Article
Pharmacology & Pharmacy
Dehua Yu, Simin Qi, Xiaoqing Guan, Wenkai Yu, Xuefei Yu, Maohua Cai, Qinglin Li, Weiyi Wang, Weidong Zhang, Jiang-Jiang Qin
Summary: In this study, the marine-derived natural product terphenyllin was identified to directly interact with STAT3 and exhibit potent anticancer efficacy against gastric cancer through inhibiting the STAT3 signaling pathway.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Integrative & Complementary Medicine
Li Zhong-Rui, Gu Meng-Zhen, Xu Xiao, Zhang Jing-Han, Zhang Hai-Li, Han Chao
Summary: This review highlights recent advances in natural LSD1 inhibitors, including their discovery and identification process, natural sources, chemical structures, anticancer effects, and structure-activity relationships. Natural products play an important role in drug discovery, particularly in cancer therapy.
CHINESE JOURNAL OF NATURAL MEDICINES
(2022)
Article
Multidisciplinary Sciences
Matteo Rossi, Patricia Altea-Manzano, Margherita Demicco, Ginevra Doglioni, Laura Bornes, Marina Fukano, Anke Vandekeere, Alejandro M. Cuadros, Juan Fernandez-Garcia, Carla Riera-Domingo, Cristina Jauset, Melanie Planque, H. Furkan Alkan, David Nittner, Dongmei Zuo, Lindsay A. Broadfield, Sweta Parik, Antonino Alejandro Pane, Francesca Rizzollo, Gianmarco Rinaldi, Tao Zhang, Shao Thing Teoh, Arin B. Aurora, Panagiotis Karras, Ines Vermeire, Dorien Broekaert, Joke Van Elsen, Maximilian M. L. Knott, Martin F. Orth, Sofie Demeyer, Guy Eelen, Lacey E. Dobrolecki, Ayse Bassez, Thomas Van Brussel, Karl Sotlar, Michael T. Lewis, Harald Bartsch, Manfred Wuhrer, Peter van Veelen, Peter Carmeliet, Jan Cools, Sean J. Morrison, Jean-Christophe Marine, Diether Lambrechts, Massimiliano Mazzone, Gregory J. Hannon, Sophia Y. Lunt, Thomas G. P. Grunewald, Morag Park, Jacco van Rheenen, Sarah-Maria Fendt
Summary: The loss of phosphoglycerate dehydrogenase (PHGDH) has been found to increase cancer metastasis. Heterogeneous or low expression of PHGDH in primary tumors of breast cancer patients is associated with decreased metastasis-free survival time. Loss of PHGDH activates the hexosamine-sialic acid pathway through its interaction with the glycolytic enzyme phosphofructokinase, leading to increased cell migration and invasion.
Article
Multidisciplinary Sciences
Vincent Libis, Logan W. MacIntyre, Rabia Mehmood, Liliana Guerrero, Melinda A. Ternei, Niv Antonovsky, Jan Burian, Zongqiang Wang, Sean F. Brady
Summary: The study presents a parallelized method for identifying, mobilizing, and heterologously expressing bacterial gene clusters (BGCs), leading to the discovery of therapeutically relevant bioactive molecules. The approach efficiently localizes clones carrying intact BGCs, resulting in the identification of several natural products.
NATURE COMMUNICATIONS
(2022)
Article
Nutrition & Dietetics
Yiqun Liu, Jianrong Wang, Qin Wang, Feng Han, Lili Shi, Chao Han, Zhenwu Huang, Liang Xu
Summary: This study aimed to investigate the impact of insufficient exogenous and/or endogenous serine on selenoprotein expression and health of pregnant rats and their offspring. The results showed that insufficient exogenous serine through the diet decreased selenoprotein synthesis in adult male rats, but this was not observed in pregnant rats.
FRONTIERS IN NUTRITION
(2022)
Article
Endocrinology & Metabolism
Daniela Annibali, Sarah-Maria Fendt
Summary: The study demonstrates the transition of PHGDH to the nucleus following nutrient stress, impacting the activity of c-Jun and contributing to sustained cancer cell proliferation.
Article
Agriculture, Multidisciplinary
Wenqin Li, Yi Ding, Huitang Qi, Tian Liu, Qing Yang
Summary: The study found that several phytochemicals can inhibit multiple insect chitinolytic enzymes simultaneously, with predicted interactions with key residues and good insecticidal activity. This research provides a new approach for using a multitarget high-throughput screening strategy to discover natural products as insecticide leads.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2021)
Article
Cell Biology
Xiaohan Gao, Yan Wang, Fang Lu, Xu Chen, Di Yang, Yiren Cao, Weimin Zhang, Jie Chen, Leilei Zheng, Guangchao Wang, Ming Fu, Liying Ma, Yongmei Song, Qimin Zhan
Summary: This study found that EVs derived from ESCC contain P4HB, which induces apoptosis of skeletal muscle cells. P4HB promotes apoptotic response through activating ubiquitin-dependent proteolytic pathway, leading to muscle wasting and weight loss. The P4HB inhibitor CCF642 rescues apoptosis of muscle cells in vitro and prevents body weight loss in the ESCC-induced cachexia mouse model.
JOURNAL OF EXTRACELLULAR VESICLES
(2021)
Article
Biochemistry & Molecular Biology
Liliang Shen, Junfeng Zhang, Zongtai Zheng, Fuhan Yang, Shenghua Liu, Yuan Wu, Yifan Chen, Tianyuan Xu, Shiyu Mao, Yang Yan, Wei Li, Wentao Zhang, Xudong Yao
Summary: The study revealed that PHGDH upregulates SLC7A11 expression via interaction with PCBP2, inhibiting ferroptosis and promoting malignant progression of BCa. The findings suggest that NCT-502 could be a potential therapeutic strategy for BCa.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2022)
Editorial Material
Biochemistry & Molecular Biology
Duygu Kuzuoglu-Ozturk
Summary: Recent research reveals a novel role of PHGDH, an enzyme in the de novo serine synthesis pathway, as a regulator of mitochondrial translation and tumor progression in liver cancer.
Review
Integrative & Complementary Medicine
Yang Chao, Zhong Zhang-Feng, Wang Sheng-Peng, Vong Chi-Teng, Yu Bin, Wang Yi-Tao
Summary: HIF-1, a key transcriptional regulator of metabolic adaptation to oxygen changes, plays important roles in physiological and pathological processes in the body, and is closely linked to the pathogenesis of many diseases.
CHINESE JOURNAL OF NATURAL MEDICINES
(2021)
Article
Biochemistry & Molecular Biology
Sourav Sardar, Jyotisha, Sk. Abdul Amin, Samima Khatun, Insaf Ahmed Qureshi, Umesh Kumar Patil, Tarun Jha, Shovanlal Gayen
Summary: HDAC1 is an important target for cancer epigenetics and different molecular modeling techniques have been used to study its interactions with natural inhibitors. By analyzing the molecular structures of these inhibitors, certain amino acid residues have been identified as potential binding sites. The stability of the HDAC1-natural inhibitors complexes has also been evaluated.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2023)
Article
Oncology
Meenakshi Gupta, Kumari Chandan, Maryam Sarwat
Summary: Cancer immunotherapy is a widely accepted tumor treatment but faces challenges such as inflammation and single-target strategies. Natural products and medicines have shown potential in enhancing immunotherapy by improving the tumor microenvironment and targeting immune checkpoints. This review highlights the role of cytokine/chemokine signaling, different types of immunotherapy, and the use of herbal medicine-derived natural products in cancer treatment. These natural compounds have immunomodulatory activities and can be used in combination with monoclonal antibody drugs to reverse the tumor microenvironment and improve treatment outcomes.
SEMINARS IN CANCER BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Sun Yun, Yu-Jin Lee, Jiyeon Choi, Nam Doo Kim, Dong Cho Han, Byoung-Mog Kwon
Summary: STAT3 is a crucial factor in the formation and growth of cancer cells, and acacetin inhibits its activity by directly binding to it, leading to inhibition of phosphorylation and nuclear translocation of STAT3, resulting in apoptosis. Interestingly, the inhibition of STAT3 activation by acacetin is independent of reactive oxygen species production.
Article
Chemistry, Medicinal
Meng Li, Xianlan She, Yufei Ou, Jiangxin Liu, Zaifeng Yuan, Qin-shi Zhao
Summary: Hsp90 is an ATP-dependent chaperone that plays a crucial role in protein assembly and folding. It has been found to be involved in cancer, viral infection, neurodegenerative disease, and inflammation. In this study, a series of novel analogues were designed, synthesized, and evaluated for their inhibitory activity against Hsp90. Among these analogues, compound 29 and 31 showed the most potent inhibitory activity. Mechanism studies revealed that compound 29 promoted cell apoptosis through the mitochondrial-mediated pathway. Furthermore, compound 29 exhibited anti-tumor activity in a mouse model and showed low acute toxicity. These findings suggest that compound 29 has potential for further development as a therapeutic agent.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2022)
Review
Biochemistry & Molecular Biology
Gui-Yang Xia, Shi-Jie Cao, Li-Xia Chen, Feng Qiu
Summary: This review summarizes the latest progress and perspectives on the promising natural withanolides, covering structural classification, biological activities and mechanisms, metabolism and pharmacokinetic investigations, biosynthesis, chemical synthesis and structural modifications, as well as future research directions.
NATURAL PRODUCT REPORTS
(2022)
Review
Medicine, Research & Experimental
Qinghua Jiang, Mingxue Li, Hua Li, Lixia Chen
Summary: Multi-target drugs can simultaneously regulate multiple aspects of diseases, improving efficacy and reducing adverse reactions, making them ideal for treating complex diseases. Entrectinib, a multi-target drug, has shown therapeutic effects on various diseases. This review provides a detailed introduction of the pharmacokinetics, pharmacodynamics, clinical efficacy, tolerability, and drug interactions of Entrectinib.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Correction
Biochemistry & Molecular Biology
Yueying Yang, Ke Xiang, Dejuan Sun, Mengzhu Zheng, Zhuorui Song, Mingxue Li, Xuanbin Wang, Hua Li, Lixia Chen
BIOORGANIC & MEDICINAL CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Ying Zhang, Gui-Yang Xia, Yu-Zhuo Wu, Xiao-Hong Wei, Huan Xia, Ling-Yan Wang, Peng-Cheng Lin, Ya-Nan Wang, Li-Xia Chen, Sheng Lin
Summary: Two new nor-seco isodhilarane meroterpenoids were isolated from the cultures of an endophytic fungus, exhibiting moderate inhibitory activity against the nitric oxide production in cells.
CHEMISTRY & BIODIVERSITY
(2022)
Review
Chemistry, Medicinal
Dandan Yu, Mengzhu Zheng, Yang Liu, Lixia Chen, Hua Li
Summary: SHP2, a non-receptor protein tyrosine phosphatase encoded by PTPN11, exhibits oncogenic activities and has emerged as a promising target for clinical therapy. Proteolysis-targeting chimera (PROTAC) technology, utilizing the degradation mechanism of the ubiquitin proteasome system, offers advantages over inhibitors. This article presents four reported PROTAC molecules targeting SHP2 and summarizes recently reported SHP2 inhibitors, which can serve as lead compounds for designing new SHP2 PROTACs. The introduction of dual PROTAC technology may replace drug combinations for treating SHP2-related diseases.
FUTURE MEDICINAL CHEMISTRY
(2022)
Review
Cell Biology
Yueying Yang, Man Zhu, Jing Liang, Hui Wang, Dejuan Sun, Hua Li, Lixia Chen
Summary: As a member of the sirtuins family, SIRT6 plays a crucial role in regulating various biological processes and maintaining organism homeostasis. This review focuses on the structural basis of SIRT6 enzyme activity, its mechanism of maintaining organism homeostasis in different phenotypes, and the regulation of SIRT6 expression and downstream substrates. Protein interaction is explored as a perspective to understand the regulatory mechanism of SIRT6 in different phenotypes.
JOURNAL OF CELLULAR PHYSIOLOGY
(2022)
Article
Genetics & Heredity
Yueying Yang, Mengzhu Zheng, Fei Han, Lei Shang, Mingxue Li, Xiaoxia Gu, Hua Li, Lixia Chen
Summary: Pancreatic ductal adenocarcinoma (PDAC) is a fatal malignant tumor for which effective treatment is lacking. Researchers have found that Ziprasidone, by inhibiting GOT1, can disrupt glutamine metabolism and redox state in PDAC cells, thereby inhibiting proliferation, preventing migration, and inducing apoptosis. Experimental results demonstrate that Ziprasidone exhibits significant anti-tumor effects in vivo.
JOURNAL OF MOLECULAR MEDICINE-JMM
(2022)
Article
Chemistry, Applied
Yang Xu, Na Zhang, Liangliang Xiong, Dejuan Sun, Zhuangzhuang Chen, Lixia Chen
Summary: A new compound was isolated from the rhizome of Smilax china, along with twelve known compounds for the first time. The structure of the new compound was elucidated based on chemical evidences and spectral data analysis. In addition, the inhibitory effects of the compounds on NO production were tested, and compound 7 showed significant inhibitory effect.
NATURAL PRODUCT RESEARCH
(2023)
Article
Chemistry, Multidisciplinary
Yang Xu, Liangliang Xiong, Yushu Yan, Dejuan Sun, Yanwei Duan, Hua Li, Lixia Chen
Summary: Stemona tuberosa, a traditional medicine widely used in China and South Asian regions, was found to contain 29 alkaloids, including eight newly discovered compounds. These compounds showed inhibitory effects on NO production in experimental cells.
FRONTIERS IN CHEMISTRY
(2022)
Review
Chemistry, Applied
Rui Zhu, Yang Liu, Yueying Yang, Qing Min, Hua Li, Lixia Chen
Summary: Steroids are a class of drugs with diverse pharmacological properties. Hydroxylation of steroids significantly affects their biological activities and properties. Achieving regio- and stereo-selective hydroxylation on steroids using modern organic synthesis techniques is extremely challenging. However, recent studies have identified and engineered cytochrome P450 monooxygenases that possess the ability to catalyze regio- and stereo-selective oxidations of nonactivated C-H bonds in complex organic molecules.
ADVANCED SYNTHESIS & CATALYSIS
(2022)
Article
Microbiology
Xiaoxia Gu, Mengzhu Zheng, Lixia Chen, Hua Li
Summary: This article summarizes NDM-1 inhibitors developed since 2018, classifies these compounds by chemical scaffolds, and points out inconsistencies and notable problems in these studies, which are expected to benefit future research.
MICROBIOLOGICAL RESEARCH
(2022)
Letter
Pharmacology & Pharmacy
Yanli Wu, Yueying Yang, Wang Wang, Dejuan Sun, Jing Liang, Man Zhu, Hua Li, Lixia Chen
ACTA PHARMACEUTICA SINICA B
(2022)
Article
Biochemistry & Molecular Biology
Yali Wang, Dejuan Sun, Qinghua Jiang, Liangliang Xiong, Na Zhang, Yingni Pan, Hua Li, Lixia Chen
Summary: The Euphorbia plant is a valuable source for natural product drug discovery. This study discovered eight new diterpenoids from Euphorbia wallichii, including a rare pentacyclic diterpenoid with inhibitory activity on NO production. Bioassays and mechanistic studies revealed its potential in suppressing inflammation.
Article
Biochemistry & Molecular Biology
Jing Liang, Mengzhu Zheng, Wei Xu, Yongkang Chen, Piyu Tang, Guoyi Wu, Peng Zou, Hua Li, Lixia Chen
Summary: This study discovered Acriflavine and Proflavine Hemisulfate as inhibitors of Mpro, showing good inhibitory activity against the SARS-CoV-2 virus.
BIOORGANIC CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Chengfeng Gao, Man Zhu, Wei Xu, Yali Wang, Liangliang Xiong, Dejuan Sun, Minge Sun, Yu Lin, Hua Li, Lixia Chen
Summary: Amomum villosum Lour. is a medicinal and edible plant. The stems and leaves of A. villosum, which are usually treated as waste, were found to contain various chemical components, including four undescribed compounds and 41 known compounds. Some of these compounds showed anti-inflammatory and antioxidant activities, with the new compound 1 exhibiting significant antioxidant effect through the activation of NRF2/HO-1 pathways. Therefore, the stems and leaves of A. villosum may serve as a potential medicine or dietary supplement for preventing and treating diseases resulting from inflammation and oxidative stress.
BIOORGANIC CHEMISTRY
(2023)
Correction
Biochemistry & Molecular Biology
Mohamed Marzouk, Shimaa M. Khalifa, Amal H. Ahmed, Ahmed M. Metwaly, Hala Sh. Mohammed, Hanan A. A. Taie
BIOORGANIC CHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Gerardo Andres Libreros-Zuniga, Danilo Pava e Pavao, Vinicius de Morais Barroso, Nathalya Cristina de Moraes Roso Mesquita, Saulo Fehelberg Pinto Braga, Glaucius Oliva, Rafaela Salgado Ferreira, Kelly Ishida, Marcio Vinicius Bertacine Dias
Summary: Tuberculosis is a major global cause of death, and the emergence of drug-resistant strains has increased the burden of this disease. New alternative therapies are constantly needed, and recent research has identified small molecules as potential inhibitors of Ldts in M. tuberculosis, which have antimycobacterial activity.
BIOORGANIC CHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Xiao-Dong Wang, Yong-Si Liu, Ming-Hao Hu
Summary: In this study, a selffolded fluorescent probe was designed to selectively illuminate G4s by unfolding its intramolecular aggregation mediated by G4 binding. This probe showed more controllable background emission and promising ability to track G4 forming dynamics compared to previous disaggregation-induced emission (DIE) probes.
BIOORGANIC CHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Yu Xiang, Zhuo Yuan, Qichuan Deng, Linshen Xie, Dongke Yu, Jianyou Shi
Summary: This review provides a brief description of the diagnosis, pathogenesis, and potential therapeutic inhibitors for renal fibrosis. Currently, there are no clear therapeutic targets or drugs for renal fibrosis; however, some natural products may have potential efficacy for treating renal fibrosis.
BIOORGANIC CHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Simone Giovannuzzi, Anna Nikitjuka, Bruna Rafaela Pereira Resende, Michael Smietana, Alessio Nocentini, Claudiu T. Supuran, Jean-Yves Winum
Summary: Boron-based compounds have been extensively studied in medicinal chemistry, playing a crucial role in designing small molecule drugs for various diseases. Boron is particularly valuable in developing inhibitors for metalloenzymes carbonic anhydrases, and it can modulate ligand recognition ability and selectivity. Recent advancements have led to the discovery of novel boron-based inhibitors that can inhibit carbonic anhydrases through a Lewis acid-base mechanism. Further research is needed to fully explore the potential of boron-based inhibitors and advance their clinical applications.
BIOORGANIC CHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Xinxin Liu, Lei Chen, Ze Chen
Summary: This study developed a nanostructured photosensitizer loaded with oxygen-throttling drug and demonstrated its enhanced cytotoxicity against tumor cells under hypoxic conditions. Animal experiments showed the enhanced tumor targeting capability of the photosensitizer and its inhibitory effect on tumor growth.
BIOORGANIC CHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Shuai Jiang, Wen-Yan Li, Zai-Feng Yuan, Qin-Shi Zhao
Summary: This study isolated two new dimeric Lycopodium alkaloids and twelve previously undescribed Lycopodium alkaloids from Lycopodiastrum casuarinoides. The structures of these compounds were determined and their inhibitory activities on the Cav3.1 channel were evaluated.
BIOORGANIC CHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Yan Yang, Dong-Xiao Yan, Rui-Xue Rong, Bing-Ye Shi, Man Zhang, Jing Liu, Jie Xin, Tao Xu, Wen-Jie Ma, Xiao-Liu Li, Ke-Rang Wang
Summary: In this study, a series of nucleolar fluorescent probes based on naphthalimide derivatives were designed and synthesized, which could achieve clear nucleolar staining in living cells. The results showed that these probes exhibited good targeting to the cell nucleolus and could bind to RNA and enhance fluorescence. This has positive implications for the diagnosis and treatment of nucleolus-related diseases.
BIOORGANIC CHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Yongxi Dong, Fang Wang, Jinlan Wen, Yongqing Mao, Shanhui Zhang, Tiemei Long, Zhangxiang Yang, Lei Li, Jiquan Zhang, Li Dong, Gang Liu, Jianwei Xu
Summary: The hybrid molecules of Scutellarein and Tertramethylpyrazine show excellent neuroprotective and antiplatelet effects in the treatment of ischemic stroke. Compound 1e is particularly effective, enhancing cell membrane permeability and inhibiting cell uptake, as well as significantly reducing cerebral infarction volume.
BIOORGANIC CHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Yu Chen, Yuanyuan Ying, Jonathan Lalsiamthara, Yuheng Zhao, Saber Imani, Xin Li, Sijing Liu, Qingjing Wang
Summary: This paper examines the role and metabolic regulation of NAD+ in bacteria, highlighting its impact on physiology and virulence. It explores enzymes associated with NAD+ metabolism as potential targets for antibacterial drugs and vaccine candidates. Additionally, it scrutinizes the medical potential of NAD+ and provides insights for its application in biomedicine.
BIOORGANIC CHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Jon Macicior, Daniel Fernandez, Silvia Ortega-Gutierrez
Summary: Hutchinson-Gilford progeria syndrome (HGPS), also known as progeria, is a rare genetic disease that causes premature aging and significantly reduces life expectancy. Currently, there is only one approved drug for treating progeria, but its efficacy is limited. Progerin levels are believed to be the most important biomarker related to disease severity.
BIOORGANIC CHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Fuko Hirano, Naoya Kondo, Yusuke Murata, Aya Sudani, Takashi Temma
Summary: Fluorinated alpha-methyl 3BPA derivatives showed improved water solubility, tumor targetability, and biodistribution compared to 3BPA and BPA, resulting in significantly improved tumor-to-normal tissue ratios.
BIOORGANIC CHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Ying Shi, Jiaqin Tang, Shumeng Zhi, Ruiqi Jiang, Qing Huang, Lei Sun, Zhizhong Wang, Yanran Wu
Summary: Necroptosis is a type of cell death associated with various diseases. In this study, we identified a small molecule inhibitor, SY-1, that effectively blocks necroptosis by inhibiting the phosphorylation of RIP1/RIP3/MLKL pathway. SY-1 also showed protective effects against TNF-induced hypothermia and improved survival in mice with SIRS. These findings highlight the potential therapeutic applications of SY-1.
BIOORGANIC CHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Andrea Bagan, Sonia Abas, Judith Pala-Pujadas, Alba Irisarri, Christian Grinan-Ferre, Merce Pallas, Itziar Muneta-Arrate, Carolina Muguruza, Luis F. Callado, Belen Perez, Elies Molins, Jose A. Morales-Garcia, Carmen Escolano
Summary: Recent studies have identified the modulation of imidazoline I-2 receptors (I-2-IR) by selective ligands as a potential strategy for treating neurodegenerative diseases. This study reports a family of bicyclic alpha-iminophosphonates that show high affinity and selectivity for I-2-IR and demonstrates their neuroprotective and anti-inflammatory effects in in vitro and in vivo models. The findings emphasize the importance of exploring structurally novel I-2-IR ligands for therapeutic strategies in neurodegeneration.
BIOORGANIC CHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Qiuping Xiang, Tianbang Wu, Cheng Zhang, Chao Wang, Hongrui Xu, Qingqing Hu, Jiankang Hu, Guolong Luo, Xiaoxi Zhuang, Xishan Wu, Yan Zhang, Yong Xu
Summary: This study reports the discovery of a 1-(indolizin-3-yl)ethan-1-one derivative as a potent and selective CBP bromodomain inhibitor for AML drug development.
BIOORGANIC CHEMISTRY
(2024)
