Insect ATP-Binding Cassette (ABC) Transporters: Roles in Xenobiotic Detoxification and Bt Insecticidal Activity

The ABC transporter Snu and the extracellular protein Snsl cooperate in the formation of the lipid-based inward and outward barrier in the skin of Drosophila

(2018) Renata Zuber et al.   EUROPEAN JOURNAL OF CELL BIOLOGY

Extracellular loop structures in silkworm ABCC transporters determine their specificities forBacillus thuringiensisCry toxins

(2018) Haruka Endo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Specific Binding Protein ABCC1 Is Associated With Cry2Ab Toxicity in Helicoverpa armigera

(2018) Lin Chen et al.   Frontiers in Physiology

A Point Mutation V419L in the Sodium Channel Gene from Natural Populations of Aedes aegypti Is Involved in Resistance to λ-Cyhalothrin in Colombia

(2018) Yurany Granada et al.   Insects

ABC transporter mis-splicing associated with resistance to Bt toxin Cry2Ab in laboratory- and field-selected pink bollworm

(2018) Lolita G. Mathew et al.   Scientific Reports

Transcriptional response of ATP-binding cassette (ABC) transporters to insecticides in the cotton bollworm, Helicoverpa armigera

(2018) Minghui Jin et al.   PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY

FOXA transcriptional factor modulates insect susceptibility to Bacillus thuringiensis Cry1Ac toxin by regulating the expression of toxin-receptor ABCC2 and ABCC3 genes

(2017) Jianghuai Li et al.   INSECT BIOCHEMISTRY AND MOLECULAR BIOLOGY

Mdr65 decreases toxicity of multiple insecticides in Drosophila melanogaster

(2017) Haina Sun et al.   INSECT BIOCHEMISTRY AND MOLECULAR BIOLOGY

The ABC transporter ABCH-9C is needed for cuticle barrier construction in Locusta migratoria

(2017) Zhitao Yu et al.   INSECT BIOCHEMISTRY AND MOLECULAR BIOLOGY

CRISPR/Cas9 mediated genome editing of Helicoverpa armigera with mutations of an ABC transporter gene HaABCA2 confers resistance to Bacillus thuringiensis Cry2A toxins

(2017) Jing Wang et al.   INSECT BIOCHEMISTRY AND MOLECULAR BIOLOGY

Multidrug transporters and organic anion transporting polypeptides protect insects against the toxic effects of cardenolides

(2017) Simon C. Groen et al.   INSECT BIOCHEMISTRY AND MOLECULAR BIOLOGY

Bombyx mori ABC transporter C2 structures responsible for the receptor function of Bacillus thuringiensis Cry1Aa toxin

(2017) Shiho Tanaka et al.   INSECT BIOCHEMISTRY AND MOLECULAR BIOLOGY

Expressing a moth abcc2 gene in transgenic Drosophila causes susceptibility to Bt Cry1Ac without requiring a cadherin-like protein receptor

(2017) Tristan Stevens et al.   INSECT BIOCHEMISTRY AND MOLECULAR BIOLOGY

Describing the role of Drosophila melanogaster ABC transporters in insecticide biology using CRISPR-Cas9 knockouts

(2017) Shane Denecke et al.   INSECT BIOCHEMISTRY AND MOLECULAR BIOLOGY

Cap n collar transcription factor regulates multiple genes coding for proteins involved in insecticide detoxification in the red flour beetle, Tribolium castaneum

(2017) Megha Kalsi et al.   INSECT BIOCHEMISTRY AND MOLECULAR BIOLOGY

Detoxification of ivermectin by ATP binding cassette transporter C4 and cytochrome P450 monooxygenase 6CJ1 in the human body louse, Pediculus humanus humanus

(2017) J. H. Kim et al.   INSECT MOLECULAR BIOLOGY

Multiple ATP-binding cassette transporters are involved in insecticide resistance in the small brown planthopper, Laodelphax striatellus

(2017) H. Sun et al.   INSECT MOLECULAR BIOLOGY

Down-regulation of aminopeptidase N and ABC transporter subfamily G transcripts in Cry1Ab and Cry1Ac resistant Asian corn borer, Ostrinia furnacalis (Lepidoptera: Crambidae)

(2017) Tiantao Zhang et al.   International Journal of Biological Sciences

Implicating ABC Transporters in Insecticide Resistance: Research Strategies and a Decision Framework

(2017) Ryan C. Gott et al.   JOURNAL OF ECONOMIC ENTOMOLOGY

Invited review: Architectures and mechanisms of ATP binding cassette proteins

(2016) Karl-Peter Hopfner   BIOPOLYMERS

Characterization and expression profiling of ATP-binding cassette transporter genes in the diamondback moth, Plutella xylostella (L.)

(2016) Weiping Qi et al.   BMC GENOMICS

Know your ABCs: Characterization and gene expression dynamics of ABC transporters in the polyphagous herbivore Helicoverpa armigera

(2016) Anne Bretschneider et al.   INSECT BIOCHEMISTRY AND MOLECULAR BIOLOGY

Three toxins, two receptors, one mechanism: Mode of action of Cry1A toxins from Bacillus thuringiensis in Heliothis virescens

(2016) Anne Bretschneider et al.   INSECT BIOCHEMISTRY AND MOLECULAR BIOLOGY

Mechanistic diversity in ATP-binding cassette (ABC) transporters

(2016) Kaspar P Locher   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Phylogenetic analysis of the ATP-binding cassette transporter family in three mosquito species

(2016) Hong Lu et al.   PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY

Mechanistic diversity in ATP-binding cassette (ABC) transporters

(2016) Kaspar P Locher   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Splice form variant and amino acid changes in MDR49 confers DDT resistance in transgenic Drosophila

(2016) Keon Mook Seong et al.   Scientific Reports

A P-Glycoprotein Is Linked to Resistance to the Bacillus thuringiensis Cry3Aa Toxin in a Leaf Beetle

(2016) Yannick Pauchet et al.   Toxins

How herbivores coopt plant defenses: natural selection, specialization, and sequestration

(2016) Georg Petschenka et al.   Current Opinion in Insect Science

RNAi-mediated mortality of the whitefly through transgenic expression of double-stranded RNA homologous to acetylcholinesterase and ecdysone receptor in tobacco plants

(2016) Hassan Jamil Malik et al.   Scientific Reports

The plastic response of Manduca sexta to host and non-host plants

(2015) Christopher Koenig et al.   INSECT BIOCHEMISTRY AND MOLECULAR BIOLOGY

Linkage of an ABCC transporter to a single QTL that controls Ostrinia nubilalis larval resistance to the Bacillus thuringiensis Cry1Fa toxin

(2015) Brad S. Coates et al.   INSECT BIOCHEMISTRY AND MOLECULAR BIOLOGY

Down-regulation of a novel ABC transporter gene (Pxwhite) is associated with Cry1Ac resistance in the diamondback moth, Plutella xylostella (L.)

(2015) Zhaojiang Guo et al.   INSECT BIOCHEMISTRY AND MOLECULAR BIOLOGY

RNAi validation of resistance genes and their interactions in the highly DDT-resistant 91-R strain of Drosophila melanogaster

(2015) Kyle J. Gellatly et al.   PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY

Full crop protection from an insect pest by expression of long double-stranded RNAs in plastids

(2015) Jiang Zhang et al.   SCIENCE

Marine medaka ATP-binding cassette (ABC) superfamily and new insight into teleost Abch nomenclature

(2015) Chang-Bum Jeong et al.   Scientific Reports

The novel ABC transporter ABCH1 is a potential target for RNAi-based insect pest control and resistance management

(2015) Zhaojiang Guo et al.   Scientific Reports

Genetic Markers for Western Corn Rootworm Resistance to Bt Toxin

(2015) Lex E. Flagel et al.   G3-Genes Genomes Genetics

MAPK Signaling Pathway Alters Expression of Midgut ALP and ABCC Genes and Causes Resistance to Bacillus thuringiensis Cry1Ac Toxin in Diamondback Moth

(2015) Zhaojiang Guo et al.   PLoS Genetics

Insect Resistance to Bacillus thuringiensis Toxin Cry2Ab Is Conferred by Mutations in an ABC Transporter Subfamily A Protein

(2015) Wee Tek Tay et al.   PLoS Genetics

ABCs of Insect Resistance to Bt

(2015) Bruce E. Tabashnik   PLoS Genetics

Thermodynamics of ABC transporters

(2015) Xuejun C. Zhang et al.   Protein & Cell

A Survey of the ATP-Binding Cassette (ABC) Gene Superfamily in the Salmon Louse (Lepeophtheirus salmonis)

(2015) Greta Carmona-Antoñanzas et al.   PLoS One

ABCC transporters mediate insect resistance to multiple Bt toxins revealed by bulk segregant analysis

(2014) Youngjin Park et al.   BMC BIOLOGY

Allelic-specific expression in relation to Bombyx mori resistance to Bt toxin

(2014) Yazhou Chen et al.   INSECT BIOCHEMISTRY AND MOLECULAR BIOLOGY

Structural diversity of ABC transporters

(2014) Josy ter Beek et al.   JOURNAL OF GENERAL PHYSIOLOGY

Tissue-Specific Transcript Profiling for ABC Transporters in the Sequestering Larvae of the Phytophagous Leaf Beetle Chrysomela populi

(2014) Anja S. Strauss et al.   PLoS One

Transcriptome-Based Identification of ABC Transporters in the Western Tarnished Plant Bug Lygus hesperus

(2014) J. Joe Hull et al.   PLoS One

The locust genome provides insight into swarm formation and long-distance flight

(2014) Xianhui Wang et al.   Nature Communications

Mis-splicing of the ABCC2 gene linked with Bt toxin resistance in Helicoverpa armigera

(2014) Yutao Xiao et al.   Scientific Reports

Functional analysis of the ATP-binding cassette (ABC) transporter gene family of Tribolium castaneum

(2013) Gunnar Broehan et al.   BMC GENOMICS

A burst of ABC genes in the genome of the polyphagous spider mite Tetranychus urticae

(2013) Wannes Dermauw et al.   BMC GENOMICS

Mutation of a novel ABC transporter gene is responsible for the failure to incorporate uric acid in the epidermis of ok mutants of the silkworm, Bombyx mori

(2013) Lingyan Wang et al.   INSECT BIOCHEMISTRY AND MOLECULAR BIOLOGY

Abamectin resistance in Drosophila is related to increased expression of P-glycoprotein via the dEGFR and dAkt pathways

(2013) Liang Luo et al.   INSECT BIOCHEMISTRY AND MOLECULAR BIOLOGY

The ABC gene family in arthropods: Comparative genomics and role in insecticide transport and resistance

(2013) Wannes Dermauw et al.   INSECT BIOCHEMISTRY AND MOLECULAR BIOLOGY

Silencing ofP-glycoproteinincreases mortality in temephos-treatedAedes aegyptilarvae

(2013) J. Figueira-Mansur et al.   INSECT MOLECULAR BIOLOGY

Transcriptome profiling of the whiteflyBemisia tabacireveals stage-specific gene expression signatures for thiamethoxam resistance

(2013) N. Yang et al.   INSECT MOLECULAR BIOLOGY

Crystal structure of a folate energy-coupling factor transporter from Lactobacillus brevis

(2013) Ke Xu et al.   NATURE

Structure of a bacterial energy-coupling factor transporter

(2013) Tingliang Wang et al.   NATURE

A heterozygous moth genome provides insights into herbivory and detoxification

(2013) Minsheng You et al.   NATURE GENETICS

Resistance in the highly DDT-resistant 91-R strain of Drosophila melanogaster involves decreased penetration, increased metabolism, and direct excretion

(2013) Joseph P. Strycharz et al.   PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY

Genome-Wide Identification, Characterization and Phylogenetic Analysis of 50 Catfish ATP-Binding Cassette (ABC) Transporter Genes

(2013) Shikai Liu et al.   PLoS One

Transcriptomic and Proteomic Responses of Sweetpotato Whitefly, Bemisia tabaci, to Thiamethoxam

(2013) Nina Yang et al.   PLoS One

Functional evidence for physiological mechanisms to circumvent neurotoxicity of cardenolides in an adapted and a non-adapted hawk-moth species

(2013) G. Petschenka et al.   PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

ABC transporter functions as a pacemaker for sequestration of plant glucosides in leaf beetles

(2013) Anja S Strauss et al.   eLife

Peroxisomal ABC transporters: Structure, function and role in disease

(2012) Masashi Morita et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

RNA-Seq and molecular docking reveal multi-level pesticide resistance in the bed bug

(2012) Praveen Mamidala et al.   BMC GENOMICS

Developmental and insecticide-resistant insights from the de novo assembled transcriptome of the diamondback moth, Plutella xylostella

(2012) Weiyi He et al.   GENOMICS

Genome-wide analysis of the ATP-binding cassette (ABC) transporter gene family in the silkworm, Bombyx mori

(2012) Xiaodong Xie et al.   MOLECULAR BIOLOGY REPORTS

Learning the ABCs of Bt: ABC transporters and insect resistance to Bacillus thuringiensis provide clues to a crucial step in toxin mode of action

(2012) David G. Heckel   PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY

Comparative Transcriptome Analyses of Deltamethrin-Resistant and -Susceptible Anopheles gambiae Mosquitoes from Kenya by RNA-Seq

(2012) Mariangela Bonizzoni et al.   PLoS One

Single amino acid mutation in an ATP-binding cassette transporter gene causes resistance to Bt toxin Cry1Ab in the silkworm, Bombyx mori

(2012) S. Atsumi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Perspectives on the structure–function of ABC transporters: The Switch and Constant Contact Models

(2012) Anthony M. George et al.   PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY

Gene Amplification, ABC Transporters and Cytochrome P450s: Unraveling the Molecular Basis of Pyrethroid Resistance in the Dengue Vector, Aedes aegypti

(2012) Vassiliki Bariami et al.   PLoS Neglected Tropical Diseases

Genome-wide identification and characterization of ATP-binding cassette transporters in the silkworm, Bombyx mori

(2011) Shumin Liu et al.   BMC GENOMICS

Lipid transport by mammalian ABC proteins

(2011) Faraz Quazi et al.   Essays in Biochemistry

The P-glycoprotein multidrug transporter

(2011) Frances J. Sharom   Essays in Biochemistry

Positional cloning of silkworm white egg 2 (w-2) locus shows functional conservation and diversification of ABC transporters for pigmentation in insects

(2011) Ken-ichiro Tatematsu et al.   GENES TO CELLS

Parallel Evolution ofBacillus thuringiensisToxin Resistance in Lepidoptera

(2011) Simon W. Baxter et al.   GENETICS

Expression of multidrug resistance proteins is localized principally to the Malpighian tubules in larvae of the cabbage looper moth, Trichoplusia ni

(2011) R. Labbe et al.   JOURNAL OF EXPERIMENTAL BIOLOGY

The structural basis of modularity in ECF-type ABC transporters

(2011) Guus B Erkens et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Ribosome recycling depends on a mechanistic link between the FeS cluster domain and a conformational switch of the twin-ATPase ABCE1

(2011) D. Barthelme et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

P-glycoprotein ATPase from the resistant pest, Helicoverpa armigera: Purification, characterization and effect of various insecticides on its transport function

(2010) Ravindra M. Aurade et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Phylogenetic analysis of fungal ABC transporters

(2010) Andriy Kovalchuk et al.   BMC GENOMICS

Acaricide resistance mechanisms in the two-spotted spider mite Tetranychus urticae and other important Acari: A review

(2010) Thomas Van Leeuwen et al.   INSECT BIOCHEMISTRY AND MOLECULAR BIOLOGY

Decreased detoxification genes and genome size make the human body louse an efficient model to study xenobiotic metabolism

(2010) S. H. Lee et al.   INSECT MOLECULAR BIOLOGY

Characterization of an Asymmetric Occluded State of P-glycoprotein with Two Bound Nucleotides

(2010) Alena Siarheyeva et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Stress-Activated Cap'n'collar Transcription Factors in Aging and Human Disease

(2010) G. P. Sykiotis et al.   Science Signaling

An ABC Transporter Mutation Is Correlated with Insect Resistance to Bacillus thuringiensis Cry1Ac Toxin

(2010) Linda J. Gahan et al.   PLoS Genetics

Overexpression ofDrosophila mitoferrinin l(2)mbn cells results in dysregulation of Fer1HCH expression

(2009) Christoph Metzendorf et al.   BIOCHEMICAL JOURNAL

The ABC transporter gene family of Daphnia pulex

(2009) Armin Sturm et al.   BMC GENOMICS

Selection for cold resistance alters gene transcript levels in Drosophila melanogaster

(2009) M. Telonis-Scott et al.   JOURNAL OF INSECT PHYSIOLOGY

Evolutionary Conservation of Vertebrate Blood-Brain Barrier Chemoprotective Mechanisms in Drosophila

(2009) F. Mayer et al.   JOURNAL OF NEUROSCIENCE

A novel ABC transporter: The first insight into zebrafish (Danio rerio) ABCH1

(2009) Marta Popovic et al.   MARINE ENVIRONMENTAL RESEARCH

ABC transporters: the power to change

(2009) Douglas C. Rees et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

DrosophilaABC Transporter, DmHMT-1, Confers Tolerance to Cadmium

(2008) Thanwalee Sooksa-nguan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Plant ABC proteins – a unified nomenclature and updated inventory

(2008) Paul J. Verrier et al.   TRENDS IN PLANT SCIENCE

Interaction of pesticides with p-glycoprotein and other ABC proteins: A survey of the possible importance to insecticide, herbicide and fungicide resistance

(2007) D.S. Buss et al.   PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY