Frontline Science: Abnormalities in the gut mucosa of non‐obese diabetic mice precede the onset of type 1 diabetes

Compartmentalized gut lymph node drainage dictates adaptive immune responses

(2019) Daria Esterházy et al.   NATURE

Innate lymphoid cells in autoimmunity and chronic inflammatory diseases

(2018) Tingting Xiong et al.   Seminars in Immunopathology

Evaluation of different mucosal microbiota leads to gut microbiota-based prediction of type 1 diabetes in NOD mice

(2018) Youjia Hu et al.   Scientific Reports

Akkermansia muciniphilainduces gut microbiota remodelling and controls islet autoimmunity in NOD mice

(2017) Arno Hänninen et al.   GUT

Mucosal administration of CD3-specific monoclonal antibody inhibits diabetes in NOD mice and in a preclinical mouse model transgenic for the CD3 epsilon chain

(2017) Chantal Kuhn et al.   JOURNAL OF AUTOIMMUNITY

Tissue adaptation: Implications for gut immunity and tolerance

(2017) Ana M.C. Faria et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The cytosolic sensor STING is required for intestinal homeostasis and control of inflammation

(2017) M C C Canesso et al.   Mucosal Immunology

Natural polyreactive IgA antibodies coat the intestinal microbiota

(2017) Jeffrey J. Bunker et al.   SCIENCE

History and mechanisms of oral tolerance

(2017) Rafael M. Rezende et al.   SEMINARS IN IMMUNOLOGY

Proteobacteria: A Common Factor in Human Diseases

(2017) G. Rizzatti et al.   Biomed Research International

Intestinal Epithelial Cell Regulation of Adaptive Immune Dysfunction in Human Type 1 Diabetes

(2017) Christina L. Graves et al.   Frontiers in Immunology

Gut microbiota translocation to the pancreatic lymph nodes triggers NOD2 activation and contributes to T1D onset

(2016) Frederico R.C. Costa et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Lactobacillus salivarius reverse diabetes-induced intestinal defense impairment in mice through non-defensin protein

(2016) Pei-Hsuan Chung et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Classical dendritic cells are required for dietary antigen–mediated induction of peripheral Treg cells and tolerance

(2016) Daria Esterházy et al.   NATURE IMMUNOLOGY

Innate lymphoid cells as regulators of immunity, inflammation and tissue homeostasis

(2016) Christoph S N Klose et al.   NATURE IMMUNOLOGY

Oral Probiotic VSL#3 Prevents Autoimmune Diabetes by Modulating Microbiota and Promoting Indoleamine 2,3-Dioxygenase-Enriched Tolerogenic Intestinal Environment

(2016) Jayashree Dolpady et al.   Journal of Diabetes Research

DCIR2+cDC2 DCs and Zbtb32 Restore CD4+T-Cell Tolerance and Inhibit Diabetes

(2015) Jeffrey D. Price et al.   DIABETES

Alterations in Intestinal Microbiota Correlate With Susceptibility to Type 1 Diabetes

(2015) Aimon K. Alkanani et al.   DIABETES

Mast cells control insulitis and increase Treg cells to confer protection against STZ-induced type 1 diabetes in mice

(2015) Daniela Carlos et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Prolonged antibiotic treatment induces a diabetogenic intestinal microbiome that accelerates diabetes in NOD mice

(2015) Kirsty Brown et al.   ISME Journal

Antigen administration by continuous feeding enhances oral tolerance and leads to long-lasting effects

(2015) Rafael Pires Oliveira et al.   JOURNAL OF IMMUNOLOGICAL METHODS

Functional characterization of IgA-targeted bacterial taxa from undernourished Malawian children that produce diet-dependent enteropathy

(2015) Andrew L. Kau et al.   Science Translational Medicine

Cross-fostering immediately after birth induces a permanent microbiota shift that is shaped by the nursing mother

(2015) Joseph G Daft et al.   Microbiome

Immunoglobulin A Coating Identifies Colitogenic Bacteria in Inflammatory Bowel Disease

(2014) Noah W. Palm et al.   CELL

Development, Differentiation, and Diversity of Innate Lymphoid Cells

(2014) Andreas Diefenbach et al.   IMMUNITY

The mucus and mucins of the goblet cells and enterocytes provide the first defense line of the gastrointestinal tract and interact with the immune system

(2014) Thaher Pelaseyed et al.   IMMUNOLOGICAL REVIEWS

Dendritic cell subsets in the intestinal lamina propria: Ontogeny and function

(2013) Emma K. Persson et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Is type 1 diabetes a food-induced disease?

