Ovarian cancer and the evolution of subtype classifications using transcriptional profiling†

Ovarian cancer statistics, 2018

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Interfaces of Malignant and Immunologic Clonal Dynamics in Ovarian Cancer

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Single-Cell Map of Diverse Immune Phenotypes in the Breast Tumor Microenvironment

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Precious GEMMs: emergence of faithful models for ovarian cancer research

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Commonly Occurring Cell Subsets in High-Grade Serous Ovarian Tumors Identified by Single-Cell Mass Cytometry

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Copy number signatures and mutational processes in ovarian carcinoma

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Joint profiling of chromatin accessibility and gene expression in thousands of single cells

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Methylation of all BRCA1 copies predicts response to the PARP inhibitor rucaparib in ovarian carcinoma

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Ovarian Cancer Immunotherapy: Preclinical Models and Emerging Therapeutics

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Advances in prediction for ovarian cancer treatment stratification

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Maintenance Olaparib in Patients with Newly Diagnosed Advanced Ovarian Cancer

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Identification of grade and origin specific cell populations in serous epithelial ovarian cancer by single cell RNA-seq

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BRCA Reversion Mutations in Circulating Tumor DNA Predict Primary and Acquired Resistance to the PARP Inhibitor Rucaparib in High-Grade Ovarian Carcinoma

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Single cell sequencing reveals heterogeneity within ovarian cancer epithelium and cancer associated stromal cells

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Ovarian cancer stem cells: still an elusive entity?

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Simultaneous epitope and transcriptome measurement in single cells

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Massively parallel digital transcriptional profiling of single cells

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Dissecting Immune Circuits by Linking CRISPR-Pooled Screens with Single-Cell RNA-Seq

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Perturb-Seq: Dissecting Molecular Circuits with Scalable Single-Cell RNA Profiling of Pooled Genetic Screens

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PD-L1 expression is associated with tumor-infiltrating T cells and favorable prognosis in high-grade serous ovarian cancer

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Divergent modes of clonal spread and intraperitoneal mixing in high-grade serous ovarian cancer

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High-throughput single-cell gene-expression profiling with multiplexed error-robust fluorescence in situ hybridization

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Visualization and analysis of gene expression in tissue sections by spatial transcriptomics

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Dissecting the multicellular ecosystem of metastatic melanoma by single-cell RNA-seq

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The GAS6-AXL signaling network is a mesenchymal (Mes) molecular subtype-specific therapeutic target for ovarian cancer

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Molecular Subtyping of Serous Ovarian Cancer Based on Multi-omics Data

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The GAS6-AXL signaling network is a mesenchymal (Mes) molecular subtype-specific therapeutic target for ovarian cancer

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Highly Parallel Genome-wide Expression Profiling of Individual Cells Using Nanoliter Droplets

(2015) Evan Z. Macosko et al.   CELL

Targeting Programmed Cell Death 1 in Ovarian Cancer

(2015) Krisztian Homicsko et al.   JOURNAL OF CLINICAL ONCOLOGY

Efficient molecular subtype classification of high-grade serous ovarian cancer

(2015) Huei San Leong et al.   JOURNAL OF PATHOLOGY

Standard chemotherapy with or without bevacizumab for women with newly diagnosed ovarian cancer (ICON7): overall survival results of a phase 3 randomised trial

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Robust enumeration of cell subsets from tissue expression profiles

(2015) Aaron M Newman et al.   NATURE METHODS

Spatially resolved, highly multiplexed RNA profiling in single cells

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Stroma-associated master regulators of molecular subtypes predict patient prognosis in ovarian cancer

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Multiplatform Analysis of 12 Cancer Types Reveals Molecular Classification within and across Tissues of Origin

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Prognostic and Therapeutic Relevance of Molecular Subtypes in High-Grade Serous Ovarian Cancer

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PD-1 blockade induces responses by inhibiting adaptive immune resistance

(2014) Paul C. Tumeh et al.   NATURE

Tackling the cancer stem cells — what challenges do they pose?

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Single-cell RNA-seq highlights intratumoral heterogeneity in primary glioblastoma

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Nonequivalent Gene Expression and Copy Number Alterations in High-Grade Serous Ovarian Cancers with BRCA1 and BRCA2 Mutations

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Functional genomics identifies five distinct molecular subtypes with clinical relevance and pathways for growth control in epithelial ovarian cancer

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Emerging landscape of oncogenic signatures across human cancers

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EGFR/HER-targeted therapeutics in ovarian cancer

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Olaparib Maintenance Therapy in Platinum-Sensitive Relapsed Ovarian Cancer

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Technical challenges and limitations of current mouse models of ovarian cancer

(2012) Kenneth Garson et al.   Journal of Ovarian Research

Prognostic significance of tumor-infiltrating T cells in ovarian cancer: A meta-analysis

(2011) Wei-Ting Hwang et al.   GYNECOLOGIC ONCOLOGY

Olaparib in patients with recurrent high-grade serous or poorly differentiated ovarian carcinoma or triple-negative breast cancer: a phase 2, multicentre, open-label, non-randomised study

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Integrated genomic analyses of ovarian carcinoma

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Incorporation of Bevacizumab in the Primary Treatment of Ovarian Cancer

(2011) Robert A. Burger et al.   NEW ENGLAND JOURNAL OF MEDICINE

A Phase 3 Trial of Bevacizumab in Ovarian Cancer

(2011) Timothy J. Perren et al.   NEW ENGLAND JOURNAL OF MEDICINE

Mass Cytometry: Technique for Real Time Single Cell Multitarget Immunoassay Based on Inductively Coupled Plasma Time-of-Flight Mass Spectrometry

(2009) Dmitry R. Bandura et al.   ANALYTICAL CHEMISTRY

mRNA-Seq whole-transcriptome analysis of a single cell

(2009) Fuchou Tang et al.   NATURE METHODS

A Gene Signature Predicting for Survival in Suboptimally Debulked Patients with Ovarian Cancer

(2008) T. Bonome et al.   CANCER RESEARCH

Novel Molecular Subtypes of Serous and Endometrioid Ovarian Cancer Linked to Clinical Outcome

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A candidate precursor to pelvic serous cancer (p53 signature) and its prevalence in ovaries and fallopian tubes from women with BRCA mutations

(2008) Ann K. Folkins et al.   GYNECOLOGIC ONCOLOGY

Comprehensive genomic characterization defines human glioblastoma genes and core pathways

(2008) Roger McLendon et al.   NATURE

Imaging individual mRNA molecules using multiple singly labeled probes

(2008) Arjun Raj et al.   NATURE METHODS