Review
Medicine, General & Internal
Sofia Tejada, Marta Leal-dos-Santos, Yolanda Pena-Lopez, Stijn Blot, Emine Alp, Jordi Rello
Summary: Antiseptic barrier caps are more effective in reducing CLABSI risk compared to manual disinfection, especially in ICU patients and adults, showing potential cost savings in medical expenses.
EUROPEAN JOURNAL OF INTERNAL MEDICINE
(2022)
Article
Public, Environmental & Occupational Health
Hillary Hei, Marisse Plaras, Elina Paul, Lauren Satchell, Orysia Bezpalko, Lori Handy
Summary: This article describes a team that used Lean Six Sigma methodology to create a standardized data collection process to track and confirm ambulatory central line-associated bloodstream infections (CLABSIs) in a pediatric healthcare system. They developed criteria for surveillance and a novel attribution method for complex patient populations, enabling accurate monitoring of ambulatory CLABSI data.
AMERICAN JOURNAL OF INFECTION CONTROL
(2023)
Article
Medicine, General & Internal
Sarah E. Firmani, Holly D. Maples, Archana Balamohan
Summary: Lactococcus spp. is generally considered to be of low virulence and rarely pathogenic, with few reported cases of significant infections in children, mostly outside of the United States. Limited data exists on antimicrobial susceptibility testing for Lactococcus spp. Our study presents three pediatric cases of central line bloodstream infections caused by Lactococcus spp. between 2018 and 2020, along with a review of pediatric literature.
FRONTIERS IN MEDICINE
(2022)
Article
Pediatrics
Ilker Devrim, Ozlem Sarac Sandal, Miray Yilmaz celebi, Pinar Hepduman, Ahmet Gonullu, Gulhan Atakul, Aybuke Akaslan Kara, Yeliz Oruc, Gamze Guelfidan, Nuri Bayram, Hasan Agin
Summary: This study suggests that the use of central line bundles not only reduces the incidence of CLABSI but also delays the time to onset of infection in CLABSI patients. Additionally, as a direct consequence of the CLB, the number of CLABSIs caused by gram-positive cocci did not increase, while the proportion of CLABSIs caused by C. parapsilosis decreased.
EUROPEAN JOURNAL OF PEDIATRICS
(2023)
Review
Immunology
Manreet Dhaliwal, Nick Daneman
Summary: Differential time to positivity (DTP) can be used to diagnose central line-associated bloodstream infections (CLABSIs) and help rule them in or out. Meta-analysis of 23 studies found that DTP has a sensitivity of 81% and specificity of 91% in diagnosing CLABSIs. However, the higher contamination rates from catheter cultures should be taken into consideration when obtaining paired catheter and peripheral blood cultures for DTP.
CLINICAL INFECTIOUS DISEASES
(2023)
Article
Public, Environmental & Occupational Health
Keyvan Rahmani, Anurag Garikipati, Gina Barnes, Jana Hoffman, Jacob Calvert, Qingqing Mao, Ritankar Das
Summary: The study developed and validated a machine learning algorithm for predicting CLABSI risk, showing high accuracy in prediction at 48 hours. This suggests that machine learning algorithms may provide effective clinical decision support for assessing CLABSI risk.
AMERICAN JOURNAL OF INFECTION CONTROL
(2022)
Article
Public, Environmental & Occupational Health
T. Scheier, D. Saleschus, M. Dunic, M. R. Frohlich, R. Schupbach, C. Falk, H. Sax, S. P. Kuster, P. W. Schreiber
Summary: Daily chlorhexidine bathing can reduce the incidence of central line-associated bloodstream infections in ICU patients. However, it has limited impact on the causative pathogens.
JOURNAL OF HOSPITAL INFECTION
(2021)
Article
Immunology
Iris Kristinsdottir, Asgeir Haraldsson, Olafur Gudlaugsson, Valtyr Thors
Summary: This study conducted in Iceland showed a very low rate of central line-associated bloodstream infections (CLABSIs) in pediatric oncology patients, with 4 consecutive CLABSI-free years. The main pathogens were Staphylococci, including Staphylococcus aureus. While some CLABSIs led to line removal, no deaths were directly linked to CLABSIs.
PEDIATRIC INFECTIOUS DISEASE JOURNAL
(2021)
Article
Public, Environmental & Occupational Health
Ilker Devrim, Hakan Erdem, Amani El-Kholy, Abdullah Almohaizeie, Mateja Logar, Bilal Ahmad Rahimi, Fatma Amer, Sevil Alkan-Ceviker, Meliha Cagla Sonmezer, Maya Belitova, Jamal Wadi Al-Ramahi, Natalia Pshenichnaya, Maha Ali Gad, Lurdes Santos, Reham Khedr, Abdullahi Nur Hassan, Elif Boncuoglu, Andrea Cortegiani, Andrea Marino, Anna Liskova, Atousa Hakamifard, Corneliu Petru Popescu, Mumtaz Ali Khan, Ralitsa Marinova, Nikolaj Petrov, Emmanuel Nsutebu, Ghaydaa Shehata, Hamed Azhdari Tehrani, Handan Alay, Ivana Marekovic, Joanna Zajkowska, Aidos Konkayev, Manar Ezzelarab Ramadan, Michele Pagani, Hasan Agin, Pierre Tattevin, Rehab El-Sokkary, Rezaul Karim Ripon, Ricardo Fernandez, Rosa Fontana Del Vecchio, Simona Daniela Popescu, Souha Kanj
Summary: This study investigated the use of central line bundles in different countries and found significant differences between low-income countries and high-income countries. Additional measures should be taken to address the inequity in the management of vascular access in resource-limited countries.
AMERICAN JOURNAL OF INFECTION CONTROL
(2022)
Article
Public, Environmental & Occupational Health
Thomas Scheier, Stefan P. Kuster, Mesida Dunic, Christian Falk, Hugo Sax, Peter W. Schreiber
Summary: A positive correlation was found between CLABSI incidence rates and turnover of nursing personnel, especially those with advanced training, at University Hospital Zurich. However, there was no significant correlation between physician turnover and CLABSI incidence rates. Maintaining continuity in nursing staff may help in reducing CLABSI rates.
ANTIMICROBIAL RESISTANCE AND INFECTION CONTROL
(2021)
Article
Emergency Medicine
Joseph Inhofer, Anthony Bertasi, Matthew Gangidine, Steven J. Repas, Jasmine Holmes, Micah Harris, Madeline Stull, Catherine Marco
Summary: This study found that there is no significant difference in CLABSI rates following catheter placement between the emergency department and the intensive care unit. Factors such as age, sex, indication, site, location, and type of healthcare professional placing the line did not affect the odds of CLABSI.
AMERICAN JOURNAL OF EMERGENCY MEDICINE
(2022)
Article
Public, Environmental & Occupational Health
Jessica Lowery, Matthew Jensen Hays, Andrea Burch, Debra Behr, Steven Brown, Elise Kearney, Deborah Senseney, Sky Arce
Summary: Cognitive science-based online training can effectively reduce the incidence of central line-associated bloodstream infections (CLABSI) and sustain the reductions for an extended period.
AMERICAN JOURNAL OF INFECTION CONTROL
(2022)
Article
Infectious Diseases
David Odada, Hellen Munyi, Japhet Gatuiku, Ruth Thuku, Jared Nyandigisi, Anne Wangui, Emilie Ashihundu, Beatrice Nyakiringa, Jemimah Kimeu, Martin Musumbi, Rodney D. Adam
Summary: Improvement projects to reduce central line-associated bloodstream infections face challenges and complexities associated with implementing interventions in real-world healthcare settings. Continuous monitoring, evaluation, readjustment, and adaptation of interventions are needed to achieve desired results and sustain improvements in patient outcomes.
BMC INFECTIOUS DISEASES
(2023)
Article
Public, Environmental & Occupational Health
Madhuri Tirumandas, Inessa Gendlina, Jamie Figueredo, Ariel Shiloh, Polina Trachuk, Ruchika Jain, Marilou Corpuz, Brian Spund, Aloke Maity, Dmitriy Shmunko, Melba Garcia, Diahann Barthelemy, Gregory Weston, Theresa Madaline
Summary: The study found that a CCM-driven vascular access model may lead to unnecessary CVC insertion, CLABSI infections, inefficient physician effort, and financial losses; nurse-driven vascular access models offer potential cost savings and risk reduction.
AMERICAN JOURNAL OF INFECTION CONTROL
(2021)
Article
Infectious Diseases
Luisa A. Denkel, Frank Schwab, Jorg Clausmeyer, Michael Behnke, Jennifer Golembus, Solvy Wolke, Petra Gastmeier, Christine Geffers
Summary: The study aimed to compare the effects of chlorhexidine, octenidine, or routine bathing with water and soap on CLABSI rates in ICUs. However, both antiseptic methods did not show a significant preventive effect on CLABSI rates in the ICU setting.
CLINICAL MICROBIOLOGY AND INFECTION
(2022)
Review
Nursing
Amanda Corley, Nicole Marsh, Amanda J. Ullman, Claire M. Rickard
Summary: This integrative review examines the evidence related to medical adhesive tapes and supplementary securement products for peripheral intravenous catheters in adults. Nonsterile tape was found to be associated with increased failure and complications, while sutureless securement devices potentially reduce failure and complications. However, there is limited and conflicting evidence for other tapes and secondary securement products.
JOURNAL OF CLINICAL NURSING
(2023)
Article
Immunology
Brian M. Forde, Haakon Bergh, Thom Cuddihy, Krispin Hajkowicz, Trish Hurst, E. Geoffrey Playford, Belinda C. Henderson, Naomi Runnegar, Julia Clark, Amy Jennison, Susan Moss, Anna Hume, Hugo Leroux, Scott A. Beatson, David L. Paterson, Patrick N. A. Harris
Summary: This study implemented a program of routine sequencing of multi-drug resistant organisms and used custom analysis pipeline to automate reporting and support infection control interventions. The results showed the identification of transmission events within three hospitals, highlighting the feasibility of routine WGS for MDR pathogens.
CLINICAL INFECTIOUS DISEASES
(2023)
Article
Health Care Sciences & Services
Brighid Scanlon, David Wyld, Paul Firman, Midori Nakagaki, Jo Durham, Glen Kennedy, Paul Moran, Michael Smith, Nicole Gavin
Summary: This study investigated COVID-19 vaccine hesitancy, acceptance, and unmet informational needs in a cancer population during the initial phase of vaccination rollout in Australia. A survey was conducted in a tertiary hospital to assess health beliefs, pandemic experiences, vaccine hesitancy, and informational needs. The results showed that although most respondents planned to receive the COVID-19 vaccine, hesitancy remained and there was a demand for information regarding cancer treatments, blood clotting, and bone marrow transplantation.
AUSTRALIAN HEALTH REVIEW
(2023)
Article
Cardiac & Cardiovascular Systems
Amanda Corley, Amanda J. Ullman, Nicole Marsh, Jodie Genzel, Emily N. Larsen, Emily Young, Catriona Booker, Patrick N. A. Harris, Claire M. Rickard
Summary: This study aimed to determine the feasibility of using evidence-based securement bundles to reduce peripheral intravenous catheter (PIVC) failure. The results showed that conducting a large randomized controlled trial (RCT) on securement bundles is feasible, with adjustments to the screening process. Innovative dressing and securement solutions are needed to reduce the unacceptable PIVC failure rates.
Review
Nursing
Marion Eckert, Kate Kennedy, Kim Neylon, Claire M. Rickard, Samantha Keogh, Richard Gray, Sandy Middleton, Caroline Homer, Lisa Whitehead, Greg Sharplin
Summary: This scoping review found that nurse-led research activities are relatively low, with more registered trials than published studies. Additional support in infrastructure, funding, and career frameworks is needed to enable nurses to design, conduct, and publish clinical trials and improve health outcomes.
JOURNAL OF CLINICAL NURSING
(2023)
Article
Medicine, General & Internal
Claire M. Rickard, Emily Larsen, Rachel M. Walker, Gabor Mihala, Joshua Byrnes, Masnoon Saiyed, Marie Cooke, Julie Finucane, Peter J. Carr, Nicole Marsh
Summary: The study compared complications between integrated PIVCs and traditional non-integrated PIVCs, showing that integrated PIVCs have a significant advantage in reducing device failure risk and significantly prolonging dwell time. However, there was no significant difference in mean per-patient costs between the two types of PIVCs.
JOURNAL OF HOSPITAL MEDICINE
(2023)
Article
Health Care Sciences & Services
Jessica A. Schults, Nicole Marsh, Amanda J. Ullman, Tricia M. Kleidon, Robert S. Ware, Joshua Byrnes, Emily Young, Lisa Hall, Gerben Keijzers, Louise Cullen, Pauline Calleja, Steven McTaggart, Nathan Peters, Stuart Watkins, Amanda Corley, Christine Brown, Zhen Lin, Frances Williamson, Luke Burgess, Fiona Macfarlane, Marie Cooke, Callan Battley, Claire M. Rickard
Summary: This study aims to optimize ultrasound-guided peripheral intravenous catheter (PIVC) insertion in patients with Difficult IntraVenous Access (DIVA) through co-design interventions, implementation, and evaluation. A stepped-wedge cluster randomized controlled trial will be conducted in three hospitals in Australia. The findings will help improve DIVA identification and escalation tools and provide actionable knowledge for scale-up activities.
BMC HEALTH SERVICES RESEARCH
(2023)
Article
Emergency Medicine
Hui (Grace) Xu, Claire M. Rickard, Mari Takashima, Michael Butterfield, Edward Pink, Amanda J. Ullman
Summary: This study aimed to assess the knowledge, attitude, and adherence of Australian ED clinicians to the national peripheral intravenous catheter (PIVC) Clinical Care Standard. The findings revealed that although many respondents claimed to be unfamiliar with the Standard, they still had adequate knowledge of the key standards. However, their attitudes and self-reported practices did not align with the Standard. The top barriers to adherence were unawareness of the Standard and non-practical recommendations.
EMERGENCY MEDICINE AUSTRALASIA
(2023)
Article
Medicine, General & Internal
Hiu L. A. Yuen, Robert Weinkove, Amanda Ullman, Nicole Marsh, Claire M. Rickard, Sanjeev Chunilal, Zoe McQuilten
Summary: This study conducted an online survey among clinicians in haematology centres in Australia and New Zealand to investigate the management of central venous access devices (CVADs). The results showed variations in clinical practice regarding CVAD selection, insertion, management, and removal, indicating research gaps in CVAD care.
INTERNAL MEDICINE JOURNAL
(2023)
Review
Nursing
Hui (Grace) Xu, Samantha Keogh, Amanda J. Ullman, Nicole Marsh, Georgia Tobiano, Claire M. Rickard, Justin Clark, Bronwyn Griffin
Summary: The study aimed to evaluate implementation frameworks, strategies, and outcomes for optimizing peripheral intravenous catheter (PIVC) care and guideline adherence. Although there is a considerable amount of research on PIVC interventions and treatments, there is a lack of understanding on how to effectively implement these findings in clinical settings. The systematic review found that implementation frameworks and multifaceted strategies were commonly used, but there is a need for improved study design and evaluation to translate evidence into better patient outcomes.
JOURNAL OF CLINICAL NURSING
(2023)
Article
Nutrition & Dietetics
Nicole C. Gavin, Emily Larsen, Naomi Runnegar, Gabor Mihala, Samantha Keogh, David McMillan, Gillian Ray-Barruel, Claire M. Rickard
Summary: Distinguishing primary bloodstream infections (BSIs) related to central venous access devices (CVADs) from other mechanisms is difficult. This study analyzed data from a large randomized trial to investigate the influence of intravenous lipid emulsion (ILE PN) on primary BSIs in patients with CVADs. The results showed that twice as many primary BSIs in ILE PN patients were due to mucosal barrier injury compared to CVADs.
JOURNAL OF PARENTERAL AND ENTERAL NUTRITION
(2023)
Article
Acoustics
Nathan Peters, Frances Williamson, Michelle J. Bauer, Stacey Llewellyn, Peter J. Snelling, Nicole Marsh, Patrick N. A. Harris, Adam G. Stewart, Claire M. Rickard
Summary: This study compared the effectiveness of low-level disinfection (LLD) to high-level disinfection (HLD) on ultrasound transducers contaminated with skin microorganisms. The results showed that after disinfection, 100% of CFUs were eliminated in LLD transducer samples and 99.0% of CFUs were eliminated in HLD transducer samples. Therefore, using LLD for ultrasound transducers involved in percutaneous procedures would not pose a higher infection risk compared to HLD.
JOURNAL OF ULTRASOUND IN MEDICINE
(2023)
Article
Peripheral Vascular Disease
Nicole C. Gavin, Elizabeth Wignall, Nicole Marsh, Louise Marquart, Karen L. Dobeli, Catherine O'Brien, Anthony D. Verderosa, Makrina Totsika, Samantha Keogh
Summary: This pilot study suggests that perforated PIVCs provide the expected flow rate and there is no evidence of differences in contrast enhancement compared to non-perforated PIVCs. The feasibility of conducting a larger powered RCT was demonstrated.
JOURNAL OF VASCULAR ACCESS
(2023)
Article
Public, Environmental & Occupational Health
Nicole Marsh, Emily N. Larsen, Catherine O'Brien, Peter Groom, Tricia M. Kleidon, Evan Alexandrou, Emily Young, Kate McCarthy, Claire M. Rickard
Summary: This study found that a fully powered randomized controlled trial comparing MCs with PICCs is currently not feasible in their setting. They recommend a robust process evaluation before the introduction of MCs into clinical practice.
INFECTION DISEASE & HEALTH
(2023)
Article
Urology & Nephrology
Yeoungjee Cho, Kai-Ming Chow, Philip Kam-Tao Li, Naomi Runnegar, David W. Johnson
Summary: Peritoneal dialysis is an important treatment option for patients with kidney failure, providing various benefits such as enhanced participation in daily activities, flexibility in schedules, cost savings, and improved quality of life. However, the utilization of peritoneal dialysis has remained static or declining in certain regions due to concerns about PD-related infections. This review aims to provide an overview of the definition, epidemiology, risk factors, prevention, and treatment of PD-related infections based on current evidence.
CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2023)