Article
Clinical Neurology
Zitong He, Fei Zhao, Yilong Shan, Zulin Dou, Hongmei Wen
Summary: This case report presents a patient diagnosed with NMOSD with medulla oblongata involvement and dysphagia. Despite traditional treatment, the patient still experienced swallowing difficulties. However, after combining BTX injection with traditional treatment, her swallowing function improved.
FRONTIERS IN NEUROLOGY
(2022)
Article
Otorhinolaryngology
Theofano Tikka, Mark Andrew Hall, Sarah Margaret de Blieck, Malcolm Alexander Buchanan
Summary: Incomplete closure of the pharynx after laryngectomy can lead to a protrusion of the anterior wall below the tongue base, known as a pseudo-diverticulum. The prolapsed mucosa separating the neopharynx from the pseudo-diverticulum is called a pseudo-epiglottis. Surgical division of the pseudo-epiglottis significantly improves swallowing function.
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK
(2023)
Article
Multidisciplinary Sciences
Maximilian J. Wessel, Chang-hyun Park, Elena Beanato, Estelle A. Cuttaz, Jan E. Timmermann, Robert Schulz, Takuya Morishita, Philipp J. Koch, Friedhelm C. Hummel
Summary: The study found that multisession motorcortical stimulation is beneficial for skill acquisition, while monofocal cerebellar stimulation or sequential multifocal motorcortico-cerebellar stimulation did not show additional effects. Baseline task performance and structural integrity of the bilateral superior cerebellar peduncle are the most influential predictors of training success.
SCIENTIFIC REPORTS
(2021)
Article
Audiology & Speech-Language Pathology
Kristin J. Teplansky, Corinne A. Jones
Summary: This study found that pharyngeal swallowing pressure variability increases during volitional swallowing tasks in healthy individuals. The type of swallowing task and the pharyngeal region both have significant effects on pressure variability, but there is no significant interaction between the two.
JOURNAL OF SPEECH LANGUAGE AND HEARING RESEARCH
(2022)
Article
Neurosciences
Lindsay Griffin, Erin Kamarunas, Christina Kuo, Cynthia O'Donoghue
Summary: The purpose of this study was to determine the most effective amplitude criterion of anodal tDCS for promoting neuroplasticity in dysphagia rehabilitation. The results showed that during a swallowing task, healthy volunteers receiving 1 mA of anodal tDCS demonstrated a suppressed hemodynamic response, while those receiving 2 mA of anodal tDCS had an increase in the hemodynamic response. There was no significant effect on submental muscle contraction regardless of amplitude. Anodal tDCS was well tolerated in healthy adults.
EXPERIMENTAL BRAIN RESEARCH
(2022)
Article
Medicine, General & Internal
Juan Yang, Huozhong Yuan
Summary: This case report highlights the rare and challenging nature of cricopharyngeal dysfunction and swallowing apraxia after stroke, with successful management through pharmacotherapy and rehabilitation therapy. The use of transcranial direct current stimulation shows promise in treating patients with these conditions.
Article
Clinical Neurology
Huiwen Mao, Yi Lyu, Yan Li, Lin Gan, Jiawei Ni, Liang Liu, Zhengguang Xiao
Summary: The combination of transcranial direct current stimulation (tDCS) with routine training can significantly improve swallowing function and nutritional status of patients with dysphagia after brainstem stroke, reducing the risk of infection.
NEUROLOGICAL SCIENCES
(2022)
Article
Geriatrics & Gerontology
Daisuke Takagi, Tomohisa Ohno, Motoki Moriwaki, Norimasa Katagiri, Yoshiko Umeda, Haruka Tohara, Akiko Nomoto, Ichiro Fujishima
Summary: This study aimed to investigate the effects of dentures on pharyngeal swallowing function in patients with dysphagia. It was found that denture removal caused pharyngeal expansion, leading to increased vallecular residue. A treatment plan considering the impact of dentures on swallowing function may result in more effective rehabilitation.
GERIATRICS & GERONTOLOGY INTERNATIONAL
(2021)
Article
Health Care Sciences & Services
Hyemi Hwang, Yeonjae Han, Geun-Young Park, Soohwan Lee, Hae-Yeon Park, Sun Im
Summary: This study investigated the effects of tDCS on swallowing function in individuals with different COMT gene polymorphisms. The results showed that individuals with COMT Val/Val polymorphism experienced improvement in swallowing motor function after tDCS, while those with COMT Met carrier group did not show significant changes.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Health Care Sciences & Services
Motoyoshi Morishita, Masahiko Okubo, Tatsuro Sekine
Summary: This study aimed to determine the efficacy of carbonated and sweetened drinks added to thickened liquids in improving dysphagia. The results showed that carbonated thickened drink was easier to swallow and may improve penetration and/or aspiration.
Article
Audiology & Speech-Language Pathology
Rameen K. Walters, Rachana Gudipudi, Kate Davidson, Melissa Cooke, Jenna Barengo, Drasti Smyre, Kendrea L. Garand, Bonnie Martin-Harris, Maria G. Matheus, Shaun A. Nguyen, Ashli K. O'Rourke
Summary: This study investigates the impact of cervical spinal pathology on swallowing function in dysphagic individuals. The results show that most patients with dysphagia have spinal pathology, and in some cases, spinal pathology is the primary cause of dysphagia. Compared with healthy controls, patients with spinal pathology have lower scores on swallow metrics.
AMERICAN JOURNAL OF SPEECH-LANGUAGE PATHOLOGY
(2023)
Article
Otorhinolaryngology
Nicole E. Schaen-Heacock, Corinne A. Jones, Timothy M. McCulloch
Summary: Measuring pharyngeal swallowing pressures in patients with radiation-associated dysphagia using HRM can help clinicians form more precise treatment plans, as these patients exhibit alterations in swallowing pressure.
Article
Multidisciplinary Sciences
Sonia Turrini, Francesca Fiori, Emilio Chiappini, Emiliano Santarnecchi, Vincenzo Romei, Alessio Avenanti
Summary: Cortico-cortical paired associative stimulation (ccPAS) is an effective method for inducing associative plasticity in the brain. This study investigated the physiological changes during ccPAS administration and found both facilitatory and inhibitory effects. Monitoring motor-evoked potentials (MEPs) online could provide insights into the effectiveness of the protocol.
SCIENTIFIC REPORTS
(2022)
Review
Clinical Neurology
Brenton Hordacre, Alana B. McCambridge, Michael C. Ridding, Lynley V. Bradnam
Summary: Personalizing transcranial direct current stimulation treatments to individual neuroanatomy and physiology may offer the best opportunity for producing robust and meaningful clinical benefits in stroke recovery.
Article
Neurosciences
Ayodele Sasegbon, Nikola Niziolek, Mengqing Zhang, Craig J. Smith, Philip M. Bath, John Rothwell, Shaheen Hamdy
Summary: The study aimed to compare the effects of 10 Hz cerebellar vermis repetitive transcranial magnetic stimulation (rTMS) on cortical neuroelectrical activity and swallowing behavior. The findings showed that cerebellar vermis rTMS suppresses cortical pharyngeal motor activity and impacts swallowing behavior.
Correction
Neurosciences
Antonio Bruno, Ettore Dolcetti, Francesca Romana Rizzo, Diego Fresegna, Alessandra Musella, Antonietta Gentile, Francesca De Vito, Silvia Caioli, Livia Guadalupi, Silvia Bullitta, Valentina Vanni, Sara Balletta, Krizia Sanna, Fabio Buttari, Mario Stampanoni Bassi, Diego Centonze, Georgia Mandolesi
FRONTIERS IN CELLULAR NEUROSCIENCE
(2021)
Article
Cell Biology
Georgia Mandolesi, Francesca Romana Rizzo, Sara Balletta, Mario Stampanoni Bassi, Luana Gilio, Livia Guadalupi, Monica Nencini, Alessandro Moscatelli, Colleen Patricia Ryan, Valerio Licursi, Ettore Dolcetti, Alessandra Musella, Antonietta Gentile, Diego Fresegna, Silvia Bullitta, Silvia Caioli, Valentina Vanni, Krizia Sanna, Antonio Bruno, Fabio Buttari, Chiara Castelli, Carlo Presutti, Francesca De Santa, Annamaria Finardi, Roberto Furlan, Diego Centonze, Francesca De Vito
Summary: The study found that levels of let-7b-5p in cerebrospinal fluid of MS patients are correlated with various microRNAs and inflammation-related protein factors, showing specific expression patterns. Additionally, reduced CSF let-7b-5p levels were associated with progressive MS and negatively correlated with hallmark processes of the disease phases, indicating potential use as a biomarker for MS course.
Editorial Material
Clinical Neurology
Diego Centonze, Mario Stampanoni Bassi
Summary: Neurology and medicine are conflicted between the universality of guidelines from clinical trials and the singularity of personalized medicine. Centonze and Stampanoni Bassi suggest that psychoanalysis could serve as a bridge between these two realms.
Article
Biochemistry & Molecular Biology
Mario Stampanoni Bassi, Tommaso Nuzzo, Luana Gilio, Mattia Miroballo, Alessia Casamassa, Fabio Buttari, Paolo Bellantonio, Roberta Fantozzi, Giovanni Galifi, Roberto Furlan, Annamaria Finardi, Arianna De Rosa, Anna Di Maio, Francesco Errico, Diego Centonze, Alessandro Usiello
Summary: The study found that levels of cerebrospinal fluid L-glutamate (L-Glu) were slightly reduced in patients with multiple sclerosis, and were correlated with disability progression and inflammatory molecules like interleukin. Abnormal expression of L-Glu was associated with disability progression, oxidative stress, and inflammation.
JOURNAL OF NEUROCHEMISTRY
(2021)
Review
Clinical Neurology
Giuseppe Cosentino, Micol Avenali, Antonio Schindler, Nicole Pizzorni, Cristina Montomoli, Giovanni Abbruzzese, Angelo Antonini, Filippo Barbiera, Marco Benazzo, Eduardo Elias Benarroch, Giulia Bertino, Emanuele Cereda, Pere Clave, Pietro Cortelli, Roberto Eleopra, Chiara Ferrari, Shaheen Hamdy, Maggie-Lee Huckabee, Leonardo Lopiano, Rosario Marchese Ragona, Stefano Masiero, Emilia Michou, Antonio Occhini, Claudio Pacchetti, Ronald F. Pfeiffer, Domenico A. Restivo, Mariangela Rondanelli, Giovanni Ruoppolo, Giorgio Sandrini, Anthony H. Schapira, Fabrizio Stocchi, Eduardo Tolosa, Francesca Valentino, Mauro Zamboni, Roberta Zangaglia, Mario Zappia, Cristina Tassorelli, Enrico Alfonsi
Summary: Parkinson's disease is a neurodegenerative disorder characterized by motor and non-motor dysfunction, with dysphagia being a common yet often underdiagnosed symptom. A multinational group of experts conducted a systematic review and consensus conference to provide guidance on the screening, diagnosis, and impact of dysphagia on the prognosis and quality of life of PD patients. The consensus statements offer a framework for timely detection and accurate diagnosis of dysphagia in PD.
JOURNAL OF NEUROLOGY
(2022)
Article
Clinical Neurology
Francesca De Vito, Alessandra Musella, Diego Fresegna, Francesca Romana Rizzo, Antonietta Gentile, Mario Stampanoni Bassi, Luana Gilio, Fabio Buttari, Claudio Procaccini, Alessandra Colamatteo, Silvia Bullitta, Livia Guadalupi, Silvia Caioli, Valentina Vanni, Sara Balletta, Krizia Sanna, Antonio Bruno, Ettore Dolcetti, Roberto Furlan, Annamaria Finardi, Valerio Licursi, Jelena Drulovic, Tatjana Pekmezovic, Clorinda Fusco, Sara Bruzzaniti, Eran Hornstein, Antonio Uccelli, Marco Salvetti, Giuseppe Matarese, Diego Centonze, Georgia Mandolesi
Summary: MiR-142-3p is a potential negative prognostic CSF marker of MS, showing positive correlations with clinical progression, IL-1 beta signalling, and synaptic excitability. Treatment with DMF, a disease-modifying therapy, had a superior effect on patients with low levels of miR-142-3p.
NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY
(2022)
Article
Geriatrics & Gerontology
Mario Stampanoni Bassi, Luana Gilio, Ennio Iezzi, Alessandro Moscatelli, Tatjana Pekmezovic, Jelena Drulovic, Roberto Furlan, Annamaria Finardi, Georgia Mandolesi, Alessandra Musella, Giovanni Galifi, Roberta Fantozzi, Paolo Bellantonio, Marianna Storto, Diego Centonze, Fabio Buttari
Summary: In patients with RR-MS, older age at onset is associated with reduced disease activity, increased oxidative stress, enhanced central inflammation, and altered synaptic plasticity. Older patients show less clinical and radiological focal inflammatory disease activity, but have higher levels of lactate and pro-inflammatory molecules in their cerebrospinal fluid, with a negative correlation between age and synaptic plasticity evidenced by TMS.
FRONTIERS IN AGING NEUROSCIENCE
(2021)
Article
Immunology
Francesca Romana Rizzo, Livia Guadalupi, Krizia Sanna, Valentina Vanni, Diego Fresegna, Francesca De Vito, Alessandra Musella, Silvia Caioli, Sara Balletta, Silvia Bullitta, Antonio Bruno, Ettore Dolcetti, Mario Stampanoni Bassi, Fabio Buttari, Luana Gilio, Georgia Mandolesi, Diego Centonze, Antonietta Gentile
Summary: Exercise is recommended as a beneficial supportive therapy for people with MS, improving motor disability and pathological features. Chronic voluntary exercise has positive effects on motor disability, cognition, and hippocampal damage in an animal model of MS, by reducing inflammation, promoting synaptic plasticity, and protecting neurons. Overall, regular exercise improves cognitive function and brain pathology in EAE/MS.
BRAIN BEHAVIOR AND IMMUNITY
(2021)
Review
Clinical Neurology
Antonio Schindler, Nicole Pizzorni, Emanuele Cereda, Giuseppe Cosentino, Micol Avenali, Cristina Montomoli, Giovanni Abbruzzese, Angelo Antonini, Filippo Barbiera, Marco Benazzo, Eduardo Benarroch, Giulia Bertino, Pere Clave, Pietro Cortelli, Roberto Eleopra, Chiara Ferrari, Shaheen Hamdy, Maggie-Lee Huckabee, Leonardo Lopiano, Rosario Marchese-Ragona, Stefano Masiero, Emilia Michou, Antonio Occhini, Claudio Pacchetti, Ronald F. Pfeiffer, Domenico A. Restivo, Mariangela Rondanelli, Giovanni Ruoppolo, Giorgio Sandrini, Anthony Schapira, Fabrizio Stocchi, Eduardo Tolosa, Francesca Valentino, Mauro Zamboni, Roberta Zangaglia, Mario Zappia, Cristina Tassorelli, Enrico Alfonsi
Summary: This study conducted a systematic review on the treatment and nutrition of patients with PD and dysphagia, resulting in the development of 26 consensus statements to guide a multidisciplinary approach to dysphagia treatment.
JOURNAL OF THE NEUROLOGICAL SCIENCES
(2021)
Article
Genetics & Heredity
Ettore Dolcetti, Antonio Bruno, Federica Azzolini, Luana Gilio, Alessandro Moscatelli, Francesca De Vito, Luigi Pavone, Ennio Iezzi, Stefano Gambardella, Emiliano Giardina, Rosangela Ferese, Fabio Buttari, Francesca Romana Rizzo, Roberto Furlan, Annamaria Finardi, Alessandra Musella, Georgia Mandolesi, Livia Guadalupi, Diego Centonze, Mario Stampanoni Bassi
Summary: The role of BDFN Val66Met polymorphism in multiple sclerosis (MS) is still controversial. A study on 218 relapsing-remitting MS patients found that the presence of the Met genotype is associated with elevated levels of certain pro-inflammatory cytokines and reduced cortical thickness at the time of diagnosis.
Article
Clinical Neurology
Luana Gilio, Giovanni Galifi, Diego Centonze, Mario Stampanoni Bassi
Summary: Long-lasting symptoms have been observed in many patients after SARS-CoV-2 infection, which may overlap with functional neurological disorders (FNDs). We report a case of a 23-year-old man who developed complex symptoms including fatigue, shortness of breath, tachycardia, and chest pain after asymptomatic COVID-19, and was diagnosed with FND. Targeted interventions, including psychoanalytic psychotherapy and physical therapy, improved the symptoms but mild limitations in physical activities persisted.
FRONTIERS IN NEUROLOGY
(2022)
Article
Biochemistry & Molecular Biology
Federica Azzolini, Luana Gilio, Luigi Pavone, Ennio Iezzi, Ettore Dolcetti, Antonio Bruno, Fabio Buttari, Alessandra Musella, Georgia Mandolesi, Livia Guadalupi, Roberto Furlan, Annamaria Finardi, Teresa Micillo, Fortunata Carbone, Giuseppe Matarese, Diego Centonze, Mario Stampanoni Bassi
Summary: The study found that GFAP and sTREM-2 are suitable biomarkers for central inflammation in multiple sclerosis (MS) and are associated with certain inflammatory factors and clinical characteristics. Enhanced CSF expression of GFAP may indicate a higher risk of progression in patients.
Article
Genetics & Heredity
Antonio Bruno, Ettore Dolcetti, Federica Azzolini, Alessandro Moscatelli, Stefano Gambardella, Rosangela Ferese, Francesca Romana Rizzo, Luana Gilio, Ennio Iezzi, Giovanni Galifi, Angela Borrelli, Fabio Buttari, Roberto Furlan, Annamaria Finardi, Francesca De Vito, Alessandra Musella, Livia Guadalupi, Georgia Mandolesi, Diego Centonze, Mario Stampanoni Bassi
Summary: This study found an association between the rs1818879 polymorphism in the IL-6 gene and subclinical neuroinflammatory activity in RR-MS patients, suggesting that interindividual differences in the IL-6 gene may influence the immune activation profile in MS.
Article
Neurosciences
Luana Gilio, Diego Fresegna, Antonietta Gentile, Livia Guadalupi, Krizia Sanna, Francesca De Vito, Sara Balletta, Silvia Caioli, Francesca Romana Rizzo, Alessandra Musella, Ennio Iezzi, Alessandro Moscatelli, Giovanni Galifi, Roberta Fantozzi, Paolo Bellantonio, Roberto Furlan, Annamaria Finardi, Valentina Vanni, Ettore Dolcetti, Antonio Bruno, Fabio Buttari, Georgia Mandolesi, Diego Centonze, Mario Stampanoni Bassi
Summary: Exercise has an immunomodulatory effect in MS patients, reducing levels of proinflammatory cytokines and improving mood disorders. IL-2 plays a causal role in mood disorders and synaptic dysfunction in MS. Further studies are needed to investigate the long-term effects of exercise as a disease-modifying therapy in MS.
NEUROBIOLOGY OF DISEASE
(2022)
Article
Clinical Neurology
Mario Stampanoni Bassi, Jelena Drulovic, Tatjana Pekmezovic, Ennio Iezzi, Francesco Sica, Luana Gilio, Antonietta Gentile, Alessandra Musella, Georgia Mandolesi, Roberto Furlan, Annamaria Finardi, Girolama Alessandra Marfia, Paolo Bellantonio, Roberta Fantozzi, Diego Centonze, Fabio Buttari
THERAPEUTIC ADVANCES IN NEUROLOGICAL DISORDERS
(2020)
