Advanced Evolution of Pathogenesis Concepts in Cardiomyopathies

Altered force generation and cell-to-cell contractile imbalance in hypertrophic cardiomyopathy

(2019) Theresia Kraft et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Hereditary heart disease: pathophysiology, clinical presentation, and animal models of HCM, RCM, and DCM associated with mutations in cardiac myosin light chains

(2019) Sunil Yadav et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Current Mechanistic Concepts in Ischemia and Reperfusion Injury

(2018) Meng-Yu Wu et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

ClinGen’s RASopathy Expert Panel consensus methods for variant interpretation

(2018) Bruce D Gelb et al.   GENETICS IN MEDICINE

New Insights into the Immune Molecular Regulation of the Pathogenesis of Acute Respiratory Distress Syndrome

(2018) Chin-Yao Yang et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The Genetic and Molecular Bases for Hypertrophic Cardiomyopathy: The Role for Calcium Sensitization

(2018) Xianfeng Ren et al.   JOURNAL OF CARDIOTHORACIC AND VASCULAR ANESTHESIA

Spectrum of Restrictive and Infiltrative Cardiomyopathies

(2018) Naveen L. Pereira et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Spectrum of Restrictive and Infiltrative Cardiomyopathies

(2018) Naveen L. Pereira et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Prevalence of clinically apparent hypertrophic cardiomyopathy in Germany—An analysis of over 5 million patients

(2018) Daniela Husser et al.   PLoS One

Cardiomyopathies and Related Changes in Contractility of Human Heart Muscle

(2018) Petr Vikhorev et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Genetics of Dilated Cardiomyopathy

(2018) Yiwen Fu et al.   Current Cardiology Reports

Arrhythmic Genotypes in Familial Dilated Cardiomyopathy: Implications for Genetic Testing and Clinical Management

(2018) Stacey Peters et al.   Heart Lung and Circulation

The continuing evolution of cardiac troponin I biomarker analysis: from protein to proteoform

(2017) Daniel Soetkamp et al.   Expert Review of Proteomics

Molecular and clinical spectra of FBXL4 deficiency

(2017) Ayman W. El-Hattab et al.   HUMAN MUTATION

New Insights into the Role of Inflammation in the Pathogenesis of Atherosclerosis

(2017) Meng-Yu Wu et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Role of titin in cardiomyopathy: from DNA variants to patient stratification

(2017) James S. Ware et al.   Nature Reviews Cardiology

Current insights into LMNA cardiomyopathies: Existing models and missing LINCs

(2017) Daniel Brayson et al.   Nucleus

Current insights into LMNA cardiomyopathies: Existing models and missing LINCs

(2017) Daniel Brayson et al.   Nucleus

Hypertrophic Cardiomyopathy—Past, Present and Future

(2017) Alphonsus Liew et al.   Journal of Clinical Medicine

Pathophysiology and prevention of sudden cardiac death

(2016) Vineet Goyal et al.   CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY

Contractile Dysfunction in Sarcomeric Hypertrophic Cardiomyopathy

(2016) David H. MacIver et al.   JOURNAL OF CARDIAC FAILURE

Obstructive Form of Hypertrophic Cardiomyopathy-Left Ventricular Outflow Tract Gradient: Novel Methods of Provocation, Monitoring of Biomarkers, and Recent Advances in the Treatment

(2016) Pawel Petkow Dimitrow et al.   Biomed Research International

Genetic Spectrum of Idiopathic Restrictive Cardiomyopathy Uncovered by Next-Generation Sequencing

(2016) Anna Kostareva et al.   PLoS One

The Genetic Landscape of Cardiomyopathy and Its Role in Heart Failure

(2015) Elizabeth M. McNally et al.   Cell Metabolism

Traditional vs. genetic pathogenesis of arrhythmogenic right ventricular cardiomyopathy

(2015) Dongdong Que et al.   EUROPACE

Clinical diabetic cardiomyopathy: a two-faced disease with restrictive and dilated phenotypes

(2015) Petar M. Seferović et al.   EUROPEAN HEART JOURNAL

Left ventricular non-compaction cardiomyopathy

(2015) Jeffrey A Towbin et al.   LANCET

Diagnosis, prevalence, and screening of familial dilated cardiomyopathy

(2015) Mary E Sweet et al.   Expert Opinion on Orphan Drugs

Enhanced Bioactive Myocardial Transforming Growth Factor-β in Advanced Human Heart Failure

