Article
Food Science & Technology
Claude Lambre, Jose Manuel Barat Baviera, Claudia Bolognesi, Pier Sandro Cocconcelli, Riccardo Crebelli, David Michael Gott, Konrad Grob, Evgenia Lampi, Marcel Mengelers, Alicja Mortensen, Gilles Riviere, Inger-Lise Steffensen, Christina Tlustos, Henk Van Loveren, Laurence Vernis, Holger Zorn, Boet Glandorf, Ursula Gundert-Remy, Lieve Herman, Dominique Turck, Magdalena Andryszkiewicz, Natalia Kovalkovicova, Joaquim Maia, Yi Liu, Rainieri Sandra, Andrew Chesson
Summary: This passage describes a food enzyme complex obtained from porcine pancreas and manufactured by American Laboratories, Inc., USA. The enzyme is primarily used for hydrolyzing milk proteins. However, it contains a higher amount of solvent residue than the maximum residue level set by the EU.
Article
Chemistry, Applied
Yi Zhang, Shudong He, Xin Rui, Benjamin K. Simpson
Summary: The study demonstrates the molecular mechanisms of marine-derived peptides in inhibiting multiple enzymes involved in chronic diseases. In silico analyses showed that one peptide could inhibit multiple enzymes by forming specific interactions with their active sites. Peptides with different mechanisms were found to inhibit ACE and α-amylase, while another peptide inhibited ACE, α-amylase, and lipase through direct interactions with catalytic residues.
Article
Biochemistry & Molecular Biology
Aneta Wojdylo, Paulina Nowicka
Summary: This study identified and characterized the polyphenolic constituents of apricot tree leaves using advanced mass spectrometry techniques, revealing their potential activity in antioxidant, antidiabetic, anti-obesity, anti-cholinesterase, and anti-inflammatory functions. The results indicated that apricot leaf extract is a promising source of raw materials for various commercial sectors, particularly in food, cosmetics, and pharmaceutical production.
Article
Multidisciplinary Sciences
Nidal Jaradat, Mohammad Qneibi, Mohammed Hawash, Anood Sawalha, Sana Qtaishat, Fatima Hussein, Linda Issa
Summary: This study evaluated the chemical compositions, antioxidant, anti-lipase, and anti-alpha-amylase activities of four fractions of Helichrysum sanguineum. The hexane fraction showed the highest phenol and flavonoid contents and the best antioxidant activity, while the aqueous fraction exhibited potential inhibitory effects on alpha-amylase and lipase.
ARABIAN JOURNAL FOR SCIENCE AND ENGINEERING
(2021)
Article
Food Science & Technology
Vincenzo Sicari, Rosa Romeo, Antonio Mincione, Simone Santacaterina, Rosa Tundis, Monica Rosa Loizzo
Summary: This study investigated the phytochemical content and bioactivity of Lycium barbarum collected in Calabria and evaluated the possibility of enriching traditional ciabatta bread with goji fresh flesh puree. The enriched bread showed good levels of bioactive compounds and exhibited antioxidant and inhibitory activities against metabolic enzymes. Sensory analysis confirmed the slight modification in appearance but not in flavor and taste of the bread.
Review
Chemistry, Analytical
Jiaju Yin, Tianrui Cui, Yi Yang, Tian-Ling Ren
Summary: This paper provides a comprehensive review of pancreatic enzyme detection techniques, focusing on the importance of early diagnosis and the use of portable and Point-of-Care testing methods. The implementation of chemical sensing and probe design is highlighted, along with the application of novel sensing technology for early screening of pancreatitis in remote areas or at home.
Article
Pharmacology & Pharmacy
S. Aydogan, I. Sert, G. Okut, A. Dursun, T. Ergenc, H. Esin
Summary: This study aimed to identify preoperative, perioperative, and postoperative conditions that may cause postoperative pancreatic fistula (POPF) and examine the predictive value of drain fluid amylase (DFA) values in assessing the severity of POPF. The results showed that an increased body mass index and excessive perioperative bleeding increase the risk of POPF. DFA level is an easily applicable method for early diagnosis of POPF.
EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES
(2023)
Article
Chemistry, Applied
Dino Davosir, Ivana Sola
Summary: Interspecific metabolite transfer (ISMT) is a new method for enhancing the content of caffeine and catechins in broccoli, cauliflower, and kale using tea as a donor plant. The addition of EDTA and Tween as membrane permeabilizers enhances the transfer effect. Results show that the combination of tea and EDTA significantly increases the vitamin C content in broccoli and kale.
Article
Pediatrics
Belal Al Droubi, Eyad Altamimi
Summary: This retrospective study analyzed a cohort of children with acute pancreatitis at a tertiary care hospital in Jordan, revealing that serum lipase is a more sensitive diagnostic tool for pancreatitis compared to serum amylase. Anatomical abnormalities were the most common etiology of pancreatitis.
FRONTIERS IN PEDIATRICS
(2022)
Article
Plant Sciences
Subhadip Paul, Amitava Rakshit
Summary: The study investigated the impact of seed bio-priming with Trichoderma viride on degradation of stored foods, phenol content, and nutrient absorption in germinating soybean. The activities of various enzymes were measured to assess hydrolysis of starch, lipid, and protein. Bio-primed seeds showed faster degradation of lipid and starch, as well as higher protein hydrolysis. The phenol content in bio-primed cotyledons reduced lipid peroxidation and exhibited stronger radical scavenging activity. Higher potassium content was observed in bio-primed cotyledons, while nitrogen and phosphorus concentrations were significantly higher on day 5. These factors contributed to faster and more vigorous germination of bio-primed soybean seeds compared to non-primed ones.
JOURNAL OF PLANT GROWTH REGULATION
(2023)
Article
Chemistry, Applied
Karolina Tkacz, Aneta Wojdylo, Igor Piotr Turkiewicz, Paulina Nowicka
Summary: The study evaluated the potential of sea buckthorn-based smoothies in anti-diabetic and antioxidant properties, with significant inhibitory effects on certain cholinesterases and lipase. The products also showed sensory attractiveness in compositions with higher fruit or vegetable content.
Article
Food Science & Technology
Yunhao Lu, Qing Peng, Qiang He
Summary: In this study, it was found that Zanthoxylum bungeanum maxim (ZBM) and Capsicum annuum L. (CAL) extracts, as well as their compounds, showed inhibitory effects on pancreatic lipase and alpha-amylase. The combination of hydroxy-alpha-sanshool and capsaicin exhibited similar inhibition trends to that of the extracts, suggesting their association with the functions of the crude extracts. The in vitro digestion experiment showed lower inhibition rates. Kinetic studies revealed mixed-type inhibition by ZBM extract, hydroxy-alpha-sanshool, and capsaicin on the two enzymes, and molecular modelling suggested a higher affinity of capsaicin to these enzymes.
INTERNATIONAL JOURNAL OF FOOD SCIENCE AND TECHNOLOGY
(2023)
Article
Food Science & Technology
Maria Joao Santos, Elisete Correia, Alice Vilela
Summary: This study aimed to investigate the influence of different types of alcoholic beverages (beer, wine, and brandy) on lipase and alpha-amylase activity and in-mouth pH. The results showed significant differences in pH values (drink and saliva) compared to the initial drinks. Transparent brandy (Grappa), red wine, and wood-aged brandy induced higher alpha-amylase activity than white wine and blonde beer. Tawny port wine also exhibited greater alpha-amylase activity than red wine. These findings suggest that the chemical interactions between saliva and beverages depend on saliva composition as well as the chemical composition of the drink, including acid content, alcohol concentration, and tannin content. This research is an important contribution to the development of a sensor system that mimics human perception of flavor.
Article
Biochemistry & Molecular Biology
Ouijdane Benayad, Mohamed Bouhrim, Salima Tiji, Loubna Kharchoufa, Mohamed Addi, Samantha Drouet, Christophe Hano, Jose Manuel Lorenzo, Hasnae Bendaha, Mohamed Bnouham, Mostafa Mimouni
Summary: This study evaluated the peel of C. aurantium to be a valuable by-product rich in non-toxic phytoconstituents, particularly those with potential antidiabetic action. The research found that the peel extracts inhibited alpha-amylase and alpha-glycosidase in vitro, suggesting potential benefits for diabetes management. Additionally, the oral administration of C. aurantium extracts at a high dose did not show any signs of acute toxicity in mice, indicating their safety for consumption.
Article
Environmental Sciences
Sichen Gao, Tong Li, Jie Pan, Dengcheng Han, Jing Lin, Qigui Niu, Rutao Liu
Summary: The study demonstrated that UFCB induced toxicity in splenocytes through oxidative stress and altered enzyme activity via the formation of protein corona. This provides important insights into the toxic effects of UFCB on the spleen and digestive system.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2021)
Article
Plant Sciences
Niko S. S. Radulovic, Marko Z. Z. Mladenovic, Dusan R. Vukicevic, Nikola M. M. Stojanovic, Pavle J. J. Randjelovic, Zorica Z. Z. Stojanovic-Radic, Fabio Boylan
Summary: In this study, the ethnopharmacological use of Pulicaria dysenterica was examined, and the extracted essential oil was found to have antimicrobial, antispasmodic, and other activities. Furthermore, several compounds were synthesized and tested, showing low toxicity and promising antimicrobial potential. These findings suggest that the ethnopharmacological application of Pulicaria dysenterica plant material for the treatment of gastrointestinal infections may be related to the active components in the essential oil.
Article
Biology
Pavle Randjelovic, Nikola Stojanovic, Ivan Ilic, Dragan Vuckovic
Summary: The study found that exposure to artificial light at night with a predominant blue spectrum has a significant impact on circadian rhythm and sleep. Reducing the amount of blue light emitted from smartphone screens during the night has been shown to improve sleep quality among medical students.
CHRONOBIOLOGY INTERNATIONAL
(2023)
Article
Immunology
Nikola M. Stojanovic, Katarina Mitic, Slavica Stojnev, Dusan Sokolovic, Marija Vukelic Nikolic, Dragana Trickovic-Vukic, Pavle J. Randjelovic, Miljan Krstic, Niko S. Radulovic
Summary: The present study investigated the metabolic activity and adherence capacity of whole bone marrow cells (wBMC) and changes in bone marrow architecture following acute pancreatitis (AP) induction. The adherence capacity and total number of wBMCs significantly increased after AP induction, while pre-treatment with allopurinol reduced their adherence capability. No significant changes were observed in the metabolic activity of wBMCs. The alterations in bone marrow may reflect the general activation of myelopoiesis, consistent with increased mobilization of mesenchymal stem cells after AP induction.
EUROPEAN JOURNAL OF INFLAMMATION
(2023)
Article
Biochemistry & Molecular Biology
Nikola M. Stojanovic, Pavle J. Randjelovic, Aleksandra Maslovaric, Milos Kostic, Vidak Raicevic, Marija Sakac, Srdan Bjedov
Summary: This study evaluated the immunomodulatory potential of a selected library of bile acid derivatives (BAD) and found that these substances can affect the function of macrophages and have anti-inflammatory effects within a certain concentration range.
CHEMICO-BIOLOGICAL INTERACTIONS
(2023)
Article
Plant Sciences
Nikola M. Stojanovic, Marko Z. Mladenovic, Pavle J. Randjelovic, Niko S. Radulovic
Summary: This study evaluated the anxiolytic activity of lemon balm essential oil on anxiety. The results show that lemon balm essential oil has anti-anxiety potential in different experimental settings and can affect multiple neurotransmitter systems. This provides a basis for future mechanistic studies.
JOURNAL OF ETHNOPHARMACOLOGY
(2023)
Article
Medicine, General & Internal
Vesna Nikolov, Misa Radisavljevic, Boban Jelenkovic, Nikola Stojanovic
Summary: The study aims to assess the efficacy of treatment modalities for brain metastasis patients based on the type (solitary or multiple) and primary cancer site. The retrospective study found that multiple metastases were more common in primary lung cancer, while single metastases were more common in adenocarcinoma patients. Surgery and radiation remain the cornerstone of therapy, and efforts should be made to improve surgical techniques and minimize damage to healthy tissue. Radiosurgery and whole brain radiotherapy are still the primary treatment for multiple metastases.
VOJNOSANITETSKI PREGLED
(2023)
Article
Medicine, General & Internal
Maja Simonovic, Bojan Nedovic, Misa Radisavljevic, Nikola Stojanovic
Summary: Post-traumatic stress disorder (PTSD) is a prevalent psychiatric disorder that often occurs following war trauma. Recent research has shed light on the biological basis of PTSD, with neuroimaging studies revealing altered brain connectivity patterns in affected individuals. This study aimed to compare the severity of PTSD and depression in patients with and without a history of traumatic brain injury (TBI) to shed light on the impact of comorbid TBI on the presentation of PTSD symptoms.
MEDICINA-LITHUANIA
(2023)
Article
Medicine, General & Internal
Nikola M. Stojanovic, Sara Mladenovic, Bogdan Stojiljkovic, Aleksandar Markovic, Dragana Pavlovic, Pavle Randjelovic, Jelena Zvezdanovic, Ljiljana Stanojevic
Summary: This study tested the effects of Melissa officinalis leaves hydrolate on gastric motility and found that low doses had no significant impact, while high doses increased basal tone of the stomach fundus. The dominant compound in the hydrolate was rosmarinic acid. Further research could explore the pharmacological activity and potential application of this by-product.
ACTA FACULTATIS MEDICAE NAISSENSIS
(2023)
Article
Toxicology
Nikola M. Stojanovic, Aleksandra Maslovaric, Ivana Mihajlovic, Aleksandar Markovic, Pavle J. Randjelovic, Dusan Sokolovic
Summary: This study investigated the neuroprotective properties of melatonin in Wistar rats exposed to carbon tetrachloride. Results showed that melatonin was able to reverse the disturbance in antioxidant enzymes and alleviate oxidative stress-induced tissue damage, suggesting its potential therapeutic use in neurodegenerative disorders.
TOXICOLOGY RESEARCH
(2023)
Review
Medicine, General & Internal
Milica Veljkovic, Dragana R. Pavlovic, Nikola M. Stojanovic, Tanja Dzopalic, Lidija Popovic Dragonjic
Summary: This study aims to investigate the influence of behavioral and dietary habits on the prevention of COVID-19 and provide new insights. The research found that maintaining good mental health, sufficient sleep, and moderate exercise are crucial for enhancing immunity during lockdown. Mediterranean and vegetarian diets are beneficial for boosting immunity. Adequate hydration, green tea intake, and supplementation with vitamins D, C, and E can also help prevent infection.
MEDICINA-LITHUANIA
(2022)