γ-Secretase Processing and Effects of γ-Secretase Inhibitors and Modulators on Long Aβ Peptides in Cells
Published 2013 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
γ-Secretase Processing and Effects of γ-Secretase Inhibitors and Modulators on Long Aβ Peptides in Cells
Authors
Keywords
-
Journal
JOURNAL OF BIOLOGICAL CHEMISTRY
Volume 289, Issue 6, Pages 3276-3287
Publisher
American Society for Biochemistry & Molecular Biology (ASBMB)
Online
2013-12-19
DOI
10.1074/jbc.m113.512921
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Acute Effect on the Aβ Isoform Pattern in CSF in Response to γ-Secretase Modulator and Inhibitor Treatment in Dogs
- (2017) Erik Portelius et al. JOURNAL OF ALZHEIMERS DISEASE
- Major Carboxyl Terminal Fragments Generated by γ-Secretase Processing of the Alzheimer Amyloid Precursor Are 50 and 51 Amino Acids Long
- (2013) Inga Pinnix et al. AMERICAN JOURNAL OF GERIATRIC PSYCHIATRY
- Aβ43 Is the Earliest-Depositing Aβ Species in APP Transgenic Mouse Brain and Is Converted to Aβ41 by Two Active Domains of ACE
- (2013) Kun Zou et al. AMERICAN JOURNAL OF PATHOLOGY
- γ-Secretase inhibitors and modulators
- (2013) Todd E. Golde et al. BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES
- Steroids as γ-secretase modulators
- (2013) Joo In Jung et al. FASEB JOURNAL
- γ-Secretase Modulators and Presenilin 1 Mutants Act Differently on Presenilin/γ-Secretase Function to Cleave Aβ42 and Aβ43
- (2013) Masayasu Okochi et al. Cell Reports
- BMS-708,163 Targets Presenilin and Lacks Notch-Sparing Activity
- (2012) Christina J. Crump et al. BIOCHEMISTRY
- Effects of Membrane Lipids on the Activity and Processivity of Purified γ-Secretase
- (2012) Oliver Holmes et al. BIOCHEMISTRY
- The mechanism of γ-Secretase dysfunction in familial Alzheimer disease
- (2012) Lucía Chávez-Gutiérrez et al. EMBO JOURNAL
- Overlapping profiles of Abeta peptides in the Alzheimer's disease and pathological aging brains
- (2012) Brenda D Moore et al. Alzheimers Research & Therapy
- Dissociation between the Processivity and Total Activity of γ-Secretase: Implications for the Mechanism of Alzheimer's Disease-Causing Presenilin Mutations
- (2011) Omar Quintero-Monzon et al. BIOCHEMISTRY
- Substrate Sequence Influences γ-Secretase Modulator Activity, Role of the Transmembrane Domain of the Amyloid Precursor Protein
- (2011) Sarah A. Sagi et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Lysine 624 of the Amyloid Precursor Protein (APP) Is a Critical Determinant of Amyloid β Peptide Length
- (2011) Thomas L. Kukar et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- A simplified polyethylenimine-mediated transfection process for large-scale and high-throughput applications
- (2011) Céline Raymond et al. METHODS
- Anti-Aβ Therapeutics in Alzheimer's Disease: The Need for a Paradigm Shift
- (2011) Todd E. Golde et al. NEURON
- Alzheimer's Disease: The Challenge of the Second Century
- (2011) D. M. Holtzman et al. Science Translational Medicine
- The secretases: enzymes with therapeutic potential in Alzheimer disease
- (2010) Bart De Strooper et al. Nature Reviews Neurology
- A novel Aβ isoform pattern in CSF reflects γ-secretase inhibition in Alzheimer disease
- (2010) Erik Portelius et al. Alzheimers Research & Therapy
- -Secretase: Successive Tripeptide and Tetrapeptide Release from the Transmembrane Domain of -Carboxyl Terminal Fragment
- (2009) M. Takami et al. JOURNAL OF NEUROSCIENCE
- Hypothetical model of dynamic biomarkers of the Alzheimer's pathological cascade
- (2009) Clifford R Jack et al. LANCET NEUROLOGY
- Discovery of Begacestat, a Notch-1-Sparing γ-Secretase Inhibitor for the Treatment of Alzheimer’s Disease
- (2008) Scott C. Mayer et al. JOURNAL OF MEDICINAL CHEMISTRY
Find Funding. Review Successful Grants.
Explore over 25,000 new funding opportunities and over 6,000,000 successful grants.
ExploreDiscover Peeref hubs
Discuss science. Find collaborators. Network.
Join a conversation