Review
Engineering, Biomedical
Martin Birkett, Abdul Wasy Zia, Dinesh Kumar Devarajan, Soni Mihalis I. Panayiotidis, Thomas J. Joyce, Murtaza M. Tambuwala, Angel Serrano-Aroca
Summary: Diamond-like carbon (DLC) coatings doped with bioactive elements of silver (Ag) and copper (Cu) have attracted increasing attention in recent years, as they have the potential to enhance antimicrobial and mechanical performance. These multi-functional coatings offer great potential to improve wear resistance and antimicrobial properties of load-bearing medical implants.
ACTA BIOMATERIALIA
(2023)
Article
Polymer Science
Oana Gherasim, Gianina Popescu-Pelin, Paula Florian, Madalina Icriverzi, Anca Roseanu, Valentina Mitran, Anisoara Cimpean, Gabriel Socol
Summary: The study successfully loaded ibuprofen into PLGA polymer coatings, demonstrating long-term and stable drug release suitable for surface modification of implantable medical devices. Excellent cytocompatibility was shown in dynamic testing, indicating promising potential for future applications.
Article
Materials Science, Multidisciplinary
Sadia Hassan, Tooba Javaid Khan, Murtaza Najabat Ali, Namra Bilal
Summary: This study aimed to evaluate the potential use of natural drugs to impede the coagulation cascades after biomedical implantation. The natural drugs were incorporated into a degradable matrix and tested for their antioxidant potential, anticoagulation, and hemocompatibility. The results showed that the drug composite exhibited high anticoagulation activity and hemocompatibility, making it a viable candidate for biomedical implant coatings.
MATERIALS TODAY COMMUNICATIONS
(2022)
Review
Pharmacology & Pharmacy
Dragana Bjelic, Matjaz Finsgar
Summary: The use of therapeutic agents that inhibit bone resorption is important for the longevity of implants, revision surgeries, and the healthcare system. This review focuses on incorporating osteoclast inhibitors into bioactive coatings for bone implants and discusses the challenges of systemic treatment. It also explores the suitable concentrations, release times, and effects of the antiresorptive agents on nearby cells or bone tissue. However, further research is needed to optimize implant design and personalize the coating material and antiresorptive agent selection.
PHARMACOLOGICAL RESEARCH
(2022)
Article
Engineering, Biomedical
Divya Chopra, Anjana Jayasree, Tianqi Guo, Karan Gulati, Saso Ivanovski
Summary: This extensive review discusses the importance and development of surface modification techniques for zirconium-based implants to enhance their bioactivity and therapeutic effects, leading to improved implant integration.
BIOACTIVE MATERIALS
(2022)
Article
Materials Science, Multidisciplinary
Tamara V. Basova, Evgeniia S. Vikulova, Svetlana I. Dorovskikh, Aseel Hassan, Natalya B. Morozova
Summary: This review discusses the use of noble metals and silver and gold nanoparticles to improve the performance of medical implants in orthopedic and reconstructive surgery. It analyzes the current use and limitations of traditional biomaterials, while exploring alternative solutions. The focus is on the analysis of noble metals as biocompatible and antibacterial materials, and the importance of modifying implant surfaces with thin films and nanoparticles for future implant development.
MATERIALS & DESIGN
(2021)
Article
Materials Science, Coatings & Films
Ana Barbara Batista, Michael Stanley, Ana Carolina Ferreira de Brito, Rebecca Vasconcellos, Michele Munk, Mario Jose-Bueno, Cristina Godoy, Erika Costa de Alvarenga, Claudia Karina Barbosa de Vasconcelos, Ariete Righi, Edesia M. B. de Sousa, Alan Barros de Oliveira, Ronaldo Junio Campos Batista, Jaqueline dos Santos Soares, Bernardo Ruegger Almeida Neves, Ana Paula Moreira Barbosa, Taise Matte Manhabosco
Summary: Nano-talc was successfully incorporated in the hydroxyapatite matrix through an eco-friendly liquid-phase exfoliation process, and it significantly improves the performance of bioceramic materials, including higher stiffness, reduced friction coefficient and wear damage, as well as corrosion resistance and biocompatibility.
