Development of a High-Throughput Cytometric Screen to Identify Anti-Wolbachia Compounds: The Power of Public–Private Partnership

AWZ1066S, a highly specific anti-Wolbachia drug candidate for a short-course treatment of filariasis

(2019) W. David Hong et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Single dose moxidectin versus ivermectin for Onchocerca volvulus infection in Ghana, Liberia, and the Democratic Republic of the Congo: a randomised, controlled, double-blind phase 3 trial

(2018) Nicholas O Opoku et al.   LANCET

Challenges and recent progress in drug discovery for tropical diseases

(2018) Manu De Rycker et al.   NATURE

Industrial scale high-throughput screening delivers multiple fast acting macrofilaricides

(2018) Rachel H. Clare et al.   Nature Communications

Therapeutic Efficacy and Macrofilaricidal Activity of Doxycycline for the Treatment of River Blindness

(2014) Martin Walker et al.   CLINICAL INFECTIOUS DISEASES

Wolbachia endosymbionts and human disease control

(2014) Barton E. Slatko et al.   MOLECULAR AND BIOCHEMICAL PARASITOLOGY

Modelling the impact of ivermectin on River Blindness and its burden of morbidity and mortality in African Savannah: EpiOncho projections

(2014) Hugo C Turner et al.   Parasites & Vectors

The role of modern drug discovery in the fight against neglected and tropical diseases

(2014) Jeremy N. Burrows et al.   MedChemComm

Repurposing drugs for the treatment and control of helminth infections

(2014) Gordana Panic et al.   International Journal for Parasitology-Drugs and Drug Resistance

Repurposing of approved drugs from the human pharmacopoeia to target Wolbachia endosymbionts of onchocerciasis and lymphatic filariasis

(2014) Kelly L. Johnston et al.   International Journal for Parasitology-Drugs and Drug Resistance

European Lead Factory opens for business

(2013) Asher Mullard   NATURE REVIEWS DRUG DISCOVERY

Anti-Wolbachia drug discovery and development: safe macrofilaricides for onchocerciasis and lymphatic filariasis

(2013) MARK J. TAYLOR et al.   PARASITOLOGY

Wolbachiafilarial interactions

(2012) Mark J. Taylor et al.   CELLULAR MICROBIOLOGY

Retarded Onchocerca volvulus L1 to L3 larval development in the Simulium damnosum vector after anti-wolbachial treatment of the human host

(2012) Anna Albers et al.   Parasites & Vectors

Apparent activity in high-throughput screening: origins of compound-dependent assay interference

(2010) Natasha Thorne et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Grants4Targets – an innovative approach to translate ideas from basic research into novel drugs

(2010) Monika Lessl et al.   DRUG DISCOVERY TODAY

Lipoprotein biosynthesis as a target for anti-Wolbachia treatment of filarial nematodes

(2010) Kelly L Johnston et al.   Parasites & Vectors

The Wolbachia endosymbiont as an anti-filarial nematode target

(2010) Barton E. Slatko et al.   SYMBIOSIS

Macrofilaricidal Activity after Doxycycline Only Treatment of Onchocerca volvulus in an Area of Loa loa Co-Endemicity: A Randomized Controlled Trial

(2010) Joseph D. Turner et al.   PLoS Neglected Tropical Diseases

WolbachiaLipoprotein Stimulates Innate and Adaptive Immunity through Toll-like Receptors 2 and 6 to Induce Disease Manifestations of Filariasis

(2009) Joseph D. Turner et al.   JOURNAL OF BIOLOGICAL CHEMISTRY