Function and Regulation of Acid Resistance Antiporters

Structure of the human LAT1–4F2hc heteromeric amino acid transporter complex

(2019) Renhong Yan et al.   NATURE

Hyperactive mutation occurs adjacent to the essential glutamate 286 for transport in the yeast tryptophan permease Tat2

(2019) Kaori Amano et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Transport of cystine across xC− antiporter

(2019) Maryam Ghasemitarei et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

L amino acid transporter structure and molecular bases for the asymmetry of substrate interaction

(2019) Ekaitz Errasti-Murugarren et al.   Nature Communications

Insights into the Structure, Function, and Ligand Discovery of the Large Neutral Amino Acid Transporter 1, LAT1

(2018) Natesh Singh et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Effects of Mutations and Ligands on the Thermostability of the l-Arginine/Agmatine Antiporter AdiC and Deduced Insights into Ligand-Binding of Human l-Type Amino Acid Transporters

(2018) Hüseyin Ilgü et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Tribute to Marcelle Grenson (1925–1996), A Pioneer in the Study of Amino Acid Transport in Yeast

(2018) Bruno André   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

On the Evolution of Specificity in Members of the Yeast Amino Acid Transporter Family as Parts of Specific Metabolic Pathways

(2018) Christos Gournas et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Mutations in L-type amino acid transporter-2 support SLC7A8 as a novel gene involved in age-related hearing loss

(2018) Meritxell Espino Guarch et al.   eLife

Molecular mechanism of substrate selectivity of the arginine-agmatine Antiporter AdiC

(2018) Eva-Maria Krammer et al.   Scientific Reports

In silico Description of LAT1 Transport Mechanism at an Atomistic Level

(2018) Luca Palazzolo et al.   Frontiers in Chemistry

Molecular features of the L-type amino acid transporter 2 determine different import and export profiles for thyroid hormones and amino acids

(2017) Katrin M. Hinz et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Thyroid hormone transport across L-type amino acid transporters: What can molecular modelling tell us?

(2017) Gerd Krause et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Transition of yeast Can1 transporter to the inward-facing state unveils an α-arrestin target sequence promoting its ubiquitylation and endocytosis

(2017) Christos Gournas et al.   MOLECULAR BIOLOGY OF THE CELL

LAT-1 activity of meta -substituted phenylalanine and tyrosine analogs

(2016) Evan Augustyn et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Impaired Amino Acid Transport at the Blood Brain Barrier Is a Cause of Autism Spectrum Disorder

(2016) Dora C. Tărlungeanu et al.   CELL

X-ray structures and mechanism of the human serotonin transporter

(2016) Jonathan A. Coleman et al.   NATURE

When pathogenic bacteria meet the intestinal microbiota

(2016) Nathalie Rolhion et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Insights into the molecular basis for substrate binding and specificity of the wild-type L-arginine/agmatine antiporter AdiC

(2016) Hüseyin Ilgü et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dissection of Transporter Function: From Genetics to Structure

(2016) G. Diallinas   TRENDS IN GENETICS

Unveiling the Mechanism of Arginine Transport through AdiC with Molecular Dynamics Simulations: The Guiding Role of Aromatic Residues

(2016) Eva-Maria Krammer et al.   PLoS One

TheAspergillus nidulansProline Permease as a Model for Understanding the Factors Determining Substrate Binding and Specificity of Fungal Amino Acid Transporters

(2015) Christos Gournas et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structural Insights Into Thyroid Hormone Transport Mechanisms of the L-Type Amino Acid Transporter 2

(2015) Katrin M. Hinz et al.   MOLECULAR ENDOCRINOLOGY

Neurotransmitter and psychostimulant recognition by the dopamine transporter

(2015) Kevin H. Wang et al.   NATURE

X-ray structures of Drosophila dopamine transporter in complex with nisoxetine and reboxetine

(2015) Aravind Penmatsa et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

X-ray structures of Drosophila dopamine transporter in complex with nisoxetine and reboxetine

(2015) Aravind Penmatsa et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Functional mapping and implications of substrate specificity of the yeast high-affinity leucine permease Bap2

(2014) Yuki Usami et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Converting the Yeast Arginine Can1 Permease to a Lysine Permease

(2014) Kassem Ghaddar et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Substrate-Induced Ubiquitylation and Endocytosis of Yeast Amino Acid Permeases

(2014) K. Ghaddar et al.   MOLECULAR AND CELLULAR BIOLOGY

Structural bases for the interaction and stabilization of the human amino acid transporter LAT2 with its ancillary protein 4F2hc

(2014) A. Rosell et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Molecular mechanism of pH-dependent substrate transport by an arginine-agmatine antiporter

(2014) S. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Common Folds and Transport Mechanisms of Secondary Active Transporters

(2013) Yigong Shi   Annual Review of Biophysics

Structural and Functional Implications of the Yeast High-Affinity Tryptophan Permease Tat2

(2013) Naoko Kanda et al.   BIOCHEMISTRY

L-glutamine provides acid resistance for Escherichia coli through enzymatic release of ammonia

(2013) Peilong Lu et al.   CELL RESEARCH

Substrate Selectivity of the Acid-activated Glutamate/γ-Aminobutyric acid (GABA) Antiporter GadC fromEscherichia coli

(2013) Dan Ma et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The SLC3 and SLC7 families of amino acid transporters

(2013) Dimitrios Fotiadis et al.   MOLECULAR ASPECTS OF MEDICINE

X-ray structure of dopamine transporter elucidates antidepressant mechanism

(2013) Aravind Penmatsa et al.   NATURE

Structure-based ligand discovery for the Large-neutral Amino Acid Transporter 1, LAT-1

(2013) E. G. Geier et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Substrate selectivity in glutamate-dependent acid resistance in enteric bacteria

(2013) M.-F. Tsai et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Substrate selectivity in arginine-dependent acid resistance in enteric bacteria

(2013) M.-F. Tsai et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Sided Functions of an Arginine–Agmatine Antiporter Oriented in Liposomes

(2012) Ming-Feng Tsai et al.   BIOCHEMISTRY

The Amino Acid-Polyamine-Organocation Superfamily

(2012) Foon H. Wong et al.   JOURNAL OF MOLECULAR MICROBIOLOGY AND BIOTECHNOLOGY

Glutamate decarboxylase-dependent acid resistance in orally acquired bacteria: function, distribution and biomedical implications of thegadBCoperon

(2012) Daniela De Biase et al.   MOLECULAR MICROBIOLOGY

Structure and mechanism of a glutamate–GABA antiporter

(2012) Dan Ma et al.   NATURE

Protonation of Glutamate 208 Induces the Release of Agmatine in an Outward-facing Conformation of an Arginine/Agmatine Antiporter

(2011) Elia Zomot et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Molecular basis of substrate-induced permeation by an amino acid antiporter

(2011) L. Kowalczyk et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The structural basis of secondary active transport mechanisms

(2010) Lucy R. Forrest et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Substrate recognition and transport behavior analyses of amino acid antiporter with coarse-grained models

(2010) Shan Chang et al.   Molecular BioSystems

Mechanism of substrate recognition and transport by an amino acid antiporter

(2010) Xiang Gao et al.   NATURE

Mutation of His465Alters the pH-dependent Spectroscopic Properties of Escherichia coli Glutamate Decarboxylase and Broadens the Range of Its Activity toward More Alkaline pH

(2009) Eugenia Pennacchietti et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structure of a prokaryotic virtual proton pump at 3.2 Å resolution

(2009) Yiling Fang et al.   NATURE

Unlocking the molecular secrets of sodium-coupled transporters

(2009) Harini Krishnamurthy et al.   NATURE

The Rocking Bundle: A Mechanism for Ion-Coupled Solute Flux by Symmetrical Transporters

(2009) Lucy R. Forrest et al.   PHYSIOLOGY

Structure and Mechanism of an Amino Acid Antiporter

(2009) X. Gao et al.   SCIENCE

Structure and Mechanism of a Na+-Independent Amino Acid Transporter

(2009) P. L. Shaffer et al.   SCIENCE