Targeting the SPOCK1-snail/slug axis-mediated epithelial-to-mesenchymal transition by apigenin contributes to repression of prostate cancer metastasis

Apigenin: A dietary flavonoid with diverse anticancer properties

(2018) Josip Madunić et al.   CANCER LETTERS

Epithelial mesenchymal transition Transcription Factor (TF): The structure, function and microRNA feedback loop

(2018) Neda Alidadiani et al.   GENE

Profiling Prostate Cancer Therapeutic Resistance

(2018) Cameron Wade et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Downregulating CD26/DPPIV by apigenin modulates the interplay between Akt and Snail/Slug signaling to restrain metastasis of lung cancer with multiple EGFR statuses

(2018) Jer-Hwa Chang et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Epithelial-to-mesenchymal transition in cancer: complexity and opportunities

(2018) Yun Zhang et al.   Frontiers of Medicine

Advancing therapies in metastatic castration-resistant prostate cancer

(2018) Giulia Baciarello et al.   EXPERT OPINION ON PHARMACOTHERAPY

Apigenin suppresses PD-L1 expression in melanoma and host dendritic cells to elicit synergistic therapeutic effects

(2018) Lu Xu et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

New insights into the mechanisms of epithelial–mesenchymal transition and implications for cancer

(2018) Anushka Dongre et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The Role and Mechanism of Epithelial-to-Mesenchymal Transition in Prostate Cancer Progression

(2017) U-Ging Lo et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Dual strands of pre-miR-150 (miR-150-5p and miR-150-3p) act as antitumor miRNAs targeting SPOCK1 in naïve and castration-resistant prostate cancer

(2017) Atsushi Okato et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Matrix Metalloproteinases: A challenging paradigm of cancer management

(2017) Ali Alaseem et al.   SEMINARS IN CANCER BIOLOGY

Apigenin in cancer therapy: anti-cancer effects and mechanisms of action

(2017) Xiaohui Yan et al.   Cell and Bioscience

SPOCK1 is upregulated in recurrent glioblastoma and contributes to metastasis and Temozolomide resistance

(2016) Fengbo Yu et al.   CELL PROLIFERATION

Apigenin inhibits glioma cell growth through promoting microRNA-16 and suppression of BCL-2 and nuclear factor-κB/MMP-9

(2016) Xin-Jun Chen et al.   Molecular Medicine Reports

SPOCK1 promotes tumor growth and metastasis in human prostate cancer

(2016) Zhong Wang et al.   Drug Design Development and Therapy

Natural Polyphenols for Prevention and Treatment of Cancer

(2016) Yue Zhou et al.   Nutrients

SPOCK1 Is a Novel Transforming Growth Factor-β–Induced Myoepithelial Marker That Enhances Invasion and Correlates with Poor Prognosis in Breast Cancer

(2016) Li-Ching Fan et al.   PLoS One

Multinucleation and Mesenchymal-to-Epithelial Transition Alleviate Resistance to Combined Cabazitaxel and Antiandrogen Therapy in Advanced Prostate Cancer

(2015) S. K. Martin et al.   CANCER RESEARCH

Keap1-Nrf2 Interaction Suppresses Cell Motility in Lung Adenocarcinomas by Targeting the S100P Protein

(2015) M.-H. Chien et al.   CLINICAL CANCER RESEARCH

Up-regulation of SPOCK1 induces epithelial–mesenchymal transition and promotes migration and invasion in esophageal squamous cell carcinoma

(2015) Xiaopeng Song et al.   JOURNAL OF MOLECULAR HISTOLOGY

Current mechanistic insights into the roles of matrix metalloproteinases in tumour invasion and metastasis

(2015) Gordon T Brown et al.   JOURNAL OF PATHOLOGY

SPOCK1 as a potential cancer prognostic marker promotes the proliferation and metastasis of gallbladder cancer cells by activating the PI3K/AKT pathway

(2015) Yi-Jun Shu et al.   Molecular Cancer

A new role for the PI3K/Akt signaling pathway in the epithelial-mesenchymal transition

(2015) Wenting Xu et al.   Cell Adhesion & Migration

Targeting the PI3K/Akt pathway in prostate cancer: Challenges and opportunities (Review)

(2014) PAUL TOREN et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Apigenin inhibits migration and invasion via modulation of epithelial mesenchymal transition in prostate cancer

(2014) YI ZHU et al.   Molecular Medicine Reports

Targeting the PI3K/Akt/mTOR Axis by Apigenin for Cancer Prevention

(2013) Xin Tong et al.   Anti-Cancer Agents in Medicinal Chemistry

Maintenance of Androgen Receptor Inactivation by S-Nitrosylation

(2013) Y. Qin et al.   CANCER RESEARCH

Phase 2 Trial of Single-agent Everolimus in Chemotherapy-naive Patients with Castration-resistant Prostate Cancer (SAKK 08/08)

(2013) Arnoud J. Templeton et al.   EUROPEAN UROLOGY

Angiopoietin-like protein 1 suppresses SLUG to inhibit cancer cell motility

(2013) Tsang-Chih Kuo et al.   JOURNAL OF CLINICAL INVESTIGATION

Alpha Emitter Radium-223 and Survival in Metastatic Prostate Cancer

(2013) C. Parker et al.   NEW ENGLAND JOURNAL OF MEDICINE

Testican-1-mediated epithelial–mesenchymal transition signaling confers acquired resistance to lapatinib in HER2-positive gastric cancer

(2013) H-P Kim et al.   ONCOGENE

Prostate cancer progression after androgen deprivation therapy: mechanisms of castrate resistance and novel therapeutic approaches

(2013) T Karantanos et al.   ONCOGENE

SPOCK1 Is Regulated by CHD1L and Blocks Apoptosis and Promotes HCC Cell Invasiveness and Metastasis in Mice

(2012) Yan Li et al.   GASTROENTEROLOGY

Diverse biological functions of the SPARC family of proteins

(2012) Amy D. Bradshaw   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Oral Administration of Apigenin Inhibits Metastasis through AKT/P70S6K1/MMP-9 Pathway in Orthotopic Ovarian Tumor Model

(2012) Jun He et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Vertical inhibition of the PI3K/Akt/mTOR pathway for the treatment of osteoarthritis

(2012) Jiezhong Chen et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Downregulation of Akt and FAK phosphorylation reduces invasion of glioblastoma cells by impairment of MT1-MMP shuttling to lamellipodia and downregulates MMPs expression

(2011) Aneta Kwiatkowska et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Reciprocal Feedback Regulation of PI3K and Androgen Receptor Signaling in PTEN-Deficient Prostate Cancer

(2011) Brett S. Carver et al.   CANCER CELL

Overexpression of MMP-9 Contributes to Invasiveness of Prostate Cancer Cell Line LNCaP

(2011) Ravikumar Aalinkeel et al.   IMMUNOLOGICAL INVESTIGATIONS

Slug enhances invasion ability of pancreatic cancer cells through upregulation of matrix metalloproteinase-9 and actin cytoskeleton remodeling

(2011) Kejun Zhang et al.   LABORATORY INVESTIGATION

Cyclophilin A promotes human hepatocellular carcinoma cell metastasis via regulation of MMP3 and MMP9

(2011) Mingjun Zhang et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Review: Castration-resistant prostate cancer: new science and therapeutic prospects

(2010) Joaquim Bellmunt et al.   Therapeutic Advances in Medical Oncology

Matrix metalloproteinases: Evolution, gene regulation and functional analysis in mouse models

(2009) Miriam Fanjul-Fernández et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Matrix metalloproteinases stimulate epithelial-mesenchymal transition during tumor development

(2008) Lidiya S. Orlichenko et al.   CLINICAL & EXPERIMENTAL METASTASIS

Regulation of androgen receptor transcriptional activity by rapamycin in prostate cancer cell proliferation and survival

(2008) Y Wang et al.   ONCOGENE