SURFACE & COATINGS TECHNOLOGY
(2022)
Article
Materials Science, Biomaterials
Megan Wancura, Abbey Nkansah, Malgorzata Chwatko, Andrew Robinson, Ashauntee Fairley, Elizabeth Cosgriff-Hernandez
Summary: Bioactive hydrogel coatings offer a promising route to introduce durable thromboresistance and bioactivity to cardiovascular devices. In this study, a durable hydrogel coating was developed using interpenetrating networks of PEUDAm and pNAGA, providing resistance to surgical damage and promoting endothelial cell adhesion. This conformable and durable hydrogel coating provides an improved approach for cardiovascular device fabrication with targeted biological activity.
JOURNAL OF MATERIALS CHEMISTRY B
(2023)
Article
Biochemistry & Molecular Biology
Katja Andrina Kravanja, Matjaz Finsgar
Summary: The study focuses on the importance of characterization techniques for bioactive coatings for orthopedic implants and describes various advanced analytical techniques used for characterizing the coatings in order to further improve their properties.
Review
Materials Science, Multidisciplinary
Kaka Ma, Yufeng Zheng, Sriswaroop Dasari, Dalong Zhang, Hamish L. Fraser, Rajarshi Banerjee
Summary: This article reviews the scientific discovery of precipitation in nanostructured or ultrafine grain alloys in the past 20 years, including the formation mechanism and growth of precipitates, the interplay between precipitates and solid solutes, dislocations, or grain boundaries, as well as the consequent mechanical behavior. Specific alloys such as Al, Mg, Ti, and high-entropy alloys are covered, with a highlight on modern research trends in the field.
Article
Nanoscience & Nanotechnology
Peikun Xin, Shuyan Han, Jun Huang, Xinru You, Jun Wu
Summary: This study investigates the multifunctionality of soybean milk as a bioactive coating for wound healing. The results demonstrate that soybean milk exhibits good biocompatibility and biological activity, enhancing tissue remodeling and wound healing.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Nanoscience & Nanotechnology
Peikun Xin, Shuyan Han, Jun Huang, Xinru You, Jun Wu
Summary: This study found that soybean milk as a bioactive coating has good potential for promoting wound healing. Soybean milk has antioxidation and tissue remodeling properties, effectively scavenges intracellular reactive oxygen species, enhances epithelial cell migration and angiogenesis, thereby accelerating wound healing.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Engineering, Biomedical
Eben Adarkwa, Abhijit Roy, John Ohodnicki, Boeun Lee, Prashant N. Kumta, Salil Desai
Summary: Three-dimensional printing is used to modify titanium alloy substrates with multilayered biofunctional polymeric coatings. The coatings contain therapeutic agents to promote osseointegration and antibacterial activity. The PCL coatings show better cell adhesion and controlled release of therapeutic agents compared to the PLGA coatings. This research lays the foundation for developing antibacterial biocompatible coatings for orthopedic implants.
INTERNATIONAL JOURNAL OF BIOPRINTING
(2023)
Review
Chemistry, Physical
Marija Djosic, Ana Jankovic, Vesna Miskovic-Stankovic
Summary: Current trends in biomaterials science focus on designing multifunctional implant coatings that can inhibit bacterial growth while promoting osseointegration to ensure prolonged implant functionality.
Review
Chemistry, Physical
Maria P. Nikolova, Margarita D. Apostolova
Summary: In orthopedic surgery, implants are almost always required to fix bones, and metals are commonly used for load-bearing applications due to their physical and mechanical properties. However, metallic implants face challenges such as low biocompatibility, excessive wear, low corrosion resistance, infections, and shielding stress. Various coatings have been applied to improve their in vitro and in vivo performance, creating composite implants with bioactive, osteogenic, antibacterial, or biodegradable properties when combined with bio-ceramic or polymer coatings. This review systematically examines bioactive and high-performance coatings for metallic bone implants and discusses their biocompatibility. It also provides updates on coating materials and formulations for metallic implants, as well as their production routes. Additionally, methods of enhancing bioactive coating performance through controlled release of bioactive moieties such as growth factors, osteogenic factors, immunomodulatory factors, antibiotics, or other drugs are addressed.
Article
Materials Science, Multidisciplinary
Sylwia Rzepa, Zuzanka Trojanova, Jan Dzugan, Ruslan Z. Valiev, Martina Koukolikova, Daniel Melzer, Michal Brazda
Summary: Additive manufacturing (AM) allows faster and cheaper production of complex-shaped parts. Equal channel angular pressing (ECAP) induces strain and dislocations, leading to material strengthening. This study investigates the combination of directed energy deposition (DED) and ECAP processing on titanium alloy Ti-6Al-4V. The ECAP-processed specimens show significant improvement in mechanical properties.
MATERIALS CHARACTERIZATION
(2023)
Article
Chemistry, Multidisciplinary
Elvira R. Shakurova, Svetlana S. Efimova, Olga S. Ostroumova, Lyudmila V. Parfenova
Summary: 31 examples of C30-quaternized derivatives of lupane triterpenoids were synthesized with high yield using organic tribromides and pyridines. These derivatives showed activity against S. aureus, C. neoformans and C. albicans with low MICs and minimal cytotoxic and hemolytic effects. The quaternized products had a selective effect on phosphatidylglycerol-containing membranes and showed potential as antibacterial agents and auxiliary components for enhancing the effectiveness of known drugs against bacteria and fungi.
NEW JOURNAL OF CHEMISTRY
(2023)
Article
Chemistry, Physical
Elena V. Bobruk, Maxim Yu. Murashkin, Ilnar A. Ramazanov, Vil U. Kazykhanov, Ruslan Z. Valiev
Summary: This study aims to achieve superplasticity of ultrafine-grained (UFG) Al 2024 alloy at temperatures lower than traditional commercial Al alloys. Complex tensile tests were conducted at various temperatures and strain rates, and the UFG alloy exhibited superplastic behavior at 240 and 270 degrees C. The UFG alloy also demonstrated higher strength compared to the standard strengthening heat treatment T6.
Article
Materials Science, Multidisciplinary
Andrew K. Hoffman, Yongfeng Zhang, Maalavan Arivu, Li He, Kumar Sridharan, Yaqiao Wu, Rinat K. Islamgaliev, Ruslan Z. Valiev, Haiming Wen
Summary: In nuclear reactor environments, nanocrystalline 304 stainless steel exhibits unique radiation-induced segregation behavior with the enrichment of Cr at grain boundaries. Lattice-based atomic kinetic Monte Carlo simulations reveal the influences of grain size, injected interstitials, and self-ion injection on grain boundary segregation.
Article
Biochemistry & Molecular Biology
Lyudmila V. Parfenova, Pavel V. Kovyazin, Almira Kh. Bikmeeva, Eldar R. Palatov, Pavel V. Ivchenko, Ilya E. Nifant'ev, Leonard M. Khalilov
Summary: Through the study of structurally diverse zirconocenes and co-catalysts activating the system, the mechanism of alkene dimerization reaction was revealed, providing a solution for the efficient synthesis of alkene transformation products (such as dimers, oligomers, and polymers).
Article
Mechanics
G. V. Klevtsov, L. R. Botvina, N. A. Klevtsova, R. Z. Valiev, I. N. Pigaleva
Summary: Fatigue failure is the most common type of failure in various engineering systems, and its study is crucial for predicting system's service life. The investigation of fatigue failure in new ultrafine-grained nanostructured metal materials is particularly interesting. This study demonstrates the possibility of determining the maximum cycle stress and cycle asymmetry coefficient from the depth of plastic zones beneath the surface of fatigue fractures.
PHYSICAL MESOMECHANICS
(2023)
Article
Chemistry, Physical
Veta Aubakirova, Dmitry Gunderov, Ruzil Farrakhov, Vasily Astanin, Andrey Stotskiy, Arseny Sharipov, Alexey Demin, Leonard Khalilov, Evgeny Parfenov
Summary: This paper investigates the effect of current density distribution on plasma electrolytic oxidation (PEO) process and its resultant coatings on a Zr-1Nb alloy. The distance between the plates in the electrolyzer is evaluated to assess the throwing power of the PEO process. The current density on the facing surfaces of the plates decreases with a smaller distance, impacting the surface morphology and corrosion resistance of the PEO coatings.
Article
Materials Science, Multidisciplinary
Gennadiy V. Klevtsov, Ruslan Z. Valiev, Natal'ya A. Klevtsova, Maksim N. Tyurkov, Irina N. Pigaleva, Denis A. Aksenov
Summary: This paper analyzes the fracture kinetics and mechanisms of different ultrafine-grained materials with different crystal lattices in the low-cycle fatigue region. The tests conducted show that the formation of ultrafine-grained structure has an unclear effect on the total number of cycles to failure of the samples. The fatigue crack initiation cycles account for about 20% of the total life of the samples, regardless of the material state and crystal lattice type. The fatigue crack propagation rates of the majority of investigated ultrafine-grained materials are close to or lower than that of the initial coarse-grained materials.
Article
Crystallography
Shivam Dangwal, Kaveh Edalati, Ruslan Z. Z. Valiev, Terence G. G. Langdon
Summary: Strengthening and softening mechanisms in ultrafine-grained materials have been debated for many years. This study examines the Hall-Petch relationship in ultrafine-grained magnesium, aluminum, copper, and iron. The results show that while the materials follow the Hall-Petch relationship initially, an up-break occurs for grain sizes below 500-1000 nm. This is due to enhanced dislocation contribution. However, a down-break occurs for grain sizes smaller than 70-150 nm due to diminished dislocation contribution and increased thermally-activated phenomena. The study also finds that strategies other than grain refinement, such as microstructural stabilization by segregation or precipitation, are necessary to achieve extra strengthening.
Article
Biochemistry & Molecular Biology
Elena V. Salimova, Oleg S. Mozgovoj, Svetlana S. Efimova, Olga S. Ostroumova, Lyudmila V. Parfenova
Summary: The study aimed to investigate the antimicrobial effect of FA amines and their potential biological targets. It was found that pyrazinecarboxamide-substituted analogues of FA exhibited high antibacterial activity against MRSA. Furthermore, FA derivatives containing spermine and spermidine were effective against Gram-negative bacteria and had fungicidal effects. The study also demonstrated that these compounds could interact with cell membranes and disrupt lipids, and spermine-based compounds could form ion-permeable pores. Molecular docking suggested that the inhibition of the protein synthesis elongation factor EF-G played a key role in the antibacterial effect of these compounds.
Article
Materials Science, Multidisciplinary
Roman R. Valiev, Alexey V. Panin, Emil I. Usmanov, Yana N. Savina, Ruslan Z. Valiev
Summary: This study demonstrates for the first time the influence of high-pressure torsion (HPT) on microstructural refinement and mechanical strength of Ti-6Al-4V titanium alloy produced by wire-feed electron-beam additive manufacturing. HPT processing results in an ultrafine-grained (UFG) structure and significantly increases the microhardness of the alloy. Microscopic studies reveal that the UFG structure consists predominantly of alpha and beta phases.
ADVANCED ENGINEERING MATERIALS
(2023)
Article
Chemistry, Physical
Anwar Qasim Ahmed, Daniel Olasz, Elena V. Bobruk, Ruslan Z. Valiev, Nguyen Q. Chinh
Summary: A supersaturated Al-Zn-Mg-Zr alloy with ultrafine-grained structure was obtained through the ECAP technique, resulting in significantly improved hardness and changes in subsequent thermal processes.
Article
Materials Science, Biomaterials
Alexander A. Matchin, Evgeniy V. Nosov, Alexander A. Stadnikov, Gennadiy V. Klevtsov, Luiza R. Rezyapova, Natalia A. Sayapina, Elena V. Blinova, Ruslan Z. Valiev
Summary: This study focuses on the osseointegration behavior of medical implants made from nanostructured grade 4 titanium in maxillofacial surgery. The results show that nanotitanium implants have a significantly faster fixation rate due to osseointegration compared to standard factory-made implants, indicating better osseointegration for nanotitanium implants.
ACS BIOMATERIALS SCIENCE & ENGINEERING
(2023)
Article
Biochemistry & Molecular Biology
Mikhail V. Dubinin, Anna I. Ilzorkina, Elena V. Salimova, Manish S. Landage, Ekaterina I. Khoroshavina, Sergey V. Gudkov, Konstantin N. Belosludtsev, Lyudmila V. Parfenova
Summary: This paper assesses the membranotropic action of fusidic acid and its derivatives. The authors found that a derivative with ethylenediamine moiety can increase the mobility of lipid bilayer and induce permeabilization of liposome membranes. A similar effect was observed in rat liver mitochondrial membranes. Moreover, the derivatives reduced mitochondrial Delta psi and OXPHOS efficiency, leading to a decrease in mitochondrial calcium retention capacity.
Article
Chemistry, Physical
Lyudmila V. Parfenova, Pavel V. Kovyazin, Almira Kh. Bikmeeva, Eldar R. Palatov, Pavel V. Ivchenko, Ilya E. Nifant'ev
Summary: By using NMR spectroscopy, it was found that different bimetallic hydride intermediates were formed in the reactions of vanadium and zirconium complexes with HAlBui2 and MMAO-12 activator. The zirconium complexes tended to form [L2ZrH3] structures, and the vanadium and zirconium complexes formed complexes with MMAO-12. These complexes served as precursors for the catalytically active sites for alkene dimerization and oligomerization reactions.
REACTION KINETICS MECHANISMS AND CATALYSIS
(2023)
