SPNS2 promotes the malignancy of colorectal cancer cells via regulating Akt and ERK pathway

Sphingosine-1-phosphate promotes the proliferation and attenuates apoptosis of Endothelial progenitor cells via S1PR1/S1PR3/PI3K/Akt pathway

(2018) Hang Wang et al.   CELL BIOLOGY INTERNATIONAL

MiR-125b-1-3p Exerts Antitumor Functions in Lung Carcinoma Cells by Targeting S1PR1

(2018) Liang-Cheng Zheng et al.   CHINESE MEDICAL JOURNAL

Biological function of SPNS2: From zebrafish to human

(2018) Xiao Zhu et al.   MOLECULAR IMMUNOLOGY

The sphingosine kinase-1/sphingosine-1-phosphate axis in cancer: Potential target for anticancer therapy

(2018) Xiangjin Zheng et al.   PHARMACOLOGY & THERAPEUTICS

Effects of Glut1 gene silencing on proliferation, differentiation, and apoptosis of colorectal cancer cells by targeting the TGF-β/PI3K-AKT-mTOR signaling pathway

(2017) Xue-Liang Wu et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Tumor-derived CXCL5 promotes human colorectal cancer metastasis through activation of the ERK/Elk-1/Snail and AKT/GSK3β/β-catenin pathways

(2017) Jingkun Zhao et al.   Molecular Cancer

Genome-wide in vivo screen identifies novel host regulators of metastatic colonization

(2017) Louise van der Weyden et al.   NATURE

Lymphatic endothelial S1P promotes mitochondrial function and survival in naive T cells

(2017) Alejandra Mendoza et al.   NATURE

Rab11-FIP2 promotes colorectal cancer migration and invasion by regulating PI3K/AKT/MMP7 signaling pathway

(2016) Chang-long Xu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Overexpression of KiSS-1 reduces colorectal cancer cell invasion by downregulating MMP-9 via blocking PI3K/Akt/NF-κB signal pathway

(2016) SHAOQIN CHEN et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Resistance to 3-HTMC-Induced Apoptosis Through Activation of PI3K/Akt, MEK/ERK, and p38/COX-2/PGE2Pathways in Human HT-29 and HCT116 Colorectal Cancer Cells

(2016) Josiane Semaan et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Nitidine chloride inhibits proliferation and induces apoptosis in colorectal cancer cells by suppressing the ERK signaling pathway

(2016) HUIYUAN ZHAI et al.   Molecular Medicine Reports

miR-133b, a microRNA targeting S1PR1, suppresses nasopharyngeal carcinoma cell proliferation

(2016) NAN CHENG et al.   Experimental and Therapeutic Medicine

Pinin facilitated proliferation and metastasis of colorectal cancer through activating EGFR/ERK signaling pathway

(2016) Zhigang Wei et al.   Oncotarget

Essential role for SphK1/S1P signaling to regulate hypoxia-inducible factor 2α expression and activity in cancer

(2016) P Bouquerel et al.   Oncogenesis

Intracellular sphingosine kinase 2–derived sphingosine-1-phosphate mediates epidermal growth factor–induced ezrin-radixin-moesin phosphorylation and cancer cell invasion

(2015) Mohamad M. Adada et al.   FASEB JOURNAL

The MAP3K ZAK, a novel modulator of ERK-dependent migration, is upregulated in colorectal cancer

(2015) C Rey et al.   ONCOGENE

Chemotherapy for colorectal cancer in the elderly

(2015) Jung Han Kim   WORLD JOURNAL OF GASTROENTEROLOGY

Collagen triple helix repeat containing 1 (CTHRC1) acts via ERK-dependent induction of MMP9 to promote invasion of colorectal cancer cells

(2015) Hee Cheol Kim et al.   Oncotarget

Thymosin β4 induces invasion and migration of human colorectal cancer cells through the ILK/AKT/β-catenin signaling pathway

(2014) Zhengri Piao et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

MicroRNA-363-mediated downregulation of S1PR1 suppresses the proliferation of hepatocellular carcinoma cells

(2014) Peng Zhou et al.   CELLULAR SIGNALLING

Activation of the PI3K/Akt/mTOR/p70S6K Pathway is Involved in S100A4-induced Viability and Migration in Colorectal Cancer Cells

(2014) Haiyan Wang et al.   International Journal of Medical Sciences

Silencing of CXCR7 gene represses growth and invasion and induces apoptosis in colorectal cancer through ERK and β-arrestin pathways

(2014) XIN-XIANG LI et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Export of sphingosine-1-phosphate and cancer progression

(2014) Kazuaki Takabe et al.   JOURNAL OF LIPID RESEARCH

Osteoblast-derived sphingosine 1-phosphate to induce proliferation and confer resistance to therapeutics to bone metastasis-derived prostate cancer cells

(2014) Leyre Brizuela et al.   Molecular Oncology

Critical Role of Spns2, a Sphingosine-1-Phosphate Transporter, in Lung Cancer Cell Survival and Migration

(2014) Eric Bradley et al.   PLoS One

Aberrant expression of sphingosine-1-phosphate receptor 1 correlates with metachronous liver metastasis and poor prognosis in colorectal cancer

(2014) Qi Lin et al.   TUMOR BIOLOGY

STAT3 and sphingosine-1-phosphate in inflammation-associated colorectal cancer

(2014) Andrew V Nguyen   WORLD JOURNAL OF GASTROENTEROLOGY

Colorectal Cancer with Potentially Resectable Hepatic Metastases: Optimizing Treatment

(2014) Mathias Worni et al.   Current Oncology Reports

Sphingosine-1-phosphate promotes expansion of cancer stem cells via S1PR3 by a ligand-independent Notch activation

(2014) Naoya Hirata et al.   Nature Communications

Sphingosine-1-phosphate receptor 1 in classical Hodgkin lymphoma: assessment of expression and role in cell migration

(2013) Michael J Kluk et al.   LABORATORY INVESTIGATION

Colorectal cancer

(2013) Hermann Brenner et al.   LANCET

The functional roles of S1P in immunity

(2012) Y. Hisano et al.   JOURNAL OF BIOCHEMISTRY

The Role of Sphingosine-1-Phosphate Transporter Spns2 in Immune System Function

(2012) A. Nijnik et al.   JOURNAL OF IMMUNOLOGY

Sphingosine 1-phosphate regulates matrix metalloproteinase-9 expression and breast cell invasion through S1P3-G q coupling

(2011) E.-S. Kim et al.   JOURNAL OF CELL SCIENCE