SGEF forms a complex with Scribble and Dlg1 and regulates epithelial junctions and contractility

Scribble: A master scaffold in polarity, adhesion, synaptogenesis, and proliferation

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Drosophila melanogasterGuk-holder interacts with the Scribbled PDZ1 domain and regulates epithelial development with Scribbled and Discs Large

(2018) Sofia Caria et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Comprehensive analysis of formin localization in Xenopus epithelial cells

(2018) Tomohito Higashi et al.   MOLECULAR BIOLOGY OF THE CELL

Tools for live imaging of active Rho GTPases inXenopus

(2017) Rachel E. Stephenson et al.   GENESIS

Structural basis for the differential interaction of Scribble PDZ domains with the guanine nucleotide exchange factor β-PIX

(2017) Krystle Y. B. Lim et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A RhoG-mediated signaling pathway that modulates invadopodia dynamics in breast cancer cells

(2017) Silvia M. Goicoechea et al.   JOURNAL OF CELL SCIENCE

Regulation of circular dorsal ruffles, macropinocytosis, and cell migration by RhoG and its exchange factor, Trio

(2017) Alejandra Valdivia et al.   MOLECULAR BIOLOGY OF THE CELL

Origins of Allostery and Evolvability in Proteins: A Case Study

(2016) Arjun S. Raman et al.   CELL

Maintenance of the Epithelial Barrier and Remodeling of Cell-Cell Junctions during Cytokinesis

(2016) Tomohito Higashi et al.   CURRENT BIOLOGY

Cell Boundary Elongation by Non-autonomous Contractility in Cell Oscillation

(2016) Yusuke Hara et al.   CURRENT BIOLOGY

Remodeling the zonula adherens in response to tension and the role of afadin in this response

(2016) Wangsun Choi et al.   JOURNAL OF CELL BIOLOGY

The polarity protein Scribble positions DLC3 at adherens junctions to regulate Rho signaling

(2016) Janina Hendrick et al.   JOURNAL OF CELL SCIENCE

ZO-1 interactions with F-actin and occludin direct epithelial polarization and single lumen specification in 3D culture

(2016) Matthew A. Odenwald et al.   JOURNAL OF CELL SCIENCE

Interdomain interface-mediated target recognition by the Scribble PDZ34 supramodule

(2015) Jinqi Ren et al.   BIOCHEMICAL JOURNAL

Morpholinos: Antisense and Sensibility

(2015) Martin Blum et al.   DEVELOPMENTAL CELL

An ELMO2-RhoG-ILK network modulates microtubule dynamics

(2015) Bradley C. Jackson et al.   MOLECULAR BIOLOGY OF THE CELL

MgcRacGAP restricts active RhoA at the cytokinetic furrow and both RhoA and Rac1 at cell–cell junctions in epithelial cells

(2015) Elaina B. Breznau et al.   MOLECULAR BIOLOGY OF THE CELL

E-cadherin loss alters cytoskeletal organization and adhesion in non-malignant breast cells but is insufficient to induce an epithelial-mesenchymal transition

(2014) Augustine Chen et al.   BMC CANCER

Anillin Regulates Cell-Cell Junction Integrity by Organizing Junctional Accumulation of Rho-GTP and Actomyosin

(2014) Ciara C. Reyes et al.   CURRENT BIOLOGY

Actomyosin networks and tissue morphogenesis

(2014) Akankshi Munjal et al.   DEVELOPMENT

An Elmo–Dock complex locally controls Rho GTPases and actin remodeling during cadherin-mediated adhesion

(2014) Christopher P. Toret et al.   JOURNAL OF CELL BIOLOGY

Establishment of epithelial polarity – GEF who's minding the GAP?

(2014) Siu P. Ngok et al.   JOURNAL OF CELL SCIENCE

Molecular mechanisms of de novo lumen formation

(2014) Sara Sigurbjörnsdóttir et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Organization and execution of the epithelial polarity programme

(2014) Enrique Rodriguez-Boulan et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Characterization of Diverse Internal Binding Specificities of PDZ Domains by Yeast Two-Hybrid Screening of a Special Peptide Library

(2014) Yi Mu et al.   PLoS One

ZO-1 Knockout by TALEN-Mediated Gene Targeting in MDCK Cells: Involvement of ZO-1 in the Regulation of Cytoskeleton and Cell Shape

(2014) Shinsaku Tokuda et al.   PLoS One

The minimal cadherin-catenin complex binds to actin filaments under force

(2014) C. D. Buckley et al.   SCIENCE

ThePDB_REDOserver for macromolecular structure model optimization

(2014) Robbie P. Joosten et al.   IUCrJ

Interaction of p190RhoGAP with C-terminal Domain of p120-catenin Modulates Endothelial Cytoskeleton and Permeability

