Journal
FITOTERAPIA
Volume 103, Issue -, Pages 83-89Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.fitote.2015.03.016
Keywords
Clausena emarginata; Carbazole alkaloids; Anti-inflammatory activity; Hepatoprotective effects
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Funding
- National Natural Science Foundation of China [21272278]
- Program for Changjiang Scholars and Innovative Research Team in the University [IRT1007]
- National Megaproject for Innovative Drugs [2012ZX09301002-002]
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Seven new carbazole alkaloids, clauemarazoles A-G, together with 19 known analogues were isolated from the stems of Clausena emarginata. Their structures were established on the basis of spectroscopic analyses, and the absolute configurations of compounds 1a, 1b, 5a, and 5b were confirmed by their ECD spectroscopy. Compounds 4, 13, 15, and 17 exhibited inhibitory abilities on LPS-induced NO production. Compounds 10-12, 20, 22, and 24 displayed hepatoprotective effects against DL-galactosamine-induced damage in WB-F344 cells. (C) 2015 Elsevier B.V. All rights reserved.
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