Understanding histone H3 lysine 36 methylation and its deregulation in disease

Development of a Time-Resolved Fluorescence Resonance Energy Transfer Ultrahigh-Throughput Screening Assay for Targeting the NSD3 and MYC Interaction

(2018) Jinglin Xiong et al.   ASSAY AND DRUG DEVELOPMENT TECHNOLOGIES

Setd2 deficiency impairs hematopoietic stem cell self-renewal and causes malignant transformation

(2018) Yuan-Liang Zhang et al.   CELL RESEARCH

High-throughput screening with nucleosome substrate identifies small-molecule inhibitors of the human histone lysine methyltransferase NSD2

(2018) Nathan P Coussens et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Expression of a novel ZMYND11/MBTD1 fusion transcript in CD7+CD56+ acute myeloid leukemia with t(10;17)(p15;q21)

(2018) Katsuya Yamamoto et al.   LEUKEMIA & LYMPHOMA

Disruption ofNSD1in Head and Neck Cancer Promotes Favorable Chemotherapeutic Responses Linked to Hypomethylation

(2018) Nam Bui et al.   MOLECULAR CANCER THERAPEUTICS

The role of histone lysine methyltransferase NSD3 in cancer

(2018) Xu Han et al.   OncoTargets and Therapy

MLL-fusion-driven leukemia requires SETD2 to safeguard genomic integrity

(2018) Anna Skucha et al.   Nature Communications

Depletion of Nsd2-mediated histone H3K36 methylation impairs adipose tissue development and function

(2018) Lenan Zhuang et al.   Nature Communications

Histone H3K36M Mutation and Trimethylation Patterns in Chondroblastoma

(2018) Chuanyong Lu et al.   HISTOPATHOLOGY

Acquired SETD2 mutation and impaired CREB1 activation confer cisplatin resistance in metastatic non-small cell lung cancer

(2018) In-Kyu Kim et al.   ONCOGENE

An activating mutation of the NSD2 histone methyltransferase drives oncogenic reprogramming in acute lymphocytic leukemia

(2018) Alok Swaroop et al.   ONCOGENE

Cancer-driving H3G34V/R/D mutations block H3K36 methylation and H3K36me3–MutSα interaction

(2018) Jun Fang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cross-talk between Lysine-Modifying Enzymes Controls Site-Specific DNA Amplifications

(2018) Sweta Mishra et al.   CELL

NSD2 promotes ventricular remodelling mediated by the regulation of H3K36me2

(2018) Xue-liang Zhou et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Integrated Genomic and Proteomic Analyses Reveal Novel Mechanisms of the Methyltransferase SETD2 in Renal Cell Carcinoma Development

(2018) Lin Li et al.   MOLECULAR & CELLULAR PROTEOMICS

Gain-of-function DNMT3A mutations cause microcephalic dwarfism and hypermethylation of Polycomb-regulated regions

(2018) Patricia Heyn et al.   NATURE GENETICS

Characterization of H3.3K36M as a tool to study H3K36 methylation in cancer cells

(2017) Saumya M. Sankaran et al.   Epigenetics

Oncohistones: drivers of pediatric cancers

(2017) Faizaan Mohammad et al.   GENES & DEVELOPMENT

Phenotype comparison confirms ZMYND11 as a critical gene for 10p15.3 microdeletion syndrome

(2017) Birute Tumiene et al.   JOURNAL OF APPLIED GENETICS

Cross-talk between the H3K36me3 and H4K16ac histone epigenetic marks in DNA double-strand break repair

(2017) Lin Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Histone methyltransferase SETD2 modulates alternative splicing to inhibit intestinal tumorigenesis

(2017) Huairui Yuan et al.   JOURNAL OF CLINICAL INVESTIGATION

Enteropathy-associated T cell lymphoma subtypes are characterized by loss of function of SETD2

(2017) Andrea B. Moffitt et al.   JOURNAL OF EXPERIMENTAL MEDICINE

SETD2-mediated crosstalk between H3K36me3 and H3K79me2 in MLL-rearranged leukemia

(2017) J Bu et al.   LEUKEMIA

Intragenic DNA methylation prevents spurious transcription initiation

(2017) Francesco Neri et al.   NATURE

Impaired H3K36 methylation defines a subset of head and neck squamous cell carcinomas

(2017) Simon Papillon-Cavanagh et al.   NATURE GENETICS

NSD1- and NSD2-damaging mutations define a subset of laryngeal tumors with favorable prognosis

(2017) Suraj Peri et al.   Nature Communications

H3K36 Methylation Regulates Nutrient Stress Response in Saccharomyces cerevisiae by Enforcing Transcriptional Fidelity

(2017) Stephen L. McDaniel et al.   Cell Reports

SETting the Stage for Cancer Development: SETD2 and the Consequences of Lost Methylation

(2017) Catherine C. Fahey et al.   Cold Spring Harbor Perspectives in Medicine

The Role of Nuclear Receptor–Binding SET Domain Family Histone Lysine Methyltransferases in Cancer

(2017) Richard L. Bennett et al.   Cold Spring Harbor Perspectives in Medicine

Histone gene replacement reveals a post-transcriptional role for H3K36 in maintaining metazoan transcriptome fidelity

(2017) Michael P Meers et al.   eLife

Pharmacologic Targeting of Chromatin Modulators As Therapeutics of Acute Myeloid Leukemia

(2017) Rui Lu et al.   Frontiers in Oncology

NSD1 inactivation defines an immune cold, DNA hypomethylated subtype in squamous cell carcinoma

(2017) Kevin Brennan et al.   Scientific Reports

PBX3 and MEIS1 Cooperate in Hematopoietic Cells to Drive Acute Myeloid Leukemias Characterized by a Core Transcriptome of the MLL-Rearranged Disease

(2016) Z. Li et al.   CANCER RESEARCH

Dual Chromatin and Cytoskeletal Remodeling by SETD2

(2016) In Young Park et al.   CELL

A PWWP Domain of Histone-LysineN-Methyltransferase NSD2 Binds to Dimethylated Lys-36 of Histone H3 and Regulates NSD2 Function at Chromatin

(2016) Saumya M. Sankaran et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Combinatorial Histone Readout by the Dual Plant Homeodomain (PHD) Fingers of Rco1 Mediates Rpd3S Chromatin Recruitment and the Maintenance of Transcriptional Fidelity

(2016) Stephen L. McDaniel et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Quantitative Profiling of Combinational K27/K36 Modifications on Histone H3 Variants in Mouse Organs

(2016) Yanyan Yu et al.   JOURNAL OF PROTEOME RESEARCH

Structural basis for recognition of histone H3K36me3 nucleosome by human de novo DNA methyltransferases 3A and 3B

(2016) Grégoire Rondelet et al.   JOURNAL OF STRUCTURAL BIOLOGY

Histone modification profiling reveals differential signatures associated with human embryonic stem cell self-renewal and differentiation

(2016) Natarajan V. Bhanu et al.   PROTEOMICS

Histone H3K36 mutations promote sarcomagenesis through altered histone methylation landscape

(2016) C. Lu et al.   SCIENCE

The histone H3.3K36M mutation reprograms the epigenome of chondroblastomas

(2016) D. Fang et al.   SCIENCE

Structural Mechanism of Transcriptional Regulator NSD3 Recognition by the ET Domain of BRD4

(2016) Qiang Zhang et al.   STRUCTURE

Type II enteropathy-associated T-cell lymphoma features a unique genomic profile with highly recurrent SETD2 alterations

(2016) Annalisa Roberti et al.   Nature Communications

ASH1L Links Histone H3 Lysine 36 Dimethylation to MLL Leukemia

(2016) L. Zhu et al.   Cancer Discovery

Interrogating the Function of Metazoan Histones using Engineered Gene Clusters

(2015) Daniel J. McKay et al.   DEVELOPMENTAL CELL

Targeting EZH2 and PRC2 dependence as novel anticancer therapy

(2015) Bowen Xu et al.   EXPERIMENTAL HEMATOLOGY

H3K36 methylation promotes longevity by enhancing transcriptional fidelity

(2015) Payel Sen et al.   GENES & DEVELOPMENT

Recurrent translocation t(10;17)(p15;q21) in minimally differentiated acute myeloid leukemia results inZMYND11/MBTD1fusion

(2015) Jasmijn D.E. de Rooij et al.   GENES CHROMOSOMES & CANCER

Structure and Function of SET and MYND Domain-Containing Proteins

(2015) Nicholas Spellmon et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

NSD3-Short Is an Adaptor Protein that Couples BRD4 to the CHD8 Chromatin Remodeler

(2015) Chen Shen et al.   MOLECULAR CELL

Genomic profiling of DNA methyltransferases reveals a role for DNMT3B in genic methylation

(2015) Tuncay Baubec et al.   NATURE

Genome-wide CpG island methylation and intergenic demethylation propensities vary among different tumor sites

(2015) Seung-Tae Lee et al.   NUCLEIC ACIDS RESEARCH

SETD2 loss-of-function promotes renal cancer branched evolution through replication stress and impaired DNA repair

(2015) N Kanu et al.   ONCOGENE

Histone Variants and Epigenetics

(2015) Steven Henikoff et al.   Cold Spring Harbor Perspectives in Biology

NSD1 mutations generate a genome-wide DNA methylation signature

(2015) S. Choufani et al.   Nature Communications

NUP98/NSD1 and FLT3/ITD coexpression is more prevalent in younger AML patients and leads to induction failure: a COG and SWOG report

(2014) F. Ostronoff et al.   BLOOD

Selective inhibition of EZH2 and EZH1 enzymatic activity by a small molecule suppresses MLL-rearranged leukemia

(2014) B. Xu et al.   BLOOD

A de novo mutation in ZMYND11, a candidate gene for 10p15.3 deletion syndrome, is associated with syndromic intellectual disability

(2014) J.M. Cobben et al.   European Journal of Medical Genetics

Potent co-operation between the NUP98-NSD1 fusion and the FLT3-ITD mutation in acute myeloid leukemia induction

(2014) A. Thanasopoulou et al.   HAEMATOLOGICA

KDM4B as a Target for Prostate Cancer: Structural Analysis and Selective Inhibition by a Novel Inhibitor

(2014) Chia-Han Chu et al.   JOURNAL OF MEDICINAL CHEMISTRY

BS69/ZMYND11 Reads and Connects Histone H3.3 Lysine 36 Trimethylation-Decorated Chromatin to Regulated Pre-mRNA Processing

(2014) Rui Guo et al.   MOLECULAR CELL

ZMYND11 links histone H3.3K36me3 to transcription elongation and tumour suppression

(2014) Hong Wen et al.   NATURE

Identification of functional cooperative mutations of SETD2 in human acute leukemia

(2014) Xiaofan Zhu et al.   NATURE GENETICS

Structure and function of the nucleosome-binding PWWP domain

(2014) Su Qin et al.   TRENDS IN BIOCHEMICAL SCIENCES

Mutations in epigenetic regulators including SETD2 are gained during relapse in paediatric acute lymphoblastic leukaemia

(2014) Brenton G. Mar et al.   Nature Communications

NSD3-NUT Fusion Oncoprotein in NUT Midline Carcinoma: Implications for a Novel Oncogenic Mechanism

(2014) C. A. French et al.   Cancer Discovery

SETD2-Dependent Histone H3K36 Trimethylation Is Required for Homologous Recombination Repair and Genome Stability

(2014) Sophia X. Pfister et al.   Cell Reports

Histone Methyltransferase MMSET/NSD2 Alters EZH2 Binding and Reprograms the Myeloma Epigenome through Global and Focal Changes in H3K36 and H3K27 Methylation

(2014) Relja Popovic et al.   PLoS Genetics

Mutations in SETD2 and genes affecting histone H3K36 methylation target hemispheric high-grade gliomas

(2013) Adam M. Fontebasso et al.   ACTA NEUROPATHOLOGICA

NSD2 Is Recruited through Its PHD Domain to Oncogenic Gene Loci to Drive Multiple Myeloma

(2013) Z. Huang et al.   CANCER RESEARCH

KDM4/JMJD2 Histone Demethylases: Epigenetic Regulators in Cancer Cells

(2013) W. L. Berry et al.   CANCER RESEARCH

The Histone Mark H3K36me3 Regulates Human DNA Mismatch Repair through Its Interaction with MutSα

(2013) Feng Li et al.   CELL

NUP98-NSD1fusion in association withFLT3-ITD mutation identifies a prognostically relevant subgroup of pediatric acute myeloid leukemia patients suitable for monitoring by real time quantitative PCR

(2013) Susanna Akiki et al.   GENES CHROMOSOMES & CANCER

Variation in chromatin accessibility in human kidney cancer links H3K36 methyltransferase loss with widespread RNA processing defects

(2013) J. M. Simon et al.   GENOME RESEARCH

KDM2A promotes lung tumorigenesis by epigenetically enhancing ERK1/2 signaling

(2013) Klaus W. Wagner et al.   JOURNAL OF CLINICAL INVESTIGATION

Identification of the KDM2/7 Histone Lysine Demethylase Subfamily Inhibitor and its Antiproliferative Activity

(2013) Takayoshi Suzuki et al.   JOURNAL OF MEDICINAL CHEMISTRY

Point mutation E1099K in MMSET/NSD2 enhances its methyltranferase activity and leads to altered global chromatin methylation in lymphoid malignancies

(2013) J A Oyer et al.   LEUKEMIA

Recurrent translocation (10;17)(p15;q21) in acute poorly differentiated myeloid leukemia likely results inZMYND11–MBTD1fusion

(2013) Etienne De Braekeleer et al.   LEUKEMIA & LYMPHOMA

Kdm2b maintains murine embryonic stem cell status by recruiting PRC1 complex to CpG islands of developmental genes

(2013) Jin He et al.   NATURE CELL BIOLOGY

Distinct H3F3A and H3F3B driver mutations define chondroblastoma and giant cell tumor of bone

(2013) Sam Behjati et al.   NATURE GENETICS

Global chromatin profiling reveals NSD2 mutations in pediatric acute lymphoblastic leukemia

(2013) Jacob D Jaffe et al.   NATURE GENETICS

Acetylation limits 53BP1 association with damaged chromatin to promote homologous recombination

(2013) Jiangbo Tang et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Structural basis for high-affinity binding of LEDGF PWWP to mononucleosomes

(2013) Jocelyn O. Eidahl et al.   NUCLEIC ACIDS RESEARCH

Histone methyltransferase SETD2 coordinates FACT recruitment with nucleosome dynamics during transcription

(2013) Sílvia Carvalho et al.   NUCLEIC ACIDS RESEARCH

Tudor: a versatile family of histone methylation ‘readers’

(2013) Rui Lu et al.   TRENDS IN BIOCHEMICAL SCIENCES

Binding of PHF1 Tudor to H3K36me3 enhances nucleosome accessibility

(2013) Catherine A. Musselman et al.   Nature Communications

Ash1l Methylates Lys36 of Histone H3 Independently of Transcriptional Elongation to Counteract Polycomb Silencing

(2013) Hitomi Miyazaki et al.   PLoS Genetics

The oncogenic potential of Jumonji D2 (JMJD2/KDM4) histone demethylase overexpression

(2012) Leah C. Young et al.   Biochemistry and Cell Biology

Analysis of NUP98/NSD1 translocations in adult AML and MDS patients

(2012) F Thol et al.   LEUKEMIA

Histone Methyltransferase NSD2/MMSET Mediates Constitutive NF- B Signaling for Cancer Cell Proliferation, Survival, and Tumor Growth via a Feed-Forward Loop

(2012) P. Yang et al.   MOLECULAR AND CELLULAR BIOLOGY

An H3K36 Methylation-Engaging Tudor Motif of Polycomb-like Proteins Mediates PRC2 Complex Targeting

(2012) Ling Cai et al.   MOLECULAR CELL

Epigenetic protein families: a new frontier for drug discovery

(2012) Cheryl H. Arrowsmith et al.   NATURE REVIEWS DRUG DISCOVERY

Understanding the language of Lys36 methylation at histone H3

(2012) Eric J. Wagner et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Phf19 links methylated Lys36 of histone H3 to regulation of Polycomb activity

(2012) Cecilia Ballaré et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Polycomb PHF19 binds H3K36me3 and recruits PRC2 and demethylase NO66 to embryonic stem cell genes during differentiation

(2012) Gerard L Brien et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Molecular basis for H3K36me3 recognition by the Tudor domain of PHF1

(2012) Catherine A Musselman et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Perceiving the epigenetic landscape through histone readers

(2012) Catherine A Musselman et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Total kinetic analysis reveals how combinatorial methylation patterns are established on lysines 27 and 36 of histone H3

(2012) Y. Zheng et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Psip1/Ledgf p52 Binds Methylated Histone H3K36 and Splicing Factors and Contributes to the Regulation of Alternative Splicing

(2012) Madapura M. Pradeepa et al.   PLoS Genetics

KDM2B links the Polycomb Repressive Complex 1 (PRC1) to recognition of CpG islands

(2012) Anca M Farcas et al.   eLife

NUP98/NSD1 characterizes a novel poor prognostic group in acute myeloid leukemia with a distinct HOX gene expression pattern

(2011) I. H. I. M. Hollink et al.   BLOOD

KDM5B regulates embryonic stem cell self-renewal and represses cryptic intragenic transcription

(2011) Liangqi Xie et al.   EMBO JOURNAL

Crystal Structure of the Human Histone Methyltransferase ASH1L Catalytic Domain and Its Implications for the Regulatory Mechanism

(2011) Sojin An et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

H3K36 Methylation Antagonizes PRC2-mediated H3K27 Methylation

(2011) Wen Yuan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

FGF-2 Regulates Cell Proliferation, Migration, and Angiogenesis through an NDY1/KDM2B-miR-101-EZH2 Pathway

(2011) Filippos Kottakis et al.   MOLECULAR CELL

NSD2 Links Dimethylation of Histone H3 at Lysine 36 to Oncogenic Programming

(2011) Alex J. Kuo et al.   MOLECULAR CELL

Histone Methylation by PRC2 Is Inhibited by Active Chromatin Marks

(2011) Frank W. Schmitges et al.   MOLECULAR CELL

Splicing enhances recruitment of methyltransferase HYPB/Setd2 and methylation of histone H3 Lys36

(2011) Sérgio Fernandes de Almeida et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Analysis of copy number variations of BS69 in multiple types of hematological malignancies

(2010) Hong Yang et al.   ANNALS OF HEMATOLOGY

Histone Methyltransferase Gene SETD2 Is a Novel Tumor Suppressor Gene in Clear Cell Renal Cell Carcinoma

(2010) Gerben Duns et al.   CANCER RESEARCH

The Dnmt3a PWWP Domain Reads Histone 3 Lysine 36 Trimethylation and Guides DNA Methylation

(2010) Arunkumar Dhayalan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

CpG Islands Recruit a Histone H3 Lysine 36 Demethylase

(2010) Neil P. Blackledge et al.   MOLECULAR CELL

Systematic sequencing of renal carcinoma reveals inactivation of histone modifying genes

(2010) Gillian L. Dalgliesh et al.   NATURE

Selective inhibition of BET bromodomains

(2010) Panagis Filippakopoulos et al.   NATURE

Genome-wide chromatin maps derived from limited numbers of hematopoietic progenitors

(2010) Mazhar Adli et al.   NATURE METHODS

Methylation of histone H3 lysine 36 enhances DNA repair by nonhomologous end-joining

(2010) S. Fnu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

NUP98–NSD3 fusion gene in radiation-associated myelodysplastic syndrome with t(8;11)(p11;p15) and expression pattern of NSD family genes

(2009) Takeshi Taketani et al.   CANCER GENETICS AND CYTOGENETICS

Chromatin signature reveals over a thousand highly conserved large non-coding RNAs in mammals

(2009) Mitchell Guttman et al.   NATURE

Epigenetic inactivation of the Sotos overgrowth syndrome gene histone methyltransferase NSD1 in human neuroblastoma and glioma

(2009) M. Berdasco et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Iws1:Spt6:CTD complex controls cotranscriptional mRNA biosynthesis and HYPB/Setd2-mediated histone H3K36 methylation

(2008) S. M. Yoh et al.   GENES & DEVELOPMENT

The H3K36 demethylase Jhdm1b/Kdm2b regulates cell proliferation and senescence through p15Ink4b

(2008) Jin He et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Structural Basis for the Recognition of Methylated Histone H3K36 by the Eaf3 Subunit of Histone Deacetylase Complex Rpd3S

(2008) Chao Xu et al.   STRUCTURE

The multiple myeloma associated MMSET gene contributes to cellular adhesion, clonogenic growth, and tumorigenicity

(2007) J. Lauring et al.   BLOOD