Evidence of a developmental origin for β-cell heterogeneity using a dual lineage-tracing technology

Endogenous Reprogramming of Alpha Cells into Beta Cells, Induced by Viral Gene Therapy, Reverses Autoimmune Diabetes

(2018) Xiangwei Xiao et al.   Cell Stem Cell

Forkhead Box Protein 1 (FoxO1) Inhibits Accelerated β Cell Aging in Pancreas-specific SMAD7 Mutant Mice

(2017) Xiangwei Xiao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

CD99 as surface anchor for human islet endocrine cell purification

(2017) Geert A. Martens et al.   Journal of Tissue Engineering and Regenerative Medicine

Mechanisms of adult human β-cell in vitro dedifferentiation and redifferentiation

(2016) S. Efrat   DIABETES OBESITY & METABOLISM

Novel factors modulating human β-cell proliferation

(2016) J. Shirakawa et al.   DIABETES OBESITY & METABOLISM

Transient Suppression of TGFβ Receptor Signaling Facilitates Human Islet Transplantation

(2016) Xiangwei Xiao et al.   ENDOCRINOLOGY

Epidermal Growth Factor Receptor Signaling Regulates β Cell Proliferation in Adult Mice

(2016) Zewen Song et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Transcriptional Maintenance of Pancreatic Acinar Identity, Differentiation, and Homeostasis by PTF1A

(2016) Chinh Q. Hoang et al.   MOLECULAR AND CELLULAR BIOLOGY

Identification of proliferative and mature β-cells in the islets of Langerhans

(2016) Erik Bader et al.   NATURE

Impact of islet architecture on β-cell heterogeneity, plasticity and function

(2016) Sara S. Roscioni et al.   Nature Reviews Endocrinology

Human islets contain four distinct subtypes of β cells

(2016) Craig Dorrell et al.   Nature Communications

Novel Heterotypic Rox Sites for Combinatorial Dre Recombination Strategies

(2015) Katherine Chuang et al.   G3-Genes Genomes Genetics

Pancreatic β Cell Dedifferentiation in Diabetes and Redifferentiation following Insulin Therapy

(2014) Zhiyu Wang et al.   Cell Metabolism

Pdx1 Maintains β Cell Identity and Function by Repressing an α Cell Program

(2014) Tao Gao et al.   Cell Metabolism

Dominant and context-specific control of endodermal organ allocation by Ptf1a

(2014) S. G. Willet et al.   DEVELOPMENT

M2 macrophages promote beta-cell proliferation by up-regulation of SMAD7

(2014) Xiangwei Xiao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Pancreas-Specific Cre Driver Lines and Considerations for Their Prudent Use

(2013) Mark A. Magnuson et al.   Cell Metabolism

A Smad Signaling Network Regulates Islet Cell Proliferation

(2013) Y. El-Gohary et al.   DIABETES

Hypoglycemia Reduces Vascular Endothelial Growth Factor A Production by Pancreatic Beta Cells as a Regulator of Beta Cell Mass

(2013) Xiangwei Xiao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

No evidence for β cell neogenesis in murine adult pancreas

(2013) Xiangwei Xiao et al.   JOURNAL OF CLINICAL INVESTIGATION

β-cell dedifferentiation in diabetes is important, but what is it?

(2013) Gordon C Weir et al.   Islets

Pancreatic β Cell Dedifferentiation as a Mechanism of Diabetic β Cell Failure

(2012) Chutima Talchai et al.   CELL

Differential regulation of embryonic and adult β cell replication

(2012) Uma Gunasekaran et al.   CELL CYCLE

TGF  Receptor Signaling Is Essential for Inflammation-Induced but Not  -Cell Workload-Induced  -Cell Proliferation

(2012) X. Xiao et al.   DIABETES

Context-specific  -to- -cell reprogramming by forced Pdx1 expression

(2011) Y.-P. Yang et al.   GENES & DEVELOPMENT

Dre recombinase, like Cre, is a highly efficient site-specific recombinase in E. coli, mammalian cells and mice

(2009) K. Anastassiadis et al.   Disease Models & Mechanisms

A robust and high-throughput Cre reporting and characterization system for the whole mouse brain

(2009) Linda Madisen et al.   NATURE NEUROSCIENCE

β Cells Can Be Generated from Endogenous Progenitors in Injured Adult Mouse Pancreas

(2008) Xiaobo Xu et al.   CELL

Pdx-1 and Ptf1a concurrently determine fate specification of pancreatic multipotent progenitor cells

(2008) Jared S. Burlison et al.   DEVELOPMENTAL BIOLOGY

Developmental biology of the pancreas: A comprehensive review

(2008) George K. Gittes   DEVELOPMENTAL BIOLOGY

Reduction of Ptf1a Gene Dosage Causes Pancreatic Hypoplasia and Diabetes in Mice

(2008) A. Fukuda et al.   DIABETES