Article
Chemistry, Applied
Hossam E. Emam, Tharwat Shaheen
Summary: In this study, new stimuli-responsive hybrid hydrogels were successfully created by incorporating succinylated cellulose nanocrystals (Su-CNC) into the hydrogel network. The hydrogels exhibited pH and thermo-responsive characteristics, with significant swelling behavior at pH 6 and shrinkage at temperatures above 35 degrees C.
CARBOHYDRATE POLYMERS
(2022)
Article
Chemistry, Physical
Dilara Gundogdu, Cemre Alemdar, Cagri Turan, H. Hazal Husnugil, Sreeparna Banerjee, Irem Erel-Goktepe
Summary: This study aimed to enhance the stimuli-responsive properties of physical alginate (ALG) hydrogels through layer-by-layer (LbL) modification and explore their potential as dual responsive, dual drug releasing platforms for antibacterial applications. It was found that LbL modification imparted temperature and pH responsiveness to ALG hydrogel, and enhanced the release of CIP. The LbL-coated hydrogels exhibited strong antibacterial activity, particularly at pH 7.4.
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
(2023)
Article
Chemistry, Multidisciplinary
Mingxin Wang, Somia Yassin Hussain Abdalkarim, Ruixin Gong, Haibin Ji, Zhiming Chen, Yunfei Shen, Ying Zhou, Jiayuan Shen, Hou-Yong Yu
Summary: Polymer composite microspheres with excellent biodegradable and controlled long-term release characteristics have gained significant attention. However, producing polymer microspheres with controlled properties and customizable drug release is still a major challenge. In this study, dual-responsive cellulose nanocrystals were engineered and incorporated into polylactide composite microspheres to achieve controlled and sustained drug release behavior. The results demonstrated a temperature and pH dual-responsive controlled drug release capability of the composite microspheres, highlighting their potential as multifunctional drug delivery systems for medical applications.
Review
Biotechnology & Applied Microbiology
Yanghui Xing, Buhui Zeng, Wang Yang
Summary: Light responsive hydrogels are an important drug delivery system that can accurately control drug release by incorporating photosensitive moieties into their structures. Advances in photosensitizers have enabled the use of different light sources, and hydrogels with photosensitizers have improved therapeutic effects. Existing light responsive drug delivery systems have been applied in chemotherapy, immunotherapy, photodynamic therapy, gene therapy, and other fields.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Materials Science, Ceramics
Liang Zhou, Yulin Zhang, Defu Zeng, Ting Shu, Shi Wang
Summary: Mesoporous poly-N-isopropylacrylamide-hydroxyapatite composite microspheres (PNIPAM-m-HAP) were synthesized in this study, showing biocompatibility, pH and thermo-responsiveness, which can effectively control the release of doxorubicin.
JOURNAL OF SOL-GEL SCIENCE AND TECHNOLOGY
(2021)
Article
Polymer Science
Bianca Andrade de Campos, Natalia Cristina Borges da Silva, Lucas Szmgel Moda, Pedro Vidinha, Ligia Passos Maia-Obi
Summary: pH-sensitive degradable hydrogels are smart materials that degrade upon pH variation. This study focused on the development of a hydrogel using HPG and OA, and investigated its formation process, as well as drug release for oral administration.
Article
Biophysics
Narsimha Mamidi, Ramiro Manuel Velasco Delgadillo
Summary: CNPs, as a type of nanocomposite hydrogel particles, were fabricated using an ionic gelation strategy and demonstrated dual (pH and thermo)-responsive controlled drug release in vitro. The results showed that CNPs disassembled at 55 degrees C to release the encapsulated drug molecules in a controlled fashion, indicating their potential as a promising drug delivery platform for the GI tract and colon targeted drug delivery.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2021)
Article
Engineering, Biomedical
Rossella Laurano, Monica Boffito, Michela Abrami, Mario Grassi, Alice Zoso, Valeria Chiono, Gianluca Ciardelli
Summary: The study presents a thermo- and pH-responsive hydrogel (P-CHP407) with a significant amount of -COOH groups for controlled and localized drug release, showing enhanced drug delivery kinetics and the potential use as smart delivery systems in the treatment of chronic infected wounds.
BIOACTIVE MATERIALS
(2021)
Article
Nanoscience & Nanotechnology
Hanif Haidari, Krasimir Vasilev, Allison J. Cowin, Zlatko Kopecki
Summary: A multistimuli-responsive hydrogel loaded with ultrasmall silver nanoparticles offers on-demand release of Ag+ ions triggered by changes in the wound microenvironment, showing high antibacterial efficacy in vivo.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Biochemistry & Molecular Biology
Chongyang Zhu, Xiaojun Zhang, Jing Gan, Donghui Geng, Xiaojia Bian, Yongqiang Cheng, Ning Tang
Summary: The researchers prepared a pH-sensitive hydrogel consisting of carboxymethylated konjac glucomannan (CMKGM) and sodium trime-taphosphate (STMP) for potential intestinal targeted delivery system. The CMKGM and CMKGM hydrogel were characterized by FT-IR spectra, X-ray diffraction (XRD), and thermogravimetric analysis (TGA). Results showed a coil-to-helix transition of CMKGM in alkaline conditions and the swelling behavior of the hydrogels revealed sensitivity to pH value changes, indicating its potential as a biomaterial for the intestine-targeted delivery system.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Pharmacology & Pharmacy
Mohadese Mahdian, Soheila Akbari Asrari, Mazaher Ahmadi, Tayyebeh Madrakian, Nahid Rezvani Jalal, Abbas Afkhami, Mohammadreza Moradi, Leila Gholami
Summary: We report on the synthesis and characterization of a dual stimuli-responsive hydrogel for pH and temperature-sensitive delivery of curcumin (CUR) anticancer drug. The release of CUR from the hydrogel was higher at acidic pH values, and the hydrogel remained stable at 37 degrees C. To enable thermal responsivity, polydopamine nanoparticles were embedded in the hydrogel. The GGPDNCs hydrogel is engineered to respond to both pH and temperature stimuli.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Jian-Yu Wang, Feng Jin, Xian-Zi Dong, Jie Liu, Ming-Xia Zhou, Teng Li, Mei-Ling Zheng
Summary: This study demonstrates a dual-stimuli cooperative responsive hydrogel microactuator by asymmetric fabrication via femtosecond laser direct writing. The dual response of the hydrogel microstructure is achieved through the use of responsive hydrogel with functional monomer 2-(dimethylamino)ethyl methacrylate. Raman spectra of the hydrogel microstructures suggest that the pH and temperature response of the hydrogel is generated by the changes in tertiary amine groups and hydrogen bonds, respectively. The asymmetric hydrogel microstructures show opposite bending direction when being heated to high temperature or exposed to acid solution, and can independently accomplish the grasp of polystyrene microspheres.
Article
Materials Science, Multidisciplinary
Gamze Kocal, Burcu Oktay, Gunes Ozen Eroglu, Serap Erdem Kuruca, Soner Cubuk, Nilhan Kayaman Apohan
Summary: This study successfully prepared mesoporous HAp nanoparticles with fluorescent and pH-responsive properties, and controlled the release rate of anticancer drugs through the design of nanoplatforms. The DOX@HAp/terpolymer nanoparticles exhibited different drug release characteristics under different pH conditions, showing high biocompatibility and inducing apoptosis of cancer cells.
MATERIALS TODAY COMMUNICATIONS
(2021)
Article
Engineering, Environmental
Wenxu Zhang, Xuyang Mu, Yan Xu, Sijie Li, Xiaoming Liu, Ziqiang Lei
Summary: In this study, a temperature/pH-responsive core-shell hydrogel was prepared by static template polymerization. The hydrogel exhibited good temperature responsiveness in the range of 25-55 degrees C and pH responsiveness from pH= 4 to pH= 13, with a short response time. The design of the core-shell structure enhanced the stability performance of the shell temperature-sensitive hydrogel, making it suitable for agricultural and pharmaceutical applications.
JOURNAL OF ENVIRONMENTAL CHEMICAL ENGINEERING
(2023)
Article
Materials Science, Multidisciplinary
Hao Xue, Fei Liu, Ze Wang, Delei Liu, Liang Zhou, Wenbo Su, Shichao Niu, Zhiwu Han, Luquan Ren
Summary: This article presents a simple and rapid in situ polymerization method for preparing dual-responsive photonic crystals (PCs) with ultra-precise micro-/nanoscale hierarchical structures. The obtained P(NIPAAM-co-AAc)-PCs exhibited a dual response to pH and temperature reversibility. This work allows the combination of natural hierarchical PC structures with smart hydrogel to achieve an optical response to pH and temperature, thus opening up the channels for responsive PC to multiple stimulus responses.
MATERIALS & DESIGN
(2023)
Article
Polymer Science
Gholamreza Kavoosi, Zarrintaj Bordbar, Seyed Mohammadali Dadfar, Seyed Mohammad Mahdi Dadfar
JOURNAL OF APPLIED POLYMER SCIENCE
(2017)
Article
Polymer Science
Gholamreza Kavoosi, Behroz Nateghpoor, Seyed Mohammad Mahdi Dadfar, Seyed Mohammad Ali Dadfar
JOURNAL OF APPLIED POLYMER SCIENCE
(2014)
Article
Materials Science, Multidisciplinary
S. M. Ali Dadfar, I. Alemzadeh, S. M. Reza Dadfar, M. Vosoughi
MATERIALS & DESIGN
(2011)
Article
Materials Science, Composites
Seyed Mohammad Mahdi Dadfar, Gholamreza Kavoosi, Seyed Mohammad Ali Dadfar
POLYMER COMPOSITES
(2014)
Article
Food Science & Technology
Gholamreza Kavoosi, Seyed Mohammad Mahdi Dadfar, Seyed Mohammad Ali Dadfar, Farhad Ahmadi, Mehrdad Niakosari
FOOD SCIENCE & NUTRITION
(2014)
Review
Pharmacology & Pharmacy
Seyed Mohammadali Dadfar, Karolin Roemhild, Natascha I. Drude, Saskia von Stillfried, Ruth Knuechel, Fabian Kiessling, Twan Lammers
ADVANCED DRUG DELIVERY REVIEWS
(2019)
Article
Biotechnology & Applied Microbiology
Seyed Mohammadali Dadfar, Denise Camozzi, Milita Darguzyte, Karolin Roemhild, Paola Varvara, Josbert Metselaar, Srinivas Banala, Marcel Straub, Nihan Guevener, Ulrich Engelmann, Ioana Slabu, Miriam Buhl, Jan van Leusen, Paul Koegerler, Benita Hermanns-Sachweh, Volkmar Schulz, Fabian Kiessling, Twan Lammers
JOURNAL OF NANOBIOTECHNOLOGY
(2020)
Article
Chemistry, Physical
Seyed Mohammad Reza Dadfar, Saeed Pourmahdian, Mohammad Mehdi Tehranchi, Seyed Mohammadali Dadfar
COLLOID AND POLYMER SCIENCE
(2020)
Article
Biochemical Research Methods
Milita Darguzyte, Regina Holm, Jasmin Baier, Natascha Drude, Jennifer Schultze, Kaloian Koynov, David Schwiertz, Seyed Mohammadali Dadfar, Twan Lammers, Matthias Barz, Fabian Kiessling
BIOCONJUGATE CHEMISTRY
(2020)
Article
Multidisciplinary Sciences
Robert Siepmann, Henning Nilius, Florian Mueller, Katrin Mueller, Claudio Luisi, Seyed Mohammadali Dadfar, Marcel Straub, Volkmar Schulz, Sebastian Daniel Reinartz
Summary: The study evaluated whether MPI could measure coronary blood velocities and calculate CFR, showing that MPI can reliably measure coronary blood velocities at rest and under hyperaemia, but the accuracy of CFR calculation needs substantial improvement.
Article
Engineering, Biomedical
Vertika Pathak, Teresa Nolte, Elena Rama, Anne Rix, Seyed Mohammadali Dadfar, Vera Paefgen, Srinivas Banala, Eva Miriam Buhl, Marek Weiler, Volkmar Schulz, Twan Lammers, Fabian Kiessling
Summary: This study investigated the use of microbubbles containing superparamagnetic iron oxide nanoparticles as molecular MRI contrast agents targeted against angiogenesis in breast cancer. Results indicated that RGD-SPION-MB showed higher retention in angiogenic vessels compared to SPION-MB and RAD-SPION-MB, demonstrating their potential as effective molecular MR/US contrast agents for assessing integrin expression in neovasculature.
Article
Chemistry, Multidisciplinary
Elena Rama, Saurav Ranjan Mohapatra, Christoph Melcher, Teresa Nolte, Seyed Mohammadali Dadfar, Ramona Brueck, Vertika Pathak, Anne Rix, Thomas Gries, Volkmar Schulz, Twan Lammers, Christian Apel, Stefan Jockenhoevel, Fabian Kiessling
Summary: This study presents a comprehensive molecular imaging concept using MRI and US to monitor the remodeling process of tissue-engineered vascular grafts. MRI can quantitatively monitor scaffold resorption, while molecular MRI and molecular US can depict ECM remodeling and endothelial integrity. This approach facilitates the translation from in vitro assessment to in vivo applications and ensures proper prostheses engraftment.
Article
Cardiac & Cardiovascular Systems
Filip M. E. Segers, Adele Ruder, Marijke M. Westra, Twan Lammers, Seyed Mohammadali Dadfar, Karolin Roemhild, Tin Sing Lam, Marianne Eline Kooi, Kitty B. J. M. Cleutjens, Fons K. Verheyen, Geert W. H. Schurink, Guido R. Haenen, Theo J. C. van Berkel, Ilze Bot, Bente Halvorsen, Judith C. Sluimer, Erik A. L. Biessen
Summary: This study found that superparamagnetic iron oxide nanoparticles (SPIO and USPIO) can induce apoptosis of lipid-laden macrophages in atherosclerosis in both humans and mice, potentially impacting the disease progression in patients with advanced atherosclerosis.
CARDIOVASCULAR RESEARCH
(2022)
Article
Engineering, Biomedical
Dennis Pantke, Florian Mueller, Sebastian Reinartz, Jonas Philipps, Seyed Mohammadali Dadfar, Maximilian Peters, Jochen Franke, Franziska Schrank, Fabian Kiessling, Volkmar Schulz
Summary: This study proposes a novel concept to enhance the signal and image resolution of magnetic particle imaging (MPI) using a purely passive receive coil insert. The passive dual coil resonator (pDCR) provides frequency-selective signal enhancement, and the results demonstrate improved spatial resolution. This passive coil insert is cost-efficient, easy-to-handle and adaptable to other MPI scanners, providing the basis for a new breed of passive MPI receiver systems.
PHYSICS IN MEDICINE AND BIOLOGY
(2022)