(2013) Noureddine Zebda et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

SHIP2 regulates epithelial cell polarity through its lipid product, which binds to Dlg1, a pathway subverted by hepatitis C virus core protein

(2013) Aline Awad et al.   MOLECULAR BIOLOGY OF THE CELL

The Structure of the Tiam1 PDZ Domain/ Phospho-Syndecan1 Complex Reveals a Ligand Conformation that Modulates Protein Dynamics

(2013) Xu Liu et al.   STRUCTURE

Planar Cell Polarity Links Axes of Spatial Dynamics in Neural-Tube Closure

(2012) Tamako Nishimura et al.   CELL

Scribble is required for normal epithelial cell–cell contacts and lumen morphogenesis in the mammalian lung

(2012) Laura L. Yates et al.   DEVELOPMENTAL BIOLOGY

The Scribble–Dlg–Lgl polarity module in development and cancer: from flies to man

(2012) Imogen Elsum et al.   Essays in Biochemistry

DLC1 Interaction with  -Catenin Stabilizes Adherens Junctions and Enhances DLC1 Antioncogenic Activity

(2012) V. Tripathi et al.   MOLECULAR AND CELLULAR BIOLOGY

Centralspindlin and α-catenin regulate Rho signalling at the epithelial zonula adherens

(2012) Aparna Ratheesh et al.   NATURE CELL BIOLOGY

The Scribble Polarity Protein Stabilizes E-Cadherin/p120-Catenin Binding and Blocks Retrieval of E-Cadherin to the Golgi

(2012) Madhura Lohia et al.   PLoS One

The Invasive Capacity of HPV Transformed Cells Requires the hDlg-Dependent Enhancement of SGEF/RhoG Activity

(2012) Vanitha Krishna Subbaiah et al.   PLoS Pathogens

The RhoGAP protein Deleted in Liver Cancer 3 (DLC3) is essential for adherens junctions integrity

(2012) G Holeiter et al.   Oncogenesis

Tight Junction Pore and Leak Pathways: A Dynamic Duo

(2011) Le Shen et al.   Annual Review of Physiology

Planar polarity pathway and Nance-Horan syndrome-like 1b have essential cell-autonomous functions in neuronal migration

(2011) G. S. Walsh et al.   DEVELOPMENT

Distinct roles of cadherin-6 and E-cadherin in tubulogenesis and lumen formation

(2011) Liwei Jia et al.   MOLECULAR BIOLOGY OF THE CELL

Zonula occludens-1 and -2 regulate apical cell structure and the zonula adherens cytoskeleton in polarized epithelia

(2011) Alan S. Fanning et al.   MOLECULAR BIOLOGY OF THE CELL

Spatially restricted activation of RhoA signalling at epithelial junctions by p114RhoGEF drives junction formation and morphogenesis

(2011) Stephen J. Terry et al.   NATURE CELL BIOLOGY

Integration, scaling, space-group assignment and post-refinement

(2010) Wolfgang Kabsch   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

XDS

(2010) Wolfgang Kabsch   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Features and development ofCoot

(2010) P. Emsley et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

PHENIX: a comprehensive Python-based system for macromolecular structure solution

(2010) Paul D. Adams et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Tuba, a Cdc42 GEF, is required for polarized spindle orientation during epithelial cyst formation

(2010) Yi Qin et al.   JOURNAL OF CELL BIOLOGY

Endogenous RhoG Is Rapidly Activated after Epidermal Growth Factor Stimulation through Multiple Guanine-Nucleotide Exchange Factors

(2010) Thomas Samson et al.   MOLECULAR BIOLOGY OF THE CELL

α-Catenin as a tension transducer that induces adherens junction development

(2010) Shigenobu Yonemura et al.   NATURE CELL BIOLOGY

Tumor Suppressor Scribble Regulates Assembly of Tight Junctions in the Intestinal Epithelium

(2009) Andrei I. Ivanov et al.   AMERICAN JOURNAL OF PATHOLOGY

The basics of epithelial-mesenchymal transition

(2009) Raghu Kalluri et al.   JOURNAL OF CLINICAL INVESTIGATION

ZO-1 Stabilizes the Tight Junction Solute Barrier through Coupling to the Perijunctional Cytoskeleton

(2009) Christina M. Van Itallie et al.   MOLECULAR BIOLOGY OF THE CELL

Physiology and Function of the Tight Junction

(2009) J. M. Anderson et al.   Cold Spring Harbor Perspectives in Biology

Automated macromolecular model building for X-ray crystallography using ARP/wARP version 7

(2008) Gerrit Langer et al.   Nature Protocols

Crosstalk between small GTPases and polarity proteins in cell polarization

(2008) Sandra Iden et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY