Protein Kinase C Activation as a Potential Therapeutic Strategy in Alzheimer's Disease: Is there a Role for Embryonic Lethal Abnormal Vision-like Proteins?

nELAV Proteins Alteration in Alzheimer's Disease Brain: A Novel Putative Target for Amyloid-β Reverberating on AβPP Processing

(2017) Marialaura Amadio et al.   JOURNAL OF ALZHEIMERS DISEASE

Upregulation of Cytoplasmic Gelsolin, an Amyloid-β-Binding Protein, Under Oxidative Stress Conditions: Involvement of Protein Kinase C

(2017) Lina Ji et al.   JOURNAL OF ALZHEIMERS DISEASE

Therapeutic strategies for Alzheimer's disease in clinical trials

(2016) Justyna Godyń et al.   Pharmacological Reports

Amyloid β-interacting partners in Alzheimer's disease: From accomplices to possible therapeutic targets

(2016) Sun-Ho Han et al.   PROGRESS IN NEUROBIOLOGY

Cancer-Associated Protein Kinase C Mutations Reveal Kinase’s Role as Tumor Suppressor

(2015) Corina E. Antal et al.   CELL

The function of RNA-binding proteins at the synapse: implications for neurodegeneration

(2015) Chantelle F. Sephton et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Acute Oral Bryostatin-1 Administration Improves Learning Deficits in the APP/PS1 Transgenic Mouse Model of Alzheimer’s Disease

(2015) L.M. Schrott et al.   Current Alzheimer Research

A review on Alzheimer's disease pathophysiology and its management: an update

(2015) Anil Kumar et al.   Pharmacological Reports

Positive feedback between RNA-binding protein HuD and transcription factor SATB1 promotes neurogenesis

(2015) Feifei Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Alternative polyadenylation coupled to transcription initiation: Insights from ELAV-mediated 3′ UTR extension

(2015) Valérie Hilgers   RNA Biology

Towards universal therapeutics for memory disorders

(2015) Miao-Kun Sun et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

HuD Interacts with Bdnf mRNA and Is Essential for Activity-Induced BDNF Synthesis in Dendrites

(2015) Filip Vanevski et al.   PLoS One

Targeting α4β2 Nicotinic Acetylcholine Receptors in Central Nervous System Disorders: Perspectives on Positive Allosteric Modulation as a Therapeutic Approach

(2014) Morten Grupe et al.   BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY

C1 domain-targeted isophthalates as protein kinase C modulators: structure-based design, structure–activity relationships and biological activities

(2014) Virpi Talman et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Regulation of ELAV/Hu RNA-binding proteins by phosphorylation: Figure 1

(2014) Ulrike Bräuer et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Neuroprotection requires the functions of the RNA-binding protein HuR

(2014) A Skliris et al.   CELL DEATH AND DIFFERENTIATION

HuD Regulates Coding and Noncoding RNA to Induce APP→Aβ Processing

(2014) Min-Ju Kang et al.   Cell Reports

Neuronal RNA-binding proteins in health and disease

(2014) Silvia Carolina Lenzken et al.   Wiley Interdisciplinary Reviews-RNA

The global prevalence of dementia: A systematic review and metaanalysis

(2013) Martin Prince et al.   Alzheimers & Dementia

RNA Protein Interaction in Neurons

(2013) Robert B. Darnell   Annual Review of Neuroscience

Protein Kinase C and its Inhibitors in the Regulation of Inflammation: Inducible Nitric Oxide Synthase as an Example

(2013) Tiina Leppänen et al.   BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY

Identification of Peptides with ELAV-like mRNA-Stabilizing Effect: An IntegratedIn Vitro/In SilicoApproach

(2013) Marialaura Amadio et al.   Chemical Biology & Drug Design

Selective activation of protein kinase C∊ in mitochondria is neuroprotective in vitro and reduces focal ischemic brain injury in mice

(2013) Xiaoyun Sun et al.   JOURNAL OF NEUROSCIENCE RESEARCH

ELAV proteins along evolution: Back to the nucleus?

(2013) Claudia Colombrita et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Low hippocampal PI(4,5)P2 contributes to reduced cognition in old mice as a result of loss of MARCKS

(2013) Laura Trovò et al.   NATURE NEUROSCIENCE

PKC activation during training restores mushroom spine synapses and memory in the aged rat

(2013) Jarin Hongpaisan et al.   NEUROBIOLOGY OF DISEASE

NMDA receptors and memory encoding

(2013) Richard G.M. Morris   NEUROPHARMACOLOGY

The C1 domain-targeted isophthalate derivative HMI-1b11 promotes neurite outgrowth and GAP-43 expression through PKCα activation in SH-SY5Y cells

(2013) Virpi Talman et al.   PHARMACOLOGICAL RESEARCH

Bryostatin Improves Survival and Reduces Ischemic Brain Injury in Aged Rats After Acute Ischemic Stroke

(2013) Zhenjun Tan et al.   STROKE

PKC-dependent ERK phosphorylation is essential for P2X7 receptor-mediated neuronal differentiation of neural progenitor cells

(2013) H-K Tsao et al.   Cell Death & Disease

Bryostatin-1 vs. TPPB: Dose-Dependent APP Processing and PKC-α, -δ, and -ε Isoform Activation in SH-SY5Y Neuronal Cells

(2012) P. Yi et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Protein kinase C, an elusive therapeutic target?