(2014) Shaukat Khan et al.   CIRCULATION JOURNAL

Gigantic Business

(2014) Wolfgang A. Linke et al.   CIRCULATION RESEARCH

Prevalence and significance of rare RYR2 variants in arrhythmogenic right ventricular cardiomyopathy/dysplasia: Results of a systematic screening

(2014) Nathalie Roux-Buisson et al.   HEART RHYTHM

Hypertrophic Cardiomyopathy

(2014) Barry J. Maron et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

RAF1 mutations in childhood-onset dilated cardiomyopathy

(2014) Perundurai S Dhandapany et al.   NATURE GENETICS

Myofilament dysfunction as an emerging mechanism of volume overload heart failure

(2014) Kristin Wilson et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Titin kinase is an inactive pseudokinase scaffold that supports MuRF1 recruitment to the sarcomeric M-line

(2014) J. Bogomolovas et al.   Open Biology

Investigating the role of uncoupling of troponin I phosphorylation from changes in myofibrillar Ca2+-sensitivity in the pathogenesis of cardiomyopathy

(2014) Andrew E. Messer et al.   Frontiers in Physiology

Genetics and Genomics for the Prevention and Treatment of Cardiovascular Disease: Update

(2013) Santhi K. Ganesh et al.   CIRCULATION

Fkbp1a controls ventricular myocardium trabeculation and compaction by regulating endocardial Notch1 activity

(2013) H. Chen et al.   DEVELOPMENT

Recessive TTN truncating mutations define novel forms of core myopathy with heart disease

(2013) C. Chauveau et al.   HUMAN MOLECULAR GENETICS

A Gain-of-Function Mutation in the M-domain of Cardiac Myosin-binding Protein-C Increases Binding to Actin

(2013) Kristina L. Bezold et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A study of tropomyosin’s role in cardiac function and disease using thin-filament reconstituted myocardium

(2013) Fan Bai et al.   JOURNAL OF MUSCLE RESEARCH AND CELL MOTILITY

Genetics of Arrhythmogenic Right Ventricular Cardiomyopathy

(2013) Frank I. Marcus et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Exercise Increases Age-Related Penetrance and Arrhythmic Risk in Arrhythmogenic Right Ventricular Dysplasia/Cardiomyopathy–Associated Desmosomal Mutation Carriers

(2013) Cynthia A. James et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Phosphoproteome dynamics reveal novel ERK1/2 MAP kinase substrates with broad spectrum of functions

(2013) M. Courcelles et al.   Molecular Systems Biology

Hepatic mTORC2 Activates Glycolysis and Lipogenesis through Akt, Glucokinase, and SREBP1c

(2012) Asami Hagiwara et al.   Cell Metabolism

Understanding Cardiomyopathy Phenotypes Based on the Functional Impact of Mutations in the Myosin Motor

(2012) Jeffrey R. Moore et al.   CIRCULATION RESEARCH

Syndromic non-compaction of the left ventricle: associated chromosomal anomalies

(2012) MC Digilio et al.   CLINICAL GENETICS

Beyond the Cardiac Myofilament: Hypertrophic Cardiomyopathy- Associated Mutations in Genes that Encode Calcium-Handling Proteins

(2012) A. P. Landstrom et al.   CURRENT MOLECULAR MEDICINE

Disheveled mediated planar cell polarity signaling is required in the second heart field lineage for outflow tract morphogenesis

(2012) Tanvi Sinha et al.   DEVELOPMENTAL BIOLOGY

A Mutation inTNNC1-encoded Cardiac Troponin C, TNNC1-A31S, Predisposes to Hypertrophic Cardiomyopathy and Ventricular Fibrillation

(2012) Michelle S. Parvatiyar et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Barth syndrome in a female patient

(2012) Laure Cosson et al.   MOLECULAR GENETICS AND METABOLISM

Cardiac Sodium Channel Nav1.5 Mutations and Cardiac Arrhythmia

(2012) Weihua Song et al.   PEDIATRIC CARDIOLOGY

Diabetes, oxidative stress, molecular mechanism, and cardiovascular disease – an overview

(2012) Vaithinathan Selvaraju et al.   TOXICOLOGY MECHANISMS AND METHODS

Review and Metaanalysis of the Frequency of Familial Dilated Cardiomyopathy

(2011) Mario Petretta et al.   AMERICAN JOURNAL OF CARDIOLOGY

2011 ACCF/AHA Guideline for the Diagnosis and Treatment of Hypertrophic Cardiomyopathy: Executive Summary

(2011) et al.   CIRCULATION

FKBP12 Is a Critical Regulator of the Heart Rhythm and the Cardiac Voltage-Gated Sodium Current in Mice

(2011) Mitsunori Maruyama et al.   CIRCULATION RESEARCH

Sarcomere Gene Mutations in Isolated Left Ventricular Noncompaction Cardiomyopathy Do Not Predict Clinical Phenotype

(2011) Susanne Probst et al.   Circulation-Cardiovascular Genetics

Phosphoinositide-3 Kinase Signaling in Cardiac Hypertrophy and Heart Failure

(2011) Toshinori Aoyagi et al.   CURRENT PHARMACEUTICAL DESIGN

Diabetic Downregulation of Nrf2 Activity via ERK Contributes to Oxidative Stress-Induced Insulin Resistance in Cardiac Cells In Vitro and In Vivo

(2011) Y. Tan et al.   DIABETES

RAS signaling pathway mutations and hypertrophic cardiomyopathy: getting into and out of the thick of it

(2011) Bruce D. Gelb et al.   JOURNAL OF CLINICAL INVESTIGATION

Cytoskeletal protein kinases: titin and its relations in mechanosensing

(2011) Mathias Gautel   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Adenine Nucleotide Translocase 1 Deficiency Results in Dilated Cardiomyopathy With Defects in Myocardial Mechanics, Histopathological Alterations, and Activation of Apoptosis

(2011) Nupoor Narula et al.   JACC-Cardiovascular Imaging

PLN-encoded phospholamban mutation in a large cohort of hypertrophic cardiomyopathy cases: Summary of the literature and implications for genetic testing

(2010) Andrew P. Landstrom et al.   AMERICAN HEART JOURNAL

A Common MLP (Muscle LIM Protein) Variant Is Associated With Cardiomyopathy

(2010) Ralph Knöll et al.   CIRCULATION RESEARCH

The Importance of Genetic Counseling, DNA Diagnostics, and Cardiologic Family Screening in Left Ventricular Noncompaction Cardiomyopathy

(2010) Yvonne M. Hoedemaekers et al.   Circulation-Cardiovascular Genetics

The sarcomeric cytoskeleton: who picks up the strain?

(2010) Mathias Gautel   CURRENT OPINION IN CELL BIOLOGY

Apoptosis and fibrosis are early features of heart failure in an animal model of metabolic cardiomyopathy

(2010) Barbara Gürtl et al.   INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY

Cardiac Troponin Mutations and Restrictive Cardiomyopathy

(2010) Michelle S. Parvatiyar et al.   JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY

Roles of Titin in the Structure and Elasticity of the Sarcomere

(2010) Larissa Tskhovrebova et al.   JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY

Targeting GSK-3 family members in the heart: A very sharp double-edged sword

(2010) Hui Cheng et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Transforming growth factor (TGF)-β signaling in cardiac remodeling

(2010) Marcin Dobaczewski et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Binding of the N-terminal fragment C0–C2 of cardiac MyBP-C to cardiac F-actin

(2010) Robert W. Kensler et al.   JOURNAL OF STRUCTURAL BIOLOGY

Left ventricular noncompaction is associated with mutations in the mitochondrial genome

(2010) Sha Tang et al.   MITOCHONDRION

Molecular distinction between physiological and pathological cardiac hypertrophy: Experimental findings and therapeutic strategies

(2010) Bianca C. Bernardo et al.   PHARMACOLOGY & THERAPEUTICS

Left Ventricular Noncompaction: A New Form of Heart Failure

(2010) Jeffrey A. Towbin   Heart Failure Clinics

Cardiomyopathy: A Systematic Review of Disease-Causing Mutations in Myosin Heavy Chain 7 and Their Phenotypic Manifestations

(2009) R. Walsh et al.   CARDIOLOGY

Cardiac Myosin-Binding Protein C Mutations and Hypertrophic Cardiomyopathy

(2009) Sabine J. van Dijk et al.   CIRCULATION

The role of Akt/GSK-3β signaling in familial hypertrophic cardiomyopathy

(2009) Stephen W. Luckey et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Phosphorylation and function of cardiac myosin binding protein-C in health and disease

(2009) David Barefield et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

The Development and Structure of the Ventricles in the Human Heart

(2009) Deborah J. Henderson et al.   PEDIATRIC CARDIOLOGY

Non–Cell-Autonomous Roles for the Planar Cell Polarity Gene Vangl2 in Development of the Coronary Circulation

(2008) Helen M. Phillips et al.   CIRCULATION RESEARCH

Idiopathic restrictive cardiomyopathy in children is caused by mutations in cardiac sarcomere protein genes

(2008) J P Kaski et al.   HEART

Mechanoenzymatics of titin kinase

(2008) E. M. Puchner et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA