Anti-aging effects exerted by Tetramethylpyrazine enhances self-renewal and neuronal differentiation of rat bMSCs by suppressing NF-kB signaling

Local delivery of tetramethylpyrazine eliminates the senescent phenotype of bone marrow mesenchymal stromal cells and creates an anti-inflammatory and angiogenic environment in aging mice

(2018) Bo Gao et al.   AGING CELL

Autophagy induction in the skeletal myogenic differentiation of human tonsil-derived mesenchymal stem cells

(2017) Saeyoung Park et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Du-Huo-Ji-Sheng-Tang and its active component Ligusticum chuanxiong promote osteogenic differentiation and decrease the aging process of human mesenchymal stem cells

(2017) Jir-You Wang et al.   JOURNAL OF ETHNOPHARMACOLOGY

Preconditioning of bone marrow-derived mesenchymal stromal cells by tetramethylpyrazine enhances cell migration and improves functional recovery after focal cerebral ischemia in rats

(2017) Lin Li et al.   Stem Cell Research & Therapy

Neuroprotective Effect of Ligustilide through Induction of α-Secretase Processing of Both APP and Klotho in a Mouse Model of Alzheimer’s Disease

(2017) Xi Kuang et al.   Frontiers in Aging Neuroscience

Cancer Stem Cells and Their Microenvironment: Biology and Therapeutic Implications

(2017) Eunice Yuen-Ting Lau et al.   Stem Cells International

Profilin-PTEN interaction suppresses NF- B activation via inhibition of IKK phosphorylation

(2016) A. H. Zaidi et al.   BIOCHEMICAL JOURNAL

Antihepatocellular Carcinoma Potential of Tetramethylpyrazine Induces Cell Cycle Modulation and Mitochondrial-Dependent Apoptosis

(2016) Lei Bi et al.   INTEGRATIVE CANCER THERAPIES

Tetramethylpyrazine induces differentiation of human umbilical cord-derived mesenchymal stem cells into neuron-like cells in vitro

(2016) CHENGRUI NAN et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Induction of hepatocyte-like cells from human umbilical cord-derived mesenchymal stem cells by defined microRNAs

(2016) Xia Zhou et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Telomerase reverse transcriptase promotes cancer cell proliferation by augmenting tRNA expression

(2016) Ekta Khattar et al.   JOURNAL OF CLINICAL INVESTIGATION

Resveratrol Exerts Dosage-Dependent Effects on the Self-Renewal and Neural Differentiation of hUC-MSCs

(2016)   MOLECULES AND CELLS

Cardiovascular Actions and Therapeutic Potential of Tetramethylpyrazine (Active Component Isolated fromRhizoma Chuanxiong): Roles and Mechanisms

(2016) Ming Guo et al.   Biomed Research International

NF-κB in cancer therapy

(2015) Feng Li et al.   ARCHIVES OF TOXICOLOGY

In vivo tracking of human placenta derived mesenchymal stem cells in nude mice via 14C-TdR labeling

(2015) Cheng-Guang Wu et al.   BMC BIOTECHNOLOGY

Rap1 induces cytokine production in pro-inflammatory macrophages through NFκB signaling and is highly expressed in human atherosclerotic lesions

(2015) Yin Cai et al.   CELL CYCLE

Mesenchymal stem cells-based therapy as a potential treatment in neurodegenerative disorders: is the escape from senescence an answer?

(2015) Alessandro Castorina et al.   Neural Regeneration Research

Atherogenic Cytokines Regulate VEGF-A-Induced Differentiation of Bone Marrow-Derived Mesenchymal Stem Cells into Endothelial Cells

(2015) Izuagie Attairu Ikhapoh et al.   Stem Cells International

Liguzinediol improved the heart function and inhibited myocardial cell apoptosis in rats with heart failure

(2014) Yu Li et al.   ACTA PHARMACOLOGICA SINICA

Neuroprotective Effects of Tetramethylpyrazine against Dopaminergic Neuron Injury in a Rat Model of Parkinson's Disease Induced by MPTP

(2014) Chen Lu et al.   International Journal of Biological Sciences

DEAD-box helicase DP103 defines metastatic potential of human breast cancers

(2014) Eun Myoung Shin et al.   JOURNAL OF CLINICAL INVESTIGATION

Overexpression of stearoyl-CoA desaturase 1 in bone marrow mesenchymal stem cells enhance the expression of induced endothelial cells

(2014) Yuanshan Lu et al.   Lipids in Health and Disease

Tetramethylpyrazine promotes the proliferation and migration of brain endothelial cells

(2014) MINGSHUN ZHANG et al.   Molecular Medicine Reports

Combined effect of nerve growth factor and brain-derived neurotrophic factor on neuronal differentiation of neural stem cells and the potential molecular mechanisms

(2014) FEIFEI LIU et al.   Molecular Medicine Reports

Mash1 efficiently reprograms rat astrocytes into neurons

(2014) Daofang Ding et al.   Neural Regeneration Research

Aging Increases the Susceptivity of MSCs to Reactive Oxygen Species and Impairs Their Therapeutic Potency for Myocardial Infarction

(2014) Liang Li et al.   PLoS One

Cell Senescence Abrogates the Therapeutic Potential of Human Mesenchymal Stem Cells in the Lethal Endotoxemia Model

(2014) Juan Carlos Sepúlveda et al.   STEM CELLS

Metformin inhibits the senescence-associated secretory phenotype by interfering with IKK/NF-κB activation

(2013) Olga Moiseeva et al.   AGING CELL

Tetramethylpyrazine protects against scopolamine-induced memory impairments in rats by reversing the cAMP/PKA/CREB pathway

(2013) Wei Wu et al.   BEHAVIOURAL BRAIN RESEARCH

Expression ofNeurogenin 1in Mouse Embryonic Stem Cells Directs the Differentiation of Neuronal Precursors and Identifies Unique Patterns of Down-stream Gene Expression

(2013) J. Matthew Velkey et al.   DEVELOPMENTAL DYNAMICS

Neuronal cell differentiation of mesenchymal stem cells originating from canine amniotic fluid

(2013) Eun Young Kim et al.   Human Cell

Neurogenic differentiation of human adipose-derived stem cells: Relevance of different signaling molecules, transcription factors, and key marker genes

(2012) Alejandra Johana Cardozo et al.   GENE

Multifaceted link between cancer and inflammation

(2011) Gautam Sethi et al.   BIOSCIENCE REPORTS

Importance of Sox2 in maintenance of cell proliferation and multipotency of mesenchymal stem cells in low-density culture

(2011) D. S. Yoon et al.   CELL PROLIFERATION

Tetramethylpyrazine protects palmitate-induced oxidative damage and mitochondrial dysfunction in C2C12 myotubes

(2011) Xin Gao et al.   LIFE SCIENCES

Tetramethylpyrazine Inhibits Hypoxia-Induced Pulmonary Vascular Leakage in Rats via the ROS-HIF-VEGF Pathway

(2011) Le Zhang et al.   PHARMACOLOGY

A Comprehensive Review on Mesenchymal Stem Cell Growth and Senescence

(2009) Krzysztof Książek   REJUVENATION RESEARCH

Specification of DNA Binding Activity of NF- B Proteins

(2009) F. Wan et al.   Cold Spring Harbor Perspectives in Biology

Why are MSCs therapeutic? New data: new insight

(2008) AI Caplan   JOURNAL OF PATHOLOGY