Article
Infectious Diseases
Yilihamu Abulitifu, Jiangshan Lian, Munire Adilijiang, Lan Liu, Fengcong Zhao, Wen Qian, Yongping Zhang
Summary: This study investigated the effectiveness and safety of sofosbuvir-velpatasvir (SOF/VEL) with and without ribavirin (RBV) in patients with genotype 3 (GT3) hepatitis C virus (HCV) infection-related cirrhosis from Xinjiang, China. The results showed that SOF/VEL, with or without RBV, was effective and safe for the treatment of GT3 HCV-associated cirrhosis.
INFECTION AND DRUG RESISTANCE
(2022)
Article
Chemistry, Multidisciplinary
Hafiza Rida Farooq Chudhary, Amjad Ali, Sadia Bibi, Muhammad Waqas, Shazia Rafique, Muhammad Idrees, Sobia Ahsan Halim, Magda H. Abdellattif, Ajmal Khan, Ahmed Al-Harrasi
Summary: HCV is a global public health problem with a high number of infections worldwide. It is a leading cause of liver cancer due to the frequent occurrence of HCV infection, especially in those with HCV cirrhosis. This study analyzed the transcriptional analysis of the TP53 gene in HCV-infected patients treated with different antiviral therapies. The results showed that TP53 expression was significantly upregulated in patients with virological responses and HCC, and sofosbuvir + daclatasvir treatment had a significant impact on TP53 expression.
Article
Gastroenterology & Hepatology
Maria Pokorska-Spiewak, Ewa Talarek, Malgorzata Aniszewska, Magdalena Pluta, Anna Dobrzeniecka, Magdalena Marczynska, Giuseppe Indolfi
Summary: The aim of this study was to assess the effect of treatment with sofosbuvir/velpatasvir (SOF/VEL) on the health-related quality of life (HRQL) of children with chronic hepatitis C. The study found that treatment with SOF/VEL improved children's physical well-being and showed a trend towards better scores in social support and peers. However, there was poor to moderate agreement between child self-reports and parent proxy reports.
LIVER INTERNATIONAL
(2023)
Article
Pharmacology & Pharmacy
Zhaochao Liang, Jingyi Shu, Qiyu He, Fan Zhang, Lizhong Dai, Ling Wang, Fengmin Lu, Lin Wang
Summary: This study found that high doses of SOF have an inhibitory effect on HEV genotype 3 and 4 in a rabbit model, and SOF plus RBV therapy showed stronger anti-HEV effects compared to RBV monotherapy.
ANTIVIRAL RESEARCH
(2022)
Article
Gastroenterology & Hepatology
Guiseppe Indolfi, Deirdre Kelly, Gabriella Nebbia, Raffaele Iorio, Anna Mania, Vania Giacomet, Leszek Szenborn, Jiang Shao, Mun Sang Yue, Chia-Hsiang Hsueh, Bandita Parhy, Kathryn Kersey, Alessandra Mangia, Malgorzata Pawlowska, Sanjay Bansal
Summary: Sofosbuvir-velpatasvir-voxilaprevir is a highly effective and well-tolerated pangenotypic regimen for treating chronic HCV infection in adolescents aged 12 to 17 years.
Article
Multidisciplinary Sciences
Lisa Townshend-Bulson, Elena Roik, Youssef Barbour, Dana J. T. Bruden, Chriss E. Homan, Hannah G. F. Espera, Timothy J. Stevenson, Annette M. Hewitt, Wileina Rhodes, James E. Gove, Julia N. Plotnik, Mary M. Snowball, John McGilvray, Brenna C. Simons, Janet M. Johnston, Brian J. McMahon
Summary: The study evaluated the treatment outcomes of sofosbuvir-based regimens for hepatitis C in Alaska Native/American Indian patients and found that the treatment was safe, effective, and well tolerated in this population. High rates of sustained virologic response were achieved regardless of HCV genotype or cirrhosis status.
Article
Multidisciplinary Sciences
Liyu Chen, Lingyao Du, Shuang Kang, Fanghua Ma, Changmin Li, Min He, Lang Bai, Hong Tang
Summary: In Liangshan, China, people living with HIV have a high prevalence of HCV coinfection. A 24-week regimen of SOF+RBV can achieve good efficacy and is well-tolerated in this population. This treatment has the potential to be generalized in regions with limited resources.
SCIENTIFIC REPORTS
(2021)
Article
Gastroenterology & Hepatology
Yu Jun Wong, Prem Harichander Thurairajah, Rahul Kumar, Jessica Tan, Kwong Ming Fock, Ngai Moh Law, Weiquan Li, Andrew Kwek, Yu Bin Tan, Jingyun Koh, Zheng Cong Lee, Loshini Senthil Kumar, Eng Kiong Teo, Tiing-Leong Ang
Summary: This study evaluated the efficacy and safety of sofosbuvir/velpatasvir with and without ribavirin in GT3 hepatitis C virus patients, indicating that this treatment option is safe and effective in a real-world setting, especially for decompensated GT3 patients.
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
(2021)
Article
Gastroenterology & Hepatology
Chen-Hua Liu, Chi-Yi Chen, Wei-Wen Su, Kuo-Chih Tseng, Ching-Chu Lo, Chun-Jen Liu, Jyh-Jou Chen, Cheng-Yuan Peng, Yu-Lueng Shih, Sheng-Shun Yang, Chia-Sheng Huang, Ke-Jhang Huang, Chi-Yang Chang, Ming-Chang Tsai, Wei-Yu Kao, Yo-Jen Fang, Po-Yueh Chen, Pei-Yuan Su, Chih-Wei Tseng, Jow-Jyh Huang, Pei-Lun Lee, Hsueh-Chou Lai, Tsai-Yuan Hsieh, Chung-Hsin Chang, Yi-Jie Huang, Fu-Jen Lee, Chun-Chao Chang, Jia-Horng Kao
Summary: In patients with severe renal impairment and chronic hepatitis C virus infection, sofosbuvir/velpatasvir (SOF/VEL) with or without low-dose ribavirin (RBV) for 12 weeks showed high effectiveness and safety, with high sustained virological response rates and minimal adverse events.
Article
Gastroenterology & Hepatology
Maria Pokorska-Spiewak, Ewa Talarek, Malgorzata Aniszewska, Magdalena Pluta, Anna Dobrzeniecka, Magdalena Marczynska, Giuseppe Indolfi
Summary: This clinical trial examined the efficacy and safety of SOF/VEL in children aged 6-18 years with chronic HCV infection. The results showed that the treatment was highly effective and safe, especially in younger patients.
LIVER INTERNATIONAL
(2023)
Article
Gastroenterology & Hepatology
Andre Goemer, Mara Kloehn, Michelle Jagst, Maximilian K. Nocke, Sven Pischke, Thomas Horvatits, Julian Schulze zur Wiesch, Tobias Mueller, Svenja Hardtke, Markus Cornberg, Heiner Wedemeyer, Patrick Behrendt, Eike Steinmann, Daniel Todt
Summary: Chronic HEV infections are a significant issue in immunocompromised patients due to the absence of specifically approved antiviral drugs. A 24-week trial evaluated the efficacy of the nucleotide analog sofosbuvir in treating chronically HEV-infected patients, revealing the emergence of variants with lower sensitivity to the drug.
Article
Virology
Chaolun Liu, Mingzhe Guo, Lin Han, Jie Lu, Xiaogang Xiang, Qing Xie, Janin Nouhin, Veasna Duong, Yimin Tong, Jin Zhong
Summary: Despite the development of highly effective direct-acting antivirals (DAAs), hepatitis C virus (HCV) infection remains a challenge to human public health. This study shows that a novel GT-6a HCV replicon can easily develop resistance to sofosbuvir (SOF), calling for attention to potential drug resistance in HCV GT-6a patients during DAAs therapies.
JOURNAL OF MEDICAL VIROLOGY
(2023)
Article
Pharmacology & Pharmacy
Steve Leumi, Mingzhe Guo, Jie Lu, Zhaoning Wang, Tianyu Gan, Lin Han, Jackline Ngari, Yimin Tong, Xiaogang Xiang, Qing Xie, Lanfeng Wang, Jin Zhong
Summary: Despite the excellent antiviral potency of direct-acting antivirals (DAAs) against hepatitis C virus (HCV), drug-resistant viral mutations remain a potential challenge. This study identified the combination of two NS5B mutations, S282T and K74R, as a novel resistance-associated substitution (RAS) that confers substantial resistance to SOF while retaining the HCV replication capacity.
ANTIVIRAL RESEARCH
(2022)
Article
Immunology
Davaalkham Dambadarjaa, Otgonbayar Radnaa, Ser-Od Khuyag, Oyu-Erdene Shagdarsuren, Uranbaigali Enkhbayar, Yerkyebulan Mukhtar, Enkh-Oyun Tsogzolbaatar, Gunchmaa Nyam, Shatar Shaarii, Pramil Singh, Masaharu Takahashi, Bira Namdag, Hiroaki Okamoto
Summary: Hepatitis B, C, and D virus infections are a major public health problem in Mongolia, with high prevalence of dual and triple infections. The general population has a high infection rate, and most people are unaware of their infection status, especially young people.
Article
Chemistry, Analytical
Daniel Alzate, Maria C. Lopez-Osorio, Fabian Cortes-Mancera, Maria-Cristina Navas, Jahir Orozco
Summary: This study developed a highly specific, sensitive, and portable electrochemical genosensor for detecting HEV genotype 3 in wastewater. By designing specific DNA probes and using biotinylated capture probes and digoxigenin labeled signal probes, the detection of HEV genotype 3 was successfully achieved. The method exhibited high sensitivity, specificity, and reproducibility and could serve as an early warning system for viruses in wastewater.
ANALYTICA CHIMICA ACTA
(2022)
Article
Pediatrics
Giusi Mangone, Daniele Serranti, Elisa Bartolini, Veronica Vigna, Greta Mastrangelo, Silvia Ricci, Sandra Trapani, Chiara Azzari, Massimo Resti, Giuseppe Indolfi
Summary: The study confirms the association between interferon-lambda genes and the outcome of HCV infection in children. Specific SNPs in these genes have been shown to be associated with spontaneous clearance of HCV in children, indicating the important role of the innate immune system in vertically acquired HCV infection. Interferons-lambda activate the Janus kinase-Stat pathway, leading to suppression of HCV replication both in vivo and in vitro.
PEDIATRIC RESEARCH
(2022)
Review
Pediatrics
Federica Barbati, Mattia Giovannini, Teresa Oranges, Lorenzo Lodi, Simona Barni, Elio Novembre, Ermanno Baldo, Mario Cristofolini, Stefano Stagi, Silvia Ricci, Francesca Mori, Cesare Filippeschi, Chiara Azzari, Giuseppe Indolfi
Summary: Neterton syndrome is a genetic, multisystemic disease characterized by congenital ichthyosiform erythroderma, hair shaft abnormalities, and immune dysregulation. There are currently no specific therapies available, making early diagnosis and a multidisciplinary approach crucial for management. Further research is needed for more effective therapeutic options in the future.
FRONTIERS IN PEDIATRICS
(2021)
Letter
Immunology
Lorenzo Lodi, Maria Moriondo, Alessandra Pucci, Laura Pisano, Silvia Ricci, Giuseppe Indolfi, Chiara Azzari
CLINICAL INFECTIOUS DISEASES
(2022)
Editorial Material
Pediatrics
Stephanie Thee, Mirjam Voeller, Anne Mehl, Doris Staab, Christian Meisel, Horst von Bernuth, Cornelia Feiterna-Sperling, Renate Krueger
KLINISCHE PADIATRIE
(2022)
Article
Nutrition & Dietetics
Sandra Trapani, Chiara Rubino, Giuseppe Indolfi, Paolo Lionetti
Summary: Scurvy is an increasingly common clinical condition in children caused by vitamin C deficiency. It is often misdiagnosed as autoimmune diseases, infections, or neoplasia due to its wide range of clinical symptoms. Early diagnosis is crucial to avoid unnecessary investigations and potentially fatal complications.
Review
Pediatrics
Sandra Trapani, Chiara Rubino, Lorenzo Lodi, Massimo Resti, Giuseppe Indolfi
Summary: Erythema nodosum (EN) is a common form of panniculitis in children. It can be primary or secondary, with secondary cases associated with various conditions. The diagnosis is clinical, and basic work-up and further investigations should be performed based on the medical history and associated manifestations. EN has a favorable prognosis, and treatment should target the underlying condition if necessary.
Article
Pediatrics
Christopher M. Lawrence, Rowen Seckold, Scott Nightingale, Krishna Tumuluri, Bruce R. King
JOURNAL OF PAEDIATRICS AND CHILD HEALTH
(2022)
Article
Cell Biology
Mustapha Najimi, Sebastien Michel, Maria M. Binda, Kris Gellynck, Nathalie Belmonte, Giuseppe Mazza, Noelia Gordillo, Yelena Vainilovich, Etienne Sokal
Summary: The study evaluated the therapeutic effect of human allogeneic liver-derived progenitor cells in a non-alcoholic steatohepatitis (NASH) model, showing their anti-inflammatory and anti-fibrotic features and potential to reverse the progression of chronic fibro-inflammatory disease.
Article
Pediatrics
Giulia Abbati, Federica Attaianese, Anna Rosati, Giuseppe Indolfi, Sandra Trapani
Summary: This study aimed to evaluate the type and severity of neurological involvement in children with SARS-CoV-2 infection or multisystem inflammatory syndrome in children (MIS-C) and compare these findings between the two groups. The study found that neurological symptoms and signs were highly heterogeneous in COVID-19 and MIS-C, with impairment of consciousness being the most frequent manifestation in both groups. Severe complications such as ischemic stroke and GBS were also identified.
Article
Gastroenterology & Hepatology
Maria Pokorska-Spiewak, Ewa Talarek, Malgorzata Aniszewska, Magdalena Pluta, Anna Dobrzeniecka, Magdalena Marczynska, Giuseppe Indolfi
Summary: This clinical trial examined the efficacy and safety of SOF/VEL in children aged 6-18 years with chronic HCV infection. The results showed that the treatment was highly effective and safe, especially in younger patients.
LIVER INTERNATIONAL
(2023)
Letter
Medicine, General & Internal
Jessica A. Eldredge, Michael O. Stormon, Julia E. Clark, Scott Nightingale, Brendan McMullan, Brooke Andersen, Christina Travers, Winita Hardikar
MEDICAL JOURNAL OF AUSTRALIA
(2023)
Review
Microbiology
Sandra Trapani, Alice Caporizzi, Silvia Ricci, Giuseppe Indolfi
Summary: Human bocavirus (HBoV) has emerged as an increasingly reported pathogen, primarily associated with respiratory tract infections in adults and children. It can act as a co-infectious agent or an isolated viral pathogen, and has also been found in asymptomatic individuals. This review provides an overview of HBoV's epidemiology, risk factors, transmission, pathogenicity, detection methods, and clinical features, including severe infections requiring hospitalization and rare fatal cases. Tissue viral persistence, reactivation, reinfection, and the burden of HBoV disease are also evaluated.
Article
Gastroenterology & Hepatology
Maria Pokorska-Spiewak, Ewa Talarek, Malgorzata Aniszewska, Magdalena Pluta, Anna Dobrzeniecka, Magdalena Marczynska, Giuseppe Indolfi
Summary: The aim of this study was to assess the effect of treatment with sofosbuvir/velpatasvir (SOF/VEL) on the health-related quality of life (HRQL) of children with chronic hepatitis C. The study found that treatment with SOF/VEL improved children's physical well-being and showed a trend towards better scores in social support and peers. However, there was poor to moderate agreement between child self-reports and parent proxy reports.
LIVER INTERNATIONAL
(2023)
Article
Virology
Chiara Rubino, Camilla Bechini, Mariangela Stinco, Donatella Lasagni, Giuseppe Indolfi, Sandra Trapani
Summary: This study assessed the prevalence of thromboembolic events (TEs) in children hospitalized during a five-year period, particularly in patients with COVID-19 and MIS-C. The occurrence of TEs was higher in patients with COVID-19 or MIS-C compared to children without these conditions. The prevalence of TEs was significantly higher in patients with MIS-C.
Review
Microbiology
Federica Attaianese, Sara Guiducci, Sandra Trapani, Federica Barbati, Lorenzo Lodi, Giuseppe Indolfi, Chiara Azzari, Silvia Ricci
Summary: This review comprehensively summarizes the immune response to human respiratory syncytial virus (hRSV) infection, including innate and adaptive immune components, recognition of the virus, inflammatory response, natural killer cells, antigen presentation, T cell response, and antibody production. Understanding the complex immune response to hRSV infection is crucial for developing effective interventions against this significant respiratory pathogen.