Provocative questions in osteosarcoma basic and translational biology: A report from the Children's Oncology Group

Tumor Mutational Burden and Efficacy of Nivolumab Monotherapy and in Combination with Ipilimumab in Small-Cell Lung Cancer

(2018) Matthew D. Hellmann et al.   CANCER CELL

Automated quantitative image analysis for ex vivo metastasis assays reveals differing lung composition requirements for metastasis suppression by KISS1

(2018) Eric D. Young et al.   CLINICAL & EXPERIMENTAL METASTASIS

The landscape of genomic alterations across childhood cancers

(2018) Susanne N. Gröbner et al.   NATURE

Positively selected enhancer elements endow osteosarcoma cells with metastatic competence

(2018) James J Morrow et al.   NATURE MEDICINE

Practical Considerations in Studying Metastatic Lung Colonization in Osteosarcoma Using the Pulmonary Metastasis Assay

(2018) Michael M. Lizardo et al.   Jove-Journal of Visualized Experiments

Pan-cancer genome and transcriptome analyses of 1,699 paediatric leukaemias and solid tumours

(2018) Xiaotu Ma et al.   NATURE

Genome-Informed Targeted Therapy for Osteosarcoma

(2018) Leanne C Sayles et al.   Cancer Discovery

A biobank of patient-derived pediatric brain tumor models

(2018) Sebastian Brabetz et al.   NATURE MEDICINE

A phase II study of eribulin in recurrent or refractory osteosarcoma: A report from the Children's Oncology Group

(2018) Michael S. Isakoff et al.   PEDIATRIC BLOOD & CANCER

Integrative genome analysis of somatic p53 mutant osteosarcomas identifies Ets2-dependent regulation of small nucleolar RNAs by mutant p53 protein

(2017) Rasoul Pourebrahim et al.   GENES & DEVELOPMENT

Pembrolizumab in advanced soft-tissue sarcoma and bone sarcoma (SARC028): a multicentre, two-cohort, single-arm, open-label, phase 2 trial

(2017) Hussein A Tawbi et al.   LANCET ONCOLOGY

Orthotopic patient-derived xenografts of paediatric solid tumours

(2017) Elizabeth Stewart et al.   NATURE

A permanent window for the murine lung enables high-resolution imaging of cancer metastasis

(2017) David Entenberg et al.   NATURE METHODS

Germline and somatic genetics of osteosarcoma — connecting aetiology, biology and therapy

(2017) D. Matthew Gianferante et al.   Nature Reviews Endocrinology

Response Evaluation Criteria in Solid Tumors (RECIST) following neoadjuvant chemotherapy in osteosarcoma

(2017) Lillian M. Guenther et al.   PEDIATRIC BLOOD & CANCER

Radiation enhanced the local and distant anti-tumor efficacy in dual immune checkpoint blockade therapy in osteosarcoma

(2017) Yutaka Takahashi et al.   PLoS One

Mismatch repair deficiency predicts response of solid tumors to PD-1 blockade

(2017) Dung T. Le et al.   SCIENCE

Recurrent mutation of IGF signalling genes and distinct patterns of genomic rearrangement in osteosarcoma

(2017) Sam Behjati et al.   Nature Communications

Identification of Dormancy-Associated MicroRNAs for the Design of Osteosarcoma-Targeted Dendritic Polyglycerol Nanopolyplexes

(2016) Galia Tiram et al.   ACS Nano

Risks of first and subsequent cancers amongTP53mutation carriers in the National Cancer Institute Li-Fraumeni syndrome cohort

(2016) Phuong L. Mai et al.   CANCER

Evaluation of Alternative In Vivo Drug Screening Methodology: A Single Mouse Analysis

(2016) Brendan Murphy et al.   CANCER RESEARCH

Immunotherapy with a HER2-Targeting Listeria Induces HER2-Specific Immunity and Demonstrates Potential Therapeutic Effects in a Phase I Trial in Canine Osteosarcoma

(2016) N. J. Mason et al.   CLINICAL CANCER RESEARCH

The Childhood Solid Tumor Network: A new resource for the developmental biology and oncology research communities

(2016) Elizabeth Stewart et al.   DEVELOPMENTAL BIOLOGY

TP53 Mutations and Survival in Osteosarcoma Patients: A Meta-Analysis of Published Data

(2016) Zhe Chen et al.   DISEASE MARKERS

Outcome of Patients With Recurrent Osteosarcoma Enrolled in Seven Phase II Trials Through Children's Cancer Group, Pediatric Oncology Group, and Children's Oncology Group: Learning From the Past to Move Forward

(2016) Joanne P. Lagmay et al.   JOURNAL OF CLINICAL ONCOLOGY

Immune Checkpoint Inhibition for Hypermutant Glioblastoma Multiforme Resulting From Germline Biallelic Mismatch Repair Deficiency

(2016) Eric Bouffet et al.   JOURNAL OF CLINICAL ONCOLOGY

Maximum benefit of chemotherapy for osteosarcoma achieved—what are the next steps?

(2016) Eugenie Kleinerman   LANCET ONCOLOGY

Current state of pediatric sarcoma biology and opportunities for future discovery: A report from the sarcoma translational research workshop

(2016) Pooja Hingorani et al.   Cancer Genetics

Upregulation of Glucose-Regulated Protein 78 in Metastatic Cancer Cells Is Necessary for Lung Metastasis Progression

(2016) Michael M. Lizardo et al.   NEOPLASIA

Immune infiltration and PD-L1 expression in the tumor microenvironment are prognostic in osteosarcoma

(2016) Pratistha Koirala et al.   Scientific Reports

Systematic Screening Identifies Dual PI3K and mTOR Inhibition as a Conserved Therapeutic Vulnerability in Osteosarcoma

(2015) A. Gupte et al.   CLINICAL CANCER RESEARCH

Methotrexate, Doxorubicin, and Cisplatin (MAP) Plus Maintenance Pegylated Interferon Alfa-2b Versus MAP Alone in Patients With Resectable High-Grade Osteosarcoma and Good Histologic Response to Preoperative MAP: First Results of the EURAMOS-1 Good Response Randomized Controlled Trial

(2015) Stefan S. Bielack et al.   JOURNAL OF CLINICAL ONCOLOGY

Revisiting Li-Fraumeni Syndrome From TP53 Mutation Carriers

(2015) Gaëlle Bougeard et al.   JOURNAL OF CLINICAL ONCOLOGY

Enhanced T-Cell Immunity to Osteosarcoma Through Antibody Blockade of PD-1/PD-L1 Interactions

(2015) Danielle M. Lussier et al.   JOURNAL OF IMMUNOTHERAPY

Germline TP53 Variants and Susceptibility to Osteosarcoma

(2015) Lisa Mirabello et al.   JNCI-Journal of the National Cancer Institute

Oxidative stress inhibits distant metastasis by human melanoma cells

(2015) Elena Piskounova et al.   NATURE

NKD2, a negative regulator of Wnt signaling, suppresses tumor growth and metastasis in osteosarcoma

(2015) S Zhao et al.   ONCOGENE

Rapid Protocol Enrollment in Osteosarcoma: A Report From the Children's Oncology Group

(2015) Michael S. Isakoff et al.   PEDIATRIC BLOOD & CANCER

Exome sequencing of osteosarcoma reveals mutation signatures reminiscent of BRCA deficiency

(2015) Michal Kovac et al.   Nature Communications

TP53 intron 1 hotspot rearrangements are specific to sporadic osteosarcoma and can cause Li-Fraumeni syndrome

(2015) Sebastian Ribi et al.   Oncotarget

Germline TP53 Variants and Susceptibility to Osteosarcoma

(2015) Lisa Mirabello et al.   JNCI-Journal of the National Cancer Institute

Combination immunotherapy with α-CTLA-4 and α-PD-L1 antibody blockade prevents immune escape and leads to complete control of metastatic osteosarcoma

(2015) Danielle M Lussier et al.   Journal for ImmunoTherapy of Cancer

Increased CTLA-4+ T cells and an increased ratio of monocytes with loss of class II (CD14+ HLA-DRlo/neg) found in aggressive pediatric sarcoma patients

(2015) Pooja Hingorani et al.   Journal for ImmunoTherapy of Cancer

EURAMOS-1, an international randomised study for osteosarcoma: results from pre-randomisation treatment†

(2014) J. S. Whelan et al.   ANNALS OF ONCOLOGY

IGF2 Preserves Osteosarcoma Cell Survival by Creating an Autophagic State of Dormancy That Protects Cells against Chemotherapeutic Stress

(2014) T. Shimizu et al.   CANCER RESEARCH

Toward a Drug Development Path That Targets Metastatic Progression in Osteosarcoma

(2014) C. Khanna et al.   CLINICAL CANCER RESEARCH

Canine Osteosarcoma: A Naturally Occurring Disease to Inform Pediatric Oncology

(2014) J. M. Fenger et al.   ILAR JOURNAL

GRM4 gene polymorphism is associated with susceptibility and prognosis of osteosarcoma in a Chinese Han population

(2014) Chaoyin Jiang et al.   MEDICAL ONCOLOGY

Li-Fraumeni syndrome: cancer risk assessment and clinical management

(2014) Kate A. McBride et al.   Nature Reviews Clinical Oncology

Complementary genomic approaches highlight the PI3K/mTOR pathway as a common vulnerability in osteosarcoma

(2014) Jennifer A. Perry et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Bayesian methods for the design and interpretation of clinical trials in very rare diseases

(2014) Lisa V. Hampson et al.   STATISTICS IN MEDICINE

Recurrent Somatic Structural Variations Contribute to Tumorigenesis in Pediatric Osteosarcoma

(2014) Xiang Chen et al.   Cell Reports

Animal Models in Osteosarcoma

(2014) Maria V. Guijarro et al.   Frontiers in Oncology

Functional characterisation of osteosarcoma cell lines and identification of mRNAs and miRNAs associated with aggressive cancer phenotypes

(2013) S U Lauvrak et al.   BRITISH JOURNAL OF CANCER

Anaplastic rhabdomyosarcoma inTP53germline mutation carriers

(2013) Simone Hettmer et al.   CANCER

 Np63 Promotes Pediatric Neuroblastoma and Osteosarcoma by Regulating Tumor Angiogenesis

(2013) H. K. Bid et al.   CANCER RESEARCH

Humanized mice: novel model for studying mechanisms of human immune-based therapies

(2013) Louis Gonzalez et al.   IMMUNOLOGIC RESEARCH

Subgroup-Specific Prognostic Implications ofTP53Mutation in Medulloblastoma

(2013) Nataliya Zhukova et al.   JOURNAL OF CLINICAL ONCOLOGY

Genome-wide association study identifies two susceptibility loci for osteosarcoma

(2013) Sharon A Savage et al.   NATURE GENETICS

Children's Oncology Group's 2013 blueprint for research: Bone tumors

(2012) Richard Gorlick et al.   PEDIATRIC BLOOD & CANCER

A genome-wide approach to comparative oncology: high-resolution oligonucleotide aCGH of canine and human osteosarcoma pinpoints shared microaberrations

(2012) Andrea Y. Angstadt et al.   Cancer Genetics

Modeling metastasis biology and therapy in real time in the mouse lung

(2010) Arnulfo Mendoza et al.   JOURNAL OF CLINICAL INVESTIGATION

Osteosarcoma in adolescents and adults: survival analysis with and without lung metastases

(2009) A. H. Aljubran et al.   ANNALS OF ONCOLOGY

Canine tumor cross-species genomics uncovers targets linked to osteosarcoma progression

(2009) Melissa Paoloni et al.   BMC GENOMICS

Transcriptional Switch of Dormant Tumors to Fast-Growing Angiogenic Phenotype

(2009) N. Almog et al.   CANCER RESEARCH

Children's and Their Parents' Views on Facing Research Risks for the Benefit of Others

(2008) David Wendler et al.   ARCHIVES OF PEDIATRICS & ADOLESCENT MEDICINE

Molecular Characterization of the Pediatric Preclinical Testing Panel

(2008) G. Neale et al.   CLINICAL CANCER RESEARCH