Mutations in L-type amino acid transporter-2 support SLC7A8 as a novel gene involved in age-related hearing loss

Molecular features of the L-type amino acid transporter 2 determine different import and export profiles for thyroid hormones and amino acids

(2017) Katrin M. Hinz et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Enrichment of low-frequency functional variants revealed by whole-genome sequencing of multiple isolated European populations

(2017) Yali Xue et al.   Nature Communications

Analysis of protein-coding genetic variation in 60,706 humans

(2016) Monkol Lek et al.   NATURE

C-Raf deficiency leads to hearing loss and increased noise susceptibility

(2015) Rocío de Iriarte Rodríguez et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Transport of Iodothyronines by Human L-Type Amino Acid Transporters

(2015) Chantal Zevenbergen et al.   ENDOCRINOLOGY

Molecular architecture of the stria vascularis membrane transport system, which is essential for physiological functions of the mammalian cochlea

(2015) Satoru Uetsuka et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Age-regulated function of autophagy in the mouse inner ear

(2015) Rocío de Iriarte Rodríguez et al.   HEARING RESEARCH

The timecourse of apoptotic cell death during postnatal remodeling of the mouse cochlea and its premature onset by triiodothyronine (T3)

(2015) R.P. Peeters et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Nutrient-sensing mechanisms and pathways

(2015) Alejo Efeyan et al.   NATURE

The Mouse as a Model for Age-Related Hearing Loss - A Mini-Review

(2014) Michael R. Bowl et al.   GERONTOLOGY

Cerebral Cortex Hyperthyroidism of Newborn Mct8-Deficient Mice Transiently Suppressed by Lat2 Inactivation

(2014) Bárbara Núñez et al.   PLoS One

Structural bases for the interaction and stabilization of the human amino acid transporter LAT2 with its ancillary protein 4F2hc

(2014) A. Rosell et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A rare variant in APOC3 is associated with plasma triglyceride and VLDL levels in Europeans

(2014) Nicholas J. Timpson et al.   Nature Communications

Current concepts in age-related hearing loss: Epidemiology and mechanistic pathways

(2013) Tatsuya Yamasoba et al.   HEARING RESEARCH

Genetic characterization of northeastern Italian population isolates in the context of broader European genetic diversity

(2012) Tõnu Esko et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

Inner Hair Cells Are Not Required for Survival of Spiral Ganglion Neurons in the Adult Cochlea

(2012) Y. Zilberstein et al.   JOURNAL OF NEUROSCIENCE

Unknown

(2012) Silvia Murillo-Cuesta et al.   MOLECULAR MEDICINE

X-ray structures of LeuT in substrate-free outward-open and apo inward-open states

(2012) Harini Krishnamurthy et al.   NATURE

Expression of human heteromeric amino acid transporters in the yeast Pichia pastoris

(2012) Meritxell Costa et al.   PROTEIN EXPRESSION AND PURIFICATION

Aminoaciduria, but normal thyroid hormone levels and signalling, in mice lacking the amino acid and thyroid hormone transporterSlc7a8

(2011) Doreen Braun et al.   BIOCHEMICAL JOURNAL

Developmental and Cell-Specific Expression of Thyroid Hormone Transporters in the Mouse Cochlea

(2011) David S. Sharlin et al.   ENDOCRINOLOGY

Genetic background effects on age-related hearing loss associated with Cdh23 variants in mice

(2011) Kelly L. Kane et al.   HEARING RESEARCH

Na+/K+-ATPase α1 Identified as an Abundant Protein in the Blood-Labyrinth Barrier That Plays an Essential Role in the Barrier Integrity

(2011) Yue Yang et al.   PLoS One

Molecular basis of substrate-induced permeation by an amino acid antiporter

(2011) L. Kowalczyk et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Pou3f4 deficiency causes defects in otic fibrocytes and stria vascularis by different mechanisms

(2010) Mee Hyun Song et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Age-related hearing loss or presbycusis

(2010) Qi Huang et al.   EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY

Mitochondrial oxidative damage and apoptosis in age-related hearing loss

(2010) Shinichi Someya et al.   MECHANISMS OF AGEING AND DEVELOPMENT

ANNOVAR: functional annotation of genetic variants from high-throughput sequencing data

(2010) K. Wang et al.   NUCLEIC ACIDS RESEARCH

RNA Microarray Analysis in Prenatal Mouse Cochlea Reveals Novel IGF-I Target Genes: Implication of MEF2 and FOXM1 Transcription Factors

(2010) Hortensia Sanchez-Calderon et al.   PLoS One

A comparative study of age-related hearing loss in wild type and insulin-like growth factor I deficient mice

(2010) Riquelme   Frontiers in Neuroanatomy

Education, occupation, noise exposure history and the 10-yr cumulative incidence of hearing impairment in older adults

(2009) Karen J. Cruickshanks et al.   HEARING RESEARCH

Age-related loss of spiral ganglion neurons

(2009) Jianxin Bao et al.   HEARING RESEARCH

Melanin precursors prevent premature age-related and noise-induced hearing loss in albino mice

(2009) Silvia Murillo-Cuesta et al.   Pigment Cell & Melanoma Research

Deafness in mice lacking the T-box transcription factor Tbx18 in otic fibrocytes

(2008) M.-O. Trowe et al.   DEVELOPMENT

Pharmacokinetic role of L-type amino acid transporters LAT1 and LAT2

(2008) Eva M. del Amo et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES