期刊
FUTURE MEDICINAL CHEMISTRY
卷 11, 期 15, 页码 1929-1952出版社
FUTURE SCI LTD
DOI: 10.4155/fmc-2018-0416
关键词
anticancer agents; cancer; drug discovery; signaling pathways; thiazole; tumor cells
资金
- Iran National Sciences Foundation (INSF) [96011863]
Cancer is known as one of the main causes of death in the world; and many compounds have been synthesized to date with potential use in cancer therapy. Thiazole is a versatile heterocycle, found in the structure of many drugs in use as well as anticancer agents. This review provides an overview of recent advances in thiazole-bearing compounds as anticancer agents with particular emphasis on their mechanism of action in cancerous cells. Chemical designs, structure-activity relationships and relevant preclinical properties have been comprehensively described.
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