Once-Weekly Oral Dosing of MK-8591 Protects Male Rhesus Macaques From Intrarectal Challenge With SHIV109CP3

Extended Duration MK-8591-Eluting Implant as a Candidate for HIV Treatment and Prevention

(2018) Stephanie E. Barrett et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Cabotegravir in the treatment and prevention of Human Immunodeficiency Virus-1

(2018) Tristan D. McPherson et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

4′-Ethynyl-2-fluoro-2′-deoxyadenosine, MK-8591

(2018) Martin Markowitz et al.   Current Opinion in HIV and AIDS

M184I/V substitutions and E138K/M184I/V double substitutions in HIV reverse transcriptase do not significantly affect the antiviral activity of EFdA

(2017) Maureen Oliveira et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Safety and tolerability of long-acting cabotegravir injections in HIV-uninfected men (ECLAIR): a multicentre, double-blind, randomised, placebo-controlled, phase 2a trial

(2017) Martin Markowitz et al.   Lancet HIV

Structural basis of HIV inhibition by translocation-defective RT inhibitor 4′-ethynyl-2-fluoro-2′-deoxyadenosine (EFdA)

(2016) Zhe Li Salie et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Pharmacokinetics of Long-Acting Tenofovir Alafenamide (GS-7340) Subdermal Implant for HIV Prophylaxis

(2015) Manjula Gunawardana et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Strong Correlation Between Concentrations of Tenofovir (TFV) Emtricitabine (FTC) in Hair and TFV Diphosphate and FTC Triphosphate in Dried Blood Spots in the iPrEx Open Label Extension: Implications for Pre-exposure Prophylaxis Adherence Monitoring

(2015) Monica Gandhi et al.   JOURNAL OF INFECTIOUS DISEASES

Tenofovir-Based Preexposure Prophylaxis for HIV Infection among African Women

(2015) Jeanne M. Marrazzo et al.   NEW ENGLAND JOURNAL OF MEDICINE

On-Demand Preexposure Prophylaxis in Men at High Risk for HIV-1 Infection

(2015) Jean-Michel Molina et al.   NEW ENGLAND JOURNAL OF MEDICINE

Tenofovir diphosphate concentrations and prophylactic effect in a macaque model of rectal simian HIV transmission

(2014) P. L. Anderson et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

4′-Ethynyl-2-fluoro-2′-deoxyadenosine (EFdA) Inhibits HIV-1 Reverse Transcriptase with Multiple Mechanisms

(2014) Eleftherios Michailidis et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Uptake of pre-exposure prophylaxis, sexual practices, and HIV incidence in men and transgender women who have sex with men: a cohort study

(2014) Robert M Grant et al.   LANCET INFECTIOUS DISEASES

Strong Relationship between Oral Dose and Tenofovir Hair Levels in a Randomized Trial: Hair as a Potential Adherence Measure for Pre-Exposure Prophylaxis (PrEP)

(2014) Albert Y. Liu et al.   PLoS One

Long-Acting Integrase Inhibitor Protects Macaques from Intrarectal Simian/Human Immunodeficiency Virus

(2014) C. D. Andrews et al.   SCIENCE

Effects of Substitutions at the 4′ and 2 Positions on the Bioactivity of 4′-Ethynyl-2-Fluoro-2′-Deoxyadenosine

(2013) Karen A. Kirby et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Generation of Lineage-Related, Mucosally Transmissible Subtype C R5 Simian-Human Immunodeficiency Viruses Capable of AIDS Development, Induction of Neurological Disease, and Coreceptor Switching in Rhesus Macaques

(2013) W. Ren et al.   JOURNAL OF VIROLOGY

Antiretroviral-based HIV-1 prevention: antiretroviral treatment and pre-exposure prophylaxis

(2012) Connie Celum et al.   ANTIVIRAL THERAPY

Antiretroviral Prophylaxis for HIV Prevention in Heterosexual Men and Women

(2012) Jared M. Baeten et al.   NEW ENGLAND JOURNAL OF MEDICINE

Preexposure Prophylaxis for HIV Infection among African Women

(2012) Lut Van Damme et al.   NEW ENGLAND JOURNAL OF MEDICINE

Tenofovir-based pre-exposure prophylaxis for HIV prevention

(2011) Connie Celum et al.   CURRENT OPINION IN INFECTIOUS DISEASES

Preexposure Chemoprophylaxis for HIV Prevention in Men Who Have Sex with Men

(2010) Robert M. Grant et al.   NEW ENGLAND JOURNAL OF MEDICINE

Intermittent Prophylaxis with Oral Truvada Protects Macaques from Rectal SHIV Infection

(2010) J. G. Garcia-Lerma et al.   Science Translational Medicine

Mechanism of Inhibition of HIV-1 Reverse Transcriptase by 4′-Ethynyl-2-fluoro-2′-deoxyadenosine Triphosphate, a Translocation-defective Reverse Transcriptase Inhibitor

(2009) Eleftherios Michailidis et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

2′-Deoxy-4′-C-ethynyl-2-halo-adenosines active against drug-resistant human immunodeficiency virus type 1 variants

(2008) Atsushi Kawamoto et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY