Missing heritability of complex diseases: case solved?

Common Disease Is More Complex Than Implied by the Core Gene Omnigenic Model

(2018) Naomi R. Wray et al.   CELL

Pathway-induced allelic spectra of diseases in the presence of strong genetic effects

(2018) George Kanoungi et al.   HUMAN GENETICS

Comparison of methods that use whole genome data to estimate the heritability and genetic architecture of complex traits

(2018) Luke M. Evans et al.   NATURE GENETICS

Signatures of negative selection in the genetic architecture of human complex traits

(2018) Jian Zeng et al.   NATURE GENETICS

Missing compared to what? Revisiting heritability, genes and culture

(2018) Marcus W. Feldman et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Relatedness disequilibrium regression estimates heritability without environmental bias

(2018) Alexander I. Young et al.   NATURE GENETICS

Functional architecture of low-frequency variants highlights strength of negative selection across coding and non-coding annotations

(2018) Steven Gazal et al.   NATURE GENETICS

Genome-wide association analyses identify 143 risk variants and putative regulatory mechanisms for type 2 diabetes

(2018) Angli Xue et al.   Nature Communications

The NHGRI-EBI GWAS Catalog of published genome-wide association studies, targeted arrays and summary statistics 2019

(2018) Annalisa Buniello et al.   NUCLEIC ACIDS RESEARCH

Rare and low-frequency coding variants alter human adult height

(2017) Eirini Marouli et al.   NATURE

Reevaluation of SNP heritability in complex human traits

(2017) Doug Speed et al.   NATURE GENETICS

Contribution to Alzheimer's disease risk of rare variants in TREM2, SORL1, and ABCA7 in 1779 cases and 1273 controls

(2017) Céline Bellenguez et al.   NEUROBIOLOGY OF AGING

Evaluating the contribution of rare variants to type 2 diabetes and related traits using pedigrees

(2017) Goo Jun et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

CNV-association meta-analysis in 191,161 European adults reveals new loci associated with anthropometric traits

(2017) Aurélien Macé et al.   Nature Communications

The Human Microbiome and the Missing Heritability Problem

(2017) Santiago Sandoval-Motta et al.   Frontiers in Genetics

A perspective on interaction effects in genetic association studies

(2016) Hugues Aschard   GENETIC EPIDEMIOLOGY

From Common to Rare Variants: The Genetic Component of Alzheimer Disease

(2016) Gaël Nicolas et al.   HUMAN HEREDITY

Copy Number Variants in Alzheimer’s Disease

(2016) Denis Cuccaro et al.   JOURNAL OF ALZHEIMERS DISEASE

The genetic architecture of type 2 diabetes

(2016) Christian Fuchsberger et al.   NATURE

An Overview of Genome-Wide Association Studies in Alzheimer’s Disease

(2016) Luxi Shen et al.   Neuroscience Bulletin

Accuracy of heritability estimations in presence of hidden population stratification

(2016) Claire Dandine-Roulland et al.   Scientific Reports

Dominance Genetic Variation Contributes Little to the Missing Heritability for Human Complex Traits

(2015) Zhihong Zhu et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Revisiting the Polygenic Additive Liability Model through the Example of Diabetes Mellitus

(2015) Emmanuelle Génin et al.   HUMAN HEREDITY

Concepts and Misconceptions about the Polygenic Additive Model Applied to Disease

(2015) Peter M. Visscher et al.   HUMAN HEREDITY

The Missing Heritability Paradigm: A Dramatic Resurgence of the GIGO Syndrome in Genetics

(2015) Emmanuelle G�nin et al.   HUMAN HEREDITY

LD Score regression distinguishes confounding from polygenicity in genome-wide association studies

(2015) Brendan K Bulik-Sullivan et al.   NATURE GENETICS

Rare variant association studies: considerations, challenges and opportunities

(2015) Paul L Auer et al.   Genome Medicine

Genomic Heritability: What Is It?

(2015) Gustavo de los Campos et al.   PLoS Genetics

Structural Architecture of SNP Effects on Complex Traits

(2014) Eric R. Gamazon et al.   AMERICAN JOURNAL OF HUMAN GENETICS

How important are rare variants in common disease?

(2014) A. Saint Pierre et al.   Briefings in Functional Genomics

Conditions for the validity of SNP-based heritability estimation

(2014) James J. Lee et al.   HUMAN GENETICS

An epigenetic twist on the missing heritability of complex traits

(2014) Linda Koch   NATURE REVIEWS GENETICS

Measuring missing heritability: Inferring the contribution of common variants

(2014) David Golan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Searching for missing heritability: Designing rare variant association studies

(2014) O. Zuk et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Why epistasis is important for tackling complex human disease genetics

(2014) Trudy FC Mackay et al.   Genome Medicine

How meaningful are heritability estimates of liability?

(2013) Penny H. Benchek et al.   HUMAN GENETICS

Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease

(2013) Jean-Charles Lambert et al.   NATURE GENETICS

The heritability of human disease: estimation, uses and abuses

(2013) Albert Tenesa et al.   NATURE REVIEWS GENETICS

Advantage of Using Allele-Specific Copy Numbers When Testing for Association in Regions with Common Copy Number Variants

(2013) Gaëlle Marenne et al.   PLoS One

Alzheimer’s Disease: Analyzing the Missing Heritability

(2013) Perry G. Ridge et al.   PLoS One

A century after Fisher: time for a new paradigm in quantitative genetics

(2013) Ronald M. Nelson et al.   TRENDS IN GENETICS

Inclusion of Gene-Gene and Gene-Environment Interactions Unlikely to Dramatically Improve Risk Prediction for Complex Diseases

(2012) Hugues Aschard et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Improved Heritability Estimation from Genome-wide SNPs

(2012) Doug Speed et al.   AMERICAN JOURNAL OF HUMAN GENETICS

The mystery of missing heritability: Genetic interactions create phantom heritability

(2012) O. Zuk et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Population Structure Can Inflate SNP-Based Heritability Estimates

(2011) Sharon R. Browning et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Estimating Missing Heritability for Disease from Genome-wide Association Studies

(2011) Sang Hong Lee et al.   AMERICAN JOURNAL OF HUMAN GENETICS

A genome-wide study reveals rare CNVs exclusive to extreme phenotypes of Alzheimer disease

(2011) Anne Rovelet-Lecrux et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

GCTA: A Tool for Genome-wide Complex Trait Analysis

(2010) Jian Yang et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Genome-wide association study of CNVs in 16,000 cases of eight common diseases and 3,000 shared controls

(2010)   NATURE

Common SNPs explain a large proportion of the heritability for human height

(2010) Jian Yang et al.   NATURE GENETICS

Common vs. rare allele hypotheses for complex diseases

(2009) Nicholas J Schork et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

Finding the missing heritability of complex diseases

(2009) Teri A. Manolio et al.   NATURE

Potential etiologic and functional implications of genome-wide association loci for human diseases and traits

(2009) L. A. Hindorff et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Gene–environment interactions for complex traits: definitions, methodological requirements and challenges

(2008) Astrid Dempfle et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

Extending genome-wide association studies to copy-number variation

(2008) S. A. McCarroll   HUMAN MOLECULAR GENETICS

Personal genomes: The case of the missing heritability

(2008) Brendan Maher   NATURE

Genome-wide association analysis identifies 20 loci that influence adult height

(2008) Michael N Weedon et al.   NATURE GENETICS

Many sequence variants affecting diversity of adult human height

(2008) Daniel F Gudbjartsson et al.   NATURE GENETICS

Identification of ten loci associated with height highlights new biological pathways in human growth

(2008) Guillaume Lettre et al.   NATURE GENETICS

Heritability in the genomics era — concepts and misconceptions

(2008) Peter M. Visscher et al.   NATURE REVIEWS GENETICS