
Summary: Cells secrete extracellular vesicles (EVs) to communicate with surrounding cells, and when senescent cells (SnCs) secrete EVs, they can cause inflammation, senescence induction, and metabolic disorders in neighboring cells. In this study, the biomechanical properties of small EVs (sEVs) derived from SnCs were investigated using atomic force microscopy, surface potential microscopy, and Raman spectroscopy. The results showed that SnC-derived sEVs have different biomechanical properties compared to non-SnC-derived sEVs, providing insights into their formation and composition mechanisms.
NANOSCALE HORIZONS
(2022)
Article
Biophysics
Reza Khodadadi, Manouchehr Eghbal, Hamideh Ofoghi, Alireza Balaei, Ali Tamayol, Karen Abrinia, Amir Sanati-Nezhad, Mohamadmahdi Samandari
Summary: This paper introduces an integrated portable centrifugal microfluidic system that automates cell and fluid manipulation for complete blood counting (CBC) analysis at the point-of-care (POC). The system utilizes a specially designed microfluidic disc for cell separation, solution metering and mixing, and cell counting, and is equipped with a custom script for automated quantification of cells. The proposed method shows a strong correlation with the gold standard hematology analyzer for various blood parameters. The portable system offers simplicity, affordability, and low power consumption, making it a potential solution for improving healthcare delivery in resource-limited settings and remote areas.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Nabil H. Bhuiyan, Joon S. Shim
Summary: Developing herd immunity is crucial for changing the course of the COVID-19 pandemic. An AI-driven point-of-care testing platform has been proposed for analyzing the body's response to SARS-CoV-2, and it has been successfully used for quantifying viral proteins and antibodies in blood samples. A data-receptive web-based dashboard system has also been developed for real-time analysis of herd immunity progress.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Alexiane Godain, Timothy M. Vogel, Pascal Fongarland, Naoufel Haddour
Summary: This study provides comprehensive insights into the intricate relationship between shear stress and electroactive biofilms in microbial fuel cells, highlighting the pivotal role of shear stress in influencing the growth kinetics, electrical performance, and physical structure of the biofilms. The study also emphasizes the complexities of extracellular electron transfer mechanisms and the need for complementary metaproteomic analyses.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Linjie Wang, Yixin Chen, Yang Ji, Shujun Zheng, Fei Wang, Caolong Li
Summary: A paper-based biosensor incorporating surface-enhanced Raman spectroscopy (SERS) and colorimetric detection has been developed for efficient quantification of intracellular glutathione (GSH). The biosensor exhibits excellent selectivity, stability, and precision, with low detection limits in both SERS and colorimetric modes. It has been successfully utilized for intracellular GSH detection and validated against a commercial GSH assay kit.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Quan Zhou, Jing Wang, Zhen Zhang, Alain Wuethrich, Richard J. Lobb, Matt Trau
Summary: This study presents a biosensor for sensitive detection of EMT-associated biomarkers on extracellular vesicles (EVs) surfaces during targeted therapy. Through longitudinal monitoring of patients, the biosensor shows its ability to identify the EMT-like phenotype switching on circulating EVs during the development of resistance.
BIOSENSORS & BIOELECTRONICS
(2024)
Review
Biophysics
Pratika Rai, Sabrina N. Hoba, Celine Buchmann, Robert J. Subirana-Slotos, Christian Kersten, Tanja Schirmeister, Kristina Endres, Bernd Bufe, Alexey Tarasov
Summary: Proteases have been proposed as potential biomarkers for various pathological conditions. The development of protease biosensors offers a more efficient way to investigate dysregulated proteases. This review article presents different optical and electrochemical detection methods for designing biosensors for all major protease families.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Chengxin Liu, Xu Shen, Li Yan, Runlian Qu, Yue Wang, Yaqin He, Zixuan Zhan, Piaopiao Chen, Feng Lin
Summary: In this study, a homogeneous rapid electrochemical aptasensor was developed to quantitatively detect CTCs in lung cancer patients. The aptasensor utilized a DNA nanosphere structure and a complementary aptamer to specifically detect mucin 1 as a marker for CTCs. The assay exhibited high specificity and sensitivity, and the results were consistent with other detection methods.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Danni Xue, Xing Dai, Jialong Zhao, Jiayao Zhang, Huan Liu, Kui Liu, Tao Xu, Chenjie Gu, Xingfei Zhou, Tao Jiang
Summary: In this study, a dual-enhancement SERS substrate based on Ti3C2TX and Ag nanocubes was fabricated for precise quantification of ritonavir and ibrutinib in serum. The formation of numerous electromagnetic hotspots between Ag nanocubes facilitated effective photo-induced charge transfer. The composite substrate showed excellent sensitivity, achieving low detection limits and high recoveries, making it promising for monitoring and identification of clinical blood drug concentration.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Tenghua Zhang, Zihui Xie, Xiaohe Zheng, Yuxin Liang, Yao Lu, Hankang Zhong, Feiyang Qian, Yuqing Zhu, Ruiting Sun, Yan Sheng, Jiaming Hu
Summary: This study reports a technology based on cationic lipid-polymer hybrid nanoparticles for efficient extracellular vesicle (EV) enrichment and in-situ detection of internal microRNAs. The technology demonstrates high EV enrichment efficiency and sensitive internal RNA detection, making it potentially useful for early pancreatic cancer diagnosis.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Wenjie Dai, Gaoxu Chen, Xiaoyan Wang, Shujun Zhen, Chengzhi Huang, Lei Zhan, Yuanfang Li
Summary: In this study, a novel metal organic gel (MOG) with dual electrochemiluminescence (ECL) properties was prepared by simple mixing. The MOG exhibited strong and stable anodic and cathodic ECL signals. By utilizing this MOG, an ECL resonance energy transfer (ECL-RET) biosensor was constructed for ultrasensitive detection of a specific gene. The study developed a straightforward technique for obtaining a single luminescent material with dual signals and expanded the analytical application of MOGs in the realm of ECL.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Lais Canniatti Brazaca, Amanda Hikari Imamura, Rodrigo Vieira Blasques, Jessica Rocha Camargo, Bruno Campos Janegitz, Emanuel Carrilho
Summary: The use of microfluidic paper-based analytical devices (muPADs) for medical diagnosis is a growing trend due to their low cost, easy use, simple manufacturing, and potential for application in low-resource settings. This review focuses on the advances in muPADs for medical diagnostics, discussing their use in detecting various biomarkers in common human biofluids. The challenges of biomarker detection in each sample are examined, along with innovative techniques to overcome these limitations. The commercialization difficulties of muPADs are also considered, along with future trends such as wearable devices and integrated platforms.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Minghong Jian, Xudong Sun, Hua Zhang, Xiaotong Li, Shasha Li, Zhenxin Wang
Summary: Matrix metalloproteinases (MMPs) are attractive biomarkers for cancer diagnosis and treatment, but their low abundance in biological samples, especially in the early stages of tumors, makes it challenging to precisely analyze MMP activities. In this study, a peptide microarray-based metal-enhanced fluorescence assay (PMMEFA) is proposed as a sensitive and specific method to simultaneously detect MMP-1, -2, -3, -7, -9, and -13 activities. The PMMEFA showed excellent sensitivity and was capable of detecting MMP activities in various matrices.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Kyung Ho Kim, Eunsu Ryu, Zinah Hilal Khaleel, Sung Eun Seo, Lina Kim, Yong Ho Kim, Hyun Gyu Park, Oh Seok Kwon
Summary: We have developed a novel strategy for discriminative detection of SARS-CoV-2 variants using the plasmonic photothermal effect of gold nanofilms and digital polymerase chain reaction (dPCR) technology. With this method, we were able to detect the delta and omicron variants with high sensitivity within 25 minutes from COVID-19 patients' clinical samples, making it a rapid and accurate point-of-care testing tool.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Zepeng Kang, Yuanming Wang, Haiyan Song, Xueli Wang, Job Zhang, Zhiguang Zhu
Summary: By designing a wearable and flexible lactic-acid/O2 EBFC with an air-breathing biocathode, the limitations of biocathode are effectively solved. The optimal performance conditions are determined through experiments, and the EBFC is successfully applied to power a low-power device.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Huayun Chen, Zhiheng You, Yuhui Hong, Xiao Wang, Mingming Zhao, Yushi Luan, Yibin Ying, Yixian Wang
Summary: This study developed a colorimetric sensor array using gas-responsive two-dimensional metal-organic framework (MOF) composites for highly sensitive detection of volatile organic compounds (VOCs). The dye/Zn-2(bim)(4) composites-based sensor arrays showed enhanced sensitivity and anti-interference properties. The findings demonstrate the potential use of dye/Zn-2(bim)(4) sensor arrays for early perception of plant diseases.
BIOSENSORS & BIOELECTRONICS
(2024)
