Epigenetic Methylations on N6-Adenine and N6-Adenosine with the same Input but Different Output

Transcriptome‐wide analysis of N6‐methyladenosine uncovers its regulatory role in gene expression in the lepidopteran Bombyx mori

(2019) B. Li et al.   INSECT MOLECULAR BIOLOGY

Profiling of m6A RNA modifications identified an age-associated regulation of AGO2 mRNA stability

(2018) Kyung-Won Min et al.   AGING CELL

RNA N6-methyladenosine modification in cancers: current status and perspectives

(2018) Xiaolan Deng et al.   CELL RESEARCH

DNA N 6 -Adenine Methylation in Arabidopsis thaliana

(2018) Zhe Liang et al.   DEVELOPMENTAL CELL

METTL3 regulates alternative splicing of MyD88 upon the lipopolysaccharide-induced inflammatory response in human dental pulp cells

(2018) Zhihui Feng et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

N 6 -Methyladenine DNA Modification in the Human Genome

(2018) Chuan-Le Xiao et al.   MOLECULAR CELL

Xio is a component of theDrosophilasex determination pathway and RNAN6-methyladenosine methyltransferase complex

(2018) Jian Guo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Interactions, localization, and phosphorylation of the m 6 A generating METTL3–METTL14–WTAP complex

(2018) Eva Schöller et al.   RNA

The m6A reader protein YTHDC2 interacts with the small ribosomal subunit and the 5′-3′ exoribonuclease XRN1

(2018) Jens Kretschmer et al.   RNA

N6-methyladenosine links RNA metabolism to cancer progression

(2018) Dongjun Dai et al.   Cell Death & Disease

Transient N-6-Methyladenosine Transcriptome Sequencing Reveals a Regulatory Role of m6A in Splicing Efficiency

(2018) Annita Louloupi et al.   Cell Reports

DNA methylation on N6-adenine in lepidopteran Bombyx mori

(2018) Xiaoyan Wang et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

mRNA circularization by METTL3–eIF3h enhances translation and promotes oncogenesis

(2018) Junho Choe et al.   NATURE

The m6A-methylase complex recruits TREX and regulates mRNA export

(2018) Simon Lesbirel et al.   Scientific Reports

The m6A Writer: Rise of a Machine for Growing Tasks

(2018) Dario L. Balacco et al.   BIOCHEMISTRY

The role of RNA adenosine demethylases in the control of gene expression

(2018) Veronika Rajecka et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

The m6A‑methylase complex and mRNA export

(2018) Simon Lesbirel et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Mechanistic insights into m6A RNA enzymes

(2018) Tina Lence et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

m6A: Widespread regulatory control in virus replication

(2018) Oliver Manners et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

N6-Methyladenine DNA Methylation in Japonica and Indica Rice Genomes and Its Association with Gene Expression, Plant Development, and Stress Responses

(2018) Qian Zhang et al.   Molecular Plant

N6-methyldeoxyadenine is a transgenerational epigenetic signal for mitochondrial stress adaptation

(2018) Chengchuan Ma et al.   NATURE CELL BIOLOGY

Epigenetics of Modified DNA Bases: 5-Methylcytosine and Beyond

(2018) Suresh Kumar et al.   Frontiers in Genetics

Regulatory Role of N6 -methyladenosine (m6 A) Methylation in RNA Processing and Human Diseases

(2017) Wenqiang Wei et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Promoter-bound METTL3 maintains myeloid leukaemia by m6A-dependent translation control

(2017) Isaia Barbieri et al.   NATURE

Adenine N6-methylation in diverse fungi

(2017) Michael F Seidl   NATURE GENETICS

Widespread adenine N6-methylation of active genes in fungi

(2017) Stephen J Mondo et al.   NATURE GENETICS

RNA fate determination through cotranscriptional adenosine methylation and microprocessor binding

(2017) Philip Knuckles et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

DNA N6-methyladenine in metazoans: functional epigenetic mark or bystander?

(2017) Guan-Zheng Luo et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

MODOMICS: a database of RNA modification pathways. 2017 update

(2017) Pietro Boccaletto et al.   NUCLEIC ACIDS RESEARCH

N6-adenine DNA methylation is associated with the linker DNA of H2A.Z-containing well-positioned nucleosomes in Pol II-transcribed genes in Tetrahymena

(2017) Yuanyuan Wang et al.   NUCLEIC ACIDS RESEARCH

mRNA N6-methyladenosine methylation of postnatal liver development in pig

(2017) Shen He et al.   PLoS One

m 6 A in mRNA: An Ancient Mechanism for Fine-Tuning Gene Expression

(2017) Jean-Yves Roignant et al.   TRENDS IN GENETICS

FTO is required for myogenesis by positively regulating mTOR-PGC-1α pathway-mediated mitochondria biogenesis

(2017) Xiaobo Wang et al.   Cell Death & Disease

DNA methylation and DNA methyltransferases

(2017) John R. Edwards et al.   Epigenetics & Chromatin

DNA N6-methyladenine is dynamically regulated in the mouse brain following environmental stress

(2017) Bing Yao et al.   Nature Communications

RNA fate determination through cotranscriptional adenosine methylation and microprocessor binding

(2017) Philip Knuckles et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

DNA N6-methyladenine in metazoans: functional epigenetic mark or bystander?

(2017) Guan-Zheng Luo et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Role of DNA and RNA N6-Adenine Methylation in Regulating Stem Cell Fate

(2017) Yunshu Wu et al.   Current Stem Cell Research & Therapy

N6-Methyladenosine Sequencing Highlights the Involvement of mRNA Methylation in Oocyte Meiotic Maturation and Embryo Development by Regulating Translation inXenopus laevis

(2016) Shu-Tao Qi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structural Basis for Cooperative Function of Mettl3 and Mettl14 Methyltransferases

(2016) Ping Wang et al.   MOLECULAR CELL

The m 6 A Methyltransferase METTL3 Promotes Translation in Human Cancer Cells

(2016) Shuibin Lin et al.   MOLECULAR CELL

m6A potentiates Sxl alternative pre-mRNA splicing for robust Drosophila sex determination

(2016) Irmgard U. Haussmann et al.   NATURE

m6A modulates neuronal functions and sex determination in Drosophila

(2016) Tina Lence et al.   NATURE

DNA methylation on N6-adenine in mammalian embryonic stem cells

(2016) Tao P. Wu et al.   NATURE

Structural basis of N6-adenosine methylation by the METTL3–METTL14 complex

(2016) Xiang Wang et al.   NATURE

m6A RNA methylation promotes XIST-mediated transcriptional repression

(2016) Deepak P. Patil et al.   NATURE

Abundant DNA 6mA methylation during early embryogenesis of zebrafish and pig

(2016) Jianzhao Liu et al.   Nature Communications

Recent advances in dynamic m6A RNA modification

(2016) Guangchao Cao et al.   Open Biology

The Epigenomic Landscape of Prokaryotes

(2016) Matthew J. Blow et al.   PLoS Genetics

N6-methyladenosine of HIV-1 RNA regulates viral infection and HIV-1 Gag protein expression

(2016) Nagaraja Tirumuru et al.   eLife

N6-Methyladenine: A Potential Epigenetic Mark in Eukaryotic Genomes

(2015) Daniel Summerer   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Adenine methylation in eukaryotes: Apprehending the complex evolutionary history and functional potential of an epigenetic modification

(2015) Lakshminarayan M. Iyer et al.   BIOESSAYS

An Adenine Code for DNA: A Second Life for N6-Methyladenine

(2015) Holger Heyn et al.   CELL

DNA Methylation on N6-Adenine in C. elegans

(2015) Eric Lieberman Greer et al.   CELL

N6-Methyladenine DNA Modification in Drosophila

(2015) Guoqiang Zhang et al.   CELL

N6-Methyldeoxyadenosine Marks Active Transcription Start Sites in Chlamydomonas

(2015) Ye Fu et al.   CELL

HNRNPA2B1 Is a Mediator of m6A-Dependent Nuclear RNA Processing Events

(2015) Claudio R. Alarcón et al.   CELL

The Arabidopsis epitranscriptome

(2015) Rupert G Fray et al.   CURRENT OPINION IN PLANT BIOLOGY

DNA N6-methyladenine: a new epigenetic mark in eukaryotes?

(2015) Guan-Zheng Luo et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Identification of methylated deoxyadenosines in vertebrates reveals diversity in DNA modifications

(2015) Magdalena J Koziol et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Widespread occurrence ofN6-methyladenosine in bacterial mRNA

(2015) Xin Deng et al.   NUCLEIC ACIDS RESEARCH

m6A mRNA methylation facilitates resolution of naïve pluripotency toward differentiation

(2015) Shay Geula et al.   SCIENCE

Epigenetic regulatory functions of DNA modifications: 5-methylcytosine and beyond

(2015) Achim Breiling et al.   Epigenetics & Chromatin

Identification of methylated deoxyadenosines in vertebrates reveals diversity in DNA modifications

(2015) Magdalena J Koziol et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Determination of DNA adenine methylation in genomes of mammals and plants by liquid chromatography/mass spectrometry

(2015) Wei Huang et al.   RSC Advances

FTO-dependent demethylation of N6-methyladenosine regulates mRNA splicing and is required for adipogenesis

(2014) Xu Zhao et al.   CELL RESEARCH

Mammalian WTAP is a regulatory subunit of the RNA N6-methyladenosine methyltransferase

(2014) Xiao-Li Ping et al.   CELL RESEARCH

m6A RNA Modification Controls Cell Fate Transition in Mammalian Embryonic Stem Cells

(2014) Pedro J. Batista et al.   Cell Stem Cell

Gene expression regulation mediated through reversible m6A RNA methylation

(2014) Ye Fu et al.   NATURE REVIEWS GENETICS

Unique features of the m6A methylome in Arabidopsis thaliana

(2014) Guan-Zheng Luo et al.   Nature Communications

Perturbation of m6A Writers Reveals Two Distinct Classes of mRNA Methylation at Internal and 5′ Sites

(2014) Schraga Schwartz et al.   Cell Reports

High-Resolution Mapping Reveals a Conserved, Widespread, Dynamic mRNA Methylation Program in Yeast Meiosis

(2013) Schraga Schwartz et al.   CELL

RNA-Methylation-Dependent RNA Processing Controls the Speed of the Circadian Clock

(2013) Jean-Michel Fustin et al.   CELL

Diverse Functions of Restriction-Modification Systems in Addition to Cellular Defense

(2013) K. Vasu et al.   MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS

A METTL3–METTL14 complex mediates mammalian nuclear RNA N6-adenosine methylation

(2013) Jianzhao Liu et al.   Nature Chemical Biology

Structure and Function of Noncanonical Nucleobases

(2012) Thomas Carell et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

ALKBH5 Is a Mammalian RNA Demethylase that Impacts RNA Metabolism and Mouse Fertility

(2012) Guanqun Zheng et al.   MOLECULAR CELL

Topology of the human and mouse m6A RNA methylomes revealed by m6A-seq

(2012) Dan Dominissini et al.   NATURE

Functions of DNA methylation: islands, start sites, gene bodies and beyond

(2012) Peter A. Jones   NATURE REVIEWS GENETICS

The last rRNA methyltransferase of E. coli revealed: The yhiR gene encodes adenine-N6 methyltransferase specific for modification of A2030 of 23S ribosomal RNA

(2012) A. Y. Golovina et al.   RNA

Epigenetics in C. elegans: Facts and challenges

(2011) Dirk Wenzel et al.   GENESIS

N6-Methyladenosine in nuclear RNA is a major substrate of the obesity-associated FTO

(2011) Guifang Jia et al.   Nature Chemical Biology

Insects as innovative models for functional studies of DNA methylation

(2011) Frank Lyko et al.   TRENDS IN GENETICS

RNA nucleotide methylation

(2011) Yuri Motorin et al.   Wiley Interdisciplinary Reviews-RNA

Conversion of 5-Methylcytosine to 5-Hydroxymethylcytosine in Mammalian DNA by MLL Partner TET1

(2009) M. Tahiliani et al.   SCIENCE

The ybiN Gene of Escherichia coli Encodes Adenine-N6 Methyltransferase Specific for Modification of A1618 of 23 S Ribosomal RNA, a Methylated Residue Located Close to the Ribosomal Exit Tunnel

(2007) Petr V. Sergiev et al.   JOURNAL OF MOLECULAR BIOLOGY