Influence of the bispecific antibody IgG subclass on T cell redirection

Development of CDX-1140, an agonist CD40 antibody for cancer immunotherapy

(2018) Laura A. Vitale et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Immune Effector Functions of Human IgG2 Antibodies against EGFR

(2018) Thies Rösner et al.   MOLECULAR CANCER THERAPEUTICS

The making of bispecific antibodies

(2017) Ulrich Brinkmann et al.   mAbs

Antibody Isotypes for Tumor Immunotherapy

(2017) Anna Kretschmer et al.   TRANSFUSION MEDICINE AND HEMOTHERAPY

IgG Fc engineering to modulate antibody effector functions

(2017) Xinhua Wang et al.   Protein & Cell

An anti-CD3/anti–CLL-1 bispecific antibody for the treatment of acute myeloid leukemia

(2016) Steven R. Leong et al.   BLOOD

“NextGen” Biologics: Bispecific Antibodies and Emerging Clinical Results

(2016) Archana Thakur et al.   EXPERT OPINION ON BIOLOGICAL THERAPY

Efficient production of bispecific IgG of different isotypes and species of origin in single mammalian cells

(2016) Michael Dillon et al.   mAbs

Immune-mediated liver injury of the cancer therapeutic antibody catumaxomab targeting EpCAM, CD3 and Fcγ receptors

(2016) Jürgen Borlak et al.   Oncotarget

FDA Approval: Blinatumomab

(2015) D. Przepiorka et al.   CLINICAL CANCER RESEARCH

Bispecific antibodies

(2015) Roland E. Kontermann et al.   DRUG DISCOVERY TODAY

Impact of Cell-surface Antigen Expression on Target Engagement and Function of an Epidermal Growth Factor Receptor × c-MET Bispecific Antibody

(2015) Stephen W. Jarantow et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Induced Expression of FcγRIIIa (CD16a) on CD4+T Cells Triggers Generation of IFN-γhighSubset

(2015) Anil K Chauhan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Alternative molecular formats and therapeutic applications for bispecific antibodies

(2015) Christoph Spiess et al.   MOLECULAR IMMUNOLOGY

Novel immunotherapies in lymphoid malignancies

(2015) Connie Lee Batlevi et al.   Nature Reviews Clinical Oncology

A novel, native-format bispecific antibody triggering T-cell killing of B-cells is robustly active in mouse tumor models and cynomolgus monkeys

(2015) Eric J. Smith et al.   Scientific Reports

In-depth analysis of subclass-specific conformational preferences of IgG antibodies

(2015) Xinsheng Tian et al.   IUCrJ

Structural design of disialoganglioside GD2 and CD3-bispecific antibodies to redirect T cells for tumor therapy

(2014) Ming Cheng et al.   INTERNATIONAL JOURNAL OF CANCER

Non–antigen-contacting region of an asymmetric bispecific antibody to factors IXa/X significantly affects factor VIII-mimetic activity

(2014) Zenjiro Sampei et al.   mAbs

Controlled Fab-arm exchange for the generation of stable bispecific IgG1

(2014) Aran F Labrijn et al.   Nature Protocols

The Myc-miR-17-92 axis amplifies B-cell receptor signaling via inhibition of ITIM proteins: a novel lymphomagenic feed-forward loop

(2013) J. N. Psathas et al.   BLOOD

An engineered Fc variant of an IgG eliminates all immune effector functions via structural perturbations

(2013) Omid Vafa et al.   METHODS

Efficient generation of stable bispecific IgG1 by controlled Fab-arm exchange

(2013) A. F. Labrijn et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Constant domains influence binding of mouse–human chimeric antibodies to the capsular polypeptide ofBacillus anthracis

(2013) Mark A Hubbard et al.   Virulence

Generation of single-chain bispecific green fluorescent protein fusion antibodies for imaging of antibody-induced T cell synapses

(2012) Slava Stamova et al.   ANALYTICAL BIOCHEMISTRY

Generating Bispecific Human IgG1 and IgG2 Antibodies from Any Antibody Pair

(2012) Pavel Strop et al.   JOURNAL OF MOLECULAR BIOLOGY

Disulfide bond structures of IgG molecules

(2012) Hongcheng Liu et al.   mAbs

Biophysical mechanism of T-cell receptor triggering in a reconstituted system

(2012) John R. James et al.   NATURE

Mechanisms for Size-Dependent Protein Segregation at Immune Synapses Assessed with Molecular Rulers

(2011) Juha-Matti Alakoskela et al.   BIOPHYSICAL JOURNAL

PIM2 inhibition as a rational therapeutic approach in B-cell lymphoma

(2011) C. Gomez-Abad et al.   BLOOD

Immunoglobulin domain crossover as a generic approach for the production of bispecific IgG antibodies

(2011) W. Schaefer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Epitope distance to the target cell membrane and antigen size determine the potency of T cell-mediated lysis by BiTE antibodies specific for a large melanoma surface antigen

(2010) Claudia Bluemel et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Development and approval of the trifunctional antibody catumaxomab (anti-EpCAM×anti-CD3) as a targeted cancer immunotherapy

(2010) Diane Seimetz et al.   CANCER TREATMENT REVIEWS

Retargeting of T cells to prostate stem cell antigen expressing tumor cells: Comparison of different antibody formats

(2010) Anja Feldmann et al.   PROSTATE

Engineered therapeutic antibodies with improved effector functions

(2009) Tsuguo Kubota et al.   CANCER SCIENCE

Therapeutic IgG4 antibodies engage in Fab-arm exchange with endogenous human IgG4 in vivo

(2009) Aran F Labrijn et al.   NATURE BIOTECHNOLOGY

Examination of the contributions of size and avidity to the neutralization mechanisms of the anti-HIV antibodies b12 and 4E10

(2009) J. S. Klein et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural characterization of a human Fc fragment engineered for lack of effector functions

(2008) Vaheh Oganesyan et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Radius of gyration as an indicator of protein structure compactness

(2008) M. Yu. Lobanov et al.   MOLECULAR BIOLOGY