ER complex proteins are required for rhodopsin biosynthesis and photoreceptor survival in Drosophila and mice

The V-ATPase V1 subunit A1 is required for rhodopsin anterograde trafficking in Drosophila

(2018) Haifang Zhao et al.   MOLECULAR BIOLOGY OF THE CELL

The ER membrane protein complex interacts cotranslationally to enable biogenesis of multipass membrane proteins

(2018) Matthew J Shurtleff et al.   eLife

EMC Is Required to Initiate Accurate Membrane Protein Topogenesis

(2018) Patrick J. Chitwood et al.   CELL

Tmem30a deficiency leads to retinal rod bipolar cell degeneration

(2018) Yeming Yang et al.   JOURNAL OF NEUROCHEMISTRY

EMC3 coordinates surfactant protein and lipid homeostasis required for respiration

(2017) Xiaofang Tang et al.   JOURNAL OF CLINICAL INVESTIGATION

The ER membrane protein complex is a transmembrane domain insertase

(2017) Alina Guna et al.   SCIENCE

The β-alanine transporter BalaT is required for visual neurotransmission in Drosophila

(2017) Yongchao Han et al.   eLife

A novel splice variant in EMC1 is associated with cerebellar atrophy, visual impairment, psychomotor retardation with epilepsy

(2017) Thenral S. Geetha et al.   Molecular Genetics & Genomic Medicine

Monoallelic and Biallelic Variants in EMC1 Identified in Individuals with Global Developmental Delay, Hypotonia, Scoliosis, and Cerebellar Atrophy

(2016) Tamar Harel et al.   AMERICAN JOURNAL OF HUMAN GENETICS

A CRISPR screen defines a signal peptide processing pathway required by flaviviruses

(2016) Rong Zhang et al.   NATURE

Genetic dissection of Flaviviridae host factors through genome-scale CRISPR screens

(2016) Caleb D. Marceau et al.   NATURE

EMC6/TMEM93 suppresses glioblastoma proliferation by modulating autophagy

(2016) X Shen et al.   Cell Death & Disease

Identification of Zika Virus and Dengue Virus Dependency Factors using Functional Genomics

(2016) George Savidis et al.   Cell Reports

EMC1-dependent stabilization drives membrane penetration of a partially destabilized non-enveloped virus

(2016) Parikshit Bagchi et al.   eLife

CULD is required for rhodopsin and TRPL channel endocytic trafficking and survival of photoreceptor cells

(2015) Ying Xu et al.   JOURNAL OF CELL SCIENCE

A CRISPR-Based Screen Identifies Genes Essential for West-Nile-Virus-Induced Cell Death

(2015) Hongming Ma et al.   Cell Reports

dPob/EMC is essential for biosynthesis of rhodopsin and other multi-pass membrane proteins in Drosophila photoreceptors

(2015) Takunori Satoh et al.   eLife

A Fluorescence-Based Genetic Screen to Study Retinal Degeneration in Drosophila

(2015) Yu Huang et al.   PLoS One

Phospholipid flippase ATP8A2 is required for normal visual and auditory function and photoreceptor and spiral ganglion cell survival

(2014) J. A. Coleman et al.   JOURNAL OF CELL SCIENCE

Rapid and Deep Proteomes by Faster Sequencing on a Benchtop Quadrupole Ultra-High-Field Orbitrap Mass Spectrometer

(2014) Christian D. Kelstrup et al.   JOURNAL OF PROTEOME RESEARCH

Proteomic analysis of mouse astrocytes and their secretome by a combination of FASP and StageTip-based, high pH, reversed-phase fractionation

(2014) Dohyun Han et al.   PROTEOMICS

A Conserved Endoplasmic Reticulum Membrane Protein Complex (EMC) Facilitates Phospholipid Transfer from the ER to Mitochondria

(2014) Sujoy Lahiri et al.   PLOS BIOLOGY

Mutations in Four Glycosyl Hydrolases Reveal a Highly Coordinated Pathway for Rhodopsin Biosynthesis and N-Glycan Trimming in Drosophila melanogaster

(2014) Erica E. Rosenbaum et al.   PLoS Genetics

Biosynthesis of ionotropic acetylcholine receptors requires the evolutionarily conserved ER membrane complex

(2013) Magali Richard et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Rhodopsin homeostasis and retinal degeneration: lessons from the fly

(2013) Bo Xiong et al.   TRENDS IN NEUROSCIENCES

A novel ER-localized transmembrane protein, EMC6, interacts with RAB5A and regulates cell autophagy

(2012) Yanjun Li et al.   Autophagy

Autozygome-guided exome sequencing in retinal dystrophy patients reveals pathogenetic mutations and novel candidate disease genes

(2012) L. Abu-Safieh et al.   GENOME RESEARCH

ADrosophilametallophosphoesterase mediates deglycosylation of rhodopsin

(2011) Jinguo Cao et al.   EMBO JOURNAL

Defining human ERAD networks through an integrative mapping strategy

(2011) John C. Christianson et al.   NATURE CELL BIOLOGY

A genome-scale shRNA resource for transgenic RNAi in Drosophila

(2011) Jian-Quan Ni et al.   NATURE METHODS

XPORT-Dependent Transport of TRP and Rhodopsin

(2011) Erica E. Rosenbaum et al.   NEURON

Suppression of retinal degeneration in Drosophila by stimulation of ER-associated degradation

(2009) M.-J. Kang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Comprehensive Characterization of Genes Required for Protein Folding in the Endoplasmic Reticulum

(2009) M. C. Jonikas et al.   SCIENCE

One step at a time: endoplasmic reticulum-associated degradation

(2008) Shruthi S. Vembar et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The SOCS Box Protein STOPS Is Required for Phototransduction through Its Effects on Phospholipase C

(2008) Tao Wang et al.   NEURON