Journal
APPLIED PHYSICS A-MATERIALS SCIENCE & PROCESSING
Volume 122, Issue 7, Pages -Publisher
SPRINGER HEIDELBERG
DOI: 10.1007/s00339-016-0029-4
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Funding
- Leading Personnel Plan of Shandong Province [tsls 20150214]
- National Natural Science Foundation of China [21407050]
- Fundamental Research Funds for the Central Universities [22A201514019]
- Yunnan cooperation academician workstation
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Functionalized graphene oxide with its unique physical and chemical properties is widely applied in bio-materials, especially in drug carrier materials. In the past few years, a number of different drugs have been loaded on functionalized graphene oxide via pi-pi stacking and hydrophobic interactions. The present report described a new approach, dexamethasone phosphate successfully loaded onto graphene oxide-chitosan nanocomposites as drug carrier materials by covalent bonding of phosphate ester linkage. Compared with the graphene oxide-chitosan nanocomposites that dexamethasone phosphate was loaded on via simple physical attachment, covalently linked composites as drug carrier materials were more biocompatible which effectively reduced the burst release of drug, and controlled the release of drug in different pH conditions.
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