Acetohydroxyacid synthases: evolution, structure, and function

Commercial Herbicides Can Trigger the Oxidative Inactivation of Acetohydroxyacid Synthase

(2016) Thierry Lonhienne et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Mechanisms of bacterial acetohydroxyacid synthase (ahas) and specific inhibitors of Mycobacterium tuberculosis ahas as potential drug candidates against tuberculosis

(2015) Kunal Gokhale et al.   CURRENT DRUG TARGETS

Functional evaluation of residues in the herbicide-binding site of Mycobacterium tuberculosis acetohydroxyacid synthase by site-directed mutagenesis

(2015) In-Pil Jung et al.   ENZYME AND MICROBIAL TECHNOLOGY

Metabolic engineering of Corynebacterium glutamicum ATCC13869 for l -valine production

(2015) Cheng Chen et al.   METABOLIC ENGINEERING

Analysis of acetohydroxyacid synthase variants from branched-chain amino acids-producing strains and their effects on the synthesis of branched-chain amino acids in Corynebacterium glutamicum

(2015) Yanfeng Guo et al.   PROTEIN EXPRESSION AND PURIFICATION

Characterization and modification of enzymes in the 2-ketoisovalerate biosynthesis pathway of Ralstonia eutropha H16

(2014) Jingnan Lu et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Perturbation of the Monomer–Monomer Interfaces of the Benzoylformate Decarboxylase Tetramer

(2014) Forest H. Andrews et al.   BIOCHEMISTRY

Detailed Structure-Function Correlations ofBacillus subtilisAcetolactate Synthase

(2014) Bettina Sommer et al.   CHEMBIOCHEM

Acetohydroxyacid Synthase: A Target for Antimicrobial Drug Discovery

(2014) Nason Pue et al.   CURRENT PHARMACEUTICAL DESIGN

Structural and functional significance of the highly-conserved residues in Mycobacterium tuberculosis acetohydroxyacid synthase

(2014) Irshad Ahmed Baig et al.   ENZYME AND MICROBIAL TECHNOLOGY

A QM/MM study on the reaction pathway leading to 2-Aceto-2-hydroxybutyrate in the catalytic cycle of AHAS

(2014) Leslie Sánchez et al.   JOURNAL OF COMPUTATIONAL CHEMISTRY

The modular structure of ThDP-dependent enzymes

(2014) Constantin Vogel et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

Metabolic engineering of Corynebacterium glutamicum for 2-ketoisocaproate production

(2013) Verena Bückle-Vallant et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

A Bulky Hydrophobic Residue Is Not Required To Maintain the V-Conformation of Enzyme-Bound Thiamin Diphosphate

(2013) Forest H. Andrews et al.   BIOCHEMISTRY

Alternating Sites Reactivity Is a Common Feature of Thiamin Diphosphate-Dependent Enzymes As Evidenced by Isothermal Titration Calorimetry Studies of Substrate Binding

(2013) Kathrin Schröder-Tittmann et al.   BIOCHEMISTRY

Biochemical characterization and evaluation of potent inhibitors of the Pseudomonas aeruginosa PA01 acetohydroxyacid synthase

(2013) June-Haeng Cho et al.   BIOCHIMIE

The Minimum Activation Peptide from ilvH Can Activate the Catalytic Subunit of AHAS from Different Species

(2013) Yuefang Zhao et al.   CHEMBIOCHEM

Molecular Drug Resistance Prediction for Acetohydroxyacid Synthase Mutants Against Chlorsulfuron Using MB-QSAR

(2013) Yinwu He et al.   CHINESE JOURNAL OF CHEMISTRY

Role of a highly conserved proline-126 in ThDP binding of Mycobacterium tuberculosis acetohydroxyacid synthase

(2013) Irshad Ahmed Baig et al.   ENZYME AND MICROBIAL TECHNOLOGY

Discovery of Novel Acetohydroxyacid Synthase Inhibitors as Active Agents against Mycobacterium tuberculosis by Virtual Screening and Bioassay

(2013) Di Wang et al.   Journal of Chemical Information and Modeling

Pushing product formation to its limit: Metabolic engineering of Corynebacterium glutamicum for l-leucine overproduction

(2013) Michael Vogt et al.   METABOLIC ENGINEERING

The Coil-to-Helix Transition in IlvN Regulates the Allosteric Control of Escherichia coli Acetohydroxyacid Synthase I

(2012) N. Megha Karanth et al.   BIOCHEMISTRY

Arginine 26 and Aspartic Acid 69 of the Regulatory Subunit are Key Residues of Subunits Interaction of Acetohydroxyacid Synthase Isozyme III fromE. coli

(2012) Yuefang Zhao et al.   CHEMBIOCHEM

Many of the functional differences between acetohydroxyacid synthase (AHAS) isozyme I and other AHASs are a result of the rapid formation and breakdown of the covalent acetolactate-thiamin diphosphate adduct in AHAS I

(2012) Inna Belenky et al.   FEBS Journal

Bacterial acetohydroxyacid synthase and its inhibitors - a summary of their structure, biological activity and current status

(2012) Vinayakumar Gedi et al.   FEBS Journal

Co-expression of feedback-resistant threonine dehydratase and acetohydroxy acid synthase increase l-isoleucine production in Corynebacterium glutamicum

(2012) Lianghong Yin et al.   METABOLIC ENGINEERING

Unexpected tautomeric equilibria of the carbanion-enamine intermediate in pyruvate oxidase highlight unrecognized chemical versatility of thiamin

(2012) D. Meyer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Preliminary X-ray crystallographic studies of the catalytic subunit ofEscherichia coliAHAS II with its cofactors

(2011) Xuhui Niu et al.   Acta Crystallographica Section F-Structural Biology and Crystallization Communications

Improvement of the Redox Balance Increases l-Valine Production by Corynebacterium glutamicum under Oxygen Deprivation Conditions

(2011) Satoshi Hasegawa et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Allosteric regulation in Acetohydroxyacid Synthases (AHASs) – Different structures and kinetic behavior in isozymes in the same organisms

(2011) Ze’ev Barak et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Role of the C-terminal domain of the regulatory subunit of AHAS isozyme III: Use of random mutagenesis with in vivo reconstitution (REM-ivrs)

(2011) Alexander Slutzker et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Genome Sequence of Acinetobacter calcoaceticus PHEA-2, Isolated from Industry Wastewater

(2011) Y. Zhan et al.   JOURNAL OF BACTERIOLOGY

Valine 375 and Phenylalanine 109 Confer Affinity and Specificity for Pyruvate as Donor Substrate in Acetohydroxy Acid Synthase Isozyme II fromEscherichia coli

(2010) Andrea Steinmetz et al.   BIOCHEMISTRY

Characterization of Acetohydroxyacid Synthase I fromEscherichia coliK-12 and Identification of Its Inhibitors

(2010) Pham Ngoc CHIEN et al.   BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY

The Thiamine diphosphate dependent Enzyme Engineering Database: A tool for the systematic analysis of sequence and structure relations

(2010) Michael Widmann et al.   BMC BIOCHEMISTRY

Computational study on the carboligation reaction of acetohidroxyacid synthase: New approach on the role of the HEThDP−intermediate

(2010) Gonzalo Jaña et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

Interactions between Large and Small Subunits of Different Acetohydroxyacid Synthase Isozymes ofEscherichia coli

(2009) Maria Vyazmensky et al.   BIOCHEMISTRY

Reaction mechanisms of thiamin diphosphate enzymes: new insights into the role of a conserved glutamate residue

(2009) Boaz Shaanan et al.   FEBS Journal

Origin of the specificities of acetohydroxyacid synthases and glyoxylate carboligase

(2009) David M. Chipman et al.   JOURNAL OF MOLECULAR CATALYSIS B-ENZYMATIC

Homologous and heterologous interactions between catalytic and regulatory subunits of Escherichia coli acetohydroxyacid synthase I and III

(2009) CongWei Niu et al.   Science in China. Series B, Chemistry

Acetohydroxyacid Synthase, a Novel Target for Improvement of L-Lysine Production by Corynebacterium glutamicum

(2008) B. Blombach et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Escherichia coliilvN Interacts with the FAD Binding Domain of ilvB and Activates the AHAS I Enzyme†

(2008) Ashima Mitra et al.   BIOCHEMISTRY

Glyoxylate carboligase lacks the canonical active site glutamate of thiamine-dependent enzymes

(2008) Alexander Kaplun et al.   Nature Chemical Biology