Article
Chemistry, Analytical
Di Liu, Huimin Gao, Wenji Jiang, Su Yan, Hao Liu, Junjie Chen, Sisi Wen, Wei Zhang, Xu Wang, Bing Zhao, Wei Song
Summary: In this study, three-dimensional Ag aerogel-supported Hg single-atom catalysts were used as an efficient SERS substrate for monitoring enhanced oxidase-like reactions. The effect of Hg2+ concentrations on the SERS properties of 3D Hg/Ag aerogel networks was investigated, and an optimized addition of Hg2+ resulted in specific enhancement. The formation of Ag-supported Hg SACs was confirmed using HAADF-STEM imaging and XPS measurement, and the oxidase-like catalytic mechanism of Hg/Ag SACs was revealed using DFT. This research provides a mild synthetic strategy for fabricating Ag aerogel-supported Hg single atoms with promising prospects in various catalytic fields.
ANALYTICAL CHEMISTRY
(2023)
Article
Chemistry, Analytical
Ailing Su, Yuan Liu, Xiumian Cao, Junyi Zhao, Weiqing Xu, Chongyang Liang, Ping Li, Shuping Xu
Summary: In this study, a surface-enhanced Raman scattering (SERS) detection method was developed based on the CRISPR/dCas9 technique and enzyme catalysis amplification reaction to achieve a simple and rapid detection of low-content HPV genes.
ANALYTICAL CHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Brinton King Eldridge, Saghar Gomrok, James W. Barr, Elise Anne Chaffin, Lauren Fielding, Christian Sachs, Katie Stickels, Paiton Williams, Yongmei Wang
Summary: Gap-enhanced Raman tags are a new type of optical probe that utilize the strong electric field inside the gap between two plasmonic metals to enhance the surface-enhanced Raman scattering response. Our study investigated Au@SiO22@Au nanoparticles with varying shell and gap thicknesses and found that the near-field enhancement spectra inside the gap were stronger than on the outer surface of the nanoparticle. We also discovered that a thin shell combined with a thin gap produced the greatest near-field enhancement.
Article
Chemistry, Physical
Faezeh Mohaghegh, Alireza Mazaheri Tehrani, Arnulf Materny
Summary: The increase in inelastically scattered signal observed in Surface-enhanced Raman spectroscopy (SERS) is attributed to different mechanisms. The study revealed a transition to pure electromagnetic enhancement when molecules are separated from the metal surface. By preventing direct contact between molecules and the metal surface, the electronic (chemical) enhancement mechanism can be switched.
JOURNAL OF PHYSICAL CHEMISTRY C
(2021)
Article
Chemistry, Physical
Yan Zhao, Shuqing Zhang, Bo Xu, Shishu Zhang, Shiyi Han, Jin Zhang, Lianming Tong
Summary: The study reports direct monitoring of the evolution of DP and FI under strain in layered MoS2 using circularly polarized Raman spectroscopy, and finds the relative proportions of DP and FI can be evaluated by the circular polarization ratio of the E-2g(1) mode. It further demonstrates that the strain control of DP and FI in MoS2 is dominated by the excitonic effect, and the method can be extended to other 2D semiconductors for manipulating exciton-phonon couplings by strain.
JOURNAL OF PHYSICAL CHEMISTRY LETTERS
(2021)
Article
Chemistry, Physical
Georgios N. Mathioudakis, Amaia Soto Beobide, Spiros H. Anastasiadis, George A. Voyiatzis
Summary: Surface-enhanced Raman scattering (SERS) using colloidal suspensions of silver nanoparticles (AgNPs) has been applied to detect brilliant green (BG) at very low concentrations. Proper stimulated surface-enhanced resonance Raman scattering (SERRS) spectra collected from BG aqueous solutions at different low concentration ranges reveal a variation of the relative intensity ratio of certain BG bands attributed to the molecular orientation alteration of the analyte with respect to the AgNPs. The addition of cetyl thrimethyl ammonium bromide (CTAB) to the BG aqueous solutions enhances the detection limit of the analyte by tuning the interparticle distances of AgNPs.
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
(2021)
Article
Chemistry, Analytical
W. Cheuquepan, S. Hernandez, M. Perez-Estebanez, L. Romay, A. Heras, A. Colina
Summary: Electrochemistry can be used to generate SERS substrates, utilizing the plasmonic properties of nanos-tructures and the chemical mechanism, with time-resolved Raman spectroelectrochemistry providing valuable information. Comparing Au and Ag metals for folic acid detection in drugs, it was found that Ag SERS substrates outperformed Au SERS substrates in complex samples.
JOURNAL OF ELECTROANALYTICAL CHEMISTRY
(2021)
Article
Chemistry, Multidisciplinary
Petra Pal, Attila Bonyar, Miklos Veres, Laura Juhasz, Melinda Szaloki, Istvan Csarnovics
Summary: Metallic nanoislands were prepared by thermal annealing of gold thin film on a glass substrate to investigate surface-enhanced Raman scattering (SERS) effect. The enhancement factors of SERS substrates were influenced by the analytes' adsorption tendency and electronic structure, with higher enhancement factors observed for specific molecules under different excitation wavelengths.
APPLIED SCIENCES-BASEL
(2021)
Article
Chemistry, Multidisciplinary
Shi Xuan Leong, Charlynn Sher Lin Koh, Howard Yi Fan Sim, Yih Hong Lee, Xuemei Han, Gia Chuong Phan-Quang, Xing Yi Ling
Summary: The study successfully achieves direct, label-free SERS sensing of biologically important enantiomers by synergizing asymmetric nanoporous gold (NPG) nanoparticles with electrochemical-SERS. This strategy is versatile and can be readily extended to detect various enantiomers, and allows for multiplex quantification of enantiomeric ratios with excellent predictive performance. The research offers a paradigm shift in achieving label-free chiral SERS sensing of various enantiomers.
Article
Chemistry, Multidisciplinary
Myoung Gyu Kim, Miyeon Jue, Kwan Hee Lee, Eun Yeong Lee, Yeonjeong Roh, Minju Lee, Hyo Joo Lee, Sanghwa Lee, Huifang Liu, Bonhan Koo, Yoon Ok Jang, Eui Yeon Kim, Qiao Zhen, Sung-Han Kim, Jun Ki Kim, Yong Shin
Summary: The study introduces a deep learning assisted ZnO-Au-SERS-based direct amplification (ZADA) system for rapid, sensitive molecular diagnostics. The system can amplify target nucleic acids directly on the SERS surface, eliminating the need for post-amplification hybridization and Raman reporters. Clinical validation with COVID-19 samples yielded high sensitivity and specificity. The integration of a deep learning program further enhanced sensitivity and specificity to 100%.
Article
Electrochemistry
Sheila Hernandez, Juan Perales-Rondon, Aranzazu Heras, Alvaro Colina
Summary: EC-SOERS is a new phenomenon that enhances the Raman signal during the oxidation of a metal surface. Studies show that carbonyl and carboxyl groups are necessary to observe this phenomenon, with a delocated charge being important factor. Evaluating the enhancement factors for different molecules with highly delocated charge and a carboxyl group sheds more light on the interaction of molecules with the electrochemically generated SOERS substrates.
ELECTROCHIMICA ACTA
(2021)
Article
Chemistry, Multidisciplinary
Koichiro Saito, Keegan McGehee, Yasuo Norikane
Summary: The study successfully synthesized beta-CD-capped AuNPs with diameters ranging from 24 to 85 nm using a seed-mediated growth method. Monolayers of beta-CD-capped AuNPs were fabricated via liquid-liquid interfacial self-assembly for surface-enhanced Raman scattering (SERS) applications, which showed significantly improved intensity. Additionally, the higher sensitivity of beta-CDs in detecting pyrene compared to alpha-CDs was attributed to differences in molecular recognition ability.
NANOSCALE ADVANCES
(2021)
Review
Biochemistry & Molecular Biology
Antonio Sasso, Angela Capaccio, Giulia Rusciano
Summary: This review focuses on the recent studies conducted by our group in the past decade, where novel nanofabrication techniques were successfully applied to SERS and TERS experiments for studying bio-systems and molecular species of environmental interest.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Chemistry, Multidisciplinary
Shiyu Sun, Jingying Zheng, Ruihao Sun, Dan Wang, Guanliang Sun, Xingshuang Zhang, Hongyu Gong, Yong Li, Meng Gao, Dongwei Li, Guanchen Xu, Xiu Liang
Summary: Defect-containing monolayer MoS2 with abundant density of states and effective photoinduced charge transfer resonance becomes a promising and versatile substrate capable of detecting a wide range of dye molecules and enhancing Raman enhancement.
Article
Materials Science, Multidisciplinary
Miao Yu, Qihang Tian, Guangyuan He, Kaimin Cui, Jihong Zhang
Summary: Surface-enhanced Raman scattering (SERS) is a novel method for low concentration molecular detection, and tapered fiber SERS probes based on silver nanocubes exhibit high sensitivity. These probes can be used for both qualitative and quantitative analysis, with an optimal cone angle of 8.3 degrees.
ADVANCED FIBER MATERIALS
(2021)
Article
Immunology
Ben Mulhearn, Danyang Li, Fionnuala McMorrow, Hui Lu, Neil J. McHugh, Sarah L. Tansley
Summary: This study demonstrates that the new commercial ELISA method reliably detects anti-TIF1 gamma, with high sensitivity and specificity, which is important for the diagnosis of cancer-associated dermatomyositis and juvenile onset dermatomyositis.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Chemistry, Physical
Xin Jiang, Lin Xu, Wei Ji, Weie Wang, Juan Du, Libin Yang, Wei Song, Xiaoxia Han, Bing Zhao
Summary: The effects of electron-hole separation on the sensitivity of semiconductor-based surface enhanced Raman scattering (SERS) were investigated using TiO2/ZnO heterojunction as an example. The results showed that the formation of TiO2/ZnO heterojunction improved the separation of the photogenerated electron-hole pairs and significantly enhanced SERS activity. These findings provide insights into the role of electron-hole separation in semiconductor SERS enhancement and offer a new strategy for designing semiconductor SERS-active substrates with high charge transfer contribution.
APPLIED SURFACE SCIENCE
(2022)
Article
Hematology
Qinglian Wang, Jiangong Lin, Hui Han, Dongfeng Wu, Yan Zhou, Bing Zhao
Summary: This study found that preoperative cardiac index is associated with the maturation and patency of radiocephalic arteriovenous fistula. A decreased cardiac index may be a predictor of an increased risk of failed maturation and a shorter primary patency time.
BLOOD PURIFICATION
(2022)
Article
Materials Science, Ceramics
Wei Li, Hak Jin Sim, Hui Lu, Huatang Cao, Ying Chen, Ping Xiao
Summary: Reduced graphene oxide (rGO)-reinforced Al2O3 composites were fabricated by spark plasma sintering, and the effect of graphene oxide (GO) dimensions on the microstructure and mechanical properties of the composites was studied. Thin GO resulted in grain size refinement and grain boundary pinning effects, leading to higher hardness of the composites.
CERAMICS INTERNATIONAL
(2022)
Article
Engineering, Environmental
Jing Jin, Wei Song, Jiaqi Wang, Linjia Li, Yu Tian, Shoujun Zhu, Yuping Zhang, Shuping Xu, Bai Yang, Bing Zhao
Summary: A uniform and small-sized core-shell Ag/oxidized graphene quantum dots (o-GQDs) nanohybrid with enhanced SERS sensitivity and biocompatibility was prepared for intracellular SERS analysis and potential cancer cell therapy.
CHEMICAL ENGINEERING JOURNAL
(2022)
Article
Chemistry, Physical
Yanan Wang, Jing Jin, Hao Ma, Meng Zhang, Qianwen Li, He Wang, Bing Zhao, Weidong Ruan, Guan Yan
Summary: This study investigates the importance of enhancing charge transfer in the AZO/MPy/Ag sandwich structure, and identifies a significant CT route from the CB of AZO to the LUMO of the MPy molecule, which can effectively improve the degree of CT. This discovery is expected to play a crucial role in enhancing SERS.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2022)
Article
Spectroscopy
Yan Ma, Qianwen Li, Siyu Wang, Yanan Wang, Hongye Liu, Xu Wang, Bing Zhao, Ziping Jiang, Weidong Ruan
Summary: The application of surface enhanced infrared absorption (SEIRA) is limited by the use of expensive noble metal substrates. This study introduces a new semiconductor SEIRA substrate, indium tin oxide (ITO) nanoparticles, and demonstrates their SEIRA property. Furthermore, the results show that the doping ratio of tin heteroatoms in ITO nanoparticles affects the enhancement factor.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2022)
Article
Biochemistry & Molecular Biology
Han Xie, Li Song, Sagie Katz, Jinyu Zhu, Yawen Liu, Jinping Tang, Linjun Cai, Peter Hildebrandt, Xiao Xia Han
Summary: This study investigates the correlation between ROS production and electron transfer between cytochrome c (Cyt c) and the microsomal monooxygenase (MMO) system using resonance Raman spectroscopy. The results reveal that the binding of Cyt c to MMO induces ROS production, which is quantitatively determined by in-situ RR spectroscopy. The research further highlights the important role of oxidized Cyt c in accelerating apoptosis and proposes the involvement of electron transfer in the mitochondria-endoplasmic reticulum pathway. This study provides important insights into the regulation of apoptotic pathways and may have implications in the design of antitumor drugs for cancer therapy.
Article
Chemistry, Physical
Lin Zhu, Xiaoyue Su, Hao Ma, Lianze Shan, Bing Zhao
Summary: The CH3NH3PbBr3 substrate in SERS technology shows advantages in improving quantitative analysis capability and alleviating background problems. It also exhibits specific enhancement effect for pyridine-containing probe molecules.
APPLIED SURFACE SCIENCE
(2022)
Article
Immunology
Aravinthan Loganathan, Fionnuala McMorrow, Hui Lu, Danyang Li, Ben Mulhearn, Neil John McHugh, Sarah Louise Tansley
Summary: This study evaluated the reliability of a commercial ELISA method in detecting myositis-specific autoantibodies and found that it had good agreement with immunoprecipitation, accurately detecting anti-synthetase, anti-Mi2, and anti-MDA5 autoantibodies.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Kwan Ting Kan, Michael G. Nelson, Chris M. Grant, Simon J. Hubbard, Hui Lu
Summary: Yme1 is a multifunctional protein that plays important roles in maintaining mitochondrial protein homeostasis and regulating biogenesis and function of mitochondrial proteins. This study shows that YME1 deletion affects yeast growth, chronological life span, mitochondrial protein homeostasis and function. It also reveals that Yme1 plays a key role in longevity and is important for maintaining the level and function of mitochondrial oxidative phosphorylation complexes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Hak Jin Sim, Zheling Li, Ping Xiao, Hui Lu
Summary: The study investigates the effect of graphene oxide (GO) lateral size and degree of oxidation on its reduction efficiency and electrical conductivity. The findings suggest that the reduction efficiency in film is affected not only by GO size and oxidation but also by interlayer spacing, and the electrical conductivity of reduced GO films depends on the C/O ratio of GO. An optimal reduction is achieved using a mixture of large and small GO.
Article
Chemistry, Analytical
Yawen Liu, Hao Ma, Junqi Zhao, Jihong Wang, Xiaoxia Han, Bing Zhao
Summary: This study conducted a comprehensive SERS analysis of flavins containing lumichrome and lumiflavin on silver nanoparticles. The results indicated that the flavin molecules were adsorbed on the silver nanoparticles via the N-3 site of the isoalloxazine moiety, which had a stronger adsorption ability than the adenine moiety in the FAD. The SERS spectra of the flavins at different pH values also supported this conclusion. The feasibility of SERS for the structural characterization of flavins was demonstrated, paving the way for the functional exploration of flavin-labeled detection sensors and flavoprotein researches.
Article
Chemistry, Multidisciplinary
Jinping Tang, Li Song, Han Xie, Jinyu Zhu, Wei Li, Guangyang Xu, Linjun Cai, Xiao Xia Han
Summary: The study demonstrates the potential of SERRS for monitoring the interaction between mitochondria and endoplasmic reticula in apoptosis. SERRS allows for label-free, in situ, and real-time monitoring of ROS formation and cytochrome c release, providing a novel strategy for cancer treatment.