(2012) Daria Mochly-Rosen et al.   NATURE REVIEWS DRUG DISCOVERY

Mouse models of Alzheimer's disease

(2011) Alicia M. Hall et al.   BRAIN RESEARCH BULLETIN

Crystal Structure and Allosteric Activation of Protein Kinase C βII

(2011) Thomas A. Leonard et al.   CELL

The complex world of post-transcriptional mechanisms: is their deregulation a common link for diseases? Focus on ELAV-like RNA-binding proteins

(2011) Alessia Pascale et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Current Status and Future Prospects of C1 Domain Ligands as Drug Candidates

(2011) Gustav Boije af Gennas et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

HuR function in disease

(2011) Subramanya Srikantan   Frontiers in Bioscience-Landmark

Cholinergic modulation of amyloid precursor protein processing with emphasis on M1 muscarinic receptor: perspectives and challenges in treatment of Alzheimer’s disease

(2011) Abraham Fisher   JOURNAL OF NEUROCHEMISTRY

Volume reduction in subcortical regions according to severity of Alzheimer’s disease

(2011) Jee Hoon Roh et al.   JOURNAL OF NEUROLOGY

PKC   Activation Prevents Synaptic Loss, A  Elevation, and Cognitive Deficits in Alzheimer's Disease Transgenic Mice

(2011) J. Hongpaisan et al.   JOURNAL OF NEUROSCIENCE

ERK1-independent α-secretase cut of β-amyloid precursor protein via M1 muscarinic receptors and PKCα/ε

(2011) Moustapha Cisse et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Neuron-specific ELAV/Hu proteins suppress HuR mRNA during neuronal differentiation by alternative polyadenylation

(2011) Kyle D. Mansfield et al.   NUCLEIC ACIDS RESEARCH

Design, synthesis, and evaluation of potent bryostatin analogs that modulate PKC translocation selectivity

(2011) P. A. Wender et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hu proteins regulate alternative splicing by inducing localized histone hyperacetylation in an RNA-dependent manner

(2011) H.-L. Zhou et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

ELAV–GAP43 pathway activation following combined exposure to cocaine and stress

(2011) Alessia Pascale et al.   PSYCHOPHARMACOLOGY

Senescence of the Brain: Focus on Cognitive Kinases

(2010) S. Govoni et al.   CURRENT PHARMACEUTICAL DESIGN

Tandem Phosphorylation of Serines 221 and 318 by Protein Kinase C  Coordinates mRNA Binding and Nucleocytoplasmic Shuttling of HuR

(2010) A. Doller et al.   MOLECULAR AND CELLULAR BIOLOGY

Pharmacology of protein kinase C activators: Cognition-enhancing and antidementic therapeutics

(2010) Miao-Kun Sun et al.   PHARMACOLOGY & THERAPEUTICS

Searching for Disease Modifiers-PKC Activation and HDAC Inhibition-A Dual Drug Approach to Alzheimer's Disease that Decreases Aβ Production while Blocking Oxidative Stress

(2009) Alan P. Kozikowski et al.   ChemMedChem

Promising multifunctional anti-Alzheimer's dimer bis(7)-Cognitin acting as an activator of protein kinase C regulates activities of α-secretase and BACE-1 concurrently

(2009) Hongjun Fu et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Design, Synthesis, and Biological Activity of Isophthalic Acid Derivatives Targeted to the C1 Domain of Protein Kinase C

(2009) Gustav Boije af Gennäs et al.   JOURNAL OF MEDICINAL CHEMISTRY

Discovery of Small Peptides Derived from Embryonic Lethal Abnormal Vision Proteins Structure Showing RNA-Stabilizing Properties

(2009) Daniela Rossi et al.   JOURNAL OF MEDICINAL CHEMISTRY

Simultaneous PKC and cAMP activation induces differentiation of human dental pulp stem cells into functionally active neurons

(2009) Marianna Király et al.   NEUROCHEMISTRY INTERNATIONAL

Novel recognition motifs and biological functions of the RNA-binding protein HuD revealed by genome-wide identification of its targets

(2009) Federico Bolognani et al.   NUCLEIC ACIDS RESEARCH

Postischemic PKC activation rescues retrograde and anterograde long-term memory

(2009) M.-K. Sun et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Diverse molecular functions of Hu proteins

(2008) M. N. Hinman et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Signalling pathways regulating nucleo-cytoplasmic shuttling of the mRNA-binding protein HuR

(2008) Anke Doller et al.   CELLULAR SIGNALLING

Wealth of Opportunity - The C1 Domain as a Target for Drug Development

(2008) P. Blumberg et al.   CURRENT DRUG TARGETS

The protein kinase C phosphorylation site on GAP-43 differentially regulates information storage

(2008) Matthew Holahan et al.   HIPPOCAMPUS

Conformationally Constrained Analogues of Diacylglycerol. 29. Cells Sort Diacylglycerol-Lactone Chemical Zip Codes to Produce Diverse and Selective Biological Activities

(2008) Dehui Duan et al.   JOURNAL OF MEDICINAL CHEMISTRY

Posttranslational Modification of the AU-Rich Element Binding Protein HuR by Protein Kinase C  Elicits Angiotensin II-Induced Stabilization and Nuclear Export of Cyclooxygenase 2 mRNA

(2008) A. Doller et al.   MOLECULAR AND CELLULAR BIOLOGY

Conserved GU-Rich Elements Mediate mRNA Decay by Binding to CUG-Binding Protein 1

(2008) Irina A. Vlasova et al.   MOLECULAR CELL

Structural Basis of Protein Kinase C Isoform Function

(2008) Susan F. Steinberg   PHYSIOLOGICAL REVIEWS

RNA–protein interactions and control of mRNA stability in neurons

(2007) Federico Bolognani et al.   JOURNAL OF NEUROSCIENCE RESEARCH

PKCβII/HuR/VEGF: A new molecular cascade in retinal pericytes for the regulation of VEGF gene expression

(2007) Marialaura Amadio et al.   PHARMACOLOGICAL RESEARCH