Article
Biochemistry & Molecular Biology
Wisnu Arfian A. Sudjarwo, Jose L. Toca-Herrera
Summary: This study examines the hysteresis phenomenon in DPPC monolayers, focusing on the impact of various variables on key indicators such as the pi-A isotherm curve and compression modulus. The findings reveal that these factors significantly influence the structural and dynamic properties of the monolayers, with the hysteresis loop providing valuable insights into their viscoelasticity and phase transition changes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Spectroscopy
Yu Zaytseva, N. Surovtsev
Summary: The use of deuterocarbons is an effective method in Raman spectroscopy for studying multicomponent lipid materials and biological samples. This study investigated the Raman spectra of hydrated multilamellar vesicles and mixtures of certain lipids to identify the indicators of conformational and lateral orders. The results showed that the intensity ratio of specific peaks can be used to evaluate the conformational order of the lipid chains, and the lateral order can enhance the effect of conformational ordering.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2022)
Article
Biotechnology & Applied Microbiology
Nabil Adrar, Fatemeh Bahadori, Fatma D. Ceylan, Gulacti Topcu, Fatiha Bedjou, Esra Capanoglu
Summary: Combination of different phospholipids in formulations resulted in interdigitated liposomes with good physical stability, showing minimal changes in size and PDI during storage.
JOURNAL OF CHEMICAL TECHNOLOGY AND BIOTECHNOLOGY
(2021)
Article
Chemistry, Physical
Risa Fujita, Mai Yotsumoto, Yuta Yamaguchi, Muneyuki Matsuo, Koichi Fukuhara, Osamu Takahashi, Shinobu Nakanishi, Mitsuhiro Denda, Satoshi Nakata
Summary: The study found that odorants with an aromatic ring can form complexes with NE and be eliminated from the DOPC membrane, contributing to the masking effect on the DOPC-NE mixed monolayer.
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
(2022)
Article
Instruments & Instrumentation
Zhe Li, Xin Gao, Xinyang Yan, Yihui Deng, Haiying Ma
Summary: Injections of PEG-modified nanomedicines can result in an accelerated clearance, known as the accelerated blood clearance (ABC) phenomenon. Anti-PEG IgM plays a crucial role in inducing this phenomenon, but the addition of 1,2-distearoyl-snglycero-3-phosphoglycerol (DSPG) can inhibit the recognition and binding of anti-PEG IgM, thereby weakening the ABC phenomenon.
DRUG DELIVERY AND TRANSLATIONAL RESEARCH
(2022)
Article
Chemistry, Physical
Alicja Sek, Paulina Perczyk, Aleksandra Szczes, Pawel Wydro
Summary: The influence of different surfactants (DTAB, TTAB, CTAB, SDS) on mixed DPPC/cholesterol layers was investigated. The study found that even tiny amounts of surfactants can significantly alter the zeta potential of cholesterol-containing liposomes, with a greater effect observed for anionic surfactants. The surfactant effect increased with increasing concentration and carbon chain length. Langmuir monolayer studies provided additional evidence of surfactant interactions with membrane lipids. The presence of cholesterol molecules favored the penetration of DTAB and SDS surfactants in DPPC layers.
JOURNAL OF MOLECULAR LIQUIDS
(2022)
Article
Chemistry, Applied
Daniel Zuniga-Nunez, Francisco Mura, Nory Marino-Ocampo, Patricio Briones-Rebolledo, Horacio Poblete, Jean-Maurice Mallet, Denis Fuentealba, Alexis Aspee
Summary: A fluorescent probe C-DMPE was synthesized to monitor interfacial membrane properties. The probe showed shorter fluorescence lifetimes and rotational correlation times in mixed vesicles containing DPPC and DOPC, indicating favorable sensing of lipid domain boundaries.
Article
Multidisciplinary Sciences
C. Breazu, M. Socol, N. Preda, O. Rasoga, A. Costas, G. Socol, G. Petre, A. Stanculescu
Summary: The use of 2D nanostructured transparent conductive electrode can influence the morphological, structural, optical and electrical properties of nucleobases thin films, affecting both optical (transmission and emission) properties and electrical properties through modifications at the organic/electrode interface. These results suggest potential applications in green optoelectronic devices.
SCIENTIFIC REPORTS
(2021)
Article
Chemistry, Medicinal
Noriyuki Uchida, Masayoshi Yanagi, Hiroki Hamada
Summary: The mixture of DPPC phospholipid and sodium chelate formed bicelles at around 50 degrees C. Quadrupole splitting of D2O, an index of the ability to orient molecules, was observed in the H-2 nuclear magnetic resonance measurement of the dispersion of DPPC-SC bicelle.
NATURAL PRODUCT COMMUNICATIONS
(2022)
Article
Chemistry, Multidisciplinary
Dong Han, Baolin Zhang, Jianghui Dong, Boning Yang, Yuntao Peng, Junfeng Wang, Liping Wang
Summary: DMPC-modified SPIONs have advantages in faster transport to the brain and easier cellular uptake, with potential applications in drug delivery and activation of neuronal membrane channels.
Article
Chemistry, Multidisciplinary
Jinju Jeong, Chul Kim
Summary: The study investigated the flip-flop movement using dithionite assay of NBD-PE fluorescence in vesicles with varying DMPC/DHPC ratios. Results showed that adding DHPC increased activation energy, but changes in thermodynamic functions did not exhibit a consistent trend, indicating DHPC promoted the flip-flop movement of NBD-PE.
BULLETIN OF THE KOREAN CHEMICAL SOCIETY
(2021)
Article
Multidisciplinary Sciences
Mahan Hosseinzadeh Fakhr, Natalia Beshchasna, Sascha Balakin, Ivan Lopez Carrasco, Alexander Heitbrink, Fabian Goehler, Niels Roesch, Joerg Opitz
Summary: Surface cleaning of the working electrode is crucial for enhancing the electrochemical and physicochemical properties of biosensors. This study investigates the effects of various chemical and electrochemical treatments on gold finish electrode surfaces deposited onto different substrates using different deposition technologies. The results show that different treatments have different effects on the gold content and electrochemical responses of the electrodes.
SCIENTIFIC REPORTS
(2022)
Article
Chemistry, Multidisciplinary
Wouter J. M. Lokerse, Artur Lazarian, Alisa Kleinhempel, Matteo Petrini, Patricia Schwarz, Martin Hossann, Lesca M. Holdt, Volker Mailaender, Lars H. Lindner
Summary: Various thermosensitive liposome formulations have been described, and it remains unclear which is optimal for solid tumor treatment. Most liposomes achieve sufficient circulation half-life through polyethylene glycol surface modification, while DPPG(2) has been identified as a promising alternative. In vitro and in vivo studies suggest that higher mol% DPPG(2) increases Apolipoprotein E adsorption, decreases complement activation, and does not exhibit accelerated blood clearance, potentially offering advantages over PEG-TSL. Additionally, low complement activation for 20-30 mol% DPPG(2)-TSL presents a unique attribute for clinical evaluation.
JOURNAL OF CONTROLLED RELEASE
(2021)
Article
Electrochemistry
Brittany L. Huffman, Carrie L. Donley, Jillian L. Dempsey
Summary: In this study, the covalent attachment of 6-bromohexylferrocene to glassy carbon electrodes was successfully achieved through a Grignard reaction, and the interfacial electron transfer and disorder in these modified electrodes were characterized using cyclic voltammetry. The results showed that the surface of the modified electrodes exhibited phase segregation, leading to variations in the full width at half max of the cyclic voltammogram features.
JOURNAL OF THE ELECTROCHEMICAL SOCIETY
(2023)
Article
Chemistry, Physical
Mong-Wen Gu, Hao Howard Peng, I-Wen Peter Chen, Chun-hsien Chen
Summary: Understanding chemical bonding and conductivity at the electrode-molecule interface is crucial for the operation of single-molecule junctions. By applying d-band theory and surface d-band model, it is possible to explain and optimize these devices. Coating Au electrodes with Ag or Cu monolayers can improve the molecule-electrode binding strength and electrical conductivity, attributed to the tuning of the metal's surface d bands.
Article
Chemistry, Multidisciplinary
Julia Alvarez-Malmagro, ZhangFei Su, J. Jay Leitch, Francisco Prieto, Manuela Rueda, Jacek Lipkowski
Article
Chemistry, Multidisciplinary
Fatemeh Abbasi, ZhangFei Su, Julia Alvarez-Malmagro, J. Jay Leitch, Jacek Lipkowski
Article
Chemistry, Multidisciplinary
ZhangFei Su, Derek Ho, A. Rod Merrill, Jacek Lipkowski
Article
Chemistry, Multidisciplinary
ZhangFei Su, XueQin Ran, J. Jay Leitch, Adrian L. Schwan, Robert Faragher, Jacek Lipkowski
Article
Chemistry, Multidisciplinary
ZhangFei Su, Joanna Juhaniewicz-Debinska, Slawomir Sek, Jacek Lipkowski
Article
Biochemistry & Molecular Biology
Julia Alvarez-Malmagro, ZhangFei Su, J. Jay Leitch, Francisco Prieto, Manuela Rueda, Jacek Lipkowski
BIOELECTROCHEMISTRY
(2020)
Article
Chemistry, Physical
Yue-jiao Zhang, Zhang-Fei Su, Jian-Feng Li, Jacek Lipkowski
JOURNAL OF PHYSICAL CHEMISTRY C
(2020)
Article
Biochemistry & Molecular Biology
Dusan Mrdenovic, Piotr Zarzycki, Marta Majewska, Izabela S. Pieta, Robert Nowakowski, Wlodzimierz Kutner, Jacek Lipkowski, Piotr Pieta
Summary: K162 inhibits the permeation of A beta Os-induced BLM, preserving BLM integrity. It modifies A beta aggregation by bypassing the formation of toxic A beta Os, producing only nontoxic A beta Ms, dimers, and fibrils. This unique mechanism may offer a new therapeutic strategy for AD.
ACS CHEMICAL NEUROSCIENCE
(2021)
Article
Electrochemistry
Francisco Prieto-Dapena, ZhangFei Su, Julia Alvarez-Malmagro, Manuela Rueda, Jacek Lipkowski
Summary: Chronocoulometry, immersion method, and PM-IRRAS were used to determine the charge distribution in a monolayer of nucleolipid on a gold electrode surface, as well as the formation mechanism of the Watson-Crick complex between nucleolipid and guanine. The study demonstrated that the complex is formed when the interface is positively charged, and the orientation angle of the cytosine moiety also affects the formation process.
ELECTROCHIMICA ACTA
(2021)
Article
Chemistry, Multidisciplinary
ZhangFei Su, J. Jay Leitch, Slawomir Sek, Jacek Lipkowski
Summary: This study investigates the role of anions on the ionophore properties of valinomycin in a model floating bilayer lipid membrane. The findings indicate that the solvation energy of the anion affects the membrane resistance and the formation of valinomycin-K+ complex. Specifically, the presence of KClO4 promotes the binding of valinomycin to K+ and enhances ion conductivity in the bilayers.
Article
Pharmacology & Pharmacy
Monica C. Garcia, Nabila Naitlho, Jose Manuel Calderon-Montano, Estrella Drago, Manuela Rueda, Marcela Longhi, Antonio M. Rabasco, Miguel Lopez-Lazaro, Francisco Prieto-Dapena, Maria Luisa Gonzalez-Rodriguez
Summary: Stimulus-responsive liposomes were evaluated for controlled drug release in cancer therapy, with findings showing that cholesterol levels and temperature play crucial roles in drug release profiles.
Article
Chemistry, Multidisciplinary
ZhangFei Su, J. Jay Leitch, Jacek Lipkowski
Summary: The inhibitory effect of amiloride on alamethicin ion channels was studied in a model zwitterionic floating bilayer lipid membrane. The results showed that amiloride prevents ion transport through the channels, increasing the membrane resistance. It was also found that amiloride does not affect the secondary structure of alamethicin, but restricts peptide insertion into the membrane and blocks ion transport through preformed channels. Furthermore, the study compared the effects of amiloride on ion channel formation in different lipid membranes and found that it strongly depends on the mobility and charge of the membrane lipids.
Article
Electrochemistry
Julia Alvarez-Malmagro, Manuela Rueda, Francisco Prieto-Dapena
Summary: The adsorption of guanine on gold electrodes was studied using cyclic voltammetry and ATR-SEIRA spectroscopy. The results showed that the adsorption process depends on the pH value, and different tautomeric forms of guanine were observed in solution and in the adsorbed state. The orientation of the adsorbed guanine molecules and the preponderance of different tautomeric forms were also influenced by the electric field.
ELECTROCHIMICA ACTA
(2023)
Article
Multidisciplinary Sciences
Yue-Jiao Zhang, Huajie Ze, Ping-Ping Fang, Yi-Fan Huang, Andrzej Kudelski, Julia Fernandez-Vidal, Laurence J. Hardwick, Jacek Lipkowski, Zhong-Qun Tian, Jian-Feng Li
Summary: Surface-enhanced Raman spectroscopy (SERS) is a highly sensitive technique for non-destructive detection at the single-molecule level. Shell-isolated nanoparticle-enhanced Raman spectroscopy (SHINERS) overcomes the limitations of traditional SERS substrates and morphology, expanding the applications of SERS. This Primer provides an introduction to the origin and enhancement mechanism of SHINERS, and describes the experimental details, including the types and characterization of shell-isolated nanoparticles, experimental instruments, reproducibility, and data analysis. It also highlights recent advances and discusses the limitations and potential optimizations of SHINERS.
NATURE REVIEWS METHODS PRIMERS
(2023)
Article
Chemistry, Multidisciplinary
Dusan Mrdenovic, Zhangfei Su, Wlodzimierz Kutner, Jacek Lipkowski, Piotr Pieta
NANOSCALE ADVANCES
(2020)