Demonstrating suitability of the Caco‐2 cell model for BCS ‐based biowaiver according to the recent FDA and ICH harmonised guidelines

Quantitative analysis of lab-to-lab variability in Caco-2 permeability assays

(2017) Jong Bong Lee et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

It is high time to discontinue use of misidentified and contaminated cells: Guidelines for description and authentication of cell lines

(2017) Tea Lanišnik Rižner et al.   JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY

BCS Biowaivers: Similarities and Differences Among EMA, FDA, and WHO Requirements

(2016) Barbara M. Davit et al.   AAPS Journal

Genetically Modified Caco-2 Cells With Improved Cytochrome P450 Metabolic Capacity

(2016) Jenni Küblbeck et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

The characterization of the human cell line Calu-3 under different culture conditions and its use as an optimized in vitro model to investigate bronchial epithelial function

(2015) Mateja Erdani Kreft et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Optimization of Caco-2 and HT29 co-culturein vitrocell models for permeability studies

(2015) Fengguang Pan et al.   INTERNATIONAL JOURNAL OF FOOD SCIENCES AND NUTRITION

Drug transporter gene expression in human colorectal tissue and cell lines: modulation with antiretrovirals for microbicide optimization

(2015) Indrani Mukhopadhya et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

The Effect of Excipients on the Permeability of BCS Class III Compounds and Implications for Biowaivers

(2015) Alan Parr et al.   PHARMACEUTICAL RESEARCH

Variability of permeability estimation from different protocols of subculture and transport experiments in cell monolayers

(2015) Davinia Oltra-Noguera et al.   JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS

Distinguishing between the Permeability Relationships with Absorption and Metabolism To Improve BCS and BDDCS Predictions in Early Drug Discovery

(2014) Caroline A. Larregieu et al.   MOLECULAR PHARMACEUTICS

Drug Discovery and Regulatory Considerations for Improving In Silico and In Vitro Predictions that Use Caco-2 as a Surrogate for Human Intestinal Permeability Measurements

(2013) Caroline A. Larregieu et al.   AAPS Journal

Pharmacokinetic and Pharmacodynamic Interaction of Nadolol With Itraconazole, Rifampicin and Grapefruit Juice in Healthy Volunteers

(2013) Shingen Misaka et al.   JOURNAL OF CLINICAL PHARMACOLOGY

Transcriptional and functional regulation of the intestinal peptide transporter PEPT1

(2013) Britta Spanier   JOURNAL OF PHYSIOLOGY-LONDON

Development of an Improved Three-Dimensional In Vitro Intestinal Mucosa Model for Drug Absorption Evaluation

(2013) Na Li et al.   TISSUE ENGINEERING PART C-METHODS

ADMET Evaluation in Drug Discovery. 11. PharmacoKinetics Knowledge Base (PKKB): A Comprehensive Database of Pharmacokinetic and Toxic Properties for Drugs

(2012) Dongyue Cao et al.   Journal of Chemical Information and Modeling

Suitability of Isolated Rat Jejunum Model for Demonstration of Complete Absorption in Humans for BCS-Based Biowaiver Request

(2012) Luka Peternel et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

A protocol for differentiation of human intestinal Caco-2 cells in asymmetric serum-containing medium

(2012) Simonetta Ferruzza et al.   TOXICOLOGY IN VITRO

ABCG2 Modulates Chlorothiazide Permeability In Vitro–characterization of Its Interactions

(2011) Erzsébet Beéry et al.   Drug Metabolism and Pharmacokinetics

Organic Anion Transporting Polypeptide 1B1: a Genetically Polymorphic Transporter of Major Importance for Hepatic Drug Uptake

(2011) M. Niemi et al.   PHARMACOLOGICAL REVIEWS

Influence of intestinal efflux pumps on the absorption and transport of furosemide

(2011) Abdullah M. Al-Mohizea   SAUDI PHARMACEUTICAL JOURNAL

Application of Method Suitability for Drug Permeability Classification

(2010) Donna A. Volpe   AAPS Journal

Intestinal Absorption of HMG-CoA Reductase Inhibitor Pitavastatin Mediated by Organic Anion Transporting Polypeptide and P-Glycoprotein/Multidrug Resistance 1

(2010) Yoshiyuki Shirasaka et al.   Drug Metabolism and Pharmacokinetics

Clinical Pharmacokinetics of Pregabalin in Healthy Volunteers

(2010) Howard N. Bockbrader et al.   JOURNAL OF CLINICAL PHARMACOLOGY

Towards Prediction of In Vivo Intestinal Absorption Using a 96-Well Caco-2 Assay

(2010) Suzanne Skolnik et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Ex vivo permeability experiments in excised rat intestinal tissue and in vitro solubility measurements in aspirated human intestinal fluids support age-dependent oral drug absorption

(2009) Pieter Annaert et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Comparison of drug transporter gene expression and functionality in Caco-2 cells from 10 different laboratories

(2008) Rose Hayeshi et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Effect of P-glycoprotein inhibitor, verapamil, on oral bioavailability and pharmacokinetics of irinotecan in rats

(2008) Tripta Bansal et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

The Caco-2 cell monolayer: usefulness and limitations

(2008) Huadong Sun et al.   Expert Opinion on Drug Metabolism & Toxicology

Thiolated chitosan: Development and in vitro evaluation of an oral delivery system for acyclovir

(2007) T PALMBERGER et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS