The Human Microbiome and the Missing Heritability Problem

Missing heritability of complex diseases: Enlightenment by genetic variants from intermediate phenotypes

(2016) Adrián Blanco-Gómez et al.   BIOESSAYS

Genetic Determinants of the Gut Microbiome in UK Twins

(2016) Julia K. Goodrich et al.   Cell Host & Microbe

Natural history of the infant gut microbiome and impact of antibiotic treatment on bacterial strain diversity and stability

(2016) Moran Yassour et al.   Science Translational Medicine

Revised Estimates for the Number of Human and Bacteria Cells in the Body

(2016) Ron Sender et al.   PLOS BIOLOGY

The New Era of Treatment for Obesity and Metabolic Disorders: Evidence and Expectations for Gut Microbiome Transplantation

(2016) Thilini N. Jayasinghe et al.   Frontiers in Cellular and Infection Microbiology

Systematic review with meta-analysis: long-term outcomes of faecal microbiota transplantation forClostridium difficileinfection

(2015) Y.-T. Li et al.   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

Discovering genes involved in disease and the mystery of missing heritability

(2015) Eleazar Eskin   COMMUNICATIONS OF THE ACM

The initial state of the human gut microbiome determines its reshaping by antibiotics

(2015) Frédéric Raymond et al.   ISME Journal

Polymicrobial synergy and dysbiosis in inflammatory disease

(2015) Richard J. Lamont et al.   TRENDS IN MOLECULAR MEDICINE

Host Biology in Light of the Microbiome: Ten Principles of Holobionts and Hologenomes

(2015) Seth R. Bordenstein et al.   PLOS BIOLOGY

Humans differ in their personal microbial cloud

(2015) James F. Meadow et al.   PeerJ

Weight Gain After Fecal Microbiota Transplantation

(2015) N. Alang et al.   Open Forum Infectious Diseases

Routes of Acquisition of the Gut Microbiota of the Honey Bee Apis mellifera

(2014) J. Elijah Powell et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Human Genetics Shape the Gut Microbiome

(2014) Julia K. Goodrich et al.   CELL

Defining dysbiosis and its influence on host immunity and disease

(2014) Charisse Petersen et al.   CELLULAR MICROBIOLOGY

Meta-analyses of human gut microbes associated with obesity and IBD

(2014) William A. Walters et al.   FEBS LETTERS

Estimation of Epistatic Variance Components and Heritability in Founder Populations and Crosses

(2014) Alexander I. Young et al.   GENETICS

Next-generation sequencing of nine atrial fibrillation candidate genes identified novel de novo mutations in patients with extreme trait of atrial fibrillation

(2014) Chia-Ti Tsai et al.   JOURNAL OF MEDICAL GENETICS

Diet and exercise orthogonally alter the gut microbiome and reveal independent associations with anxiety and cognition

(2014) Silvia S Kang et al.   Molecular Neurodegeneration

A role for the gut microbiota in IBS

(2014) Stephen M. Collins   Nature Reviews Gastroenterology & Hepatology

Detecting epistasis in human complex traits

(2014) Wen-Hua Wei et al.   NATURE REVIEWS GENETICS

Searching for missing heritability: Designing rare variant association studies

(2014) O. Zuk et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Shaping the oral microbiota through intimate kissing

(2014) Remco Kort et al.   Microbiome

Microbiota transplantation restores normal fecal bile acid composition in recurrent Clostridium difficile infection

(2013) Alexa R. Weingarden et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Richness of human gut microbiome correlates with metabolic markers

(2013) Emmanuelle Le Chatelier et al.   NATURE

Finding the sources of missing heritability in a yeast cross

(2013) Joshua S. Bloom et al.   NATURE

Duodenal Infusion of Donor Feces for Recurrent Clostridium difficile

(2013) Els van Nood et al.   NEW ENGLAND JOURNAL OF MEDICINE

Developmental origins of nonalcoholic fatty liver disease

(2013) David E. Brumbaugh et al.   PEDIATRIC RESEARCH

Estimating Overweight Risk in Childhood From Predictors During Infancy

(2013) S. F. Weng et al.   PEDIATRICS

The Impact of the Gut Microbiota on Human Health: An Integrative View

(2012) Jose C. Clemente et al.   CELL

The microbiome as a human organ

(2012) F. Baquero et al.   CLINICAL MICROBIOLOGY AND INFECTION

Elements of ‘missing heritability’

(2012) Ali J. Marian   CURRENT OPINION IN CARDIOLOGY

Heritability in the genome-wide association era

(2012) Noah Zaitlen et al.   HUMAN GENETICS

The interpersonal and intrapersonal diversity of human-associated microbiota in key body sites

(2012) Luke K. Ursell et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Antibiotics in early life alter the murine colonic microbiome and adiposity

(2012) Ilseung Cho et al.   NATURE

Structure, function and diversity of the healthy human microbiome

(2012)   NATURE

Human gut microbiome viewed across age and geography

(2012) Tanya Yatsunenko et al.   NATURE

The human microbiome: at the interface of health and disease

(2012) Ilseung Cho et al.   NATURE REVIEWS GENETICS

The mystery of missing heritability: Genetic interactions create phantom heritability

(2012) O. Zuk et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

On the rapidity of antibiotic resistance evolution facilitated by a concentration gradient

(2012) R. Hermsen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The human gut microbiome: current knowledge, challenges, and future directions

(2012) Maneesh Dave et al.   Translational Research

Biodiversity and functional genomics in the human microbiome

(2012) Xochitl C. Morgan et al.   TRENDS IN GENETICS

Six Degrees of Epistasis: Statistical Network Models for GWAS

(2012) B. A. McKinney et al.   Frontiers in Genetics

Variability in the Heritability of Body Mass Index: A Systematic Review and Meta-Regression

(2012) Cathy E. Elks et al.   Frontiers in Endocrinology

Estimating Missing Heritability for Disease from Genome-wide Association Studies

(2011) Sang Hong Lee et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Unravelling the effects of the environment and host genotype on the gut microbiome

(2011) Aymé Spor et al.   NATURE REVIEWS MICROBIOLOGY

Changes in the Composition of the Human Fecal Microbiome After Bacteriotherapy for Recurrent Clostridium Difficile-associated Diarrhea

(2010) Alexander Khoruts et al.   JOURNAL OF CLINICAL GASTROENTEROLOGY

Comparative Metagenomic Study of Alterations to the Intestinal Microbiota and Risk of NosocomialClostridum difficile–Associated Disease

(2010) Amee R. Manges et al.   JOURNAL OF INFECTIOUS DISEASES

A human gut microbial gene catalogue established by metagenomic sequencing

(2010) Junjie Qin et al.   NATURE

Breast- v. formula-feeding: impacts on the digestive tract and immediate and long-term health effects

(2010) Isabelle Le Huërou-Luron et al.   NUTRITION RESEARCH REVIEWS

Succession of microbial consortia in the developing infant gut microbiome

(2010) J. E. Koenig et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Delivery mode shapes the acquisition and structure of the initial microbiota across multiple body habitats in newborns

(2010) M. G. Dominguez-Bello et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Epigenetic Inheritance and the Missing Heritability Problem

(2009) M. Slatkin   GENETICS

Epigenetic control

(2009) Geneviève P. Delcuve et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Finding the missing heritability of complex diseases

(2009) Teri A. Manolio et al.   NATURE

The Effect of Diet on the Human Gut Microbiome: A Metagenomic Analysis in Humanized Gnotobiotic Mice

(2009) P. J. Turnbaugh et al.   Science Translational Medicine

Caesarean section is associated with an increased risk of childhood-onset type 1 diabetes mellitus: a meta-analysis of observational studies

(2008) C. R. Cardwell et al.   DIABETOLOGIA

Molecular analysis of the gut microbiota of identical twins with Crohn's disease

(2008) Johan Dicksved et al.   ISME Journal

Decreased Diversity of the Fecal Microbiome in RecurrentClostridium difficile–Associated Diarrhea

(2008) Ju Young Chang et al.   JOURNAL OF INFECTIOUS DISEASES

A core gut microbiome in obese and lean twins

(2008) Peter J. Turnbaugh et al.   NATURE

Heritability in the genomics era — concepts and misconceptions

(2008) Peter M. Visscher et al.   NATURE REVIEWS GENETICS

The Pervasive Effects of an Antibiotic on the Human Gut Microbiota, as Revealed by Deep 16S rRNA Sequencing

(2008) Les Dethlefsen et al.   PLOS BIOLOGY

Horizontal versus Familial Transmission of Helicobacter pylori

(2008) Sandra Schwarz et al.   PLoS Pathogens