Article
Chemistry, Multidisciplinary
Yanping Wang, Yusen Yang, Dingke Zhang, Tong Zhang, Shiyi Xie, Yu Zhang, Yong-Biao Zhao, Xiaoyun Mi, Xiuling Liu
Summary: This study reports an exciton sensitizing approach to improve the performance of quantum-dot light-emitting diodes (QLEDs) by forming excitons on a phosphorescent-dye-doped layer and transferring their energies to adjacent quantum-dot layer. The fabricated red QLEDs using this method achieve record high efficiency and good stability.
ADVANCED MATERIALS
(2023)
Article
Engineering, Environmental
Qian Zhang, Ran Zhao, Yan Zhang, Xiaoran Zou, Chun-yang Zhang
Summary: In this study, a simple and sensitive measurement method for long non-coding RNA (lncRNA) was developed using self-assembled quantum dot (QD)-based spherical nucleic acid (SNA) nanostructures. The QD nanosensor achieved high sensitivity and accurate quantification of lncRNA expression, and it could differentiate tumor cells from normal cells and distinguish breast cancer patients from healthy individuals. This versatile paradigm provides a promising tool for biomedical research and early clinic diagnostics.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Nanoscience & Nanotechnology
Paniz Rahmani, Melissa Goodlad, Yehan Zhang, Yichen Li, Tao Ye
Summary: This study develops a one-step ligand-exchange method to produce water-soluble QD-DNA conjugates with high photoluminescence. These bioconjugates can be used for DNA-directed self assembly and demonstrated fluorescence quenching by adjacent gold nanoparticles. Such QD-AuNP dimers can serve as biosensors with improved sensitivity.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Nanoscience & Nanotechnology
Chien-Yu Chen, Chia-Chun Ni, Ruei-Nan Wu, Sheng-Yang Kuo, Chia-Hao Li, Yean-Woei Kiang, C. C. Yang
Summary: The study reveals that surface plasmon coupling reduces FRET efficiency and creates competition. While R6G emission efficiency can be enhanced through SP coupling, the enhancement decreases when R6G is linked onto QD and then self-assembled onto Ag NP, especially when the number of R6G molecules is high.
Article
Biophysics
Ganapathi Bharathi, Fangrui Lin, Liwei Liu, Tymish Y. Ohulchanskyy, Rui Hu, Junle Qu
Summary: Ovarian cancer is a deadly disease threatening women's health, and late diagnosis is a major reason for related deaths. Using HE4 as a biomarker can improve the accuracy of ovarian cancer diagnosis. Developing an all-graphene quantum dot FRET probe allows for ratiometric detection of the HE4 ovarian cancer biomarker.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2021)
Article
Chemistry, Multidisciplinary
Tae Won Nam, Yeonkyung Park, Yeon Sik Jung, Hyun Gyu Park
Summary: In this study, a polychromatic quantum dot array (PQDA) was developed for accurate quantification of multiple miRNAs. The PQDA, manufactured using advanced patterning techniques, showed a wide dynamic range and high specificity, enabling the identification of target miRNAs with high sensitivity.
Article
Chemistry, Analytical
Zhangcheng Fu, Tong Lv, Lili Jiang, Chao Xing, Chunhua Lu
Summary: The study developed a novel electrochemical biosensor for the analysis of tumor biomarker microRNA-141, with a wide linear range and low detection limit. The biosensor demonstrated high sensitivity and selectivity, making it a promising tool for sensitive detection of various biomarkers in clinical applications.
Article
Nanoscience & Nanotechnology
Chun Hong Li, Wen Yi Lv, Fei Fan Yang, Shu Jun Zhen, Cheng Zhi Huang
Summary: Simultaneous detection and imaging of two miRNAs was achieved using a DTN probe, showing great potential for improving detection accuracy.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Biophysics
Cheol Am Hong, Jae Chul Park, Hyebin Na, Huiju Jeon, Yoon Sung Nam
Summary: This study introduces a new DNA assay platform that utilizes short target DNA to catalyze the formation of a hydrogel, achieving fast, high sensitivity, and high specificity detection without the need for enzyme-based DNA amplification. The method allows rapid detection of single-base mismatches within 1 hour, and shows potential clinical applicability for key genes of drug-resistant pathogenic bacteria.
BIOSENSORS & BIOELECTRONICS
(2021)
Article
Chemistry, Multidisciplinary
Hsin-Yun Tsai, W. Russ Algar
Summary: Forster resonance energy transfer (FRET) is widely used for biological probes and sensors. Concentric FRET (cFRET) probes enable multiplexed sensing with a single vector. This study demonstrates that dendrimers labeled with a luminescent terbium complex (Tb) can be a viable alternative platform for cFRET probes. This dendrimer-based architecture shows the importance of cFRET for the development of a new generation of probes for biological sensing.
Article
Chemistry, Analytical
Weijie Wu, Xinyi Liu, Mengfei Shen, Lisong Shen, Xing Ke, Daxiang Cui, Wanwan Li
Summary: A novel multicolor quantum dot nanobead-based FLISA platform has been established for highly sensitive multiplexed detection of lung cancer tumor markers. The use of multicolor QDNBs as fluorescent labels enables high detection sensitivity and construction of multiplexed fluorescent biosensors, showing potential for clinical applications.
SENSORS AND ACTUATORS B-CHEMICAL
(2021)
Article
Chemistry, Multidisciplinary
Xiaotong Fan, Shuli Wang, Xiao Yang, Chenming Zhong, Guolong Chen, Changzhi Yu, Yihang Chen, Tingzhu Wu, Hao-Chung Kuo, Yue Lin, Zhong Chen
Summary: This study proposes a bicomponent perovskite nanocomposite (BPNC) for color conversion layers in micro-light-emitting-diode (micro-LED) arrays, which significantly enhances the photoluminescence intensity through the built-in Forster resonance energy transfer (FRET) from the core CsPbBr3 to the shell gamma-CsPbI3. The FRET is conducted through a pair of combined quasi-degenerate energy levels in the blue spectra region, resulting in high excitation wavelength selectivity. The BPNC exhibits the brightest single-peak red photoluminescence with near 100% quantum yield and is adaptable to a wide range of emission wavelengths when used as color downconversion layers in a blue micro-LED array.
ADVANCED MATERIALS
(2023)
Article
Chemistry, Multidisciplinary
Hao Zhang, Parinaz Moazzezi, Juanjuan Ren, Brett Henderson, Cristina Cordoba, Vishal Yeddu, Arthur M. Blackburn, Makhsud Saidaminov, Irina Paci, Stephen Hughes, Reuven Gordon
Summary: Perovskite quantum dots (PQDs) show promise in various applications, including efficient solar cells, bright light emitting devices, and quantum sources of light. Researchers used double-nanohole optical trapping to size individual dots and observed the coupling between dots. The findings provide insights for in situ control of PQD growth and studies of their coupling with quantum information applications in mind.
Article
Engineering, Biomedical
Jae Chul Park, Hyebin Na, Saehan Choi, Huiju Jeon, Yoon Sung Nam
Summary: A simple method for miRNA assay is presented, which is based on the one-pot self-assembly of Y-shaped DNAs with streptavidin via an miRNA-catalyzed TMSD cascade reaction. This method incorporates a single base-pair mismatch to facilitate RNA-triggered strand displacement while minimally disturbing nonspecific reactions. The detection limit is significantly reduced from the nanomolar level to the picomolar level.
ADVANCED HEALTHCARE MATERIALS
(2023)
Article
Chemistry, Analytical
Xiuli Fu, Hao Lin, Ji Qi, Fengling Li, Yan Chen, Bowei Li, Lingxin Chen
Summary: A paper-based colorimetric sensor functionalized with tetrahedral DNA nanostructure (TDN) was developed for ultrasensitive analysis of mercury ion (Hg2+). The sensor exhibited high capture efficiency and low detection limit, and was successfully applied in real water samples.
SENSORS AND ACTUATORS B-CHEMICAL
(2022)
Article
Chemistry, Analytical
Chen-chen Li, Yue-hong Dong, Xiaoran Zou, Xiliang Luo, Dazhong Shen, Juan Hu, Chun-yang Zhang
Summary: A label-free and template-free chemiluminescent biosensor, termed hmC-GLIB-IAS, has been developed for sensitive detection of 5hmC in genomic DNA. This method shows advantages of bisulfite-free, improved sensitivity, and genome-wide analysis of 5hmC at constant reaction temperature. It can detect 5hmC with a high reproducibility and accuracy without isotope-labeled substrates or specific antibodies.
ANALYTICAL CHEMISTRY
(2021)
Article
Chemistry, Analytical
Junjie Zhang, Xianwei Su, Ao Qi, Lulu Liu, Lijian Zhang, Yu Zhong, Simin Xu, Ximei Liu, Juan Hu, Yusen Chen, Chun-yang Zhang, Chun Cai
Summary: The study developed a targeted metabolomic method to identify potential biomarkers for differentiating healthy individuals, AIS patients, and ICH patients, with 20-OH-LTB4 and CYP4F2 identified as potential biomarkers for ICH diagnosis and risk assessment. The method may provide a powerful platform for ICH diagnosis, prevention, and treatment assessment.
Article
Chemistry, Analytical
Juan Hu, Li-yuan Pan, Yueying Li, Xiaoran Zou, Bing-jie Liu, BingHua Jiang, Chun-yang Zhang
Summary: This study demonstrates the sensitive detection of SIRT1 using a single quantum dot (QD)-based nanosensor, which can be used for enzyme kinetic parameter measurement and SIRT1 inhibitor screening.
Article
Chemistry, Analytical
Juan Hu, Wen Liu, Jufeng Wang, Jian-Ge Qiu, Chun-yang Zhang
Summary: A simple mix-and-read assay was developed for the sensitive detection of DNA glycosylase using multiple cyclic enzymatic repairing amplification, enabling rapid measurement of hOGG1 without the need for extra primers, and applicable for clinical diagnosis and drug discovery.
ANALYTICAL CHEMISTRY
(2021)
Article
Chemistry, Analytical
Xue-ru Wei, Yingying Meng, Qinfeng Xu, Juan Hu, Chun-yang Zhang
Summary: This article presents a label-free and homogeneous detection method for FEN1 based on ligation-promoted hyperbranched rolling circle amplification. The method allows isothermal detection of FEN1 activity and exhibits good specificity and high sensitivity. It can be used for screening FEN1 inhibitors and quantifying FEN1 activity in human cancer cells, with potential applications in early diagnosis and drug discovery.
Article
Chemistry, Analytical
Zi-yue Wang, Huimin Yuan, Dong-ling Li, Juan Hu, Jian-Ge Qiu, Chun-yang Zhang
Summary: In this study, a ligation-mediated nanosensor was developed for sensitive quantification of 5hmC modification in cancer cells. The nanosensor showed excellent specificity and high amplification efficiency, and could detect as low as 0.001% 5hmC DNA in complex mixtures. It also had the ability to monitor cellular 5hmC level and distinguish cancer cells from normal cells.
ANALYTICAL CHEMISTRY
(2022)
Article
Chemistry, Analytical
Shu-hua Wei, Meng Liu, Juan Hu, Chun-yang Zhang
Summary: A label-free fluorescent biosensor is developed for ultrasensitive analysis of circRNAs. The biosensor shows high sensitivity, specificity, and structural stability, and can accurately identify the levels of circRNA in human serum and cancer cells. This has significant implications for the diagnosis and treatment of circRNA-related cancers.
ANALYTICAL CHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Shuangshuang Zhang, Jin-an Hou, Juan Hu, Chun-yang Zhang
Summary: This study presents the in situ self-catalyzed growth of manganese-embedded 3D flakes-coated carbon rods as an efficient oxygen-reduction reaction (ORR) catalyst in Zinc-air batteries. The optimized precursor with a certain amount of Mn allows the synthesis of 3D graphene-like flakes-coated carbon rods. The resulting catalyst exhibits excellent ORR performance due to its unique hierarchical porous structure, high-charge transport capacity, abundant carbon defects/edges, and Mn-N-x sites.