(2013) Mona Landin-Olsson et al.   MEDICAL HYPOTHESES

Mucus Enhances Gut Homeostasis and Oral Tolerance by Delivering Immunoregulatory Signals

(2013) M. Shan et al.   SCIENCE

Sex Differences in the Gut Microbiome Drive Hormone-Dependent Regulation of Autoimmunity

(2013) J. G. M. Markle et al.   SCIENCE

New Insights into the Immunological Changes in IL-10-Deficient Mice during the Course of Spontaneous Inflammation in the Gut Mucosa

(2012) Ana Cristina Gomes-Santos et al.   Clinical & Developmental Immunology

Inflammation switches the differentiation program of Ly6Chimonocytes from antiinflammatory macrophages to inflammatory dendritic cells in the colon

(2012) Aymeric Rivollier et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Oral tolerance to food protein

(2012) O Pabst et al.   Mucosal Immunology

New and future immunomodulatory therapy in type 1 diabetes

(2012) James E. Tooley et al.   TRENDS IN MOLECULAR MEDICINE

Defective Differentiation of Regulatory FoxP3+ T Cells by Small-Intestinal Dendritic Cells in Patients With Type 1 Diabetes

(2011) E. Badami et al.   DIABETES

The gut as a regulator of early inflammation in type 1 diabetes

(2011) Outi Vaarala   Current Opinion in Endocrinology Diabetes and Obesity

Importance and regulation of the colonic mucus barrier in a mouse model of colitis

(2010) J. Petersson et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

IL-17 Immunity in Human Type 1 Diabetes

(2010) J. Honkanen et al.   JOURNAL OF IMMUNOLOGY

TGF-β Induces Surface LAP Expression on Murine CD4 T Cells Independent of Foxp3 Induction

(2010) Takatoku Oida et al.   PLoS One

Glutamic acid decarboxylase epitope protects against autoimmune diabetes through activation of Th2 immune response and induction of possible regulatory mechanism

(2010) Zhaohui Gong et al.   VACCINE

IL-17 Produced during Trypanosoma cruzi Infection Plays a Central Role in Regulating Parasite-Induced Myocarditis

(2010) Paulo Marcos da Matta Guedes et al.   PLoS Neglected Tropical Diseases

Inhibition of Th17 Cells Regulates Autoimmune Diabetes in NOD Mice

(2009) J. A. Emamaullee et al.   DIABETES

Epidemiological Perspectives on Type 1 Diabetes in Childhood and Adolescence in Germany: 20 years of the Baden-Wurttemberg Diabetes Incidence Registry (DIARY)

(2009) S. Ehehalt et al.   DIABETES CARE

Intestinal CD103+, but not CX3CR1+, antigen sampling cells migrate in lymph and serve classical dendritic cell functions

(2009) Olga Schulz et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Induction of Antigen-Specific Tolerance by Oral Administration of Lactococcus lactis Delivered Immunodominant DQ8-Restricted Gliadin Peptide in Sensitized Nonobese Diabetic Ab  Dq8 Transgenic Mice

(2009) I. L. Huibregtse et al.   JOURNAL OF IMMUNOLOGY

Increasing Incidence of Pediatric Type 1 Diabetes Mellitus in Southeastern Wisconsin: Relationship with Body Weight at Diagnosis

(2009) Jennifer Evertsen et al.   PLoS One

The "Perfect Storm" for Type 1 Diabetes: The Complex Interplay Between Intestinal Microbiota, Gut Permeability, and Mucosal Immunity

(2008) O. Vaarala et al.   DIABETES

Innocuous IFNγ induced by adjuvant-free antigen restores normoglycemia in NOD mice through inhibition of IL-17 production

(2008) Renu Jain et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Time trends in the incidence of type 1 diabetes in Finnish children: a cohort study

(2008) Valma Harjutsalo et al.   LANCET

Innate immunity and intestinal microbiota in the development of Type 1 diabetes

(2008) Li Wen et al.   NATURE