Review
Medicine, Research & Experimental
Jiajing Sun, Sikai Wu, Zixian Jin, Sijia Ren, William C. Cho, Chengchu Zhu, Jianfei Shen
Summary: Lung cancer has high morbidity and mortality rates, with tumor metastasis being a significant risk factor for death. Even after complete removal of a tumor at an early stage, there is still a risk of recurrence. Lymph node micrometastasis has been found to be associated with poor prognosis, but predicting prognosis and choosing the appropriate surgical and postoperative adjuvant chemotherapy options remain challenging for clinicians.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Cardiac & Cardiovascular Systems
Atsushi Kamigaichi, Keiju Aokage, Shinya Katsumata, Genichiro Ishii, Masashi Wakabayashi, Tomohiro Miyoshi, Kenta Tane, Joji Samejima, Masahiro Tsuboi
Summary: This study evaluated the prognostic impact of examining the number of individual mediastinal lymph nodes (mLNs) in patients with resectable non-small cell lung cancer (NSCLC). The results showed that examining >= 3 mLNs was associated with better prognosis and lower risk of lymph node recurrence.
EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY
(2022)
Article
Oncology
Pieter W. J. Lozekoot, Jean H. T. Daemen, Robert R. van den Broek, Jos G. Maessen, Michiel H. M. Gronenschild, Yvonne L. J. Vissers, Karel W. E. Hulsewe, Erik R. de Loos
Summary: VAMLA demonstrates superior sensitivity and negative predictive value in detecting N2 disease, offering a significant decrease in risk of unforeseen pN2, but is also associated with a higher risk of complications.
TRANSLATIONAL LUNG CANCER RESEARCH
(2021)
Article
Medicine, General & Internal
Chenguang Li, Yunfeng Ni, Changhao Liu, Renwang Liu, Chenlei Zhang, Zuoqing Song, Hongxu Liu, Tao Jiang, Zhenfa Zhang
Summary: This study aims to evaluate the non-inferiority of spared mediastinal lymph node dissection compared with mediastinal lymph node dissection in stage IA NSCLC patients in terms of overall survival, and to examine relapse-free survival and perioperative data.
Article
Radiology, Nuclear Medicine & Medical Imaging
Guotao Yin, Yingchao Song, Xiaofeng Li, Lei Zhu, Qian Su, Dong Dai, Wengui Xu
Summary: This study developed an SVM model based on FDG PET/CT images to predict metastatic LNs in NSCLC patients. The best model was simplified into a scoring method, which may assist clinicians in determining the clinical staging of patients with NSCLC more easily.
EUROPEAN RADIOLOGY
(2021)
Article
Surgery
Yukinori Sakao, Kenji Suzuki, Sadanori Takeo, Akihioro Hayashi, Masanori Tsuchida, Tatsuhiko Hirono, Yuichi Saito, Hideaki Miyamoto
Summary: This study aimed to discuss the underlying oncological issues in staging of mediastinal lymph node metastasis in patients with left lung cancer who underwent extended radical lymphadenectomy. The results showed that cN status and adjuvant chemotherapy were significant prognostic factors for left lung cancer with mediastinal lymph node metastasis, rather than pN status. These findings broaden the discussion of oncological issues in the staging of mediastinal lymph node metastasis of left lung cancer.
ASIAN JOURNAL OF SURGERY
(2022)
Article
Oncology
Bo-Guen Kim, Jong Ho Cho, Sun Hye Shin, Kyungjong Lee, Sang-Won Um, Hojoong Kim, Jhingook Kim, Young Mog Shim, Byeong-Ho Jeong
Summary: Endosonography is recommended for nodal staging in NSCLC patients with radiological N1. However, the diagnostic sensitivity of endosonography for detecting OMM was only 40%, indicating the need for caution in interpreting the results.
CANCER RESEARCH AND TREATMENT
(2023)
Article
Medicine, General & Internal
Jurgen Hetzel, Laetitia A. A. Mauti, Jonas Winkler, Sabine Cardoso Almeida, Philip Jermann, Miklos Pless, Lukas Bubendorf, Peter Karl Bode, Maik Haentschel
Summary: Personalized treatment of metastatic non-squamous NSCLC requires comprehensive molecular characterization of the tumor, including detection of driver mutations and PD-L1 expression. Different sampling techniques may be necessary to obtain sufficient tumor material. This case report highlights the importance of biopsy technique for precise tumor characterization. Only EBUS-TBLNC provided complete characterization, demonstrating PD-L1 expression without actionable genetic alterations.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Anatomy & Morphology
Merve Kucuker, Kadir Alper Kucuker, Isa Burak Guney, Behice Durgun
Summary: The anatomical locations of non-small cell lung carcinomas are closely related to metastatic lymph nodes, with the apicoposterior segment of the left superior lobe showing a significant association with mediastinal nodes. 18F-FDG PET/CT demonstrated diagnostic power in detecting mediastinal nodes, although there was no statistically significant relationship between tumor location and TNM staging. Further investigation in larger study groups is needed to explore this relationship.
Article
Oncology
Jianbo Guo, Lei Zhang, Liping Zhang, Junqi Wu, Long Xu, Haoran E, Chongwu Li, Hongyu Wu, Deping Zhao, Yumin Hu, Jie Zhang, Xuefei Hu
Summary: This study aimed to investigate suitable patients for adjuvant chemoradiation therapy (CRT) in non-small cell lung cancer (NSCLC) with heterogeneous pathological N2 (pN2) diseases. The study retrospectively reviewed data of pN2 NSCLC patients in Shanghai Pulmonary Hospital. The results showed that adjuvant CRT significantly improved the prognosis of pN2 patients, regardless of single or multiple lymph node metastasis.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2023)
Article
Oncology
Zaheer Ali, Malin Vildevall, Gabriela Vazquez Rodriguez, Decky Tandiono, Ioannis Vamvakaris, Georgios Evangelou, Georgios Lolas, Konstantinos N. Syrigos, Alberto Villanueva, Michael Wick, Shenga Omar, Anna Erkstam, Julia Schueler, Anna Fahlgren, Lasse D. Jensen
Summary: This study developed a zebrafish tumor xenograft (ZTX) platform that can accurately and quickly evaluate the treatment outcome and invasion/dissemination of tumors. The results showed that this platform has high clinical relevance and can predict lymph node involvement in patients.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2022)
Article
Computer Science, Information Systems
Danqing Hu, Shaolei Li, Nan Wu, Xudong Lu
Summary: In this study, a Multi-modal Heterogeneous Graph Forest (MHGF) approach was proposed to extract deep representations of Lymph Node Metastasis (LNM) from multi-modal data and predict LNM. The results showed that the proposed method achieved better performance in LNM prediction.
IEEE JOURNAL OF BIOMEDICAL AND HEALTH INFORMATICS
(2023)
Article
Surgery
Tomohiro Maniwa, Toru Kimura, Masayuki Ohue, Jiro Okami
Summary: MLND in older patients with NSCLC may not improve survival but may increase the risks of complications such as arrhythmia. Omitting MLND could be considered for advanced age patients.
Article
Oncology
Yu -Juan Jiang, Si-Cheng Zhou, Jing-Hua Chen, Jian-Wei Liang
Summary: This study aimed to investigate the effectiveness of adjuvant chemotherapy (ACT) after neoadjuvant chemoradiotherapy (nCRT) with total mesorectal excision (TME) plus lateral pelvic lymph node dissection (LLND) in patients with clinically suspected lateral pelvic lymph node metastasis (LPNM). The results showed that ACT did not provide any survival benefit, and patients with older age and early-stage disease may not benefit from ACT after nCRT followed by TME plus LLND.
Article
Automation & Control Systems
Guojie Hou, Liye Jia, Yanan Zhang, Wei Wu, Lin Zhao, Juanjuan Zhao, Long Wang, Yan Qiang
Summary: The determination of lymph node metastasis is critical to treatment options for non-small cell lung cancer. This research proposes a method for predicting lymph node metastasis by fusing imaging and genetic data, overcoming challenges in existing non-invasive prediction methods. Experimental results show that the proposed model performs well in predicting lymph node metastasis, providing a new method for non-invasive prediction.
ENGINEERING APPLICATIONS OF ARTIFICIAL INTELLIGENCE
(2023)
Article
Oncology
Fangqiu Fu, Yang Zhang, Zhendong Gao, Yue Zhao, Zhexu Wen, Han Han, Yuan Li, Haiquan Chen
INTERNATIONAL JOURNAL OF CANCER
(2020)
Article
Cardiac & Cardiovascular Systems
Yue Zhao, Han Han, Zhendong Gao, Hong Hu, Jiaqing Xiang, Yihua Sun, Haiquan Chen
SEMINARS IN THORACIC AND CARDIOVASCULAR SURGERY
(2021)
Article
Oncology
Fangqiu Fu, Yang Zhang, Zhendong Gao, Yue Zhao, Zhexu Wen, Han Han, Yuan Li, Hong Hu, Haiquan Chen
Summary: Recent studies have shown that CD47 plays a role in tumor evasion and is a potential target for cancer immunotherapy. High expression of CD47 in NSCLC patients is associated with poor prognosis, and combined use of CD47 and CD68 can predict patient survival effectively.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Fanfan Fan, Yang Zhang, Fangqiu Fu, Zhendong Gao, Yue Zhao, Han Han, Jinglei Lai, Zhexu Wen, Xiangyi Ma, Chaoqiang Deng, Zelin Ma, Shengping Wang, Lin Deng, Yuan Li, Ting Ye, Haiquan Chen
Summary: The prognosis of lung adenocarcinoma patients with ground-glass opacities (GGO) lesions exceeding 3 cm is better than that of patients with small solid lesions, even within the same clinical T category. Clinical T classification incorporating the GGO component may provide better prognostic prediction for lung cancer patients exceeding 3 cm.
ANNALS OF THORACIC SURGERY
(2022)
Article
Oncology
Subramanian Venkatesan, Mihaela Angelova, Clare Puttick, Haoran Zhai, Deborah R. Caswell, Wei-Ting Lu, Michelle Dietzen, Panagiotis Galanos, Konstantinos Evangelou, Roberto Bellelli, Emilia L. Lim, Thomas B. K. Watkins, Andrew Rowan, Vitor H. Teixeira, Yue Zhao, Haiquan Chen, Bryan Ngo, Lykourgos-Panagiotis Zalmas, Maise Al Bakir, Sebastijan Hobor, Eva Gronroos, Adam Pennycuick, Ersilia Nigro, Brittany B. Campbell, William L. Brown, Ayse U. Akarca, Teresa Marafioti, Mary Y. Wu, Michael Howell, Simon J. Boulton, Cosetta Bertoli, Tim R. Fenton, Robertus A. M. de Bruin, Apolinar Maya-Mendoza, Eric Santoni-Rugiu, Robert E. Hynds, Vassilis G. Gorgoulis, Mariam Jamal-Hanjani, Nicholas McGranahan, Reuben S. Harris, Sam M. Janes, Jirina Bartkova, Samuel F. Bakhoum, Jiri Bartek, Nnennaya Kanu, Charles Swanton
Summary: The study reveals that APOBEC3 genes are upregulated in breast and lung preinvasive lesions, and APOBEC3B exacerbates DNA replication stress to promote cellular diversity and chromosomal instability for early selection in cancer evolution.
Article
Oncology
Fangqiu Fu, Zhexu Wen, Zhendong Gao, Yue Zhao, Yuan Li, Yang Zhang, Haiquan Chen
Summary: The study aimed to investigate the potential benefit of primary tumor resection on overall survival in lung adenocarcinoma patients with occult M1a pleural disseminations receiving targeted therapy. Results showed that patients undergoing primary tumor resection had improved overall survival, especially at 2-year and 5-year follow-up.
FRONTIERS IN ONCOLOGY
(2021)
Article
Ecology
Yue Zhao, Xiao Fu, Jose I. Lopez, Andrew Rowan, Lewis Au, Annika Fendler, Steve Hazell, Hang Xu, Stuart Horswell, Scott T. C. Shepherd, Lavinia Spain, Fiona Byrne, Gordon Stamp, Tim O'Brien, David Nicol, Marcellus Augustine, Ashish Chandra, Sarah Rudman, Antonia Toncheva, Lisa Pickering, Erik Sahai, James Larkin, Paul A. Bates, Charles Swanton, Samra Turajlic, Ben Challacombe, Simon Chowdhury, William Drake, Archana Fernando, Nicos Fotiadis, Andrew Furness, Emine Hatipoglu, Karen Harrison-Phipps, Peter Hill, Catherine Horsfield, Teresa Marafioti, Jonathon Olsburgh, Alexander Polson, Sergio Quezada, Mary Varia, Hema Verma, Kevin Litchfield
Summary: The study combines whole-tumour images and genomic data to reveal more aggressive subclonal growth and metastasizing subclones in the tumor center. Spatial dynamics strongly correlate with genomic alterations and play a significant role in tumor evolution.
NATURE ECOLOGY & EVOLUTION
(2021)
Article
Oncology
Zhendong Gao, Han Han, Yue Zhao, Hui Yuan, Shanbo Zheng, Yang Zhang, Haiquan Chen
Summary: An integrated mRNA-ncRNA signature was developed to predict early relapse in early-stage lung adenocarcinoma patients after complete resection. The signature showed strong predictive power and potential utility in guiding treatment strategies, as well as providing insights into chemotherapy sensitivity, tumor microenvironment, and mutation landscape.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2021)
Article
Oncology
Haiqing Chen, Fangqiu Fu, Yue Zhao, Haoxuan Wu, Hong Hu, Yihua Sun, Yawei Zhang, Jiaqing Xiang, Yang Zhang
Summary: The study revealed a significant association between serum tumor markers and recurrence risk in non-small cell lung cancer patients. Different types of tumor markers showed varying prognostic value in different subtypes of lung cancer.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Fangqiu Fu, Zhendong Gao, Zhexu Wen, Zhendong Gao, Yue Zhao, Han Han, Shanbo Zheng, Shengping Wang, Yuan Li, Hong Hu, Yang Zhang, Haiquan Chen
Summary: This study identified that the systemic immune-inflammation index (SII) is independently associated with prognosis in patients with non-small cell lung cancer (NSCLC), especially in patients with stage I disease, solid nodules, and adenocarcinoma. The findings help to specify the target population for clinical use of SII.
TRANSLATIONAL LUNG CANCER RESEARCH
(2021)
Article
Oncology
Yueren Yan, Zhendong Gao, Han Han, Yue Zhao, Yang Zhang, Xiangyi Ma, Haiquan Chen
Summary: In this study, we found that NRAS is a novel prognostic biomarker in lung adenocarcinoma. High NRAS expression is associated with poor prognosis and may influence the tumor immune microenvironment. Additionally, NRAS expression is positively correlated with immune infiltrating cells and immune-related biomarkers.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2022)
Article
Oncology
Shiqi Chen, Ting Ye, Siqian Yang, Yue Zhao, Yang Zhang, Qingyuan Huang, Haoxuan Wu, Hong Hu, Yihua Sun, Yawei Zhang, Jiaqing Xiang, Shengping Wang, Yajia Gu, Yan Jin, Yuan Li, Haiquan Chen
Summary: This study found that tumor spread through air spaces (STAS) in lung adenocarcinoma is associated with tumor morphology and malignancy, and it has independent prognostic value for patients with pathologic N0 lung adenocarcinoma. Additionally, STAS is also associated with recurrence-free survival and overall survival in patients with acinar pattern-predominant adenocarcinoma/papillary pattern-predominant adenocarcinoma/invasive mucinous adenocarcinoma and those who underwent lobectomy.
Article
Ecology
Xiao Fu, Yue Zhao, Jose I. Lopez, Andrew Rowan, Lewis Au, Annika Fendler, Steve Hazell, Hang Xu, Stuart Horswell, Scott T. C. Shepherd, Charlotte E. Spencer, Lavinia Spain, Fiona Byrne, Gordon Stamp, Tim O'Brien, David Nicol, Marcellus Augustine, Ashish Chandra, Sarah Rudman, Antonia Toncheva, Andrew J. S. Furness, Lisa Pickering, Santosh Kumar, Dow-Mu Koh, Christina Messiou, Derfel ap Dafydd, Matthew R. Orton, Simon J. Doran, James Larkin, Charles Swanton, Erik Sahai, Kevin Litchfield, Samra Turajlic, Paul A. Bates
Summary: The study examined spatial and temporal features of clonal diversification in clear cell renal cell carcinoma using a combined modelling and real tumour analysis approach, providing insights into predicting tumour evolution patterns and subclone diversification levels.
NATURE ECOLOGY & EVOLUTION
(2022)
Article
Oncology
Fanfan Fan, Jian Gao, Yue Zhao, Jun Wang, Lu Meng, Jiaqiang Ma, Teng Li, Han Han, Jinglei Lai, Zhendong Gao, Xiongfei Li, Ran Guo, Zhiwei Cao, Yang Zhang, Xiaoming Zhang, Haiquan Chen
Summary: This study comprehensively characterized the mast cells in lung adenocarcinoma and found that they exhibit functional heterogeneity and different characteristics and functions in different types of lung adenocarcinoma. The interaction between mast cells and CCR2+ T cells is closely associated with the prognosis of lung adenocarcinoma.
Article
Medicine, General & Internal
Jun Shang, He Jiang, Yue Zhao, Jinglei Lai, Leming Shi, Jingcheng Yang, Haiquan Chen, Yuanting Zheng
Summary: Through whole-exome sequencing and RNA sequencing analysis of GGO-like lung adenocarcinoma, we identified differences compared to solid nodule lung adenocarcinoma, including lower TP53 mutation frequency and less active cell proliferation-related pathways. We also found differences between GGO-like lung adenocarcinoma and minimally invasive adenocarcinoma in terms of EGFR mutation frequency, CNV load, and immune cell abundance. Finally, we developed a transcriptomic signature that predicts the progression from GGO to solid nodule and patients' prognosis.