CHEMISTRY-A EUROPEAN JOURNAL
(2023)
Article
Chemistry, Analytical
Su Jiang, Qian Liu, Juan Hu, Dong Yuan, Yan Zhang, Chun-yang Zhang
Summary: In this study, a novel method was developed for sensitive detection of miRNA in lung tissues by target-triggered assembly of G-quadruplex DNAzyme nanowires. This method exhibited high sensitivity, a large dynamic range, and the ability to distinguish single-base mutations, holding promising applications in biomedical analysis and cancer prognosis.
SENSORS AND ACTUATORS B-CHEMICAL
(2022)
Article
Chemistry, Analytical
Lin Cui, Chen-yu Zhu, Juan Hu, Xiao-meng Meng, Mengmeng Jiang, Wenqiang Gao, Xiaolei Wang, Chun-yang Zhang
Summary: A dual-mode biosensor based on fully-pi conjugated covalent organic framework (COF) and cobalt oxyhydroxide (CoOOH) nanoflakes is demonstrated for electrochemiluminescent (ECL) and electrochemical sensing of alkaline phosphatase (ALP). This dual-mode biosensor can efficiently eliminate errors and provide more reliability and accuracy than a single-mode biosensor.
SENSORS AND ACTUATORS B-CHEMICAL
(2023)
Article
Chemistry, Analytical
Xiao-wen Liu, Wen-jing Liu, Yingying Meng, Juan Hu, Chun -yang Zhang
Summary: In this study, a label-free method for sensitive detection of PNK activity in cancer cells was developed. By utilizing a tandem signal amplification strategy, the detection signal was amplified through a ligation reaction activated by PNK. This method showed improved specificity and sensitivity due to the effective phosphorylation of the hairpin probe by target PNK. Additionally, it enabled accurate measurement of endogenous PNK activity at the single-cell level and facilitated PNK-related clinical diagnosis and drug discovery.
Article
Engineering, Environmental
Ming-hao Liu, Feng-zheng Li, Wen-jing Liu, Juan Hu, Meng Liu, Chun -Yang Zhang
Summary: A ultrasensitive chemiluminescent biosensor was developed for rapid detection of PARP-1 in human breast tissues. The biosensor combines PARP-1-directed hyperbranched poly(ADP-ribose) formation with alkaline phosphatase-mediated chemiluminescence system. It offers high sensitivity, accuracy, and potential applications in cancer diagnosis and biomedical research.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Chemistry, Analytical
Jin-zhi Zhang, Ning-ning Zhao, Zi-yue Wang, Juan Hu, Chun-yang Zhang
Summary: A target-activated T7 transcription circuit-mediated multiple cycling signal amplification platform has been developed for monitoring FEN1 activity in cancer cells. This method exhibits good specificity and high sensitivity, and can be applied for the screening of FEN1 inhibitors and the monitoring of FEN1 activity in human cells, showing great potential in drug discovery and clinical diagnosis.
Article
Chemistry, Analytical
Zi-yue Wang, Huimin Yuan, Dong-ling Li, Juan Hu, Jian-Ge Qiu, Chun-yang Zhang
Summary: This study develops a nanosensor for quantification of 5hmC modification in cancer cells, which shows high specificity and amplification efficiency.
ANALYTICAL CHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Wen-jing Liu, Xinyi Zhang, Juan Hu, Chun-yang Zhang
Summary: A label-free and self-circulated fluorescent biosensor has been developed for the sensitive detection of TET1 activity in cancer cells. This biosensor demonstrates good specificity and high sensitivity without the need for antibodies or exogenous primers, enabling accurate quantification of TET1 activity at the single-cell level. Additionally, it can be used for measuring kinetic parameters and screening inhibitors.
CHEMICAL COMMUNICATIONS
(2022)
