Fungal biotransformation of tanshinone results in [4+2] cycloaddition with sorbicillinol: evidence for enzyme catalysis and increased antibacterial activity

Chemoenzymatic Synthesis of Thiazolyl Peptide Natural Products Featuring an Enzyme-Catalyzed Formal [4 + 2] Cycloaddition

(2015) Walter J. Wever et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Biosynthesis of Versipelostatin: Identification of an Enzyme-Catalyzed [4+2]-Cycloaddition Required for Macrocyclization of Spirotetronate-Containing Polyketides

(2015) Takuya Hashimoto et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

The structure of SpnF, a standalone enzyme that catalyzes [4 + 2] cycloaddition

(2015) Christopher D Fage et al.   Nature Chemical Biology

Natural products: A continuing source of novel drug leads

(2013) Gordon M. Cragg et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Microbial transformation of cinobufotalin by Alternaria alternate AS 3.4578 and Aspergillus niger AS 3.739

(2013) Jinghua Lu et al.   JOURNAL OF MOLECULAR CATALYSIS B-ENZYMATIC

Biotransformation of 17α-ethynyl substituted steroidal drugs with microbial and plant cell cultures: A review

(2013) Syed Adnan Ali Shah et al.   STEROIDS

Current developments and challenges in the search for a naturally selected Diels-Alderase

(2012) Hak Joong Kim et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Natural Products As Sources of New Drugs over the 30 Years from 1981 to 2010

(2012) David J. Newman et al.   JOURNAL OF NATURAL PRODUCTS

Biotransformation of ent-kaur-16-ene and ent-trachylobane 7β-acetoxy derivatives by the fungus Gibberella fujikuroi (Fusarium fujikuroi)

(2012) Braulio M. Fraga et al.   PHYTOCHEMISTRY

Microbial transformations of taxadienes and the multi-drug resistant tumor reversal activities of the metabolites

(2012) Xiao Liu et al.   TETRAHEDRON

Enzyme-catalysed [4+2] cycloaddition is a key step in the biosynthesis of spinosyn A

(2011) Hak Joong Kim et al.   NATURE

Biotransformation of bufadienolides by cell suspension cultures of Saussurea involucrata

(2011) Xing Zhang et al.   PHYTOCHEMISTRY

Everolimus

(2010) P. J. Houghton   CLINICAL CANCER RESEARCH

Biotransformation of triterpenes

(2010) Kai Muffler et al.   PROCESS BIOCHEMISTRY

Recent Advances in the Chemistry and Biology of Naturally Occurring Antibiotics

(2009) K. C. Nicolaou et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Drug Discovery and Natural Products: End of an Era or an Endless Frontier?

(2009) J. W.-H. Li et al.   SCIENCE