Immunoglobulin light chains generate proinflammatory and profibrotic kidney injury

Interleukin-1βActivates a MYC-Dependent Metabolic Switch in Kidney Stromal Cells Necessary for Progressive Tubulointerstitial Fibrosis

(2018) Dario R. Lemos et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Progression of chronic kidney disease: too much cellular talk causes damage

(2017) Leslie Gewin et al.   KIDNEY INTERNATIONAL

The SWISS-MODEL Repository—new features and functionality

(2016) Stefan Bienert et al.   NUCLEIC ACIDS RESEARCH

ESRD due to Multiple Myeloma in the United States, 2001-2010

(2015) S. Reule et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Inflammasomes: mechanism of action, role in disease and therapeutics

(2015) Haitao Guo et al.   NATURE MEDICINE

Improvement in renal function and its impact on survival in patients with newly diagnosed multiple myeloma

(2015) W I Gonsalves et al.   Blood Cancer Journal

Macrophages During the Fibrotic Process: M2 as Friend and Foe

(2015) Tarcio Teodoro Braga et al.   Frontiers in Immunology

A Caenorhabditis elegans-based assay recognizes immunoglobulin light chains causing heart amyloidosis

(2014) L. Diomede et al.   BLOOD

Diphtheria toxin-based bivalent human IL-2 fusion toxin with improved efficacy for targeting human CD25+ cells

(2014) Jaclyn Stromp Peraino et al.   JOURNAL OF IMMUNOLOGICAL METHODS

SWISS-MODEL: modelling protein tertiary and quaternary structure using evolutionary information

(2014) Marco Biasini et al.   NUCLEIC ACIDS RESEARCH

Significant improvement in the survival of patients with multiple myeloma presenting with severe renal impairment after the introduction of novel agents

(2013) M. A. Dimopoulos et al.   ANNALS OF ONCOLOGY

Bortezomib before and after autologous stem cell transplantation overcomes the negative prognostic impact of renal impairment in newly diagnosed multiple myeloma: a subgroup analysis from the HOVON-65/GMMG-HD4 trial

(2013) C. Scheid et al.   HAEMATOLOGICA

Origin and function of myofibroblasts in kidney fibrosis

(2013) Valerie S LeBleu et al.   NATURE MEDICINE

HMGB1 Accelerates Alveolar Epithelial Repair via an IL-1β- and αvβ6 Integrin-dependent Activation of TGF-β1

(2013) Jean-François Pittet et al.   PLoS One

Differentiated kidney epithelial cells repair injured proximal tubule

(2013) T. Kusaba et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mechanism and prevention of acute kidney injury from cast nephropathy in a rodent model

(2012) Wei-Zhong Ying et al.   JOURNAL OF CLINICAL INVESTIGATION

Mechanisms of Light Chain Injury along the Tubular Nephron

(2012) P. W. Sanders   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

The role of novel agents on the reversibility of renal impairment in newly diagnosed symptomatic patients with multiple myeloma

(2012) M A Dimopoulos et al.   LEUKEMIA

Effect of Aging and Dietary Salt and Potassium Intake on Endothelial PTEN (Phosphatase and Tensin Homolog on Chromosome 10) Function

(2012) Wei-Zhong Ying et al.   PLoS One

Expression and purification of soluble porcine CTLA-4 in yeast Pichia pastoris

(2012) Jaclyn Peraino et al.   PROTEIN EXPRESSION AND PURIFICATION

Pivotal Role of Apoptosis Signal-Regulating Kinase 1 in Monoclonal Free Light Chain–Mediated Apoptosis

(2011) Wei-Zhong Ying et al.   AMERICAN JOURNAL OF PATHOLOGY

Early Reduction of Serum-Free Light Chains Associates with Renal Recovery in Myeloma Kidney

(2011) C. A. Hutchison et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

The Inflammasomes in Kidney Disease

(2011) H.-J. Anders et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Expression and purification of non-N-glycosylated porcine interleukin 3 in yeast Pichia pastoris

(2011) Christina E. Hermanrud et al.   PROTEIN EXPRESSION AND PURIFICATION

TG101209, a novel JAK2 inhibitor, has significant in vitro activity in multiple myeloma and displays preferential cytotoxicity for CD45+ myeloma cells

(2010) Vijay Ramakrishnan et al.   AMERICAN JOURNAL OF HEMATOLOGY

Immunoglobulin light chains activate nuclear factor- B in renal epithelial cells through a Src-dependent mechanism

(2010) W.-Z. Ying et al.   BLOOD

Preclinical characterization of the selective JAK1/2 inhibitor INCB018424: therapeutic implications for the treatment of myeloproliferative neoplasms

(2010) A. Quintas-Cardama et al.   BLOOD

Cancer Statistics, 2010

(2010) A. Jemal et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Heme Oxygenase-1 expression in M-CSF-polarized M2 macrophages contributes to LPS-induced IL-10 release

(2010) Elena Sierra-Filardi et al.   IMMUNOBIOLOGY

Light Chain–Induced Acute Renal Failure Can Be Reversed by Bortezomib-Doxorubicin-Dexamethasone in Multiple Myeloma: Results of a Phase II Study

(2010) Heinz Ludwig et al.   JOURNAL OF CLINICAL ONCOLOGY

Immunoglobulin Light Chains Activate Tubular Epithelial Cells through Redox Signaling

(2010) K. Basnayake et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Reversibility of renal failure in newly diagnosed patients with multiple myeloma and the role of novel agents

(2010) Maria Roussou et al.   LEUKEMIA RESEARCH

Amyloidogenic light chains induce cardiomyocyte contractile dysfunction and apoptosis via a non-canonical p38  MAPK pathway

(2010) J. Shi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

VMP (Bortezomib, Melphalan, and Prednisone) Is Active and Well Tolerated in Newly Diagnosed Patients With Multiple Myeloma With Moderately Impaired Renal Function, and Results in Reversal of Renal Impairment: Cohort Analysis of the Phase III VISTA Study

(2009) Meletios A. Dimopoulos et al.   JOURNAL OF CLINICAL ONCOLOGY

Kidney injury molecule-1 (KIM-1): a urinary biomarker and much more

(2009) J. V. Bonventre   NEPHROLOGY DIALYSIS TRANSPLANTATION

The SWISS-MODEL Repository and associated resources

(2008) F. Kiefer et al.   NUCLEIC ACIDS RESEARCH

Inhibition of Integrin αvβ6, an Activator of Latent Transforming Growth Factor-β, Prevents Radiation-induced Lung Fibrosis

(2007) Khalid Puthawala et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE